General

 

 

Ahmad, K. (2005). Increased Asian collaboration in fight against avian flu. Lancet Infectious Diseases 5(1): 9.  ISSN: 1473-3099.

            Descriptors:  influenza, avian prevention and control, international cooperation, southeastern Asia, birds, influenza, avian mortality.

Al Natour, M.Q. and M.N. Abo Shehada (2005). Sero-prevalence of avian influenza among broiler-breeder flocks in Jordan. Preventive Veterinary Medicine 70(1-2): 45-50.

            NAL Call Number:  SF601.P7

            Abstract:  Thirty blood samples were collected randomly from each of the 38 breeder-broiler farms in Jordan. Serum samples were examined using indirect ELISA for specific antibodies to avian influenza virus. The overall true flock-level sero-prevalence of avian influenza was 71% (95% CI: 55,83). Positive flocks had 2-30 sero-positive chickens and half of flocks had >20 sero-positive birds. The number of sero-positive flocks varied in the studied localities with more sero-positives in farms located within the migratory route of migratory wild fowl. The examined broiler-breeder flocks had no clinical signs, or noticeable decrease in egg production; mortalities were within the normal range (0.1-1%). The number of positive sera/flock correlated with flock size. There were a no significant (Pearsons r = 0.21, p = 0.21) correlation between positive flocks and age. A non-pathogenic AI virus infects broiler-breeder farms in Jordan. Wild local and migrating birds might promote the further spread of this virus in Jordan and other countries.

            Descriptors:  avian influenza, poultry, viral diseases, broiler-breeder, ELISA, age influence, Jordan.

Alexander, D.J. (1998). Avian influenza ecology: a brief review. Fish Veterinary Journal (United Kingdom) (3): 74-78.

            Descriptors:  fishes, fish diseases, avian influenza virus, etiology, salmonoidei, animal diseases, bony fishes, influenza virus, orthomyxoviridae, viruses, salmonidae.

Alexander, D.J. (1982). Avian influenza--recent developments. Veterinary Bulletin 52(6): 341-359.  ISSN: 0042-4854.

            NAL Call Number:  41.8 T752

            Descriptors:  recent developments, avian influenza virus, turkeys, ducks.

Alexander, D.J. (1981). Current situation of avian influenza in poultry in Great Britain. In: Proceedings of the First International Symposium on Avian Influenza, Beltsville, Maryland, USA, p. 35-45.

            NAL Call Number: aSF995.6.I6I5 1981a

            Descriptors: avian influenza virus, poultry, ducks, turkeys, Great Britain.

Alexander, D.J. (2000). The history of avian influenza in poultry. World Poultry (Special): 7-8.  ISSN: 1388-3119.

            NAL Call Number:  SF481.M54

            Descriptors:  avian influenza virus, poultry, Gallus gallus, outbreaks, disease transmission, history.

Alexander, D.J. (1988). Influenza A isolations from exotic caged birds. Veterinary Record 123(17): 442.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  birds microbiology, fowl plague epidemiology, influenza A virus avian isolation and purification, England, fowl plague microbiology, quarantine.

Alexander, D.J. (1998). Influenza aviare. Epidemiologia ed attuale situazione mondiale. [Avian influenza. Epidemiology and present world situation]. Selezione Veterinaria (Italy) (12): 935-951.

            NAL Call Number:  241.71 B75

            Descriptors:  aviary birds, avian influenza virus, epidemiology, etiology, viroses, animal diseases, pathogenicity, disease transmission, zoonoses, human diseases, wild animals, chickens, turkeys, ducks, ostriches, pheasants, geese, guinea fowl, quails, world, Anseriformes, biological properties, birds, domestic animals, Galliformes, infectious diseases, influenza virus, livestock, microbial properties, orthomyxoviridae, pathogenesis, poultry, Struthioniformes, useful animals, viruses, wildlife.

Alexander, D.J. (1982). Isolation of influenza A viruses from birds in Great Britain during 1980 and 1981. Veterinary Record 111(14): 319-21.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Abstract:  During 1980 and 1981 influenza A viruses of subtypes H3N2, H3N8, H4N1, H4N6, H6N2, H6N8, H7N7, H11N8 and H11N9 were isolated from birds in Great Britain, usually as a result of investigations of disease or death. However, all viruses were shown to be of low virulence for chickens in pathogenicity index tests. There was one occurrence of influenza virus infection of turkeys (H6N8) but viruses were frequently obtained from domestic ducks. Other viruses were isolated from exotic birds in zoos or bird collections.

            Descriptors:  birds microbiology, influenza A virus avian isolation and purification, animals, zoo microbiology, antibodies, viral analysis, chickens, Great Britain, hemagglutination inhibition tests veterinary, immunodiffusion veterinary, avian immunology, avian pathogenicity, poultry microbiology.

Alexander, D.J. (1981). Isolation of influenza A viruses from exotic birds in Great Britain. In: Proceedings of the First International Symposium on Avian Influenza, Beltsville, Maryland, USA, p. 79-92.

            NAL Call Number: aSF995.6.I6I5 1981a

            Descriptors: avian influenza virus, isolation of influenza A virus, aviary birds, exotic birds, Great Britain.

Alexander, D.J. (1980). Isolation of influenza viruses from avian species in Great Britain. Comparative Immunology, Microbiology and Infectious Diseases 3(1-2): 165-70.  ISSN: 0147-9571.

            NAL Call Number:  QR180.C62

            Descriptors:  birds microbiology, influenza A virus avian isolation and purification, influenza A virus isolation and purification, turkeys microbiology, Great Britain, avian classification, influenza A virus classification, serotyping.

Alexander, D.J. (2002). Keynote: Newcastle disease and avian influenza. Research in Veterinary Science 72(Suppl. A): 15.  ISSN: 0034-5288.

            NAL Call Number:  41.8 R312

            Descriptors:  infection, Newcastle disease, viral disease, influenza virus A infection, viral disease, influenza virus B infection, viral disease, influenza virus C infection, viral disease, mortality, virulence, meeting abstract.

Alexander, D.J. (1989). New definitions for avian influenza viruses requiring intervention by governments. Implications to the situation in Great Britain. State Veterinary Journal (United Kingdom) 43(123): 172-187.  ISSN: 0269-5545.

            NAL Call Number:  SF601.S8

            Descriptors:  avian influenza virus, transmission, poultry,  wild birds, Great Britain, laws.

Alexander, D.J. (1996). Orthomyxoviridae (avian influenza). In: F.T.W.  Jordan and M. Pattison (editors), Poultry Diseases, 4th edition,  London, UK, p. 156-165. ISBN: 0-7020-1912-7.

            NAL Call Number:  SF995.P65 1996

            Descriptors:  avian influenza virus, epidemiology, diagnosis, control, immunization, poultry diseases.

Alexander, D.J. (2000). A review of avian influenza in different bird species. Veterinary Microbiology 74(1-2): 3-13.  ISSN: 0378-1135.

            NAL Call Number:  SF601.V44

            Abstract:  Only type A influenza viruses are known to cause natural infections in birds, but viruses of all 15 hemagglutinin and all nine neuraminidase influenza A subtypes in the majority of possible combinations have been isolated from avian species. Influenza A viruses infecting poultry can be divided into two distinct groups on the basis of their ability to cause disease. The very virulent viruses cause highly pathogenic avian influenza (HPAI), in which mortality may be as high as 100%. These viruses have been restricted to subtypes H5 and H7, although not all viruses of these subtypes cause HPAI. All other viruses cause a much milder, primarily respiratory disease, which may be exacerbated by other infections or environmental conditions. Since 1959, primary outbreaks of HPAI in poultry have been reported 17 times (eight since 1990), five in turkeys and 12 in chickens. HPAI viruses are rarely isolated from wild birds, but extremely high isolation rates of viruses of low virulence for poultry have been recorded in surveillance studies, giving overall figures of about 15% for ducks and geese and around 2% for all other species. Influenza viruses have been shown to affect all types of domestic or captive birds in all areas of the world, but the frequency with which primary infections occur in any type of bird depends on the degree of contact there is with feral birds. Secondary spread is usually associated with human involvement, probably by transferring infective faeces from infected to susceptible birds.

            Descriptors:  influenza A virus avian isolation and purification, amino acid sequence, ducks virology, Great Britain, avian pathogenicity, molecular sequence data, turkeys virology.

Alexander, D.J. (2000). The role of the international reference laboratory. World Poultry (Special): 15-16.  ISSN: 1388-3119.

            NAL Call Number:  SF481.M54

            Descriptors:  international reference laboratory, diagnosis, avian influenza virus, poultry.

Alexander, D.J. (2003). Should we change the definition of avian influenza for eradication purposes? Avian Diseases 47(Special Issue): 976-981.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  The current definitions of high-pathogenicity avian influenza (HPAI), formulated over 10 years ago, were aimed at including viruses that were overtly virulent in in vivo tests and those that had the potential to become virulent. At that time the only virus known to have mutated to virulence was the one responsible for the 1983-84 Pennsylvania epizootic. The mechanism involved has not been seen in other viruses, but the definition set a precedent for statutory control of potentially pathogenic as well as overtly virulent viruses. The accumulating evidence is that HPAI viruses arise from low-pathogenicity avian influenza (LPAI) H5 or H7 viruses infecting chickens and turkeys after spread from free-living birds. At present it can only be assumed that all H5 and H7 viruses have this potential and mutation to virulence is a random event. Therefore, the longer the presence and greater the spread in poultry the more likely it is that HPAI virus will emerge. The outbreaks in Pennsylvania, Mexico, and Italy are demonstrations of the consequences of failing to control the spread of LPAI viruses of H5 and H7 subtypes. It therefore seems desirable to control LPAI viruses of H5 and H7 subtype in poultry to limit the probability of a mutation to HPAI occurring. This in turn may require redefining statutory AI. There appear to be three options: 1) retain the current definition with a recommendation that countries impose restrictions to limit the spread of LPAI of H5 and H7 subtypes; 2) define statutory AI as an infection of birds/poultry with any AI virus of H5 or H7 subtype; 3) define statutory AI as any infection with AI virus of H5 or H7 subtype, but modify the control measures imposed for different categories of virus and/or different types of host.

            Descriptors:  epidemiology, infection, avian influenza, infectious disease, prevention and control, respiratory system disease, viral disease, disease eradication, epizootics, viral virulence.

Alexander, D.J. and W.H. Allan (1982). Avian influenza in turkeys: a survey of farms in eastern England, 1979/80. British Veterinary Journal 138(6): 473-9.  ISSN: 0007-1935.

            NAL Call Number:  41.8 V643

            Descriptors:  fowl plague epidemiology, poultry diseases epidemiology, turkeys, England, influenza A virus avian isolation and purification.

Alexander, D.J., M.S. Collins, and R.E. Gough (1980). Isolation of an influenza A virus from avian faeces samples collected at a London reservoir.  Veterinary Record 107(2): 41-2.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  birds microbiology, feces microbiology, influenza A virus avian isolation and purification, water supply, antigens, viral analysis, avian immunology, London, water pollution.

Alexander, D.J. and R.E. Gough (1986). Isolations of avian influenza virus from birds in Great Britain. Veterinary Record 118(19): 537-8.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  birds microbiology, influenza A virus avian isolation and purification, chickens microbiology, ducks microbiology, Great Britain,  turkeys microbiology.

Alexander, D.J. and J.C. Stuart (1982). Isolation of an influenza A virus from domestic fowl in Great Britain. Veterinary Record 111(18): 416.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  chickens microbiology, fowl plague microbiology, influenza A virus avian isolation and purification, antibodies, viral analysis, chickens immunology, Great Britain, avian immunology.

Alfonso, C.P., B.S. Cowen, and H. Van Campen (1995). Influenza A viruses isolated from waterfowl in two wildlife management area of Pennsylvania. Journal of Wildlife Diseases 31(2): 179-185.  ISSN: 0090-3558.

            NAL Call Number:  41.9 W64B

            Abstract:  A survey was conducted at two wildlife management areas of Pennsylvania (USA) to evaluate an antigen capture enzyme-linked immunosorbent assay (AC-ELISA) for the detection of avian influenza viruses (AIV) in cloacal swabs from waterfowl and to determine the influenza A virus subtypes and the distribution of these viruses among waterfowl. We collected 330 cloacal swabs from hunter-killed waterfowl in the fall of 1990 and from cage-captured waterfowl in the summer of 1991. Thirty-one hemagglutinating agents were isolated by chicken embryo inoculation (CEI) of which 27 were influenza A viruses and four Newcastle disease viruses (NDV). The prevalence of AIV infection was 8.2%. Compared to CEI, AC-ELISA was only 15% sensitive and 61% specific. Based on the distribution of AIV by species of waterfowl, mallards (Anas platyrhynchos) and American wigeons (Anas americana) were at equal risk of AIV infection even though most of the AIV isolates came from mallards. Although significant crude effects of sampling site and season on AIV recovery could be established, juvenile age was identified as the primary risk factor of AIV recovery. Twelve AIV subtypes were identified by hemagglutination inhibition (HI) and neuraminidase inhibition (NI) tests. The most prevalent subytpes were H4N8 and H6N8. We concluded that AC-ELISA was not useful for the detection of AIV in cloacal swabs from waterfowl and that CEI, HI, and NI tests remain as the method of choice for AIV screening in waterfowl. Based on the results AIV infected preferentially the young which represent the high risk group in waterfowl populations. The results from the AIV subtyping in our waterfowl survey are consistent with the results from numerous longitudinal studies of waterfowl in North America.

            Descriptors:  ecology, enzymology, immune system, infection, pathology, veterinary medicine, wildlife management, ELISA, epidemiology.

Allan, W.H. (1981). Uncomplicated infection with virulent strains of avian influenza viruses. In: Proceedings of the First International Symposium on Avian Influenza, Beltsville, Maryland, USA, 4-7 p.

            NAL Call Number: aSF995.6.I6I5 1981a

            Descriptors: avian influenza virus, infection, virulence.

Almeida, J.D. and A.P. Waterson (1967). Some observations on the envelope of an influenza virus. Journal of General Microbiology 46(1): 107-10.  ISSN: 0022-1287.

            NAL Call Number:  448.3 J823

            Descriptors:  influenza A virus avian, lipoproteins analysis, microscopy, electron, viral proteins analysis.

Almond, J.W. (1977). A single gene determines the host range of influenza virus. Nature 270(5638): 617-8.  ISSN: 0028-0836.

            NAL Call Number:  472 N21

            Descriptors:  genes viral, influenza A virus avian genetics, virus replication, cell line, DNA directed RNA polymerases genetics, DNA directed RNA polymerases metabolism, avian physiology, RNA viral genetics, viral proteins genetics, viral proteins physiology.

Amin, A., M.A. Shalaby, and I.Z. Imam (1980). Studies on influenza virus isolated from migrating birds in Egypt. Comparative Immunology, Microbiology and Infectious Diseases 3(1-2): 241-6.  ISSN: 0147-9571.

            NAL Call Number:  QR180.C62

            Descriptors:  birds microbiology, influenza A virus avian isolation and purification, antigens, viral analysis, Egypt, avian classification, avian immunology, serotyping.

Anderson, R.E. (1981). Economic impact of avian influenza in domestic fowl on international trade. Feedstuffs 53(32) ISSN: 0014-9624.

            NAL Call Number:  286.81 F322

            Descriptors:  economic impact, avian influenza virus, disease control, international trade, domestic fowl.

Andral, B., C. Louzis, D. Trap, J.A. Newman, G. Bennejean, and R. Gaumont (1985). Respiratory disease (rhinotracheitis) in turkeys in Brittany, France, 1981-1982. I. Field observations and serology. Avian Diseases 29(1): 26-34.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  During the summer of 1981, a respiratory disease epidemic occurred in turkeys in Brittany, France. Since this initial epizootic, which lasted through fall, epizootic waves similar to the initial one have occurred at approximately 6-month intervals, with smaller peaks at 2-month intervals. The epidemiology, clinical signs, and postmortem findings were highly suggestive of an epizootic of chlamydiosis. Serological tests for chlamydia, paramyxoviruses, avian influenza, adenovirus 127, Mycoplasma, and Alcaligenes faecalis were conducted. The chlamydia tests were the only ones consistently positive.

            Descriptors:  disease outbreaks veterinary, poultry diseases epidemiology, respiratory tract infections veterinary, rhinitis veterinary, tracheitis veterinary, turkeys, antibodies, bacterial analysis, chlamydia immunology, complement fixation tests veterinary, France, poultry diseases immunology, respiratory tract infections epidemiology, respiratory tract infections immunology, rhinitis epidemiology, rhinitis immunology, seasons, tracheitis epidemiology, tracheitis immunology.

Andresen, M. (2004). Avian flu: WHO prepares for the worst. CMAJ Canadian Medical Association Journal; Journal De L'Association Medicale Canadienne 170(5): 777.  ISSN: 0820-3946.

            NAL Call Number:  R11.C3

            Descriptors:  influenza A virus, avian influenza A virus, human, influenza, avian virology, birds, Canada, disease outbreaks, health plan implementation, influenza vaccines therapeutic use, avian influenza drug therapy, avian influenza prevention and control, poultry, World Health Organization.

Anonymous (2004). Avian influenza. Epidemiological Bulletin 25(1): 5-8.  ISSN: 0256-1859.

            Descriptors:  avian influenza virology, Asia, birds virology, influenza A virus, avian physiology, avian influenza prevention and control, avian influenza transmission.

Anonymous (2005). Avian influenza: perfect storm now gathering? Lancet 365(9462): 820.

            NAL Call Number:  448.8 L22

            Descriptors:  influenza prevention and control, avian influenza A virus immunology, influenza epidemiology, influenza transmission, influenza virology, influenza vaccines, avian influenza prevention and control, avian influenza transmission, international cooperation, poultry.

Anonymous (1998). Avian influenza results in depopulation in Hong Kong. Journal of the American Veterinary Medical Association 212(3): 331, 335.  ISSN: 0003-1488.

            NAL Call Number:  41.8 Am3

            Descriptors:  disease outbreaks, fowl plague transmission, influenza prevention and control, influenza A virus avian, zoonoses, Hong Kong epidemiology, influenza epidemiology.

Anonymous (2004). Avian influenza should be ruffling our feathers. Lancet Infectious Diseases 4(10): 595.  ISSN: 1473-3099.

            Descriptors:  antiviral agents therapeutic use, bird diseases epidemiology, disease outbreaks veterinary, influenza veterinary, influenza vaccines therapeutic use, acetamides therapeutic use, amantadine therapeutic use, southeastern Asia epidemiology, Far East epidemiology, influenza drug therapy, influenza epidemiology, influenza prevention and control, international cooperation, neuraminidase antagonists and inhibitors, rimantadine therapeutic use, sialic acids therapeutic use, World Health Organization.

Anonymous (2004). Avian influenza--the facts from the WHO. South African Medical Journal; Suid Afrikaanse Tydskrif Vir Geneeskunde 94(3): 158.  ISSN: 0256-9574.

            Descriptors:  influenza epidemiology, influenza A virus, avian isolation and purification, human isolation and purification, avian influenza epidemiology, birds, incidence, influenza prevention and control, avian influenza prevention and control, poultry, risk assessment, survival rate, World Health Organization.

Anonymous (2004). Avian influenza: the threat looms. Lancet 363(9405): 257.  ISSN: 1474-547X.

            NAL Call Number:  448.8 L22

            Descriptors:  fowl plague transmission, influenza A virus avian isolation and purification, Asia epidemiology, communicable diseases, emerging epidemiology, communicable diseases, emerging prevention and control, communicable diseases, emerging virology, disease outbreaks prevention and control, disease outbreaks statistics and numerical data, disease outbreaks veterinary, fowl plague epidemiology, fowl plague virology, Hong Kong epidemiology, avian pathogenicity, influenza vaccine supply and distribution, poultry virology, zoonoses transmission, zoonoses virology.

Anonymous (1993). Avian influenza virus in ratites: 1993. Foreign Animal Disease Report (21-4): 9-10.  ISSN: 0091-8199.

            NAL Call Number:  aSF601.U5

            Descriptors:  United States, emus, rheas, avian influenza virus, epidemiology, birds, ratites, North America, viruses, FAD report.

Anonymous (2004). China: towards "xiaokang", but still living dangerously. Lancet  363(9407): 409.  ISSN: 1474-547X.

            NAL Call Number:  448.8 L22

            Descriptors:  public health practice standards, social change, China epidemiology, communicable disease control standards, communicable disease control trends, disease outbreaks prevention and control, disease outbreaks statistics and numerical data, influenza, avian epidemiology, avian influenza prevention and control, population surveillance methods, poultry, severe acute respiratory syndrome epidemiology, severe acute respiratory syndrome prevention and control, world health.

Anonymous (2004). Fowl flu fuels fears. Nature Medicine 10(3): 211.  ISSN: 1078-8956.

            Descriptors:  chickens virology, influenza epidemiology, influenza virology, influenza A virus, avian immunology, influenza vaccines, influenza prevention and control, influenza, avian epidemiology, zoonoses epidemiology.

Anonymous (2004). Getting out into the field, and forest. Lancet Infectious Diseases 4(3): 127.  ISSN: 1473-3099.

            Descriptors:  disease outbreaks prevention and control, avian influenza transmission, poultry diseases transmission, vaccination, animals, domestic animals, wild birds, disease notification, avian influenza epidemiology, avian influenza prevention and control, poultry, poultry diseases epidemiology, poultry diseases prevention and control, zoonoses.

Anonymous (1997). Influenza A virus subtype H5N1 infection in humans. Communicable Disease Report. CDR Weekly 7(50): 441.  ISSN: 1350-9357.

            Descriptors:  fowl plague transmission, influenza epidemiology, influenza A virus avian classification, adolescent, bacterial typing techniques,  chickens, child, preschool, fowl plague epidemiology, Hong Kong epidemiology, incidence, avian isolation and purification, middle aged, survival rate.

Anonymous (1976). An outbreak of avian influenza in commercial chickens. Foreign Animal Disease Report : 2.

            NAL Call Number:  aSF601.U5

            Descriptors:  avian influenza, commercial chickens, report, outbreaks.

Anonymous (1998). Picture story. Fight the flu. Nature Structural Biology 5(12): 1032.  ISSN: 1072-8368.

            Descriptors:  hemagglutinin glycoproteins, influenza virus ultrastructure, influenza A virus avian genetics, avian pathogenicity, hydrogen-ion concentration, influenza genetics, influenza mortality, influenza virology, avian physiology, models, molecular, protein conformation, protein precursors ultrastructure.

Anonymous (1973). Report of the Subcommittee on Avian Influenza to the Committee on Transmissible Diseases of Poultry. Proceedings of the Annual Meeting of the United States Animal Health Association (77): 246-50.  ISSN: 0082-8750.

            NAL Call Number:  449.9 Un3r

            Descriptors:  bird diseases immunology, bird diseases microbiology, fowl plague immunology, fowl plague microbiology, antibodies, viral analysis, birds, ducks, geese, influenza A virus avian immunology, avian isolation and purification, pigeons, poultry diseases immunology, poultry diseases microbiology, quail, turkeys.

Anonymous (1998). Surveillance for avian influenza continues. Public Health Reports 113(3): 194.  ISSN: 0033-3549.

            NAL Call Number:  151.65 P96

            Descriptors:  influenza virology, influenza A virus avian isolation and purification, population surveillance, chickens virology, China, fowl plague virology, World Health Organization.

Anonymous (1998). Update: isolation of avian influenza A (H5N1) viruses from humans--Hong Kong, 1997-1998. MMWR. Morbidity and Mortality Weekly Report 46(52-53): 1245-7.  ISSN: 0149-2195.

            NAL Call Number:  RA407.3.M56

            Abstract:  As of January 6, 1998, a total of 16 confirmed and three suspected cases of human infection with avian influenza A (H5N1) viruses have been identified in Hong Kong. Confirmed cases are those from which an influenza A (H5N1) virus was isolated or in which a seroconversion to influenza A (H5N1) virus was detected by a neutralization assay. Suspected cases are those with influenza-like illness (ILI) and preliminary laboratory evidence of influenza A (H5N1) infection. This report summarizes interim findings from the ongoing epidemiologic and laboratory investigation of influenza A (H5N1) cases by health officials in Hong Kong and by CDC.

            Descriptors:  influenza epidemiology, influenza virology, influenza A virus avian isolation and purification, Hong Kong epidemiology, seroepidemiologic studies.

Anonymous (2004). World is ill-prepared for "inevitable" flu pandemic. Bulletin of the World Health Organization 82(4): 317-8.  ISSN: 0042-9686.

            NAL Call Number:  449.9 W892B

            Descriptors:  disease outbreaks prevention and control, influenza epidemiology, world health, Asia epidemiology, influenza prevention and control, influenza virology, influenza A virus, avian influenza pathogenicity, avian influenza epidemiology, avian influenza prevention and control, avian influenza virology, public health practice.

Anraku, M.M.C., W.C. de Faria, and D.C. Takeyama (1971). Influenza aviaria em aves silvestres brasileiras. I. Inquerito sorologico atraves de imunodifusao. [Avian influenza in wild Brazilian birds. I. Serological survey using the immunodiffusion test]. Revista Do Instituto De Medicina Tropical De Sao Paulo 13(4) ISSN: 0036-4665.

            NAL Call Number:  RC960.R48

            Descriptors:  avian influenza, wild birds, diseases, serological survey, birds.

Anraku, M.M.C., C.V.F. de Godoy, M. da G. R. Oscar, and W.C. de Faria (1977). Influenza aviaria em aves silvestres brasilieres. II. Distribucao mensal de surtos epizooticos, detectados por tecnicas serologicas di imunodifusao. [Avian influenza in wild birds of Brazil. II. Monthly distribution of epizootic outbreaks, detected by gel diffusion tests]. Revista Do Instituto De Medicina Tropical De Sao Paulo 19(4): 237-240.  ISSN: 0036-4665.

            NAL Call Number:  RC960.R48

            Descriptors:  outbreaks, detection, gel diffusion tests, avian influenza virus, wild birds, Brazil.

Anup Bhaumik, M.K. Saha, and K.R. Viswanathan ( 2001). Avian influenza infection in chickens. Pashudhan 16(9): 3, 7.

            NAL Call Number:  SF604.P27

            Descriptors:  avian influenza infection, diagnosis, transmission, chickens, Gallus gallus.

Apisarnthanarak, A., R. Kitphati, K. Thongphubeth, P. Patoomanunt, P. Anthanont, W. Auwanit, P. Thawatsupha, M. Chittaganpitch, S. Saeng Aroon, S. Waicharoen, P. Apisarnthanarak, G.A. Storch, L.M. Mundy, and V.J. Fraser (2004). Atypical avian influenza (H5N1). Emerging Infectious Diseases 10(7): 1321-4.  ISSN: 1080-6040.

            NAL Call Number:  RA648.5.E46

            Abstract:  We report the first case of avian influenza in a patient with fever and diarrhea but no respiratory symptoms. Avian influenza should be included in the differential diagnosis for patients with predominantly gastrointestinal symptoms, particularly if they have a history of exposure to poultry.

            Descriptors:  gastrointestinal diseases physiopathology, influenza physiopathology, influenza A virus, avian pathogenicity, adult, chickens virology, fatal outcome, gastrointestinal diseases virology, health personnel, influenza virology, influenza, avian transmission, influenza, avian virology, poultry diseases transmission, poultry diseases virology.

Artois, M., R. Manvell, E. Fromont, and J.B. Schweyer (2002). Serosurvey for Newcastle disease and avian influenza A virus antibodies in great cormorants from France. Journal of Wildlife Diseases 38(1): 169-71.  ISSN: 0090-3558.

            NAL Call Number:  41.9 W64B

            Abstract:  Inland great cormorants (Phalacrocorax carbo) culled in France were examined in the winter of 1997-98 and 1998-99 for antibodies to Newcastle disease (ND) and influenza A strains H5 and H7 by the hemagglutination inhibition test. Antibodies to influenza A group antigen were tested by agar gel precipitin test. Ten of 53 adult individuals were seropositive for ND virus. All sera were negative for influenza A antibodies. It is speculated that ND occurred in the sampled population.

            Descriptors:  antibodies, viral blood, fowl plague epidemiology, influenza A virus avian immunology, Newcastle disease epidemiology, Newcastle disease virus immunology, birds, fowl plague blood, fowl plague immunology, France epidemiology, hemagglutination inhibition tests veterinary, avian isolation and purification, Newcastle disease blood, Newcastle disease immunology, Newcastle disease virus isolation and purification, seroepidemiologic studies.

Astapovich, L.G., G.A. Ivanova, and S.B. Logginov (1968). Elektronnomikroskopicheskoe izuchenie shtammov virusa klassicheskoi chumy ptits. [An electron microscopic study of strains of the virus of classic fowl plague]. Veterinariia 45(9): 24-6.  ISSN: 0042-4846.

            NAL Call Number:  41.8 V6426

            Descriptors:  influenza A virus avian cytology, chick embryo, microscopy, electron.

Atwell, J.K. (1981). Regulatory problems associated with avian influenza. In: Proceedings of the First International Symposium on Avian Influenza, Beltsville, Maryland, USA, p. 211-213.

            NAL Call Number: aSF995.6.I6I5 1981a

            Descriptors: avian influenza virus, regulatory problems, disease control.

Austin, F.J. and V.S. Hinshaw (1984). The isolation of influenza A viruses and paramyxoviruses from feral ducks in New Zealand. Australian Journal of Experimental Biology and Medical Science 62(Pt. 3): 355-60.  ISSN: 0004-945X.

            NAL Call Number:  442.8 Au7

            Abstract:  Tracheal and cloacal swabs from apparently healthy ducks, gulls, shearwaters and terns in New Zealand were tested for myxoviruses by inoculation into embryonated eggs. Seven influenza A viruses belonging to three antigenic subtypes (H4N6; H1N3; H11N3) and nine paramyxoviruses of two antigenic subtypes (PMV-1; PMV-4) were isolated from feral ducks. The occurrence of the same virus subtypes in birds, including ducks, in other countries suggests that they were introduced into New Zealand by the importation of infected poultry or game birds. Ducks experimentally infected with two of the influenza A virus isolates excreted virus in their faeces for 12 days. Infection with H4N6 subtype prevented reinfection with the same subtype but not with a different one (H11N3).

            Descriptors:  ducks microbiology, influenza A virus avian isolation and purification, paramyxoviridae isolation and purification, immunity, avian immunology, New Zealand, virus replication.

Austin, F.J. and R.G. Webster (1993). Evidence of ortho- and paramyxoviruses in fauna from Antarctica. Journal of Wildlife Diseases 29(4): 568-71.  ISSN: 0090-3558.

            NAL Call Number:  41.9 W64B

            Abstract:  Serum antibodies to influenza A viruses and paramyxoviruses were detected in Adelie penguin (Pysoscelis adeliae) and Antarctic skua (Stercorarius skua maccormicki) sera in the Ross Sea Dependency. An avian paramyxovirus was isolated from a penguin cloacal swab.

            Descriptors:  avulavirus immunology, bird diseases epidemiology, fowl plague epidemiology, influenza A virus avian immunology, respirovirus infections veterinary, antarctic regions epidemiology, antibodies, viral blood, avulavirus isolation and purification, birds, cloaca microbiology, hemagglutination inhibition tests, immunoenzyme techniques, respirovirus infections epidemiology, seals.

Bahl, A.K., M.C. Kumar, and B.S. Pomeroy (1973). Epidemiologic and field observations on avian influenza viruses in breeder and grower flocks in Minnesota. Journal of the American Veterinary Medical Association 163(10): 1197-1198.  ISSN: 0003-1488.

            NAL Call Number:  41.8 Am3

            Descriptors:  avian influenza, epidemiology, field observations, Minnesota.

Bahl, A.K., A.C. Peterson, J.H. Sautter, and B.S. Pomeroy (1974). Avian influenza A and Mycoplasma synoviae infection in turkeys: A/turkey/Butterfield/72 (Hav6 Neq2) infection superimposed with M. synoviae. Journal of the American Veterinary Medical Association 165(8): 743.  ISSN: 0003-1488.

            NAL Call Number:  41.8 Am3

            Descriptors:  Mycoplasmosis synoviae, infection, avian influenza, turkeys.

Bahl, A.K., B.S. Pomeroy, S. Mangundimedjo, and B.C. Easterday (1977). Isolation of type A influenza and Newcastle disease viruses from migratory waterfowl in the Mississippi flyway. Journal of the American Veterinary Medical Association 171(9): 949-51.  ISSN: 0003-1488.

            NAL Call Number:  41.8 Am3

            Abstract:  Twenty-seven chicken red blood cell agglutinating agents were isolated from 187 tracheal swabbings of apparently healthy migratory mallard ducks (Anas platyrhynchos) in the Mississippi flyway. Twenty-four of the isolants were type A influenza virus; 3 lentogenic Newcastle disease viruses were isolated. Isolations were not made from either 65 giant Canada geese (Branta canadensis) or 60 Franklins' gulls (Larus pipixcan).

            Descriptors:  birds microbiology, influenza A virus avian isolation and purification, Newcastle disease virus isolation and purification, ducks microbiology, geese microbiology, avian immunology, Mississippi, trachea microbiology.

Bailey, T.A., U. Wernery, R.E. Gough, R. Manvell, and J.H. Samour (1996). Serological survey for avian viruses in houbara bustards (Chlamydotis undulata macqueenii). Veterinary Record 139(10): 238-9.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  antibodies, viral blood, bird diseases diagnosis, birds blood, coronavirus infections diagnosis, fowl plague immunology, infectious bronchitis virus immunology, influenza A virus avian immunology, respirovirus immunology, respirovirus infections diagnosis, antibodies, viral immunology, bird diseases blood, bird diseases epidemiology, birds immunology, birds virology, coronavirus infections blood, coronavirus infections epidemiology, data collection, respirovirus infections blood, respirovirus infections epidemiology, United Arab Emirates epidemiology.

Bankowski, R.A. (1981). Introduction and objectives of the symposium. In: Proceedings of the First International Symposium on Avian Influenza, Beltsville, Maryland, USA, p. vii-xiv.

            NAL Call Number: aSF995.6.I6I5 1981a

            Descriptors: avian influenza virus, disease prevention, disease control, poultry, symposium.

Bankowski, R.A., R.D. Conrad, and B. Reynolde (1968). Avian influenza A and paramyxo viruses complicating respiratory disease diagnosis in poultry. Avian Diseases 12(2): 259-78.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Descriptors:  orthomyxoviridae infections veterinary, poultry diseases diagnosis, respiratory tract infections veterinary, turkeys, hemagglutination inhibition tests, influenza diagnosis, influenza veterinary, Newcastle disease diagnosis, orthomyxoviridae infections diagnosis, respiratory tract infections diagnosis.

Bankowski, R.A. and B. Samadieh (1980). Avian influenza in turkeys. Poultry Digest 39: 326-332.  ISSN: 0032-5724.

            NAL Call Number:  47.8 N219

            Descriptors:  avian influenza virus, turkeys, control, prevention.

Banks, J., E.C. Speidel, J.W. McCauley, and D.J. Alexander (2000). Phylogenetic analysis of H7 haemagglutinin subtype influenza A viruses. Archives of Virology 145(5): 1047-58.  ISSN: 0304-8608.

            NAL Call Number:  448.3 Ar23

            Abstract:  A 945 nucleotide region (bases 76-1020) of the HA1 part of the HA gene was obtained for 31 influenza viruses of H7 subtype isolated primarily from Europe, Asia and Australia over the last 20 years. These were analysed phylogenetically and compared with sequences of the same region from 23 H7 subtype viruses available in Genbank. The overall results showed two geographically distinct lineages of North American and Eurasian viruses with major sublineages of Australian, historical European and equine viruses. Genetically related sublineages and clades within these major groups appeared to reflect geographical and temporal parameters rather than being defined by host avian species. Viruses of high and low virulence shared the same phylogenetic branches, supporting the theory that virulent viruses are not maintained as a separate entity in waterfowl.

            Descriptors:  hemagglutinin glycoproteins, influenza virus genetics, influenza A virus avian classification, avian genetics, amino acid sequence, fowl plague virology, genes viral, avian isolation and purification, phylogeny, poultry, sequence homology, amino acid.

Barclay, W.S. and M. Zambon (2004). Pandemic risks from bird flu. BMJ Clinical Research 328(7434): 238-9.  ISSN: 1468-5833.

            Descriptors:  disease outbreaks, fowl plague epidemiology, influenza epidemiology, Asia, Southeastern epidemiology, birds, chickens, influenza A virus avian, human.

Barr, D.A., M.D. O'Rourke, D.C. Grix, R.L. Reece, A.P. Kelly, R.T. Badman, and A.R. Campey (1986). Avian influenza on a multi-age chicken farm. Australian Veterinary Journal 63(6): 195-196.  ISSN: 0005-0423.

            NAL Call Number:  41.8 Au72

            Abstract:  An account of an outbreak on a farm near Bendigo in 1985, where 120,000 birds were housed in 12 sheds. The virus, highly virulent, was subtype H7N7. The outbreak occurred in birds already affected with complex respiratory disease.

            Descriptors:  chickens, avian influenza virus, Victoria, Australia, birds, domestic animals, domesticated birds, Galliformes, influenza virus, livestock, Oceania, poultry, useful animals, viruses, chickens viruses.

Baumeister, E.G. and V.L. Savy (1998). Human circulation of avian influenza (H5N1) in Hong Kong. Boletín De La Asociación Argentina De Microbiología (129): 12-13.  ISSN: 0325-6480.

            Descriptors:  human diseases, influenza virus A, epidemics, clinical aspects, diagnosis, reviews,  Hong Kong.

Beard, C.W. (1984). Focus on ... avian influenza. Foreign Animal Disease Report 12(2): 5-11.  ISSN: 0091-8199.

            NAL Call Number:  aSF601.U5

            Descriptors:  avian influenza virus, poultry diseases, reviews.

Beard, C.W. (1997). Historical lessons about avian influenza.  Proceedings of the Western Poultry Diseases Conference 46: 29-31.

            NAL Call Number:  SF995.W4

            Descriptors:  avian influenza virus, lessons, history.

Beard, C.W. (1997). Historical lessons from avian influenza. Zootecnica International 20(6): 16-18.  ISSN: 0392-0593.

            NAL Call Number:  SF600.Z6

            Descriptors:  avian influenza virus, disease control, lessons, history, vaccination, strains, reservoir hosts, geographical distribution.

Beard, C.W. (1981). Turkey influenza vaccination. Veterinary Record 108(25): 545.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  fowl plague prevention and control, turkeys, vaccination veterinary, influenza A virus avian immunology, viral vaccines.

Beard, C.W., M. Brugh, and D.C. Johnson (1984). Laboratory studies with the Pennsylvania avian influenza viruses (H5N2). Proceedings of the Annual Meeting of the United States Animal Health Association 88: 462-473.

            NAL Call Number:  449.9 Un3r

            Descriptors:  avian influenza virus, laboratory diagnosis, survival, feces, chickens.

Beard, C.W., S.B. Hitchner, C.H. Domermuth, H.G. Purchase (ed.) and   J.E. Williams (ed.) (1975). Avian influenza. In: Isolation and Identification of Avian Pathogens, American Association of Avian Pathologists:p. 174-181.

            NAL Call Number:  SF995.I86

            Descriptors:  virus identification, detection, laboratory diagnosis, influenza, ducks, quails.

Beard, C.W. (2002). Avian influenza debate continues. Journal of the American Veterinary Medical Association 221(11): 1546.  ISSN: 0003-1488.

            NAL Call Number:  41.8 Am3

            Descriptors:  animal husbandry, infection, respiratory system, veterinary medicine, influenza, infectious disease, prevention and control, respiratory system disease, viral disease, biosecurity, disease eradication, pathogenic outbreaks.

Beare, A.S. and R.G. Webster (1991). Replication of avian influenza viruses in humans. Archives of Virology 119(1-2): 37-42.  ISSN: 0304-8608.

            NAL Call Number:  448.3 Ar23

            Abstract:  Volunteers inoculated with avian influenza viruses belonging to subtypes currently circulating in humans (H1N1 and H3N2) were largely refractory to infection. However 11 out of 40 volunteers inoculated with the avian subtypes, H4N8, H6N1, and H10N7, shed virus and had mild clinical symptoms: they did not produce a detectable antibody response. This was presumably because virus multiplication was limited and insufficient to stimulate a detectable primary immune response. Avian influenza viruses comprise hemagglutinin (HA) subtypes 1-14 and it is possible that HA genes not so far seen in humans could enter the human influenza virus gene pool through reassortment between avian and circulating human viruses.

            Descriptors:  influenza A virus avian pathogenicity, adult, antibodies, viral blood, hemagglutinin glycoproteins, influenza virus, hemagglutinins viral immunology, avian isolation and purification, avian physiology, middle aged, species specificity, virus replication.

Beckford Ball, J. (2004). Building awareness of the avian flu outbreak and its symptoms. Nursing Times 100(6): 28-9.  ISSN: 0954-7762.

            Abstract:  The current outbreak of avian influenza in South East Asia has resulted in a small number of human deaths. Avian flu can pass from birds to humans, although the number of humans infected is low. The fear is that the avian flu virus could mutate in a human who was also infected with a common flu virus, creating a new strain that could pass from human to human. Nurses, especially those working in travel health, should keep themselves informed of the latest developments.

            Descriptors:  avian flu, outbreak, symptoms, South East Asia, human deaths, birds.

Becquart, P. (2003). Avian influenza: a mutant [Grippe aviaire : le grand mutant couve]. Biofutur (France)  (235): 5-6. P4220.  ISSN: 0294-3506.

            NAL Call Number:  TP248.13.B565

            Descriptors:  avian influenza virus, mutants, disease transmission, zoonoses.

Belshe, R.B. (1998). Influenza as a zoonosis: how likely is a pandemic? Lancet  351(9101): 460-1.  ISSN: 0140-6736.

            NAL Call Number:  448.8 L22

            Descriptors:  disease outbreaks, fowl plague transmission, influenza transmission, influenza virology,  influenza A virus avian, zoonoses, Asia epidemiology, chickens virology, Hong Kong epidemiology, influenza epidemiology.

Belshe, R.B. (1995). A review of attenuation of influenza viruses by genetic manipulation. American Journal of Respiratory and Critical Care Medicine 152(4, Pt. 2): S72-5.  ISSN: 1073-449X.

            Descriptors:  genetic engineering methods, influenza A virus human genetics, influenza B virus genetics, influenza vaccine genetics, adult, infant, avian immunology, human immunology, human pathogenicity, influenza B virus immunology, influenza B virus pathogenicity, influenza vaccine immunology, vaccines, attenuated genetics, vaccines, attenuated immunology, vaccines, combined genetics,  vaccines, combined immunology.

Bennejean, G. (1981). Is an international regulation of avian influenza feasible? In: Proceedings of the First International Symposium on Avian Influenza, Beltsville, Maryland, USA,  p. 198-210.

            NAL Call Number: aSF995.6.I6I5 1981a

            Descriptors: avian influenza virus, disease control, international regulation, symposium.

Bennink, J.R. and T.N. Palmore (2004). The promise of siRNAs for the treatment of influenza. Trends in Molecular Medicine 10(12): 571-4.  ISSN: 1471-4914.

            Abstract:  Current WHO reports on the Asian avian influenza virus outbreaks are poignant reminders of the potential for the emergence of highly virulent strains of influenza A virus (IAV) and the fact that it remains a scourge on human health. As IAV drifts and shifts its genetic and antigenic composition, it presents an ever-changing challenge for vaccines and antiviral medications. Short-interfering RNAs (siRNAs) are the latest class of potential antiviral therapeutics to be developed. Recent reports using siRNAs in mice suggest that they hold great promise for the prevention and treatment of IAV infections.

            Descriptors:  antiviral agents therapeutic use, influenza drug therapy, influenza A virus genetics, small interfering RNA therapeutic use, mice, RNA interference physiology, short-interfering RNA.

Bhattacharjee, Y. (2004). Microbiology. Scientist pleads guilty of receiving illegally imported avian flu virus. Science 305(5692): 1886.  ISSN: 1095-9203.

            NAL Call Number:  470 Sci2

            Descriptors:  crime, influenza A virus, avian, microbiology legislation and jurisprudence, chickens, commerce legislation and jurisprudence, licensure, Saudi Arabia, United States.

Bi Yingzuo and Cao Yongchang (1994). Serological investigation of avian influenza in Guangdong, China. Chinese Journal of Veterinary Medicine 21(7): 8-9.

            NAL Call Number:  SF604.C485

            Descriptors:  chickens, avian influenza virus, pathogenicity, symptoms, immunodiagnosis, Guangdong, Asia, biological properties, birds, China, diagnosis, domestic animals, domesticated birds, East Asia, Galliformes, immunological techniques, influenza virus, livestock, microbial properties, poultry, useful animals, viruses.

Biggs, P.M. (1982). The epidemiology of avian herpesviruses in veterinary medicine. Developments in Biological Standardization 52: 3-11.  ISSN: 0301-5149.

            NAL Call Number:  QR180.3.D4

            Abstract:  There are ten avian herpesviruses, which have been isolated from eight orders. Six of these are of veterinary importance: Pacheco's parrot disease virus, pigeon herpesvirus, duck plague virus, infectious laryngotracheitis virus, herpesvirus of turkeys and Marek's disease virus. The knowledge on the epidemiology of each virus and the disease it causes is discussed. Features in common to infections with most avian herpesviruses are: infection is persistent in individuals and ubiquitous in populations; virus is shed for long periods of time after infection although in some cases erratically; infection does not necessarily result in disease and at least in some avian herpesvirus infections the incidence of disease is affected by the pathogenicity of the virus; the genetic constitution of the host and stress factors affecting the host. It is concluded that man's interference with the natural history of host species often increases the threat and incidence of disease unless preventive action is taken.

            Descriptors:  birds microbiology, herpesviridae isolation and purification, herpesviridae infections veterinary, ducks microbiology, herpesvirus 1, gallid isolation and purification, herpesvirus 2, gallid isolation and purification, influenza A virus avian isolation and purification, pigeons microbiology, turkeys microbiology.

Bikour, M.H., E.H. Frost, S. Deslandes, B. Talbot, and Y. Elazhary (1995). Persistence of a 1930 swine influenza A (H1N1) virus in Quebec. Journal of General Virology 76(Pt. 10): 2539-47.  ISSN: 0022-1317.

            NAL Call Number:  QR360.A1J6

            Abstract:  Two antigenically distinct H1N1 influenza A viruses were isolated during an outbreak of respiratory disease in Quebec swine in 1990/91. Analysis of haemagglutinin and partial nucleoprotein sequences indicated that one was a variant of the swine H1N1 influenza virus circulating in the American Midwest whereas the other was very similar to virus isolated from swine in 1930. The existence of this latter isolate supports the concept that influenza viruses can be maintained for long periods in swine, perhaps in geographically limited pockets. Serological evidence indicates that these distinct strains continued to circulate widely in south-central Quebec until at least 1993.

            Descriptors:  influenza A virus, porcine genetics, influenza A virus, porcine immunology, orthomyxoviridae infections veterinary, phylogeny, swine diseases virology, amino acid sequence,  antigenic variation, antigens, viral analysis, base sequence, capsid genetics, disease outbreaks, hemagglutinin glycoproteins, influenza virus, hemagglutinins viral analysis, hemagglutinins viral genetics, avian genetics, human genetics, molecular sequence data, orthomyxoviridae infections epidemiology, orthomyxoviridae infections virology, quebec epidemiology, sequence analysis, DNA, sequence homology, amino acid, swine, swine diseases epidemiology, viral core proteins genetics.

Bisgaard, M. (1977). Virusbetingede luftvejslidelser hos fjerkrae--forekomst og diagnostik. [Respiratory diseases in poultry caused by viruses--occurrence and diagnosis (author's transl)]. Nordisk Veterinaermedicin 29(7-8): 305-24.  ISSN: 0029-1579.

            NAL Call Number:  41.8 N813

            Abstract:  The highly intensive conditions, that economic necessity has forced upon the poultry industry, have resulted in strongly changed environmental conditions and management which combined with the use of a constantly increasing number of live vaccines has highly complicated clearing up the etiology in diseased flocks. This is true not least as far as respiratory diseases concerns, which thereby often run an atypical course. A review, however, not complete, is given of the occurrence and diagnostic procedures in respiratory diseases caused by viruses, the greatest importance attached to infections caused by adeno- and infectious bronchitis virus.

            Descriptors:  poultry diseases diagnosis, poultry diseases epidemiology, respiratory tract infections veterinary, virus diseases veterinary, herpesvirus 1, gallid isolation and purification, infectious bronchitis virus isolation and purification, influenza A virus avian isolation and purification, paramyxoviridae isolation and purification, poultry, reoviridae isolation and purification, respiratory tract infections diagnosis, respiratory tract infections epidemiology, virus diseases diagnosis, virus diseases epidemiology.

Bogdan, J., O.J. Vrtiak, R. Polony, and T. Pauer (1968). Dynamics of immunomorphological changes in the organs of chickens after immunization with BPL vaccine and after challenge with fowl plague virus. Bulletin Office International Des Epizooties 69(5): 725-44.  ISSN: 0300-9823.

            NAL Call Number:  41.8 OF2

            Descriptors:  influenza A virus avian immunology, orthomyxoviridae infections veterinary, poultry diseases immunology, antibody formation, chickens, lactones, orthomyxoviridae infections immunology, vaccination , vaccines.

Bonaduce, A., G. Iovane, and F. Martone (1986). L'influenza aviaria. [Avian influenza]. Acta Medica Veterinaria 32(3-4): 143-287.  ISSN: 0001-6136.

            NAL Call Number:  41.8 AC84

            Descriptors:  avian influenza, reviews.

Bonn, D. (2004). Avian influenza: the whole world's business. Lancet Infectious Diseases 4(3): 128.  ISSN: 1473-3099.

            Descriptors:  ducks virology, avian influenza transmission, poultry diseases transmission, zoonoses, Asia epidemiology, food contamination, avian influenza epidemiology, poultry diseases epidemiology, public health.

Boudreault, A., J. Lecomte, and V.S. Hinshaw (1980). Caracterisation antigenique des virus influenza A isoles des oiseaux captures dans l'Ontario, le Quebec et les provinces maritimes durant la saison 1977. [Antigenic characterization of influenza A virus isolated from birds captured in Ontario, Quebec, and the maritime provinces during the 1977 season]. Revue Canadienne De Biologie Editee Par L'Universite De Montreal 39(2): 107-14.  ISSN: 0035-0915.

            NAL Call Number:  442.8 R325

            Abstract:  A total of 145 influenza A viruses were isolated from ducks, geese and passerine birds in Ontario, Quebec and the Maritimes in July-August 1977. Antigenic characterization of these isolates included five hemagglutinin (Hsw1, Hav4, Hav5, Hav6, Hav7) and five neuraminidase subtypes (N1, N2, Neq1, Neq2, Nav1) in nine different combinations; one combination Hav7 Neq1 had not been previously reported. The majority of these viruses were Hsw1 N1, antigenically related to influenza viruses in pigs and humans. This large reservoir of influenza A viruses circulating in ducks may well be involved in the appearance of new viruses in other species, including humans.

            Descriptors:  animal population groups microbiology, animals, wild microbiology, birds microbiology, influenza A virus avian isolation and purification, Canada, disease reservoirs, ducks microbiology, hemagglutinins viral analysis, avian immunology, neuraminidase analysis,  viral proteins analysis.

Brewster, R.ed. (1984). Proceedings, Newcastle disease and fowl plague seminar, Sydney, vi + 140 p.

            NAL Call Number: SF995.6.N4N48 1984

            Descriptors: avian influenza virus, seminar, Sydney, review, disease control, viral diseases, poultry, Newcastle disease.

Bricaire, F. (2004). La grippe aviaire, quel risque de transmission interhumaine? [Avian flu, what are the risks of inter-human transmission?]. Presse Medicale Paris, France 1983 33(6): 366-7.  ISSN: 0755-4982.

            Descriptors:  disease outbreaks, influenza A virus, avian influenza, avian influenza epidemiology, avian influenza transmission, zoonoses, human, porcine, avian influenza prevention and control, poultry, risk factors, swine.

Brown, H. (2004). WHO confirms human-to-human avian flu transmission. Lancet  363(9407): 462.  ISSN: 1474-547X.

            NAL Call Number:  448.8 L22

            Descriptors:  disease transmission, horizontal statistics and numerical data, fowl plague transmission, Asia epidemiology, fowl plague epidemiology, fowl plague prevention and control, influenza A virus avian, poultry, World Health Organization, zoonoses epidemiology, zoonoses transmission.

Brown, I.H., P.A. Harris, J.W. McCauley, and D.J. Alexander (1998). Multiple genetic reassortment of avian and human influenza A viruses in European pigs, resulting in the emergence of an H1N2 virus of novel genotype. Journal of General Virology 79(Pt. 12): 2947-55.  ISSN: 0022-1317.

            NAL Call Number:  QR360.A1J6

            Abstract:  Novel H1N2 influenza A viruses which were first detected in pigs in Great Britain in 1994 were examined antigenically and genetically to determine their origins and establish the potential mechanisms for genetic reassortment. The haemagglutinin (HA) of all swine H 1 N2 viruses examined was most closely related to, but clearly distinguishable both antigenically and genetically from, the HA of human H1N1 viruses which circulated in the human population during the early 1 980s. Phylogenetic analysis of the HA gene revealed that the swine H 1 N2 viruses formed a distinct branch on the human lineage and were probably introduced to pigs shortly after 1980. Following apparent transfer to pigs the HA gene underwent genetic variation resulting in the establishment and cocirculation of genetically and antigenically heterogeneous virus populations. Genetic analyses of the other RNA segments of all swine H1N2 viruses indicated that the neuraminidase gene was most closely related to those of early 'human-like' swine H3N2 viruses, whilst the RNA segments encoding PB2, PB1, PA, NP, M and NS were related most closely to those of avian viruses, which have been circulating recently in pigs in Northern Europe. The potential mechanisms and probable progenitor strains for genetic reassortment are discussed, but we propose that the swine H1N2 viruses examined originated following multiple genetic reassortment, initially involving human H1N1 and 'human-like' swine H3N2 viruses, followed by reassortment with 'avian-like' swine H1N1 virus. These findings suggest multiple reassortment and replication of influenza viruses may occur in pigs many years before their detection as clinical entities.

            Descriptors:  influenza A virus avian genetics, human genetics, recombination, genetic, antigens, viral immunology, base sequence, DNA, viral, Europe, genes viral, genotype, hemagglutination inhibition tests, hemagglutinin glycoproteins, influenza virus genetics, avian immunology, human immunology, molecular sequence data, phylogeny, sequence analysis, DNA, swine.

Brown, I.H., S. Ludwig, C.W. Olsen, C. Hannoun, C. Scholtissek, V.S. Hinshaw, P.A. Harris, J.W. McCauley, I. Strong, and D.J. Alexander (1997). Antigenic and genetic analyses of H1N1 influenza A viruses from European pigs. Journal of General Virology 78(pt. 3): 553-562.  ISSN: 0022-1317.

            NAL Call Number:  QR360.A1J6

            Abstract:  H1N1 influenza A viruses isolated from pigs in Europe since 1981 were examined both antigenically and genetically and compared with H1N1 viruses from other sources. H1N1 viruses from pigs and birds could be divided into three groups: avian, classical swine and 'avian-like' swine viruses. Low or no reactivity of 'avian-like' swine viruses in HI tests with monoclonal antibodies raised against classical swine viruses was associated with amino acid substitutions within antigenic sites of the haemagglutinin (HA). Phylogenetic analysis of the HA gene revealed that classical swine viruses from European pigs are most similar to each other and are closely related to North American swine strains, whilst the 'avian-like' swine viruses cluster with avian viruses. 'Avian-like' viruses introduced into pigs in the UK in 1992 apparently originated directly from strains in pigs in continental Europe at that time. The HA genes of the swine viruses examined had undergone limited variation in antigenic sites and also contained fewer potential glycosylation sites compared to human H1N1 viruses. The HA exhibited antigenic drift which was more marked in 'avian-like' swine viruses than in classical swine strains. Genetic analyses of two recent 'avian-like' swine viruses indicated that all the RNA segments are related most closely to those of avian influenza A viruses.

            Descriptors:  influenza virus A, viral hemagglutinins, nucleotide sequences, phylogenetics, viral antigens, hemagglutination inhibition test, molecular sequence data, GENBANK u72666, GENBANK u72667, GENBANK u72668, GENBANK u72669, GENBANK z46436, GENBANK z46441.

Brugh, M. (1988). Highly pathogenic virus recovered from chickens infected with mildly pathogenic 1986 isolates of H5N2 avian influenza virus. Avian Diseases 32(4): 695-703.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  A combination of in vitro and in vivo selection procedures was used to examine the possibility that certain mildly pathogenic field isolates of avian influenza (AI) virus may contain minority subpopulations of highly pathogenic virus. Two mildly pathogenic H5N2 isolates, A/chicken/New Jersey/12508/86 (NJ12508) and A/chicken/Florida/27716/86 (FL27716), recovered from chickens epidemiologically associated with urban live-bird markets, were cloned in trypsin-free chicken embryo fibroblast cultures. Selected clones were inoculated intranasally and intratracheally (IN/IT) into specific-pathogen-free laying hens, and virus reisolated from the hens that died was serially passed in hens by IN/IT inoculation. Several highly pathogenic reisolates were recovered from hens infected with the cloned NJ12508 or FL27716 virus. A highly pathogenic NJ12508 reisolate killed 19 of 24 IN/IT-inoculated hens, and a FL27716 reisolate killed all 24 inoculated hens; signs and lesions were typical of fowl plague. In contrast, uncloned NJ12508 stock virus killed 1 of 24 hens and FL27716 stock virus killed 4 of 24 hens, and neither produced the complete spectrum of lesions associated with fowl plague. Recovery of highly pathogenic viruses from these isolates demonstrates the coexistence of pathogenically distinct subpopulations of virus. Competition for dominance among such subpopulations could explain the variable pathogenicity of some AI viruses.

            Descriptors:  chickens microbiology, influenza A virus avian pathogenicity, cultured cells, cytopathogenic effect, viral, fowl plague microbiology, fowl plague mortality, avian isolation and purification, serial passage, species specificity, trypsin diagnostic use.

Brugh, M. and C.W. Beard (1986). Influence of dietary calcium stress on lethality of avian influenza viruses for laying chickens. Avian Diseases 30(4): 672-8.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  The effect of calcium stress was studied in an attempt to reproduce lethal infections in laying chickens with A/Chicken/Alabama/75 (H4N8) influenza virus and with two nonpathogenic H5N2 influenza viruses from the 1983-84 outbreak in the eastern United States. Hens were fed calcium-deficient or standard diets for 7 to 14 days; then the calcium-deficient feed was replaced with standard feed supplemented with ad libitum oyster shell, and both groups of hens were inoculated with virus. When hens were infected with the H4N8 virus, respective mortalities of those on the calcium-deficient and standard diets were 19% (27/141) and 5% (7/143). The H5N2 viruses did not kill hens fed either diet. In standard pathogenicity tests, Alabama H4N8 viruses reisolated from the hens that died generally were more lethal for 4-week-old chickens than the stock virus. These results argue for characterization of the Alabama H4N8 virus as pathogenic rather than nonpathogenic as originally determined.

            Descriptors:  calcium deficiency, calcium, dietary metabolism, chickens metabolism, influenza A virus avian pathogenicity, orthomyxoviridae infections veterinary, poultry diseases microbiology, stress veterinary, orthomyxoviridae infections metabolism, poultry diseases metabolism, stress metabolism, stress microbiology.

Buckner, R.E. and D.D. Frame (1996). Observations an outbreak of avian influenza serotype H7N3 in turkeys at the Utah State University Snow Field Station, 1995. Proceedings of the Western Poultry Diseases Conference 45: 294.

            NAL Call Number:  SF995.W4

            Descriptors:  turkeys, avian influenza virus, Utah, America, birds, Galliformes, influenza virus, mountain states United States, North America, orthomyxoviridae, United States, viruses, western states United States.

Butterfield, W.K. (1976). Avian influenza and fowl plague. In: Proceedings of 25th Western Poultry Disease Conference and 10th Poultry Health Symposium, March 8-11, 1976, p. 24-27.

            NAL Call Number: SF995.W4

            Descriptors: avian influenza, fowl plague, poultry.

Butterfield, W.K. and C.H. Campbell (1978).  Vaccination for fowl plague. American Journal of Veterinary Research 39(4): 671-4.  ISSN: 0002-9645.

            NAL Call Number:  41.8 Am3A

            Abstract:  Influenza A/turkey/Oregon/71 virus has antigenic characteristics of fowl plague virus but is avirulent for chickens. The virus was inoculated intratracheally in chickens at several dosage levels and resulted in the formation of antibody and immunity against fowl plague. The avirulent virus replicated in chickens and was recoverable by tracheal swab specimens up to 4 days after inoculation. Although the virus was transmitted to contact controls at the time when their cagemates were inoculated, it was not transmitted to contact controls placed with chickens inoculated 24 hours earlier. After 10 passages in chickens, the virus remained avirulent for chickens and turkeys.

            Descriptors:  chickens, fowl plague prevention and control, vaccination veterinary, antibodies, viral analysis, influenza A virus avian growth and development, avian immunology, avian isolation and purification, trachea microbiology, viral vaccines, virulence.

Cameron, K.R., V. Gregory, J. Banks, I.H. Brown, D.J. Alexander, A.J. Hay, and Y.P. Lin (2000). H9N2 subtype influenza A viruses in poultry in Pakistan are closely related to the H9N2 viruses responsible for human infection in Hong Kong. Virology 278(1): 36-41.  ISSN: 0042-6822.

            NAL Call Number:  448.8 V81

            Descriptors:  disease outbreaks veterinary, influenza veterinary, influenza A virus avian classification, human classification, poultry diseases virology, antigens, viral genetics, antigens, viral immunology, cloning, molecular, genome, viral, hemagglutination inhibition tests, hemagglutinins viral genetics, Hong Kong epidemiology, influenza epidemiology, avian genetics, avian immunology, human genetics, human immunology, molecular sequence data, Pakistan epidemiology, phylogeny, poultry diseases epidemiology, sequence analysis, protein, viral proteins genetics, viral proteins immunology.

Campbell, C.H., R.G. Webster, and S.S.J. Breese (1970). Fowl plague virus from man. Journal of Infectious Diseases 122(6): 513-6.  ISSN: 0022-1899.

            NAL Call Number:  448.8 J821

            Descriptors:  influenza A virus avian isolation and purification, antigens analysis, chick embryo, chickens, cross reactions, hemagglutination inhibition tests, immune sera analysis, avian classification, avian immunology, avian pathogenicity, microscopy, electron, neuraminidase analysis, neutralization tests, poultry diseases immunology, vaccination, viral vaccines administration and dosage.

Campitelli, L., C. Fabiani, S. Puzelli, A. Fioretti, E. Foni, A. De Marco, S. Krauss, R.G. Webster, and I. Donatelli (2002). H3N2 influenza viruses from domestic chickens in Italy: an increasing role for chickens in the ecology of influenza? Journal of General Virology 83(Pt. 2): 413-20.  ISSN: 0022-1317.

            NAL Call Number:  QR360.A1J6

            Abstract:  In Italy, multiple H3N2 influenza viruses were isolated from chickens with mild respiratory disease and were shown to replicate in the respiratory tracts of experimentally infected chickens; this finding is the first to show that H3N2 influenza viruses can replicate and cause disease in chickens. H3N2 influenza viruses in pigs on nearby farms seemed a likely source of the virus; however, antigenic and molecular analyses revealed that the gene segments of the viruses in chickens were mainly of Eurasian avian origin and were distinguishable from those isolated from pigs and wild aquatic birds in Italy. Thus, several different H3 influenza viruses were circulating in Italy, but we failed to identify the source of the chicken H3N2 influenza viruses that have disappeared subsequently from Italian poultry. Until recently, the transmission of influenza viruses (other than the H5 and H7 subtypes) from their reservoir in aquatic birds to chickens was rarely detected and highly pathogenic and non-pathogenic viruses were considered to be restricted to poultry species. However, the recent reports of the transmission of H9N2 and H5N1 influenza viruses to chickens in Hong Kong and, subsequently, to humans and our findings of the transmission of H3N2 influenza viruses to domestic chickens in Italy suggest an increased role for chickens as an intermediate host in the ecology of influenza.

            Descriptors:  chickens, fowl plague virology, influenza veterinary, influenza A virus avian pathogenicity, poultry diseases virology, hemagglutination inhibition tests, hemagglutinin glycoproteins, influenza virus genetics, influenza virology, avian isolation and purification, avian physiology, porcine isolation and purification, porcine pathogenicity, Italy, molecular sequence data, sequence analysis, DNA, swine diseases virology, viral proteins genetics, virus replication.

Canada. Agriculture Canada. (1985). Outbreak Alert: Avian Influenza, Publication, Vol. 1794/E, Communications Branch, Agriculture Canada: Ottawa, 1 folded sheet (6) p. ISBN: 0662138988.

            NAL Call Number:  7 C16Pu no. 1794

            Descriptors:  avian influenza, outbreak alert, Canada.

Cane, B.G., L.F. Leanes, and L.O. Mascitelli (2004). Emerging diseases and their impact on animal commerce: the Argentine lesson. Annals of the New York Academy of Sciences 1026: 12-8.  ISSN: 0077-8923.

            NAL Call Number:  500 N484

            Abstract:  As a result of the Argentine experience with foot-and-mouth disease (FMD) in 2001, a need was postulated for the establishment of efficient supranational schemes for continuous surveillance of the interrelations between tropical extractives livestock systems and the prairies that are optimal for the feeding of livestock in the southern region of South America. FMD in Argentina and in other countries, new or re-emerging risks from avian influenza with potential risks for public health, the spongiform encephalopathies, porcine reproductive and respiratory syndrome, and classical swine fever, among other animal diseases, have generated a strong reaction and evolution within the veterinary services of the country. These present lessons will influence decision-making within countries and should be accepted by the technical and scientific community. From the perspective of the official animal health sector and with the FMD eradication plan as a basis within the national territory, we have worked not only to achieve international recognition and credibility within animal health systems, but also to realize the formation of a regional block of countries that can be recognized internationally as an area with equivalent animal health status. We emphasize not only that this lesson is useful in FMD, but also that it is possible to apply the valuable conclusions reached for other emerging or re-emerging diseases.

            Descriptors:  animal husbandry, commerce, communicable diseases, emerging prevention and control, emerging transmission, foot and mouth disease prevention and control, foot and mouth disease transmission, domestic animals, Argentina, decision making, international cooperation, population surveillance, risk assessment.

Cappucci, D.T.J., D.C. Johnson, M. Brugh, T.M. Smith, C.F. Jackson, J.E. Pearson, and D.A. Senne (1985). Isolation of avian influenza virus (subtype H5N2) from chicken eggs during a natural outbreak. Avian Diseases 29(4): 1195-200.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  Avian influenza virus (A/Chicken/Pennsylvania/83; H5N2) was recovered from the yolk, albumen, and shell surface of eggs obtained from naturally infected chicken flocks in Pennsylvania and Virginia. These findings represent the first reported isolation of avian influenza virus from the internal contents of eggs from naturally infected flocks. The need for adequate safeguards to prevent spread of the virus during commercial movement of table and hatching eggs, cracked and "checked" eggs, and egg flats and other materials is emphasized.

            Descriptors:  eggs, food microbiology, fowl plague transmission, influenza A virus avian isolation and purification, chickens, fowl plague epidemiology, Pennsylvania, Virginia.

Capua, I. and D.J. Alexander (2004). Human health implications of avian influenza viruses and paramyxoviruses. European Journal of Clinical Microbiology and Infectious Diseases Official Publication of the European Society of Clinical Microbiology 23(1): 1-6.  ISSN: 0934-9723.

            Abstract:  Among avian influenza viruses and avian paramyxoviruses are the aetiological agents of two of the most devastating diseases of the animal kingdom: (i). the highly pathogenic form of avian influenza, caused by some viruses of the H5 and H7 subtypes, and (ii). Newcastle disease, caused by virulent strains of APMV type 1. Mortality rates due to these agents can exceed 50% in naive bird populations, and, for some strains of AI, nearly 100%. These viruses may also be responsible for clinical conditions in humans. The virus responsible for Newcastle disease has been known to cause conjunctivitis in humans since the 1940s. The conjunctivitis is self-limiting and does not have any permanent consequences. Until 1997, reports of human infection with avian influenza viruses were sporadic and frequently associated with conjunctivitis. Recently, however, avian influenza virus infections have been associated with fatalities in human beings. These casualties have highlighted the potential risk that this type of infection poses to public health. In particular, the pathogenetic mechanisms of highly pathogenic avian influenza viruses in birds and the possibility of reassortment between avian and human viruses in the human host represent serious threats to human health. For this reason, any suspected case should be investigated thoroughly.

            Descriptors:  avulavirus isolation and purification, communicable disease control, disease outbreaks, fowl plague epidemiology, influenza A virus avian isolation and purification, Newcastle disease epidemiology, birds, fowl plague prevention and control, Italy epidemiology, Newcastle disease prevention and control, prognosis, risk assessment, survival analysis.

Capua, I., B. Grossele, E. Bertoli, and P. Cordioli (2000). Monitoring for highly pathogenic avian influenza in wild birds in Italy. Veterinary Record 147(22): 640.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  fowl plague epidemiology, influenza A virus avian isolation and purification, wild animals, birds, disease outbreaks veterinary, avian pathogenicity, Italy epidemiology, mass screening veterinary.

Capua, I. and S. Marangon (2000). The Italian experience: what can we learn from it? World Poultry (Special): 21-22.  ISSN: 1388-3119.

            NAL Call Number:  SF481.M54

            Descriptors:  disease control, avian influenza virus, turkeys, Italy.

Capua, I., S. Marangon, M. Dalla Pozza, and U. Santucci (2000). Vaccination for avian influenza in Italy.  Veterinary Record 147(26): 751.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  disease outbreaks veterinary, fowl plague epidemiology, fowl plague prevention and control, influenza veterinary, influenza A virus avian immunology, vaccination veterinary, influenza epidemiology, influenza prevention and control, Italy epidemiology, poultry.

Capua, I., F. Mutinelli, C. Terregino, G. Cattoli, R.J. Manvell, and F. Burlini (2000). Highly pathogenic avian influenza (H7N1) in ostriches farmed in Italy. Veterinary Record 146(12): 356.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  disease outbreaks veterinary, fowl plague, influenza A virus avian pathogenicity, ostriches virology, animal husbandry, digestive system pathology, Italy, necrosis.

Capua, I. and F. Mutinelli (2001). A Colour Atlas and Text on Avian Influenza.  [Influenza Aviaria: Testo e Atlante = Atlas Sobre La Influenza Aviar], 1 edition, Papi editore: Bologna,  xxv, 236 p.: col. ill., 1 col. map 1 CD-ROM (4 3/4 in.) p. ISBN: 8888369007.

            NAL Call Number:  SF995.6.I6 C37 2001

            Descriptors:  avian influenza, color atlas, text.

Capua, I. and F. Mutinelli (2001). Mortality in Muscovy ducks (Cairina moschata) and domestic geese (Anser anser var. domestica) associated with natural infection with a highly pathogenic avian influenza virus of H7N1 subtype. Avian Pathology 30(2): 179-183.  ISSN: 0307-9457.

            NAL Call Number:  SF995.A1A9

            Abstract:  Among the 413 outbreaks of highly pathogenic avian influenza (HPAI) caused by a virus of the H7N1 subtype, which occurred in Italy during 1999 and 2000, an outbreak diagnosed in a backyard flock was characterized by mortality and nervous signs in ducks and geese. Dead geese (Anser anser var. domestica) and Muscovy ducks (Cairina moschata) were submitted to the laboratory for bacteriological, virological, histological and immunohistochemical investigations. Routine bacteriological tests resulted negative, while a HPAI virus of the H7N1 subtype was isolated from the geese. Pancreatic damage was observed in both the geese and the ducks, and the pancreas was also positive by immunohistochemistry for avian influenza in the geese. Histopathological lesions were observed in the central nervous system of both species, and this result was supported by positive immunohistochemical findings for the presence of the virus.

            Descriptors:  infection, veterinary medicine, highly pathogenic avian influenza, viral disease, immunohistochemistry, immunohistochemical, immunocytochemical techniques, diagnostic method, histology, mortality, case study.

Capua, I., F. Mutinelli, S. Marangon, and D.J. Alexander (2000). H7N1 avian influenza in Italy (1999 to 2000) in intensively reared chickens and turkeys. Avian Pathology 29(6): 537-543.  ISSN: 0307-9457.

            NAL Call Number:  SF995.A1A9

            Abstract:  From the end of March to the beginning of December 1999, an epidemic of low pathogenicity avian influenza (LPAI) affected the industrial poultry population of northern Italy. The virus responsible for the epidemic was subtyped as H7N1 with an intravenous pathogenicity index (IVPI) of 0.0, and a deduced amino acid sequence of the region coding for the cleavage site of the haemagglutinin molecule typical of low pathogenicity viruses. The circulation of the virus in a susceptible population for several months caused the emergence of a highly pathogenic virus with an IVPI of 3.0 and the presence of multiple basic amino acids in the deduced amino acid sequence for the cleavage site of the haemagglutinin molecule. Over 13 million birds were affected by the epidemic and, in the present paper, we report the results of the clinical, virological and histopathological investigations performed on affected chickens and turkeys. Clinical, gross and microscopic lesions caused by LPAI were more severe in turkeys than in chickens, while highly pathogenicity avian influenza (HPAI) caused similar mortality rates in both species. Current European legislation considers LPAI and HPAI as two completely distinct diseases, not requiring any compulsory eradication policy for LPAI but enforcing eradication for HPAI. In the Italian 1999 to 2000 epidemic, LPAI mutated to HPAI in a densely populated area, causing great economic losses. A reconsideration of the current European Union legislation on avian influenza, including LPAI of the H5 and H7 subtypes, could possibly be an aid to avoiding devastating epidemics for the poultry industry.

            Descriptors:  animal husbandry, infection, epidemiology, respiratory system, avian influenza (LPAI), high pathogenicity  (HPAI), low pathogenicity, respiratory system disease, viral disease, clinical analysis analytical method, histopathological analysis analytical method, virological analysis analytical method, European Union legislation, economic losses, industrial poultry population, intravenous pathogenicity index, mortality rates.

Catelli, E. and A. Lavazza (2000). The health of poultry in Italy during the year 2000. Selezione Veterinaria (Italy) (11): 963-970.  ISSN: 0037-1521.

            NAL Call Number:  241.71 B75

            Descriptors:  avian influenza virus, Escherichia coli, Salmonella enteritidis, health, pigeons, ducks, geese, pheasants, quails, ostriches, Italy.

Cavanagh, D. (1992). Recent advances in avian virology. British Veterinary Journal 148(3): 199-222.  ISSN: 0007-1935.

            NAL Call Number:  41.8 V643

            Abstract:  Selected, recent research on the following avian diseases, and their causative viruses, has been reviewed: chicken anaemia, infectious bursal disease, turkey rhinotracheitis, avian nephritis, fowlpox, influenza, infectious bronchitis and turkey enteritis.

            Descriptors:  bird diseases microbiology, virus diseases veterinary, birds, coronaviridae, DNA viruses, fowlpox virus, infectious bursal disease virus, influenza A virus avian, paramyxoviridae, picornaviridae, virus diseases microbiology.

Celko, A.M. and J. Rosina (1998). Epidemiologie ptaci chripky A (H5N1). [Epidemiology of avian influenza A (H5N1)]. Veterinarni Medicina UZPI (Czech Republic) 43(7): 219-220.  ISSN: 0375-8427.

            NAL Call Number:  41.9 C333

            Descriptors:  avian influenza virus, disease transmission, pathogenesis, disease resistance, disease control, influenza virus, orthomyxoviridae, pathogenesis, resistance to injurious factors, viruses.

Cernik, K., B. Tumova, B. Kaminskyj, and V. Rajtar (1985). Serologicky dukaz vyskytu aviarnich paramyuxoviru u holubu. [Serologic detection of the occurrence of avian paramyxoviruses in pigeons]. Veterinarni Medicina 30(10): 603-10.  ISSN: 0375-8427.

            NAL Call Number:  41.9 C333

            Abstract:  447 blood-serum samples of racing and free living pigeons collected in 11 districts of Czechoslovakia from August 1983 till March 1984 were examined by the haemagglutination inhibition test to the Newcastle disease virus, strain Roakin, to the pigeon PMV-1 and to the PMV-3; 121 of the samples were tested to other serotypes, PMV-2--PMV-9, and to the avian influenza A virus. 58.4% of samples were positive (greater than or equal to 2 log2) to the Roakin strain with the mean titre 3.6 log2 and 65.1% to the pigeon PMV-1 with the mean titre 4.5 log2. All samples tested were negative to other serotypes except two samples of one group positive to PMV-8 with the mean titre 4.3 log2. The titres of HI antibodies to the Roakin strain and to the pigeon PMV-1 were compared. The risk of the transmission and of the readaptation of pigeon virus to poultry was discussed.

            Descriptors:  bird diseases diagnosis, pigeons, respirovirus infections veterinary, antibodies, viral analysis, bird diseases epidemiology, Czechoslovakia, hemagglutination inhibition tests veterinary, paramyxoviridae immunology, respirovirus infections diagnosis, respirovirus infections epidemiology.

Chan, C.H., H.K. Shieh, Y.S. Lu, Y.L. Lee, D.F. Lin, and Y.K. Liao (1989). Study on avian influenza in Taiwan. 1. Epidemiology, viral isolation and identification. Taiwan Journal of Veterinary Medicine and Animal Husbandry (53): 75-88.  ISSN: 0253-9128.

            NAL Call Number:  49 J822

            Descriptors:  avian influenza virus, disease surveys, epidemiology, ducks, turkeys, quail, geese, mallards, Taiwan.

Charlton, K.G. (2000). Antibodies to selected disease agents in translocated wild turkeys in California. Journal of Wildlife Diseases 36(1): 161-4.  ISSN: 0090-3558.

            NAL Call Number:  41.9 W64B

            Abstract:  Wild turkeys (Meleagris gallopavo) trapped within California (n = 715) or imported into California from other states (n = 381) from 1986 to 1996 were tested for exposure to certain disease agents. Prevalence of antibody to Mycoplasma gallisepticum, Mycoplasma meleagridis, Salmonella pullorum, Salmonella typhimurium, Newcastle disease virus, and avian influenza virus was low (0-4%) for wild turkeys trapped within California. With the exception of antibody prevalence to M. meleagridis of 33%, the same was true for wild turkeys imported into California from other states. Antibody prevalence to Mycoplasma synoviae was 8-10% for both groups.

            Descriptors:  bird diseases epidemiology, fowl plague epidemiology, mycoplasma infections veterinary, Newcastle disease epidemiology, Salmonella infections, animal epidemiology, turkeys, agglutination tests veterinary, animals, wild, antibodies, bacterial blood, antibodies, viral blood, California epidemiology, hemagglutination inhibition tests veterinary, immunodiffusion veterinary, influenza A virus avian immunology, mycoplasma immunology, Mycoplasma infections epidemiology, Newcastle disease virus immunology, Salmonella immunology, seroepidemiologic studies.

Chen Bolun (1994). Studies on avian influenza. I. Isolation and serological identification of influenza A viruses from chickens. Chinese Journal of Veterinary Medicine 27(10): 3-5.

            NAL Call Number:  SF604.C485

            Descriptors:  chickens, influenza virus, immunology, isolation techniques, birds, domestic animals, domesticated birds, Galliformes , livestock, poultry, useful animals, viruses.

Chen, H., G. Deng, Z. Li, G. Tian, Y. Li, P. Jiao, L. Zhang, Z. Liu, R.G. Webster, and K. Yu ( 2004). The evolution of H5N1 influenza viruses in ducks in southern China. Proceedings of the National Academy of Sciences of the United States of America 101(28): 10452-7.  ISSN: 0027-8424.

            NAL Call Number:  500 N21P

            Abstract:  The pathogenicity of avian H5N1 influenza viruses to mammals has been evolving since the mid-1980s. Here, we demonstrate that H5N1 influenza viruses, isolated from apparently healthy domestic ducks in mainland China from 1999 through 2002, were becoming progressively more pathogenic for mammals, and we present a hypothesis explaining the mechanism of this evolutionary direction. Twenty-one viruses isolated from apparently healthy ducks in southern China from 1999 through 2002 were confirmed to be H5N1 subtype influenza A viruses. These isolates are antigenically similar to A/Goose/Guangdong/1/96 (H5N1) virus, which was the source of the 1997 Hong Kong "bird flu" hemagglutinin gene, and all are highly pathogenic in chickens. The viruses form four pathotypes on the basis of their replication and lethality in mice. There is a clear temporal pattern in the progressively increasing pathogenicity of these isolates in the mammalian model. Five of six H5N1 isolates tested replicated in inoculated ducks and were shed from trachea or cloaca, but none caused disease signs or death. Phylogenetic analysis of the full genome indicated that most of the viruses are reassortants containing the A/Goose/Guangdong/1/96-like hemagglutinin gene and the other genes from unknown Eurasian avian influenza viruses. This study is a characterization of the H5N1 avian influenza viruses recently circulating in ducks in mainland China. Our findings suggest that immediate action is needed to prevent the transmission of highly pathogenic avian influenza viruses from the apparently healthy ducks into chickens or mammalian hosts.

            Descriptors:  ducks virology, evolution, molecular, influenza A virus, avian genetics, avian pathogenicity, influenza, avian virology, chickens, China, genes, viral genetics, genotype, avian transmission, mice, molecular sequence data, phylogeny, virulence.

Chernetsov, I.U.V., A.N. Slepushkin, D.K. L'vov, N.A. Braude, and A.E. Gavrilov (1980). Izoliatsiia virusa grippa ot chernoi krachki (Chlidonias nigra) i serologicheskoe obsledovanie ptits na antitela k virusu grippa. [Isolation of influenza virus from Chlidonias nigra and serologic examination of the birds for antibodies to influenza virus]. Voprosy Virusologii (1): 35-40.  ISSN: 0507-4088.

            NAL Call Number:  448.8 P942

            Abstract:  Influenza A virus with the antigenic formulae Hav4Neq2 has been isolated from Chlidonias nigra in the region of mass moulting in the territory of the Kazakh SSR. Antihemagglutinins for the newly isolated virus were detected in the sera of some specimens of the sea gull order. The data obtained suggest an active circulation of the virus in this region during the summer of 1977.

            Descriptors:  animal population groups microbiology, animals, wild microbiology, birds microbiology, influenza A virus avian isolation and purification, antibodies, viral analysis, hemagglutination inhibition tests, influenza A virus avian classification, Kazakhstan, microscopy, electron, neutralization tests, orthomyxoviridae infections epidemiology, orthomyxoviridae infections veterinary, serotyping.

Chokephaibulkit, K., M. Uiprasertkul, P. Puthavathana, P. Chearskul, P. Auewarakul, S.F. Dowell, and N. Vanprapar (2005). A child with avian influenza A (H5N1) infection. Pediatric Infectious Disease Journal 24(2): 162-6.  ISSN: 0891-3668.

            Abstract:  Human infections with avian influenza viruses can be severe and may be harbingers of the evolution of a pandemic strain. We present a patient in Thailand who was infected with influenza A (H5N1) virus. Prominent features included the progression from fever and dyspnea to the acute respiratory distress syndrome in a short period, lymphopenia and thrombocytopenia. Establishing the diagnosis for this patient increased public awareness of the virus and was soon followed by a halting of poultry-to-human transmission. On the basis of available data, any child with suspected avian influenza infection should be treated with oseltamivir.

            Descriptors:  infection, pediatrics, human medicine, pharmacology, avian influenza A virus, orthomyxoviridae, child, Thailand.

Claas, E.C., J.C. de Jong, R. van Beek, G.F. Rimmelzwaan, and A.D. Osterhaus (1998). Human influenza virus A/HongKong/156/97 (H5N1) infection. Vaccine 16(9-10): 977-8.  ISSN: 0264-410X.

            NAL Call Number:  QR189.V32

            Abstract:  Introduction of influenza viruses with gene segments of avian origin into the human population may result in the emergence of new pathogenic human influenza viruses. The recent infection of a 3-year-old boy with an influenza A (H5N1) virus of avian origin can be considered as an example of such an event. However, this virus, influenza A/Hong Kong/156/97 (H5N1) and the 17 additional H5N1 viruses isolated from humans by the end of 1997 lack the ability to spread efficiently amongst humans and therefore have limited pandemic potential. However, the possibility of reassortment of these viruses with currently circulating human viruses illustrates the need for pandemic preparedness.

            Descriptors:  influenza virology, influenza A virus avian genetics, avian pathogenicity, human genetics, human pathogenicity, chickens, child, preschool, disease outbreaks veterinary, fowl plague epidemiology, fowl plague virology, Hong Kong epidemiology, influenza epidemiology, influenza transmission, avian classification, human classification, phylogeny, recombination, genetic.

Clough, J.D. (2004). Birds, viruses, and history: the current 'genuine adventure'. Cleveland Clinic Journal of Medicine 71(4): 270.  ISSN: 0891-1150.

            Descriptors:  communicable disease control organization and administration, influenza A virus, avian isolation and purification, virus diseases epidemiology, birds, communicable diseases epidemiology, incidence, influenza epidemiology, influenza prevention and control, avian influenza epidemiology, avian influenza prevention and control, risk assessment, severe acute respiratory syndrome epidemiology, severe acute respiratory syndrome prevention and control, virus diseases prevention and control, world health.

Cohen, J. (1997). The flu pandemic that might have been. Science 277(5332): 1600-1.  ISSN: 0036-8075.

            NAL Call Number:  470 Sci2

            Descriptors:  influenza transmission, influenza virology, influenza A virus avian isolation and purification, human isolation and purification, chickens virology, child preschool, China epidemiology, disease outbreaks, fowl plague virology, Hong Kong epidemiology, influenza epidemiology.

Connor, R.J., Y. Kawaoka, R.G. Webster, and J.C. Paulson (1994). Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates. Virology 205(1): 17-23.  ISSN: 0042-6822.

            NAL Call Number:  448.8 V81

            Abstract:  The receptor specificity of 56 H2 and H3 influenza virus isolates from various animal species has been determined to test the relevance of receptor specificity to the ecology of influenza virus. The results show that the receptor specificity of both H2 and H3 isolates evaluated for sialic acid linkage specificity and inhibition of hemagglutination by horse serum correlates with the species of origin, as postulated earlier for H3 strains based on a limited survey of five human, three avian, and one equine strain. Elucidation of the amino acid sequence of several human H2 receptor variants and analysis of known sequences of H2 and H3 isolates revealed that receptor specificity varies in association with an amino acid change at residues 228 in addition to the change at residue 226 previously documented to affect receptor specificity of H3 but not H1 isolates. Residues 226 and 228 are leucine and serine in human isolates, which preferentially bind sialic acid alpha 2,6-galactose beta 1,4-N-acetyl glucosamine (SA alpha 2,6Gal), and glutamine and glycine in avian and equine isolates, which exhibit specificity for sialic acid alpha-2,3-galactose beta-1,3-N-acetyl galactosamine (SA alpha 2,3Gal). The results demonstrate that the correlation of receptor specificity and species of origin is maintained across both H2 and H3 influenza virus serotypes and provide compelling evidence that influenza virus hosts exert selective pressure to maintain the receptor specificity characteristics of strains isolated from that species.

            Descriptors:  influenza A virus avian metabolism, human metabolism, metabolism, receptors, virus metabolism, amino acid sequence, amino acids genetics, carbohydrate sequence, chick embryo, hemagglutinin glycoproteins, influenza virus, hemagglutinins viral genetics, molecular sequence data, species specificity, viral envelope proteins genetics.

Cooper, R.G., J.O. Horbanczuk, and N. Fujihara ( 2004). Viral diseases of the ostrich (Struthio camelus var. Domesticus). Animal Science Journal 75(2): 89-95.  ISSN: 1344-3941.

            NAL Call Number:  SF1.A542

            Descriptors:  Crimea Congo hemorrhagic fever, Newcastle disease, avian influenza, avipoxvirus, Borna disease, disease prevention, disease control, disease transmission methods, ostrich, Struthio camelus , livestock.

Couceiro, J.N., J.R. Chaves, C.T. Brandao, and R.D. Machado (1982). Isolamento e caracterizacao de virus influenza A, em aves ornamentais, no Rio de Janeiro. [Isolation and characterization of influenza virus type A, in ornamental birds, in Rio de Janeiro]. Anais De Microbiologia 27:  159-67.  ISSN: 0485-1854.

            Descriptors:  fowl plague microbiology, influenza A virus avian isolation and purification, birds, Brazil, feces microbiology, fowl plague epidemiology, hemagglutination inhibition tests, serotyping.

Couceiro, J.N.S.S., R.D. Machado, E.S.S. Couceiro, and M.C. Cabral (1988). Study of an ornamental bird flock over a period of three years: incidence of avian influenza viruses. Revista De Microbiologia 19(4): 453-458.  ISSN: 0001-3714.

            NAL Call Number:  QR1.R4

            Descriptors:  carrier state, survey, avian influenza virus, ornamental birds, aviary birds, sparrows, doves, waxbills, Rio de Janeiro.

Crinion, R.A.P. (1988). Newcastle disease and avian influenza. Irish Veterinary News 10(5) ISSN: 0332-236X.

            Descriptors:  Newcastle disease, avian influenza virus, symptoms, diagnosis, disease control.

Curran, R. (2004). Asian bird flu. Emergency Medical Services 33(5): 38-9.  ISSN: 0094-6575.

            Descriptors:  influenza virology, influenza A virus, avian pathogenicity, zoonoses virology, chickens virology, influenza epidemiology, influenza prevention and control, influenza transmission, isolation and purification, Japan epidemiology, respiratory protective devices, zoonoses epidemiology, zoonoses transmission.

Cyranoski, D. (2004). Bird flu data languish in Chinese journals. Nature  430(7003): 955.  ISSN: 1476-4687.

            NAL Call Number:  472 N21

            Descriptors:  biomedical research, birds virology, influenza veterinary, influenza A virus, avian isolation and purification, language, periodicals, swine virology, southeastern Asia epidemiology, China epidemiology, communicable disease control, communication barriers, influenza epidemiology, influenza transmission, influenza virology, avian classification, publishing, time factors, zoonoses transmission, zoonoses virology.

Cyranoski, D. (2001). Outbreak of chicken flu rattles Hong Kong. Nature 412(6844): 261.  ISSN: 0028-0836.

            NAL Call Number:  472 N21

            Descriptors:  disease outbreaks, fowl plague epidemiology, poultry diseases epidemiology, chickens, Hong Kong epidemiology, influenza A virus avian, poultry diseases virology.

Das, P. (2004). Infectious disease surveillance update. Lancet Infectious Diseases 4(8): 481.  ISSN: 1473-3099.

            Descriptors:  chickens, disease outbreaks veterinary, influenza A virus, avian growth and development, avian influenza epidemiology, poultry diseases epidemiology, West Nile fever epidemiology, West Nile virus growth and development, Arizona epidemiology, California epidemiology, China epidemiology, influenza, avian virology, middle aged, poultry diseases virology, Vietnam epidemiology, West Nile fever virology.

Daszak, P., G.M. Tabor, A.M. Kilpatrick, J. Epstein, and R. Plowright (2004). Conservation medicine and a new agenda for emerging diseases. Annals of the New York Academy of Sciences 1026: 1-11.  ISSN: 0077-8923.

            NAL Call Number:  500 N484

            Abstract:  The last three decades have seen an alarming number of high-profile outbreaks of new viruses and other pathogens, many of them emerging from wildlife. Recent outbreaks of SARS, avian influenza, and others highlight emerging zoonotic diseases as one of the key threats to global health. Similar emerging diseases have been reported in wildlife populations, resulting in mass mortalities, population declines, and even extinctions. In this paper, we highlight three examples of emerging pathogens: Nipah and Hendra virus, which emerged in Malaysia and Australia in the 1990s respectively, with recent outbreaks caused by similar viruses in India in 2000 and Bangladesh in 2004; West Nile virus, which emerged in the New World in 1999; and amphibian chytridiomycosis, which has emerged globally as a threat to amphibian populations and a major cause of amphibian population declines. We discuss a new, conservation medicine approach to emerging diseases that integrates veterinary, medical, ecologic, and other sciences in interdisciplinary teams. These teams investigate the causes of emergence, analyze the underlying drivers, and attempt to define common rules governing emergence for human, wildlife, and plant EIDs. The ultimate goal is a risk analysis that allows us to predict future emergence of known and unknown pathogens.

            Descriptors:  clinical medicine trends, communicable diseases, emerging therapy, conservation of natural resources, disease outbreaks, ecology, interprofessional relations, zoonoses, amphibia microbiology, Chytridiomycota pathogenicity, emerging diagnosis, emerging epidemiology, forecasting, Hendra virus pathogenicity, public health, risk assessment, veterinary medicine trends, West Nile virus pathogenicity.

Davidson, W.R., H.W. Yoder, M. Brugh, and V.F. Nettles (1988). Serological monitoring of eastern wild turkeys for antibodies to Mycoplasma spp. and avian influenza viruses. Journal of Wildlife Diseases 24(2): 348-51.  ISSN: 0090-3558.

            NAL Call Number:  41.9 W64B

            Abstract:  From 1981 through 1986, plasma or serum samples were obtained from 322 wild turkeys (Meleagris gallopavo) from Georgia (n = 111), Kentucky (n = 21), Louisiana (n = 22), North Carolina (n = 118), Tennessee (n = 19), Missouri (n = 24) and Iowa (n = 7). These samples were tested for antibodies to Mycoplasma gallisepticum (MG) and in most instances, M. synoviae (MS), M. meleagridis (MM), and avian influenza (AI) virus. All 322 turkeys were seronegative for MG by the rapid plate agglutination (RPA) test. All of a subsample (n = 147) also were negative (titer less than or equal to 1:40) for MG by the hemagglutination inhibition (HI) test. Five of 253 turkeys (2%) were seropositive (+4 reaction) for MS by the RPA test; however, HI tests for MS on these five turkeys were negative as were attempts to isolate MS from trachea and homogenized lung tissue. Three of 253 turkeys (1%) were seropositive (+1 to +3 reactions) for MM by the RPA test. None of 210 turkeys had antibodies to AI by the agar gel precipitation test. These data suggest that populations of native eastern wild turkeys are not important in the epizootiology of MG, MS, MM, or AI.

            Descriptors:  antibodies, bacterial analysis, antibodies, viral analysis, influenza A virus avian immunology, Mycoplasma immunology, turkeys microbiology, animals, wild immunology, turkeys immunology.

Davison, S., D. Galligan, T.E. Eckert, A.F. Ziegler, and R.J. Eckroade (1999). Economic analysis of an outbreak of avian influenza, 1997-1998. Journal of the American Veterinary Medical Association 214(8): 1164-1167.  ISSN: 0003-1488.

            NAL Call Number:  41.8 Am3

            Descriptors:  economic losses, economic analysis, outbreaks, disease control, avian influenza virus, turkeys, United States, Pennsylvania.

de Boer, G.F., W. Back, and A.D. Osterhaus (1990). An ELISA for detection of antibodies against influenza A nucleoprotein in humans and various animal species. Archives of Virology 115(1-2): 47-61.  ISSN: 0304-8608.

            NAL Call Number:  448.3 Ar23

            Abstract:  A double antibody sandwich blocking ELISA, using a monoclonal antibody (MAb) against influenza A nucleoprotein (NP) was developed to detect antibodies against influenza. Collections of serum samples were obtained from human and various animal species. All influenza A subtypes induced antibodies against hemagglutinins and NP. A close correlation between titers of the hemagglutination inhibition (HI) test and the NP-ELISA was seen. Antibodies against influenza NP were demonstrated in serum samples from humans, ferrets, swine, horses, chickens, ducks, guinea pigs, mice, and seals. The serum samples were collected at intervals during prospective epidemiological studies, from experimental and natural infections, and vaccination studies. The decline of maternal antibodies was studied in swine and horses. The NP-ELISA enables rapid serological diagnosis and is suited for influenza A antibody screening, especially in species which harbor several influenza subtypes. The HI and neuraminidase inhibition tests, however, must still be used for subtyping.

            Descriptors:  antibodies, viral analysis, enzyme linked immunosorbent assay, influenza A virus immunology, nucleoproteins immunology, orthomyxoviridae infections immunology, viral core proteins immunology, ferrets, hemagglutination inhibition tests, horses, avian immunology, human immunology, porcine immunology, orthomyxoviridae infections veterinary, poultry, prospective studies, Rodentia, seals, species specificity, specific pathogen free organisms, swine, vaccination.

de Boer, G.F., C. van Maanen, J.T. Siebinga, and W. Back (1992). Klassieke vogelpest en mildere influenza-infecties bij vogels en zoogdieren. [Classical fowl plague and milder influenza infections in birds and mammals]. Tijdschrift Voor Diergeneeskunde 117(24): 735-40.  ISSN: 0040-7453.

            NAL Call Number:  41.8 T431

            Abstract:  Wild waterfowl are currently considered the largest reservoir of the various haemagglutinin (H) and neuraminidase (N) subtypes of influenza virus. Until now thirteen different H-types and nine different N-types have been detected in these populations. In the first instance, virus transmission from fowl to other animal species and to man is not causing disease problems. However, small changes at the molecular level of a given HN-subtype recently caused a dramatic increase in virulence for chickens. Genes fragments coding for haemagglutinin or neuraminidase can be exchanged between viruses which propagate in the same individual. This phenomenon-'genetic reassortment'-is of major epidemiological significance when it occurs in pigs. New influenza epidemics in the human population consistently originate in areas where waterfowl, pigs and human beings live close together. At the moment, the virological and serological diagnosis of influenza A infections is based ELISAs for antigen and antibody detection. Both ELISAs employ a monoclonal antibody directed against a conserved antigenic determinant of the influenza A nucleoprotein. The use of these tests can simplify the diagnosis of and screening for influenza A infections, particularly in those species which harbour several H- and N-subtypes.

            Descriptors:  fowl plague microbiology, orthomyxoviridae infections veterinary, birds microbiology, chickens microbiology, enzyme linked immunosorbent assay veterinary, influenza A virus avian genetics, avian isolation and purification, avian pathogenicity, orthomyxoviridae infections microbiology, orthomyxoviridae infections transmission, virulence.

De Clercq, K. and N. Goris (2004). Extending the foot-and-mouth disease module to the control of other diseases. Developmental Biology (Basel) 119: 333-40.  ISSN: 1424-6074.

            Abstract:  During the recent devastating epidemics of foot-and-mouth disease (FMD), bluetongue (BT), the highly pathogenic avian influenza (HPAI) and New Castle disease, more than 115 million animals were culled. The mass slaughter of animals raised serious ethical questions. These epidemics showed that the use of emergency vaccination is an essential element in disease control. During the last decade the FMD antigen banks have proved to be effective and this module should be extended. An international vaccine stock should be considered for classical swine fever and HPAI. Agreements with vaccine producers should be made easily available, with instant access to a vaccine reserve for rinderpest, peste des petits ruminants, BT, African horse sickness and Rift valley fever. These vaccines should meet international standards and should allow distinction between vaccinated and infected animals. Information should be gathered proactively on the use of vaccines for lumpy skin disease, sheep and goat pox and contagious bovine pleuropneumonia.

            Descriptors:  animals, Australia, communicable disease control methods, disease outbreaks prevention and control, veterinary disease outbreaks, drug storage, emergency treatment methods, veterinary emergency treatment, animal euthanasia, foot-and-mouth disease prevention and control, international cooperation, viral vaccines immunology, viral vaccines supply and distribution.

de Jong, J.C., G.F. Rimmelzwaan, R.A. Fouchier, and A.D. Osterhaus (2000). Influenza virus: a master of metamorphosis. Journal of Infection 40(3): 218-28.  ISSN: 0163-4453.

            Abstract:  Novel influenza viruses continuously emerge in the human population. Three times during the present century, an avian influenza virus subtype crossed the species barrier, starting a pandemic, and establishing itself for one to several decades in man. As the 1997 H5N1 event in Hong Kong indicated, the occurrence of another pandemic in the near future cannot be excluded. Sufficient vaccine may not be available to ameliorate the consequences of such an event, because of a shortage of time. During interpandemic periods, important antigenic drift variants sometimes arise at a point of time when, with the current state of the technique, production of a correspondingly adapted vaccine is also impossible. We may be able to solve these problems by increasing influenza surveillance and by adopting new ways of vaccine composition, production, formulation, presentation, and delivery. The recently developed anti-neuraminidase antivirals should only be considered as (valuable) adjuncts to vaccines.

            Descriptors:  antigenic variation, influenza epidemiology, orthomyxoviridae genetics, disease outbreaks, hn protein genetics, hemagglutinin glycoproteins, influenza virus genetics, influenza mortality, influenza prevention and control, influenza vaccine therapeutic use, orthomyxoviridae enzymology, orthomyxoviridae pathogenicity, reassortant viruses genetics, reassortant viruses pathogenicity, virulence.

de Jong, M.D., V.C. Bach, T.Q. Phan, M.H. Vo, T.T. Tran, B.H. Nguyen, M. Beld, T.P. Le, H.K. Truong, V.V. Nguyen, T.H. Tran, Q.H. Do, and J. Farrar (2005). Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. New England Journal of Medicine 352(7): 686-91.  ISSN: 1533-4406.

            NAL Call Number:  448.8 N442

            Descriptors:  coma virology, diarrhea virology, encephalitis, viral etiology, influenza complications, influenza A virus, avian influenza genetics, avian influenza isolation and purification, acute disease, child, preschool child, viral virology, fatal outcome, influenza diagnosis, influenza virology, lung radiography, seizures virology.

de Marco, M.A., V. Guberti, E. Raffini, E. Foni, M. Delogu, and I. Donatelli (1999). Influenza aviaria. Indagini epidemiologiche in specie selvatiche [Italia]. [Avian influenza. Epidemiological surveys in wild birds in Italy]. Selezione Veterinaria (Italy) (12): 897-907.

            NAL Call Number:  241.71 B75

            Abstract:  Gli AA riportano i risultati di un monitoraggio sanitario sull'influenza aviaria, svolto in Italia su diverse specie selvatiche di volatili. Nel periodo compreso tra il 1992 e il 1998 sono stati sottoposti ad indagine sierologica, per evidenziare anticorpi nei confronti della nucleoproteina dei virus influenzali di tipo A, 404 anatidi, 277 folaghe, 40 fenicotteri, 394 fagiani, 258 quaglie, 147 rapaci. Di tali campioni sono risultati sierologicamente positivi 216 anatidi, 28 folaghe, 11 fenicotteri, 2 rapaci. Tamponi cloacali effettuati nel 1993 su 120 passeriforrni hanno dato esito negativo per la ricerca di virus influenzali di tipo A.

            Descriptors:  birds, disease surveys, wild animals, monitoring, animal diseases, Italy, immunological techniques, antibiotics, biopsy, avian influenza virus, epidemiology, laboratory diagnosis, identification, etiology, biological analysis, diagnosis, Europe, histocytological analysis, influenza virus, orthomyxoviridae, surveys,  viruses, Western Europe, wildlife.

Dea, S., M.A. Elazhary, and R.S. Roy (1980). Les virus influenza chez l'homme et les animaux. Une revue de la litterature. [Influenza viruses in man and animals. A literature review (author's transl)]. Canadian Veterinary Journal Revue Veterinaire Canadienne  21(6): 171-8.  ISSN: 0008-5286.

            NAL Call Number:  41.8 R3224

            Descriptors:  animals, domestic, orthomyxoviridae infections microbiology, orthomyxoviridae infections veterinary, antigens, viral analysis, chickens, epitopes, fowl plague microbiology, horse diseases microbiology, horses, influenza microbiology, influenza A virus avian immunology, human immunology, porcine immunology, mutation, recombination, genetic, swine, swine diseases microbiology.

Deibel, R., D.E. Emord, W. Dukelow, V.S. Hinshaw, and J.M. Wood (1985). Influenza viruses and paramyxoviruses in ducks in the Atlantic flyway, 1977-1983, including an H5N2 isolate related to the virulent chicken virus. Avian Diseases 29(4): 970-85.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  From 1977 to 1983, waterfowl migrating along the Atlantic flyway were annually monitored for orthomyxoviruses and paramyxoviruses in an area in central New York State. A total of 168 influenza isolates were obtained from 1,430 waterfowl. Twenty-four combinations of hemagglutinin and neuraminidase subtypes were detected, with as many as 12 found in a single year. One combination, an H5N2 isolate in 1982, was closely related to the virulent chicken virus that appeared in Pennsylvania in 1983. The prevalence of influenza varied greatly among the common waterfowl species: mallards 42%, black ducks 30%, blue-winged teal 11%, wood ducks 2%, and Canada geese 0%. A total of 89 paramyxoviruses were also from these waterfowl. In contrast to findings with influenza virus, the prevalence of paramyxoviruses did not differ significantly among the duck species. Serotype 1 (Newcastle disease virus) was predominant; three other serotypes were also identified. These findings indicated that ducks in the Atlantic flyway continually harbor influenza viruses and paramyxoviruses. The viruses may be a source of infection for other species.

            Descriptors:  ducks microbiology, influenza A virus avian isolation and purification, orthomyxoviridae isolation and purification, paramyxoviridae isolation and purification, antigens, viral analysis, demography, New York, species specificity.

DeLay, P.D., H.L. Casey, and H.S. Tubiash (1967). Comparative study of fowl plague virus and a virus isolated from man. Public Health Reports 82(7): 615-20.  ISSN: 0094-6214.

            NAL Call Number:  151.65 P96

            Descriptors:  influenza A virus avian immunology, orthomyxoviridae infections immunology, viruses immunology, chick embryo, haplorhini, hemagglutination inhibition tests, hemagglutination tests, neutralization tests, Newcastle disease immunology, Newcastle disease virus immunology, poultry, virus diseases immunology, virus diseases pathology.

Della Porta, A. J. (ed.). (1985). Avian diseases. In: Veterinary viral diseases, their significance in South East Asia and the Western Pacific, p. 317-358.

            NAL Call Number: SF780.4.I56 1984

            Descriptors: wild birds, avian influenza, Newcastle disease, viral diseases, threat, Australia, Korea, Malaysia, conference papers.

Donis, R.O., W.J. Bean, Y. Kawaoka, and R.G. Webster (1989). Distinct lineages of influenza virus H4 hemagglutinin genes in different regions of the world. Virology 169(2): 408-17.  ISSN: 0042-6822.

            NAL Call Number:  448.8 V81

            Abstract:  To understand the determinants of influenza virus evolution, phylogenetic relationships were determined for nine hemagglutinin (HA) genes of the H4 subtype. These genes belong to a set of viruses isolated from several avian and mammalian species from various geographic locations around the world between 1956 and 1985. We found that the HA gene of the H4 subtype is 1738 nucleotides in length and is predicted to encode a polypeptide of 564 amino acids. The connecting peptide, which is removed from the precursor polypeptide by peptidases to yield the mature HA1 and HA2 polypeptides, contains only one basic amino acid. This type of connecting peptide is a feature of all avian avirulent HAs. On the basis of pairwise nucleotide sequence homology comparisons the genes can be segregated into two groups: influenza virus genes isolated in North America and those isolated from other parts of the world. A high degree of homology exists between pairs of genes from viruses of similar geographic origin. The nucleotide sequences within a group differ by 1.5 to 10.6%; in contrast, between groups the differences range from 15.8 to 19.4%. An evolutionary tree for the nine sequences suggests that North American isolates have diverged extensively from those circulating in other parts of the world. Geographic barriers which determine flyway outlay may prevent the gene pools from extensive mixing. The lack of correlation between date of isolation and evolutionary distance suggests that different H4 HA genes cocirculate in a fashion similar to avian H3 HA genes (H. Kida et al., 1987, Virology 159, 109-119) and influenza C genes (D. Buonagurio et al., 1985, Virology 146, 221-232) implying the absence of selective pressure by antibody that would give a significant advantage to antigenic variants. In contrast to avian influenza virus genes, human influenza virus genes evolve rapidly under the selective pressure of antibody.

            Descriptors:  hemagglutinins viral genetics, influenza A virus genetics, amino acid sequence, base sequence, cloning, molecular, geography, molecular sequence data, sequence homology, nucleic acid.

Dosser, E.M. (1970). Stimuliruiushchee vzaimodeistvie virusov zhivotnykh. [Stimulating interaction of animal viruses]. Voprosy Virusologii 15(4): 387-94.  ISSN: 0507-4088.

            NAL Call Number:  448.8 P942

            Descriptors:  Newcastle disease virus, viral interference, adenoviridae, arboviruses, cattle, cervix neoplasms, chick embryo, chikungunya virus, encephalomyocarditis virus, HeLa cells, influenza A virus avian, interferons antagonists and inhibitors, l cells cell line, lactones pharmacology, mice, orthomyxoviridae, parainfluenza virus 1, human drug effects, polioviruses, rabies virus, rats, respirovirus, swine, tissue culture, vesicular stomatitis Indiana virus, virus cultivation, virus replication.

Downie, J.C., V. Hinshaw, and W.G. Laver (1977). The ecology of influenza. Isolation of type 'A' influenza viruses from Australian pelagic birds. Australian Journal of Experimental Biology and Medical Science 55(6): 635-43.  ISSN: 0004-945X.

            NAL Call Number:  442.8 Au7

            Abstract:  Three different type A influenza viruses have been isolated from pelagic birds nesting on islands of the Great Barrier Reef. One of these, isolated in 1972, was of subtype Hav6Nav5. The other two, which are described in this paper, were isolated in 1975 and belonged to subtypes Hav5Nav2 and Hav3Nav6. Of eight isolates of the latter virus, seven were recovered from cloacal swabs and only one from the trachea.

            Descriptors:  birds microbiology, influenza A virus avian isolation and purification, antibodies, viral analysis, antigens, viral immunology, Australia, cloaca microbiology, hemagglutinins viral analysis, influenza A virus avian immunology, neuraminidase immunology, trachea microbiology.

Downie, J.C. and W.G. Laver (1973). Isolation of a type A influenza virus from an Australian pelagic bird. Virology 51(2): 259-269.

            NAL Call Number:  448.8 V81

            Descriptors:  influenza A virus, birds, Puffinus pacificus chlororhynchus, shearwater bird.

Easterday, B.C. (1973). Avian influenza: a growing problem. Poultry Digest 32(378): 357-359.  ISSN: 0032-5724.

            NAL Call Number:  47.8 N219

            Descriptors:  avian influenza, poultry.

Easterday, B.C. (1973). Avian influenza: a worldwide enigma. Journal of the American Veterinary Medical Association 163(10): 1197.  ISSN: 0003-1488.

            NAL Call Number:  41.8 Am3

            Descriptors:  avian influenza, global, birds, ducks.

Easterday, B.C., C.W. Beard and  M. S. Hofstad (ed.) (1984). Avian influenza. In: Diseases of Poultry, 8th edition, p. 482-496.

            NAL Call Number:  SF995.B5 1984

            Descriptors:  avian influenza virus, reviews, poultry diseases.

Easterday, B.C., D.O. Trainer, B. Tumova, and H.G. Pereira (1968). Evidence of infection with influenza viruses in migratory waterfowl. Nature 219(153): 523-4.  ISSN: 0028-0836.

            NAL Call Number:  472 N21

            Descriptors:  bird diseases microbiology, influenza veterinary, orthomyxoviridae infections veterinary, bird diseases immunology, disease reservoirs, ducks, England, geese, hemagglutination inhibition tests, Illinois, influenza immunology, influenza A virus avian isolation and purification, Michigan, Missouri, neutralization tests, Ontario, orthomyxoviridae isolation and purification, orthomyxoviridae infections immunology, South Dakota, Texas, turkeys, Wisconsin.

Easterday, B.C. and B. Tumova (1972). Avian influenza viruses: in avian species and the natural history of influenza. Advances in Veterinary Science and Comparative Medicine 16: 201-22.  ISSN: 0065-3519.

            NAL Call Number:  448.3 AC85

            Descriptors:  bird diseases etiology, influenza veterinary, orthomyxoviridae classification, orthomyxoviridae immunology, antigens, viral, bird diseases drug therapy, bird diseases prevention and control, birds, chickens, ducks, ecology, influenza drug therapy, influenza immunology, influenza pathology, influenza prevention and control, influenza A virus avian classification, avian immunology, poultry diseases, turkeys.

Easterday, B.C., B. Tumova and  M. S. Hofstad (ed.) (1972). Avian influenza. In: Diseases of Poultry, 6th edition, p. 670-700.

            NAL Call Number:  SF995.I86

            Descriptors:  avian influenza, poultry, diseases.

Easterday, B.C., B. Tumova, M. S. Hofstad (ed.) and  others (ed.) (1978). Avian influenza. In: Diseases of Poultry, 7th edition, p. 549-573.

            NAL Call Number:  SF995.B5 1972

            Descriptors:  reviews, birds, avian influenza virus, diseases.

Echaniz Aviles, G. (2004 ). Influenza aviar: debemos preocuparnos? Salud P'Ublica De M'Exico 46(2): 186-7.  ISSN: 0036-3634.

            Descriptors:  influenza epidemiology, influenza, avian epidemiology, Asia epidemiology, birds, influenza virology.

Eiros Bouza, J.M. (2004). Sindrome agudo respiratorio grave y gripe aviar [Severe acute respiratory syndrome and avian flu]. Anales De La Real Academia Nacional De Medicina 121(2): 263-88.  ISSN: 0034-0634.

            Abstract:  Severe acute respiratory syndrome (SARS) is a new disease that caused large ourbreaks in several countries in the first half of 2003, resulting in infection in more than 8.000 people and more than 900 deaths. The disease originated in southern China and a novel coronavirus (SARS CoV) has been implicated as the causative organism. We present an overview of the etiology, clinical presentation and diagnosis, based on the current state of knowledge derived from published studies and our experience in the National Microbiology Centre. Influenza is a zoonosis. This appreciation of influenza ecology facilitated recognition of the H5N1 'bird flu' incident in Hong Kong in 1997 in what was considered to be an incipient pandemic situation, the chicken being the source of virus for humans and. The current outbreak of avian influenza in South East Asia has resulted in a small number of human deaths. These findings highlight the importance of systematic virus surveillance of domestic poultry in recognizing changes in virus occurrence, host range and pathogenicity as signals at the avian level that could presage a pandemic.

            Descriptors:  disease outbreaks, avian influenza epidemiology, severe acute respiratory syndrome diagnosis, severe acute respiratory syndrome etiology, severe acute respiratory syndrome virology, southeastern Asia epidemiology, China epidemiology, diagnosis, avian influenza mortality, avian influenza virology, middle aged adult.

Ek-Kommonen, C. (1996). Avian influenza. Suomen Eläinlääkärilehti 102(7/8): 399-402.  ISSN: 0039-5501.

            NAL Call Number:  41.8 F49

            Descriptors:  avian influenza virus, poultry, disease prevalence, symptoms, diagnosis, control, vaccines.

Ekdahl, K., P. Penttinen, A. Ternhag, A. Linde, and J. Giesecke (2004). Fagelinfluensan--nasta globala infektionshot fran Asien. [Avian influenza--next global infection threat from Asia]. Lakartidningen 101(8): 683-5.  ISSN: 0023-7205.

            Descriptors:  disease outbreaks, fowl plague epidemiology, influenza epidemiology, influenza A virus avian genetics, avian pathogenicity, world health, birds, fowl plague transmission, influenza transmission, influenza virology, risk factors.

Enserink, M. (2004). Breakthrough of the year. Avian influenza: catastrophe waiting in the wings? Science 306(5704): 2016.  ISSN: 1095-9203.

            NAL Call Number:  470 Sci2

            Descriptors:  influenza virology, influenza A virus, avian pathogenicity, influenza, avian epidemiology, antiviral agents therapeutic use, Asia epidemiology, disease outbreaks veterinary, influenza epidemiology, influenza prevention and control, influenza vaccines, avian influenza prevention and control, avian influenza virology, poultry, vaccination veterinary, World Health Organization.

Enserink, M. (2005). Infectious diseases. Experts dismiss pig flu scare as nonsense. Science 307(5714): 1392.  ISSN: 1095-9203.

            NAL Call Number:  470 Sci2

            Descriptors:  genes, viral, orthomyxoviridae genetics, orthomyxoviridae isolation and purification, orthomyxoviridae infections veterinary, swine virology, swine diseases virology, databases, nucleic acid, influenza A virus, avian genetics, human genetics, Korea, orthomyxoviridae infections virology, RNA, viral genetics, World Health Organization.

Enserink, M. (2004). Influenza: girding for disaster. Looking the pandemic in the eye. Science 306(5695): 392-4.  ISSN: 1095-9203.

            NAL Call Number:  470 Sci2

            Descriptors:  disease outbreaks, influenza epidemiology, world health, cost of illness, influenza transmission, influenza virology, avian pathogenicity, influenza A virus, avian physiology, influenza vaccines administration and dosage, influenza vaccines supply and distribution, models, biological, orthomyxoviridae pathogenicity, orthomyxoviridae physiology, public health, reassortant viruses.

Enserink, M. (2004). Virology. Tiptoeing around Pandora's Box.  Science 305(5684):  594-5.  ISSN: 1095-9203.

            NAL Call Number:  470 Sci2

            Descriptors:  influenza virology, influenza A virus, avian genetics, human genetics, reassortant viruses genetics, reassortant viruses pathogenicity, bioterrorism, birds, Centers for Disease Control and Prevention U.S., containment of biohazards, disease outbreaks, genome, viral, influenza epidemiology, influenza transmission, avian influenza pathogenicity, human pathogenicity, avian influenza epidemiology, avian influenza virology, recombination, genetic, risk assessment, United States, virulence, World Health Organization.

Erasmus, B.J. (2003). The latest on avian influenza. Poultry Bulletin South Africa Poultry Association : 14-17.  ISSN: 0257-201X.

            NAL Call Number:  47.8 So89

            Descriptors:  chickens, avian influenza virus, pathogenicity, vaccination, immunization, disinfection, South Africa, Africa, Africa South of Sahara, biological properties, birds, domestic animals, Galliformes, immunization, immunostimulation, immunotherapy, livestock, microbial properties, poultry, Southern Africa, therapy, useful animals.

Erickson, G.A., M. Brugh, and C.W. Beard (1978). Newcastle disease and avian influenza virus stability under simulated shipping conditions. Proceedings of the Annual Meeting of the American Association of Veterinary Laboratory Diagnosticians 21: 309-318.

            NAL Call Number:  SF771.A53a

            Descriptors:  Newcastle disease virus, avian influenza virus, shipping, culture media, preservation, specimen handling.

Estola, T., P. Saikku, M. Pirkola, I. Hakkinen, P. Veijalainen, and C. Ek Kommonen (1980). Occurrence of influenza A viruses and their antibodies in migratory birds in Finland. Nordisk Veterinaermedicin 32(7-8): 321-4.  ISSN: 0029-1579.

            NAL Call Number:  41.8 N813

            Abstract:  A Finnish material of 455 cloacal specimens from 24 species of small migratory birds and of 54 cloacal specimens from 10 species of waterfowl was investigated for the occurrence of A type influenza virus. Influenza A virus was isolated in only one specimen, originating from a mallard (Anas platyrhynchos). Parallely, yolk material from 109 waterfowl representing 9 species was investigated for the occurrence of influenza A antibodies by complement fixation and immunodiffusion tests. In three yolk specimens, one from a widgeon (Anas penelope), one from a common gull (Larus canus) and one from a lesser blackbacked gull (Larus fuscus ), positive reactions with low titres of 1:2--1:4 were obtained. The study shows that waterfowl can carry influenza A virus, but the role of small migratory birds in this respect seems to be negligible in Finland.

            Descriptors:  antibodies, viral analysis, birds microbiology, influenza A virus avian immunology, birds immunology, cloaca microbiology, Finland, influenza A virus avian isolation and purification.

Estudillo, L.J. (1996). Consideraciones sobre el instinto migratorio de las aves silvestres y analisis de las posibilidades reales que estas hayan sido el vector del brote de influenza aviar en Mexico. [Considerations on the migratory instinct of wild birds and analysis of the actual possibilities for these birds to have served as vectors for the avian influenza outbreak in Mexico]. Proceedings of the Western Poultry Diseases Conference 45: 22-20.

            NAL Call Number:  SF995.W4

            Descriptors:  birds, vectors, avian influenza virus, Mexico, America, disease transmission, influenza virus, Latin America, North America, orthomyxoviridae, pathogenesis, viruses.

Eto, M. and M. Mase (2003). Isolation of the Newcastle disease virus and the H9N2 influenza A virus from chicken imported from China. Journal of the Japan Veterinary Medical Association 56(5): 333-339.  ISSN: 0446-6454.

            NAL Call Number:  41.9 J275

            Descriptors:  influenza A virus, Newcastle disease, avian influenza virus, imported products, chicken meat, pathogenicity, China

Fauci, A.S. (1998). New and reemerging diseases: The importance of biomedical research. Emerging Infectious Diseases 4(3): 374-378.  ISSN: 1080-6040.

            NAL Call Number:  RA648.5.E46

            Descriptors:  infection, public health, avian H5N1 influenza, outbreak response, respiratory system disease, viral disease, infectious diseases, infectious disease, new, reemerging, malaria, National Institute of Health initiatives, parasitic disease, blood and lymphatic disease, biomedical research importance, cross sector collaboration, vaccine development.

Ferguson, N.M., C. Fraser, C.A. Donnelly, A.C. Ghani, and R.M. Anderson (2004). Public health. Public health risk from the avian H5N1 influenza epidemic. Science 304(5673): 968-9.  ISSN: 1095-9203.

            NAL Call Number:  470 Sci2

            Descriptors:  disease outbreaks veterinary, influenza epidemiology, influenza transmission, influenza A virus, avian genetics, avian pathogenicity, population surveillance, public health, animals, domestic, cluster analysis, influenza virology, human genetics, human pathogenicity, avian influenza epidemiology, avian influenza prevention and control, avian influenza transmission, avian influenza virology, mathematics, reassortant viruses genetics, reassortant viruses pathogenicity, recombination, genetic, risk assessment, world health, zoonoses.

Fernandez del Campo, J.A. (2004). Datos actuales sobre virus de la gripe de patos salvajes y pollos, y virus de la gripe tipo C. Agentes antigripales [Present data on influenza virus isolated from ducks and chickens, and influenza virus C. Anti-influenza drugs]. Anales De La Real Academia Nacional De Medicina 121(2): 305-30.  ISSN: 0034-0634.

            Abstract:  Present data on influenza virus isolated from ducks and chickens, and influenza virus C. Anti-influenza drugs. Within the broad field of Glycopathology and Glycotherapeutics, research on influenza virus types A, B and C from humans and several bird species (particularly migratory birds such as ducks, since they are reservoirs for viruses), as well as the search for improved drugs designed for the prevention or treatment of epidemics/pandemics produced by most of those viruses are issues of relevant interest not only from a scientific point of view but also for repercussions on health and the important economical consequences. The research work begun by the author and collaborators at the Department of Biochemistry and Molecular Biology of the University of Salamanca (Spain) in the middle of the 1970's, developed later in close cooperation with the "(Unite d'Ecologie Virale" of the Pasteur Institute of Paris (Prof. Claude Hannoun and collaborators), has been published in about twenty papers that mainly focus on the theoretic-experimental study of: The sialidase (neuraminidase) activity of human influenza viruses types A and B. The acetylesterase activity of type C virus from humans and dogs. The sialidase activity of type A virus from ducks and pigs, in comparison with that of humans. Certain sialidase inhibitors as useful anti-influenza drugs, especially in the case of possible future influenza pandemics of avian origin.

            Descriptors:  antiviral agents therapeutic use, chickens microbiology, ducks microbiology, influenza drug therapy, avian influenza drug therapy, neuraminidase antagonists and inhibitors, orthomyxoviridae isolation and purification, acetylesterase analysis, adolescent, aged adult, aged 80 and over, child, preschool child, disease reservoirs, dogs, influenza prevention and control, influenza vaccines administration and dosage, influenza virus A enzymology, influenza virus A isolation and purification, influenza virus B enzymology, influenza virus B isolation and purification, influenza virus C enzymology, influenza virus C isolation and purification, middle aged, neuraminidase analysis, research.

Fioretti, A., M. Calabria, and A. Piccirillo (1998). Influenza aviare. [Avian influenza]. [Italian Society of Poultry Pathology Meeting on World and Italian situation of avian influenza]. Legnaro, Padua (Italy). 7 Apr 1998. Selezione Veterinaria (Italy) (12): 921-929.

            NAL Call Number:  241.71 B75

            Descriptors:  avian influenza virus, history, symptoms, postmortem examination, vaccination, mortality, diagnosis, disease surveillance, chickens, Italy.

Fiszon, B., C. Hannoun, A. Garcia Sastre, E. Villar, and J.A. Cabezas (1989). Comparison of biological and physical properties of human and animal A (H1N1) influenza viruses. Research in Virology 140(5): 395-404.  ISSN: 0923-2516.

            NAL Call Number:  QR355.A44

            Abstract:  The study of biological properties of influenza virus strains belonging to the same subtype A(H1N1) and closely antigenically related, but isolated from different animal species (man, pig and duck), demonstrated that avian strains were more resistant than those isolated from mammals to high temperature and low pH, as shown by titration of residual infectivity in cell cultures (MDCK) and by sialidase assay. The difference in behaviour could be correlated to biological adaptation of the virus to its host. Avian body temperature is 40 degrees C and influenza virus, in ducks, is enterotropic and therefore capable of passing through the low pH values in the upper digestive tract of the animal. These results do not contradict the hypothesis of a possible filiation between avian and mammalian orthomyxoviruses.

            Descriptors:  influenza A virus physiology, body temperature, cell line, ducks, hemagglutination tests, hydrogen-ion concentration, influenza A virus avian enzymology, avian growth and development, avian physiology, human enzymology, human growth and development, human physiology, porcine enzymology, porcine growth and development, porcine physiology, influenza A virus enzymology, influenza A virus growth and development, neuraminidase analysis, plaque assay, swine, temperature, virus replication.

Fleck, F. (2004). Avian flu virus could evolve into dangerous human pathogen, experts fear. Bulletin of the World Health Organization 82(3): 236-7.  ISSN: 0042-9686.

            NAL Call Number:  449.9 W892B

            Descriptors:  influenza epidemiology, influenza A virus, avian pathogenicity, zoonoses, Asia, birds.

Fleury, H.J., M. Babin, J.F. Bonnici, J.D. Poveda, M. Beyrie, A. Vuillaume, and D.J. Alexander (1986). First simultaneous isolation of influenza A virus and duck enteritis virus from commercial ducks in France. Veterinary Record 119(9): 208-9.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  ducks microbiology, fowl plague complications, herpesviridae isolation and purification, herpesviridae infections veterinary, influenza A virus avian isolation and purification, fowl plague microbiology, herpesviridae infections complications, herpesviridae infections microbiology, poultry diseases microbiology.

Fomsgaard, A., P.C. Grauballe, and S.O. Glismann (2004). Risiko for en ny influenzapandemi? [Risk of a new influenza pandemic?]. Ugeskrift for Laeger 166(10): 912-5.  ISSN: 0041-5782.

            Descriptors:  disease outbreaks prevention and control, influenza epidemiology, influenza A virus classification, influenza A virus genetics, influenza A virus pathogenicity, zoonoses virology, birds, communicable disease control, influenza prevention and control, influenza transmission, avian influenza transmission, poultry, world health, zoonoses transmission.

Fontaine, M. (1984). Influenza aviaire. [Avian influenza (review)]. Recueil De Medecine Veterinaire 160(11): 929-937.

            NAL Call Number:  41.8 R24

            Descriptors:  avian influenza virus, review, birds, mammals.

Fontaine, M. and M. Aymard Henry (1975). Contribution a l'etude antigenique des virus influenza des animaux. I. Neuraminidase des virus influenza equins. [Contribution to the antigenic study of influenza viruses in animals. I. Neuraminidase of the equine influenza viruses (author's transl)]. Annales De Recherches Veterinaires Annals of Veterinary Research 6(4):  397-410.  ISSN: 0003-4193.

            NAL Call Number:  SF602.A5

            Abstract:  From the Revised Nomenclature of WHO, the fowl influenza virus A/Duck/Ukraine/63 (Hav7 Neq2) has the same neuraminidase as the equine virus A/equi 2/Miami/63 (Heq2 Neq2); the A/Chicken Germany "N"/49 virus has the same neuraminidase as the equine virus A/equi 1/Prague/56. A comparative study of the antigenic specificities confirms that the Neq2 neuraminidases are closely connected, whatever their animal origin, and that the fowl strain Hav7 Neq2 can be used for the titration of anti Neq2 antibodies in the serums of animals immunized with the equine virus Heq2 Neq2. The Neqi neuraminidases of various animal origins are connected, but the neuraminidase of the fowl strain Hav2 Neqi is slightly inhibited by the anti Neq1 antibodies of animals immunized with the Heq1 Neq1 virus: to titrate the anti Neq1 antibodies of equine origin, the H72 Neq1 recombinant should therefore be used. The antigenic characterization of the different equine influenza strains isolated since 1967 by the study of their neuraminidase has been completed: The various neuraminidases, like the hemagglutinins of the various strains belonging to the sub-type A equi2 are closely connected; a minor antigenic variation, concerning the two surface antigens, seems to exist between the strain A equi 1/Prague/56 and the strain of the same subtype isolated in 1973.

            Descriptors:  antigens, viral, neuraminidase immunology, orthomyxoviridae immunology, cross reactions, epitopes, hemagglutination inhibition tests, horse diseases immunology, horses, influenza immunology, influenza veterinary, influenza A virus avian immunology.

Fouchier, R.A., G.F. Rimmelzwaan, T. Kuiken, and A.D. Osterhaus (2005). Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses. Current Opinion in Infectious Diseases 18(2): 141-6.  ISSN: 0951-7375.

            Abstract:  PURPOSE OF REVIEW: Recently, several previously unrecognized respiratory viral pathogens have been identified and several influenza A virus subtypes, previously known to infect poultry and wild birds, were transmitted to humans. Here we review the recent literature on these respiratory viruses. RECENT FINDINGS: Human metapneumovirus has now been detected worldwide, causing severe respiratory tract illnesses primarily in very young, elderly and immunocompromised individuals. Animal models and reverse genetic techniques were designed for human metapneumovirus, and the first vaccine candidates have been developed. Considerable genetic and antigenic diversity was observed for human metapneumovirus, but the implication of this diversity for vaccine development and virus epidemiology requires further study. Two previously unrecognized human coronaviruses were discovered in 2004 in The Netherlands and Hong Kong. Their clinical impact and epidemiology are largely unknown and warrant further investigation. Several influenza A virus subtypes were transmitted from birds to humans, and these viruses continue to constitute a pandemic threat. The clinical symptoms associated with these zoonotic transmissions range from mild respiratory illnesses and conjunctivitis to pneumonia and acute respiratory distress syndrome, sometimes resulting in death. More basic research into virus ecology and evolution and development of effective vaccines and antiviral strategies are required to limit the impact of influenza A virus zoonoses and the threat of an influenza pandemic. SUMMARY: Previously unknown and emerging respiratory viruses are an important threat to human health. Development of virus diagnostic tests, antiviral strategies, and vaccines for each of these pathogens is crucial to limit their impact.

            Descriptors:  coronavirus infections epidemiology, influenza virology, avian influenza A virus, metapneumovirus, paramyxoviridae infections epidemiology, respiratory tract infections virology, emerging communicable diseases, disease outbreaks, influenza epidemiology, risk factors, paramyxoviridae infections virology, coronavirus infections virology, influenza epidemiology.

Fukumi, H., K. Nerome, M. Nakayama, and M. Ishida (1977). Serological and virological investigations fo orthomyxovirus in birds in South-East Asian area. Developments in Biological Standardization 39: 475-60.  ISSN: 0301-5149.

            NAL Call Number:  QR180.3.D4

            Abstract:  We have previously reported that some species of migrating ducks (pintail, mallard, widgeon and falcated teal) possess in their sera antibodies against H antigens of human or avian influenza viruses. Such findings have also been reported from other workers, and the appearance of new types of influenza viruses accompanied by outbreaks of new influenza pandemics, or circulation of influenza virus antigens in animals, birds and humans have been discussed on the basis of such findings. Recently a number of orthomyxoviruses have been isolated from wild birds such as myna, banded parakeets, etc. imported from India and some areas of South-East Asia. Some of them have H antigens not recognized previously, and some are found to have more or less common reactions with human H3 antigen, and consequently antigens Hav 7 and Heq 2, which are known to show cross-reaction with H3. The significance of such a fact in connection with the appearance of a new influenza pandemic is discussed.

            Descriptors:  antibodies, viral, birds microbiology, influenza A virus avian immunology, Asia, Southeastern, ducks, hemagglutinins viral, influenza A virus avian isolation and purification, Japan, neuraminidase immunology.

Furr, A.A. (1984). Avian influenza. Foreign Animal Disease Report 12(1): 1-2.  ISSN: 0091-8199.

            NAL Call Number:  aSF601.U5

            Descriptors:  avian influenza virus, poultry, depopulation, Pennsylvania.

Furr, A.A. (1984). Avian influenza update. Foreign Animal Disease Report 12(2): 1-2.  ISSN: 0091-8199.

            NAL Call Number:  aSF601.U5

            Descriptors:  avian influenza virus, outbreaks, turkeys,  Virginia, Pennsylvania.

Garcia, M., D.L. Suarez, J.M. Crawford, J.W. Latimer, R.D. Slemons, D.E. Swayne, and M.L. Perdue (1997). Evolution of H5 subtype avian influenza A viruses in North America. Virus Research 51(2): 115-24.  ISSN: 0168-1702.

            NAL Call Number:  QR375.V6

            Abstract:  The phylogenetic relationships of the hemagglutinin (HA) and non-structural (NS) genes from avian influenza (AI) H5 subtype viruses of North American origin are presented. Analysis of the HA genes of several previously uncharacterized isolates from waterfowl and turkeys provided clear evidence of significant sequence variation and existence of multiple virus clades or sub-lineages, maintained in migratory waterfowl. Phylogenetic analysis of NS gene sequences further demonstrated multiple sub-lineages and also demonstrated re-assortment of two NS alleles in wild duck populations. Based on currently available HA1 gene sequences, at least four clades exist with waterfowl isolates included in three of the four groups. The most genetically unstable of these sub-lineages is composed of recent poultry isolates from the outbreak of AI in Central Mexico. This group of viruses, which replicated unabated in chickens for at least 16 months, exhibited an increased rate of mutation in both the HA and NS gene. Comparison of the HA1 sequence data for all available North American H5 subtype viruses demonstrated minimal variation both in and around the amino acids predicted to be involved in the HA receptor binding site. The sequences also revealed that migratory waterfowl, live poultry market chicken, and turkey isolates uniformly lack a glycosylation site at amino acid 236 in the HA protein which is present in commercial chicken isolates.

            Descriptors:  evolution, molecular, hemagglutinin glycoproteins, influenza virus genetics, influenza A virus avian genetics, viral nonstructural proteins genetics, base sequence, DNA, viral, influenza A virus avian classification, molecular sequence data, North America, phylogeny.

Gardner, I.D. and K.F. Shortridge (1979). Recombination as a mechanism in the evolution of influenza viruses: a two-year study of ducks in Hong Kong. Reviews of Infectious Diseases 1(5): 885-90.  ISSN: 0162-0886.

            NAL Call Number:  RC111.R4

            Abstract:  An analysis was made of 149 influenza A viruses isolated from ducks in Hong Kong during the period of November 1975 through October 1977. The viruses were isolated five times more frequently from ducks raised in the People's Republic of China than from those raised in Hong Kong. The isolation rate fo viruses was higher from the cloaca than it was from the trachea, but this pattern varied over the two years of investifation. The large number of different combinations (30) of hemagglutinin and neuraminidase genes suggests that recombination of viruses was taking place. Analysis of these combinations showed that their distribution was not random and that certain combinations occured more frequently, and others less frequently, than was expected. The recombination of influenza viruses and the excess or restriction of certain combinations may have implications for the evolution of pandemic strains of influenza virus in humans.

            Descriptors:  ducks microbiology, influenza A virus avian genetics, recombination, genetic, China, cloaca microbiology, evolution, gene frequency, genotype, hemagglutinins viral genetics, Hong Kong, influenza A virus avian isolation and purification, neuraminidase genetics, paramyxoviridae isolation and purification, seasons, trachea microbiology.

Germanov, A.B., M.I. Sokolov, I.A. Myasnikova, N.A. Parasiuk, T.V. Vorontsova, and G.V. Kornilaeva (1972). Some biological and physico-chemical properties of plaque mutants of fowl plague virus. Brief report. Archiv Fur Die Gesamte Virusforschung 39(4): 389-92.  ISSN: 0003-9012.

            NAL Call Number:  448.3 Ar23

            Descriptors:  influenza A virus avian drug effects, influenza A virus avian radiation effects, mutation, centrifugation, density gradient, chick embryo, chromatography, DEAE-cellulose, fibroblasts, mutagens, protamines pharmacology, radiation effects, sodium chloride, temperature, tissue culture, ultraviolet rays, virus replication.

Glass, S.E., S.A. Naqi, and L.C. Grumbles (1981). Isolation of avian influenza virus in Texas. Avian Diseases 25(2): 545-9.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  An avian influenza virus with surface antigens similar to those of fowl plague virus (Hav 1 Nav 2) was isolated in 1979 from 2 commercial turkey flocks in Central Texas. Two flocks in contact with these infected flocks developed clinical signs, gross lesions, and seroconversion but yielded no virus. This was the first recorded incidence of clinical avian influenza in Texas turkeys and only the second time that an agent with these surface antigens was isolated from turkeys in U.S.

            Descriptors:  fowl plague epidemiology, influenza A virus avian isolation and purification, turkeys, antibodies, viral analysis, fowl plague immunology, hemagglutination tests veterinary, immunodiffusion veterinary, influenza A virus avian immunology, Texas.

Goodman, L. (2004). Viral crossings. Journal of Clinical Investigation 113(6): 786.  ISSN: 0021-9738.

            NAL Call Number:  448.8 J8295

            Descriptors:  host parasite relations physiology, influenza A virus, avian metabolism, RNA virus infections epidemiology, Asia epidemiology, RNA virus infections metabolism, zoonoses.

Gordon, S. (2004). Avian influenza: a wake-up call from birds to humans. Cleveland Clinic Journal of Medicine 71(4): 273-4.  ISSN: 0891-1150.

            Descriptors:  communicable disease control organization and administration, influenza epidemiology, influenza A virus, avian isolation and purification, avian influenza epidemiology, birds, influenza prevention and control, avian influenza prevention and control, primary prevention organization and administration, risk assessment, vaccination methods, world health.

Gough, R.E., W.J. Cox, and D.J. Alexander (1990). Examination of sera from game birds for antibodies against avian viruses.  Veterinary Record 127(5): 110-1.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  antibodies, viral blood, birds immunology, coronaviridae immunology, herpesvirus 1, gallid immunology, infectious bronchitis virus immunology, infectious bursal disease virus immunology, influenza A virus avian immunology, Newcastle disease virus immunology, rotavirus immunology.

Gough, R.E. and A.S. Wallis (1986). Duck hepatitis type I and influenza in mallard ducks (Anas platyrhynchos). Veterinary Record 119(24): 602.  ISSN: 0042-4900.

            NAL Call Number:  41.8 V641

            Descriptors:  duck hepatitis virus, mallard ducks, avian influenza virus, Anas platyrhynchos.

Gould, A.R. (2004). Virus evolution: disease emergence and spread. Australian Journal of Experimental Agriculture 44(11): 1085-1094.  ISSN: 0816-1089.

            NAL Call Number:  23 Au792

            Descriptors:  viral evolution, viral replication, infection, geographic location.

Gourreau, J.M., C. Kaiser, M. Valette, A.R. Douglas, J. Labie, and M. Aymard (1994). Isolation of two H1N2 influenza viruses from swine in France. Archives of Virology 135(3-4): 365-82.  ISSN: 0304-8608.

            NAL Call Number:  448.3 Ar23

            Abstract:  Samples collected in 1987 and 1988 in Brittany from influenza-infected swine made it possible to isolate and antigenically characterize two H1N2 recombinant viruses (Sw/France/5027/87 and Sw/France/5550/88). The former virus was cloned and reinoculated to swine to allow reproduction of the disease and reisolation of a strain similar to the original one. The serodiagnostic tests carried out on both the original sera and those from the experimentally infected animals confirmed that the virus was actually type Sw/H1N2.

            Descriptors:  influenza A virus, porcine isolation and purification, swine virology, antibodies, monoclonal, antibody formation, antigens, viral analysis, birds, cloning, molecular, France, influenza immunology, influenza A virus avian classification, influenza A virus avian isolation and purification, influenza A virus human classification, influenza A virus human isolation and purification, influenza A virus, porcine genetics,  influenza A virus, porcine immunology, variation genetics.

Graves, I.L. (1992). Influenza viruses in birds of the Atlantic flyway. Avian Diseases 36(1): 1-10.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  Isolation of type A influenza viruses from the feces of 5013 birds of 16 species was attempted during a 33-month study (1977-79). Seventy viruses were isolated from the feces of 3403 ring-billed gulls in Baltimore, Md., during 16 months of sampling. Six hemagglutinin (HA) subtypes and seven neuraminidase (NA) subtypes in 15 combinations were found. The H13N6 virus was the only subtype found each year and accounted for 40% of the isolates. The rate of isolation from gulls was 0.26% in the cold months and 3.0% in the warm months. Hemagglutination-inhibition (HI) and elution-inhibition antibody profiles reflected the presence of some but not all of the viruses isolated. In mute swans, the rates of seroconversions were 16% for HA antibody and 14% for NA antibody, whereas the viral isolation rate was 0.4% over a 3-year period. Both the H5 and the N2 subtypes, which were responsible for the lethal chicken outbreaks in 1983 in Pennsylvania, were isolated from gulls in 1978 in association with subtypes not found in the chicken virus. Also, seroconversions for the H5 HA occurred in mute swans in 1978.

            Descriptors:  antibodies, viral blood, feces microbiology, fowl plague epidemiology, influenza A virus avian isolation and purification, age factors, Baltimore epidemiology, birds, hemagglutination inhibition tests, influenza A virus avian classification, influenza A virus avian immunology, mid-Atlantic region epidemiology, prevalence, seasons.

Gresikova, M., M. Sekeyova, B. Tumova, and A. Stumpa (1979). Isolation of an influenza A virus strain from a bird embryo (Larus ridibundus) collected in Slovakia. Acta Virologica 23(1): 89-92.  ISSN: 0001-723X.

            NAL Call Number:  448.3 AC85

            Abstract:  Avian influenza virus A/Larus 36/77 (Hav7Nav1) was isolated in 1977 from a trinket (Larus ridibundus) embryo. This result suggests the possibility of vertical transmission of influenza A virus.

            Descriptors:  birds microbiology, influenza A virus avian isolation and purification, antigens, viral analysis, birds embryology, Czechoslovakia, ecology, epitopes, influenza A virus avian immunology.

Groocock, C. (1994). Avian influenza in gamebirds in Maryland.  Foreign Animal Disease Report (22-2): 7.  ISSN: 0091-8199.

            NAL Call Number:  aSF601.U5

            Descriptors:  pheasants, waterfowl, avian influenza virus, disease control, birds, Galliformes, influenza virus, viruses, outbreaks.

Guan, Y., L.L. Poon, C.Y. Cheung, T.M. Ellis, W. Lim, A.S. Lipatov, K.H. Chan, K.M. Sturm Ramirez, C.L. Cheung, Y.H. Leung, K.Y. Yuen, R.G. Webster, and J.S. Peiris (2004). H5N1 influenza: a protean pandemic threat. Proceedings of the National Academy of Sciences of the United States of America 101(21): 8156-61.  ISSN: 0027-8424.

            NAL Call Number:  500 N21P

            Abstract:  Infection with avian influenza A virus of the H5N1 subtype (isolates A/HK/212/03 and A/HK/213/03) was fatal to one of two members of a family in southern China in 2003. This incident was preceded by lethal outbreaks of H5N1 influenza in waterfowl, which are the natural hosts of these viruses and, therefore, normally have asymptomatic infection. The hemagglutinin genes of the A/HK/212/03-like viruses isolated from humans and waterfowl share the lineage of the H5N1 viruses that caused the first known cases of human disease in Hong Kong in 1997, but their internal protein genes originated elsewhere. The hemagglutinin of the recent human isolates has undergone significant antigenic drift. Like the 1997 human H5N1 isolates, the 2003 human H5N1 isolates induced the overproduction of proinflammatory cytokines by primary human macrophages in vitro, whereas the precursor H5N1 viruses and other H5N1 reassortants isolated in 2001 did not. The acquisition by the viruses of characteristics that enhance virulence in humans and waterfowl and their potential for wider distribution by infected migrating birds are causes for renewed pandemic concern.

            Descriptors:  influenza epidemiology, influenza virology, birds virology, cytokines biosynthesis, cytokines immunology, hemagglutination inhibition tests, Hong Kong, inflammation mediators immunology, influenza transmission, influenza veterinary, influenza A virus, avian classification, avian genetics, avian immunology, avian pathogenicity, macrophages immunology, macrophages metabolism, mice, molecular sequence data, organ specificity, phylogeny, reassortant viruses immunology, reassortant viruses pathogenicity, time factors, virulence.

Guan, Y., K.F. Shortridge, S. Krauss, P.S. Chin, K.C. Dyrting, T.M. Ellis, R.G. Webster, and M. Peiris (2000). H9N2 influenza viruses possessing H5N1-like internal genomes continue to circulate in poultry in southeastern China. Journal of Virology 74(20): 9372-80.  ISSN: 0022-538X.

            NAL Call Number:  QR360.J6

            Abstract:  The transmission of H9N2 influenza viruses to humans and the realization that the A/Hong Kong/156/97-like (H5N1) (abbreviated HK/156/97) genome complex may be present in H9N2 viruses in southeastern China necessitated a study of the distribution and characterization of H9N2 viruses in poultry in the Hong Kong SAR in 1999. Serological studies indicated that H9N2 influenza viruses had infected a high proportion of chickens and other land-based birds (pigeon, pheasant, quail, guinea fowl, and chukka) from southeastern China. Two lineages of H9N2 influenza viruses present in the live-poultry markets were represented by A/Quail/Hong Kong/G1/97 (Qa/HK/G1/97)-like and A/Duck/Hong Kong/Y280/97 (Dk/HK/Y280/97)-like viruses. Up to 16% of cages of quail in the poultry markets contained Qa/HK/G1/97-like viruses, while about 5% of cages of other land-based birds were infected with Dk/HK/Y280/97-like viruses. No reassortant between the two H9N2 virus lineages was detected despite their cocirculation in the poultry markets. Reassortant viruses represented by A/Chicken/Hong Kong/G9/97 (H9N2) were the major H9N2 influenza viruses circulating in the Hong Kong markets in 1997 but have not been detected since the chicken slaughter in 1997. The Qa/HK/G1/97-like viruses were frequently isolated from quail, while Dk/HK/Y280/97-like viruses were predominately associated with chickens. The Qa/HK/G1/97-like viruses were evolving relatively rapidly, especially in their PB2, HA, NP, and NA genes, suggesting that they are in the process of adapting to a new host. Experimental studies showed that both H9N2 lineages were primarily spread by the aerosol route and that neither quail nor chickens showed evidence of disease. The high prevalence of quail infected with Qa/HK/G1/97-like virus that contains six gene segments genetically highly related to HK/156/97 (H5N1) virus emphasizes the need for surveillance of mammals including humans.

            Descriptors:  genome, viral, influenza A virus avian isolation and purification, poultry virology, China, hemagglutination inhibition tests, influenza A virus avian genetics, phylogeny, temperature, virus replication.

Guan, Y., K.F. Shortridge, S. Krauss, and R.G. Webster (1999). Molecular characterization of H9N2 influenza viruses: were they the donors of the "internal" genes of H5N1 viruses in Hong Kong? Proceedings of the National Academy of Sciences of the United States of America 96(16): 9363-7.  ISSN: 0027-8424.

            NAL Call Number:  500 N21P

            Abstract:  The origin of the H5N1 influenza viruses that killed six of eighteen infected humans in 1997 and were highly pathogenic in chickens has not been resolved. These H5N1 viruses transmitted directly to humans from infected poultry. In the poultry markets in Hong Kong, both H5N1 and H9N2 influenza viruses were cocirculating, raising the possibility of genetic reassortment. Here we analyze the antigenic and genetic features of H9N2 influenza viruses with different epidemiological backgrounds. The results suggest that the H9N2 influenza viruses of domestic ducks have become established in the domestic poultry of Asia. Phylogenetic and antigenic analyses of the H9N2 viruses isolated from Hong Kong markets suggest three distinct sublineages. Among the chicken H9N2 viruses, six of the gene segments were apparently derived from an earlier chicken H9N2 virus isolated in China, whereas the PB1 and PB2 genes are closely related to those of the H5N1 viruses and a quail H9N2 virus-A/quail/Hong Kong/G1/97 (Qa/HK/G1/97)-suggesting that many of the 1997 chicken H9 isolates in the markets were reassortants. The similarity of the internal genes of Qa/HK/G1/97 virus to those of the H5N1 influenza viruses suggests that the quail virus may have been the internal gene donor. Our findings indicate that the human and poultry H5N1 influenza viruses in Hong Kong in 1997 were reassortants that obtained internal gene segments from Qa/HK/G1/97. However, we cannot be certain whether the replicate complex of H5N1 originated from Qa/HK/G1/97 or whether the reverse transfer occurred; the available evidence supports the former proposal.

            Descriptors:  genes viral, influenza epidemiology, influenza veterinary, influenza A virus avian classification, influenza A virus avian genetics, influenza A virus human classification, influenza A virus human genetics, poultry diseases epidemiology, chick embryo, chickens, coturnix, ducks, feces virology, Hong Kong epidemiology, influenza virology, influenza A virus avian pathogenicity, molecular sequence data, phylogeny, pigeons, poultry diseases virology.

Gust, I.D., A.W. Hampson, and D. Lavanchy (2001). Planning for the next pandemic of influenza. Reviews in Medical Virology 11(1): 59-70.  ISSN: 1052-9276.

            Descriptors:  disease outbreaks prevention and control, influenza epidemiology, world health, antiviral agents therapeutic use, influenza drug therapy, influenza prevention and control, influenza virology, influenza vaccine administration and dosage, orthomyxoviridae genetics, orthomyxoviridae immunology, practice guidelines, vaccination, World Health Organization.

Guzhgulova, G., N. Orezhkova, and G. Georgiev (2004).  Ptichi grip i infektsii s influentsa tip "A" virusi po ptitsite. [Avian influenza and infection with avian influenza A virus]. Veterinarna Sbirka (Bulgaria). Veterinary Collection 112(3-4): 5-9.  ISSN: 0205-3829.

            NAL Call Number:  41.8 V6463

            Descriptors:  avian influenza virus, genomes, antigens, hemagglutination tests, immunological techniques, nucleic acids.

Haas, W., G. Krause, U. Marcus, K. Stark, A. Ammon, and R. Burger (2004). "Emerging infectious diseases"Dengue-fieber, West-Nil-fieber, SARS, Vogelgrippe, HIV. [Emerging infectious diseases: Dengue-fever, West-Nile-fever, SARS, Vogelgrippe, HIV]. Internist 45(6): 684-92.  ISSN: 0020-9554.

            Abstract:  Some emerging infectious diseases have recently become endemic in Germany. Others remain confined to specific regions in the world. Physicians notice them only when travelers after infection in endemic areas present themselves with symptoms. Several of these emerging infections will be explained. HIV is an example for an imported pathogen which has become endemic in Germany. SARS and avian influenza are zoonoses with the potential to spread from person to person. Avian influenza in humans provides a possibility for the reassortment of a potential new pandemic strain. Outbreaks of dengue fever in endemic areas are reflected in increased infections in travelers returning from these areas. Currently, West-Nile-virus infections are only imported into Germany. The timely implementation of diagnostic, therapeutic and infection control measures requires physicians to include these diseases in their differential diagnosis. To achieve this goal, good cooperation between physicians, laboratories and the public health service is essential.

            Descriptors:  communicable diseases, control methods, emerging diagnosis, emerging therapy, disease outbreaks prevention and control, travel, virus diseases diagnosis, virus diseases therapy, birds, emerging epidemiology, Dengue diagnosis, Dengue epidemiology, Dengue therapy, diagnosis, differential, Germany epidemiology, HIV infections diagnosis, HIV infections epidemiology, HIV infections therapy, avian influenza diagnosis, avian influenza epidemiology, avian influenza therapy, internationality, patient care management methods, severe acute respiratory syndrome diagnosis, severe acute respiratory syndrome epidemiology, severe acute respiratory syndrome therapy, virus diseases epidemiology, West Nile fever diagnosis, West Nile fever epidemiology, West Nile fever therapy.

Hafez, H.M. (2003). Geflugelpest: Alte Krankheit mit standiger Gefahr fur Geflugel. [Fowl plague: an old disease that is a continuing danger to poultry]. Tierarztliche Umschau 58(7): 343-351.  ISSN: 0049-3864.

            NAL Call Number:  41.8 T445

            Descriptors:  avian influenza virus, fowl plague virus, disease control, European Union, poultry, zoonoses.

Hafez, H.M., C. Prusas, S.C. de Jaeckel, D. Aldehoff, and O. Werner (2003). Investigations on avian influenza A in meat turkey flocks in Germany. Archiv Fuer Gefluegelkunde 67(1): 11-15.  ISSN: 0003-9098.

            NAL Call Number:  47.8 Ar2

            Abstract:  In the present investigation 315 commercial meat turkey flocks slaughtered in southern part of Germany in year 2001 were serologically examined for antibodies to avian influenza A viruses. Ten blood samples per flock were collected at the time of slaughter and examined using commercial ELISAs. Samples that reacted positively in ELISA were re-examined in haemagglutination inhibition test (HI) using subtype specific antigens. From the 3150 examined samples only 26 samples obtained from 7 flocks reacted positively in ELISA. Examination of these samples in HI revealed negative results to H1, H5, H7 and H9. On the other hand, all samples reacted positive in HI using H6 antigen. In all flocks neither clinical signs nor unusual increased mortalities were observed. End of December 2001 to January 2002 outbreaks of avian influenza were observed in three turkey flocks reared in the central-west region of Germany. In all cases sudden onset of depression, decrease in feed and water intake, respiratory signs accompanied with high mortality were observed. On necropsy pericarditis, petechial haemorrhages in pericardial fat, fibrinous airsacculitis, lung congestion and pneumonia were found. In addition, enlargement of the spleen and inflammation of pancreas were detected. Virological examinations resulted in isolation of an avian influenza A virus in embryonated chicken eggs. All isolates were identified as subtype H6N2 with an intravenous pathogenicity index (IVPI) of 0.0. The current observations indicate that low pathogenic avian influenza A of subtype 6 still circulated in German turkey flocks and in most of cases accompanied with high economic losses.

            Descriptors:  animal husbandry, epidemiology, immune system, infection, avian influenza, epidemiology, respiratory system disease, viral disease, ELISA immunologic techniques, laboratory techniques, serology clinical techniques, diagnostic techniques, meat, turkey flocks.

Hafez Mohamed Hafez  (2003). Avian influenza in poultry. World Poultry 19(Special): 11-12.  ISSN: 1388-3119.

            NAL Call Number:  SF481.M54

            Descriptors:  avian influenza virus, influenza virus A and B, clinical aspects, disease control, transmission, mortality, quarantine, vaccines, zoonoses, turkeys.

Halvorson, D., D. Karunakaran, D. Senne, C. Kelleher, C. Bailey, A. Abraham, V. Hinshaw, and J. Newman (1983). Epizootiology of avian influenza--simultaneous monitoring of sentinel ducks and turkeys in Minnesota. Avian Diseases 27(1): 77-85.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  Isolation-reared mallards (Anas platyrhynchos) were placed on ponds in turkey-rearing areas in Minnesota, and their cloacae were periodically swabbed to attempt isolating virus from embryonated chicken eggs. Nearby turkeys were sampled by taking cloacal and tracheal swabs as well as blood samples. Hemagglutinating viruses were identified at the National Veterinary Services Laboratory, U.S. Department of Agriculture, Ames, Iowa. During this two-year study, the weekly influenza virus-isolation rate from ducks varied from 0 to 24.4%. A total of 213 influenza viruses were isolated from the ducks. Twenty-six influenza virus subtypes were detected. Ninety-seven flocks of turkeys were diagnosed as having influenza by virus isolation and/or serology. Eight influenza virus subtypes were involved in the turkey outbreaks, and seven of these were also detected in the ducks and/or other avian species. The weekly infection rate of the sentinel ducks correlated directly with observations of wild ducks at the monitoring sites. Influenza virus was isolated from water samples collected near the sentinel duck sites during the study.

            Descriptors:  disease outbreaks veterinary, ducks, fowl plague epidemiology, turkeys, blood microbiology, cloaca microbiology, influenza A virus avian classification, avian isolation and purification, Minnesota, serotyping veterinary, trachea microbiology.

Halvorson, D.A. (2000). The importance of biosecurity. World Poultry (Special): 26-27.  ISSN: 1388-3119.

            NAL Call Number:  SF481.M54

            Descriptors:  avian influenza virus, disease control, prevention, transmission, biosecurity.

Halvorson, D.A. (2002). Is avian influenza research meeting the needs of the poultry veterinarian? Veterinary Journal 164(3): 173-5.  ISSN: 1090-0233.

            NAL Call Number:  SF601.V484

            Descriptors:  fowl plague prevention and control, influenza A virus avian immunology, avian physiology, influenza vaccine immunology, poultry virology, poultry diseases prevention and control, veterinary medicine, biomedical research, fowl plague immunology, poultry immunology, poultry diseases immunology.

Halvorson, D.A., D. Karunakaran, and J.A. Newman (1980). Avian influenza in caged laying chickens. Avian Diseases 24(1): 288-294.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Descriptors:  avian influenza virus, case reports, United States, Minnesota, chickens.

Halvorson, D.A., C.J. Kelleher, and D.A. Senne ( 1985). Epizootiology of avian influenza: effect of season on incidence in sentinel ducks and domestic turkeys in Minnesota. Applied and Environmental Microbiology 49(4): 914-9.  ISSN: 0099-2240.

            NAL Call Number:  448.3 Ap5

            Abstract:  Sentinel ducks and domestic turkey flocks were monitored for influenza infection during a 4-year period. The onset of infection among ducks was similar each year, occurring in late July or early August. Influenza in turkeys was also shown to be seasonal, but the usual onset was 6 to 8 weeks after the detection of influenza in sentinel ducks. Possible explanations for the delayed infection in turkeys are (i) increased waterfowl activity associated with fledging and congregating in late summer and early fall; (ii) vectors transmitting virus from the waterfowl habitat to poultry farms; (iii) cooler environmental temperature, allowing prolonged virus viability; (iv) cooler surface water temperature, allowing prolonged virus viability; (v) groundwater contamination from contaminated surface water; and (vi) virus adaptation in domestic turkeys before infection is detected. We conclude that ducks are not only a natural reservoir of influenza but also have a seasonal infection that appears to be related to seasonal influenza outbreaks in domestic turkeys in Minnesota. However, only some influenza A virus isolates circulating among waterfowl at any given time appear capable of causing detectable infection in turkeys. It is speculated that the seasonal infection in migratory waterfowl may also be related to seasonal influenza infections in other species including humans.

            Descriptors:  influenza veterinary, poultry diseases transmission, turkeys microbiology, antigens, viral analysis, disease reservoirs, ducks microbiology, influenza immunology, influenza transmission, influenza A virus avian growth and development, Minnesota, poultry diseases epidemiology, temperature, water microbiology.

Halvorson, D.A., V. Sivanandan, and D. Lauer (1992). Influenza in commercial broiler breeders. Avian Diseases 36(1): 177-9.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  Influenza was detected in a flock of broiler breeders during routine serological monitoring. Although there were no clinical signs, egg production may have been affected in hens on one story of a two-story breeder house. Intensive measures were taken to avoid transmission to other farms. Two months after the flock was found to be serologically positive, sentinel hens were placed in the flock, and they became serologically positive 1 month later. In spite of this evidence for virus being present in the flock, no detectable transmission to any other farm occurred.

            Descriptors:  antibodies, viral blood, chickens, fowl plague diagnosis, influenza A virus avian immunology, fowl plague prevention and control, precipitin tests.

Hampton, T. (2004). Clues to the deadly 1918 flu revealed. JAMA the Journal of the American Medical Association 291(13): 1553.  ISSN: 1538-3598.

            NAL Call Number:  448.9 Am37

            Descriptors:  hemagglutinins, viral genetics, influenza history, influenza A virus, avian genetics, DNA, viral analysis, disease outbreaks history, history, 20th century, influenza epidemiology, influenza virology.

Hannoun, C. (1977). Isolation from birds of influenza viruses with human neuraminidase. Developments in Biological Standardization 39: 469-72.  ISSN: 0301-5149.

            NAL Call Number:  QR180.3.D4

            Abstract:  Attempts at virus isolation from cloacal swabs resulted in the recovery of 10 strains of hemagglutinating viruses from a total of 349 ducks, mainly shelducks (Tadorna tadorna) captured in the north of France. Four of these isolates were identified as influenza strains corresponding to the following antigenic composition: Hav6-N2, Hav6-Nav4 and Hav1-N2 (2 strains). Shelduck is known to be a partially migratory species, wintering in western Europe, some of them migrating northward to Scandinavia during the summer. The captures were made between November 1976 and February 1977: one of the birds was caught four times and was found to be negative for virus in November, positive in December (isolation of a strain Hav6-Nav4), negative again in January and February. Blood taken in February did not show the presence of HI antibodies to the homologous virus.

            Descriptors:  antigens, viral, ducks microbiology, influenza A virus avian isolation and purification, neuraminidase immunology, antibodies, viral, cloaca microbiology, France, hemagglutination inhibition tests, hemagglutinins viral, avian enzymology, avian immunology, human enzymology, seasons.

Hannoun, C. and J.M. Devaux (1980). Circulation enzootique permanente de virus grippaux dans la baie de la Somme. [Circulation of influenza viruses in the bay of the Somme river (author's transl)]. Comparative Immunology, Microbiology and Infectious Diseases 3(1-2): 177-83.  ISSN: 0147-9571.

            NAL Call Number:  QR180.C62

            Descriptors:  ducks microbiology, influenza A virus avian isolation and purification, human isolation and purification, cloaca microbiology, France, avian classification, human classification, recombination, genetic, serotyping.

Hanson, B.A., D.E. Stallknecht, D.E. Swayne, L.A. Lewis, and D.A. Senne (2003). Avian influenza viruses in Minnesota ducks during 1998-2000. Avian Diseases 47(Special Issue): 867-871.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  Although wild ducks are known to be a major reservoir for avian influenza viruses (AIV), there are few recent published reports of surveillance directed at this group. Predominant AIV hemagglutinin (HA) subtypes reported in previous studies of ducks in North America include H3, H4, and H6, with the H5, H7, and H9 subtypes not well represented in these host populations. The objective of this study was to determine whether these subtype patterns have persisted. Each September from 1998 to 2000, cloacal swabs were collected from wild ducks banded in Roseau and Marshall counties, MN. Mallards (Anas platyrhynchos) were sampled all years, and northern pintails (A. acuta) were sampled only in 1999. Influenza viruses were isolated from 11%, 14%, and 8% of birds during 1998, 1999, and 2000, respectively. Prevalence, as expected, was highest in juveniles, ranging from 11% to 23% in mallards. Viruses representative of the HA subtypes 2, 3, 4, 5, 6, 7, 9, 10, 11, and 12 were isolated. Viruses in the H5, H7, and H9 subtypes, which are associated with high-pathogenicity influenza in poultry or recent infections in humans, were not uncommon, and each of these subtypes was isolated in 2 out of the 3 years of surveillance.

            Descriptors:  epidemiology, infection, avian influenza, infectious disease, respiratory system disease, viral disease, virus reservoir.

Hastings, M. and F. Guterl (2004). Bird-flu challenge. Newsweek  144(23): 67.  ISSN: 0028-9604.

            NAL Call Number:  280.8 N47

            Descriptors:  disease outbreaks prevention and control, influenza, avian prevention and control, birds virology, disease reservoirs, influenza A virus, avian pathogenicity, influenza vaccines, United States.

Heckert, R.A., M. McIsacc, M. Chan, and E.M. Zhou (1999). Experimental infection of emus (Dromaiius novaehollandiae) with avian influenza viruses of varying virulence: clinical signs, virus shedding and serology. Avian Pathology 28(1):  13-16.  ISSN: 0307-9457.

            NAL Call Number:  SF995.A1A9

            Abstract:  Two groups of emus were experimentally inoculated with a low and high pathogenic strain of avian influenza virus (AIV), type A to determine the virus susceptibility, pathogenicity, shedding and seroconversion. Emus were found susceptible to infection with AIV, with virus shedding detectable in tracheal and cloacal swabs between 3 and 10 days post-infection. Only the birds infected with the highly pathogenic viral isolate showed a brief period of mild clinical signs associated with infection. Virus recovered from the infected emus was found to be of similar pathogenicity to that of the virus inoculum. All the birds seroconverted by 10 days post-infection, as determined by haemagglutination inhibition, agar gel immunodiffusion and competitive ELISA assays. This study suggests that emus are similar to wild waterfowl in their response to AIV infection, in that they are susceptible and will replicate and shed the virus, but do not show any marked clinical signs of infection.

            Descriptors:  emus, avian influenza virus, experimental infection, virulence, clinical aspects, shedding, experimental infections, seroconversion, strain differences, susceptibility.

Heddurshetti, R.I., W.I. Pumpradit, and L.I. Lutwick (2001). Pulmonary manifestations of bioterrorism. Current Infectious Disease Reports 3(3): 249-257.  ISSN: 1523-3847.

            Descriptors:  biological warfare, human diseases, plague, avian influenza virus, Bacillus anthracis, Yersinia pestis.

Heijmans, J.F. (2000). Onrust in Nederland door dreiging hoogpathogene aviaire influenza vanuit Italie. [Unrest in the Netherlands due to the threat of highly pathogenic avian influenza from Italy]. Tijdschrift Voor Diergeneeskunde 125(6): 188-9.  ISSN: 0040-7453.

            NAL Call Number:  41.8 T431

            Descriptors:  disease outbreaks veterinary, fowl plague epidemiology, influenza A virus avian pathogenicity, fowl plague prevention and control, fowl plague transmission, Italy epidemiology, Netherlands, poultry.

Heijmans, J.F. and R.E. Komijn (2000). Vervolg aviaire influenza. Stand van zaken en maatregelen. [Future of avian influenza. State of business and measures]. Tijdschrift Voor Diergeneeskunde 125(8): 254-6.  ISSN: 0040-7453.

            NAL Call Number:  41.8 T431

            Descriptors:  fowl plague epidemiology, fowl plague prevention and control, Italy, epidemiology, poultry.

Heijnen, M.L., J.W. Dorigo Zetsma, J.W. de Jong, and M.J. Sprenger (1998). Influenza A (H5N1): stand van zaken. [Influenza A (H5N1): current status]. Tijdschrift Voor Diergeneeskunde 123(3): 86-7.  ISSN: 0040-7453.

            NAL Call Number:  41.8 T431

            Descriptors:  influenza virology, influenza A virus avian isolation and purification, adolescent, child, preschool, Hong Kong, influenza transmission, avian classification, middle aged, serotyping.

Hernandez Magdaleno, A., H.T. Casaubon, S.M. Aspargilla, and G.J. Garcia (1996). Evaluacion de la virulencia de un virus de influenza aviar (H5N2) aislado de codornices (Coturnix coturnix japonica) con signos nerviosos y alta mortalidad. [Evaluation of the virulence of one avian influenza virus (H5N2) isolated from quail (Coturnix coturnix japonica) with nervous signs and high mortality]. Proceedings of the Western Poultry Diseases Conference 45: 46-48.

            NAL Call Number:  SF995.W4

            Descriptors:  quails, avian influenza virus, mortality, birds, Galliformes, influenza virus, orthomyxoviridae, viruses.

Hernandez Magdaleno, A., M. Rico G, M. Hernandez R, J. Lopez P, and J. Garcia Garcia. (1998). Persistencia del virus de influenza aviar en canales de pollo. [Persistence of avian influenza virus in chicken carcasses]. In: 34 Reunion Nacional de Investigacion Pecuaria, Queretaro, Qro, Queretaro, Qro. (Mexico), p. 251.

            Abstract: Hasta la fecha, no existian estudios en donde haya sido evaluada la persistencia del virus de influenza aviar (IA) en la carne proveniente de aves infectadas, que son enviadas al rastro para su procesamiento y venta. Tampoco, se ha evaluado si la carne de pollo de importacion, puede ser un factor de riesgo para la introduccion al pais de nuevos subtipos de virus de IA. El objetivo de la presente investigacion, fue estudiar si la carne y visceras de pollos infectados con IA, mantienen al virus, cuando son conservadas en congelacion o en hielo. Se formaron dos grupos de 100 pollos de engorda de cuatro semanas de edad libres de IA. Uno de los grupos fue inoculado con 1 x 103 DLEP50 del virus A/Chicken/CPA-238/94 (H5N2) de baja patogenicidad (BP), por via intranasal. El segundo grupo, se inoculo con 1 x 103 DLEP50 del virus A/Chicken/Queretaro/14588-19/95 (H5N2) de alta patogenicidad (AP), por la misma via. Tres dias despues de la inoculacion, ambos grupos fueron sacrificados, simulando condiciones de rastro. A la mitad de las canales de ambos grupos, se les retiraron la totalidad de las visceras, incluyendo los pulmones y rinones (canales limpias). La mitad restante, conservo los pulmones y rinones dentro de la canal (canales completas). Posteriormente, las canales fueron conservadas bajo dos condiciones de almacenamiento, -20 C y en hielo. De una forma aleatoria, a las 0 horas, 48 horas, 7, 14, 21 y 28 dias post-sacrificio (PS), se procedio a la toma de muestras para el aislamiento viral. El aislamiento se intento a partir de una mezcla de carne de la pechuga, pierna y muslo, en las canales limpias. En las canales completas, adicionalmente, el aislamiento viral se intento de una mezcla de los pulmones y rinones. De un total de 108 muestras procesadas para el aislamiento del virus de BP, 65 fueron positivas (60.18%). En el caso del virus de AP, de 108 muestras solo se pudieron realizar 32 aislamientos (29.62%). En ambos casos el virus pudo ser aislado de la carne y de las visceras, independientemente del tipo de conservacion de las canales. El virus de BP, pudo ser aislado hasta los 28 dias PS; mientras que el aislamiento del virus de AP, fue consistente solo hasta los 14 dias PS. Los resultados obtenidos en la presente investigacion preliminar, muestran que la carne y visceras provenientes de pollos infectados con el virus de IA, tanto de BP como de AP, pueden ser un factor importante para la transmision e introduccion de la enfermedad, ya fue posible recuperar al virus, independientemente del tipo de conservacion de las canales hasta por 28 dias PS. Trabajo realizado con apoyo economico de la Direccion General de Salud Animal.

            Descriptors: chicken meat, avian influenza virus, diagnosis, animal products, influenza virus, meat, orthomyxoviridae, poultry meat, viruses.

Hess, W.R. and A.H. Dardiri (1968). Some properties of the virus od duck plague. Archiv Fur Die Gesamte Virusforschung 24(1): 148-53.  ISSN: 0003-9012.

            NAL Call Number:  448.3 Ar23

            Descriptors:  ducks, influenza A virus avian drug effects, acridines, biometry, chick embryo, chloroform pharmacology, enzymes pharmacology, ethyl ethers pharmacology, filtration, heat, hydrogen-ion concentration, staining and labeling.

Hinshaw, V.S., V.F. Nettles, L.F. Schorr, J.M. Wood, and R.G. Webster (1986). Influenza virus surveillance in waterfowl in Pennsylvania after the H5N2 avian outbreak. Avian Diseases 30(1): 207-12.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  During the latter stages of the lethal H5N2 influenza eradication program in domestic poultry in Pennsylvania in 1983-84, surveillance of waterfowl was done to determine if these birds harbored influenza viruses that might subsequently appear in poultry. From late June to November 1984, 182 hemagglutinating viruses were isolated from 2043 wild birds, primarily ducks, in the same geographical area as the earlier lethal H5N2 avian influenza outbreak. The virus isolates from waterfowl included paramyxoviruses (PMV-1, -4, and -6) and influenza viruses of 13 antigenic combinations. There was only one H5N2 isolate from a duck. Although this virus was antigenically related to the lethal H5N2 virus, genetic and antigenic analysis indicated that it could be discriminated from the virulent family of H5N2 viruses, and it did not originate from chickens. Many of the influenza viruses obtained from wild ducks were capable of replicating in chickens after experimental inoculation but did not cause disease. These studies show that many influenza A virus strains circulating in waterfowl in the vicinity of domestic poultry in Pennsylvania did not originate from domestic poultry. These influenza viruses from wild ducks were capable of infecting poultry; however, transmission of these viruses to poultry apparently was avoided by good husbandry and control measures.

            Descriptors:  animal population groups microbiology, animals, wild microbiology, ducks microbiology, geese microbiology, orthomyxoviridae isolation and purification, paramyxoviridae isolation and purification, respirovirus isolation and purification, antigens, viral analysis, chickens, orthomyxoviridae immunology, paramyxoviridae immunology, Pennsylvania, respirovirus immunology.

Hinshaw, V.S., B. Pomeroy, J. Newmon, D. Halvorson, and D. Karunakaran. (1981). Epidemiological relationship of influenza A viruses in domestic and feral avian species. In: Proceedings of the First International Symposium on Avian Influenza, Beltsville, Maryland, USA, p. 214-215.

            NAL Call Number: aSF995.6.I6I5 1981a

            Descriptors: avian influenza virus, epidemiology, feral avian species, domestic avian species.

Hinshaw, V.S., R.G. Webster, W.J. Bean, and G. Sriram (1980). The ecology of influenza viruses in ducks and analysis of influenza viruses with monoclonal antibodies. Comparative Immunology, Microbiology and Infectious Diseases 3(1-2): 155-64.  ISSN: 0147-9571.

            NAL Call Number:  QR180.C62

            Descriptors:  antigens, viral analysis, ducks microbiology, influenza A virus avian isolation and purification, influenza A virus isolation and purification, Canada, ecology, epitopes, avian growth and development, avian immunology, influenza A virus immunology, recombination, genetic, swine microbiology.

Hinshaw, V.S., R.G. Webster, and R.J. Rodriguez (1981). Influenza A viruses: combinations of hemagglutinin and neuraminidase subtypes isolated from animals and other sources. Archives of Virology 67(3): 191-201.  ISSN: 0304-8608.

            NAL Call Number:  448.3 Ar23

            Descriptors:  antigens, viral classification, hemagglutinins viral classification, influenza A virus classification, neuraminidase immunology, birds microbiology, epitopes, horses microbiology, avian classification, human classification, influenza A virus immunology, swine microbiology, terminology.

Hinshaw, V.S., R.G. Webster, and B. Turner (1980). The perpetuation of orthomyxoviruses and paramyxoviruses in Canadian waterfowl. Canadian Journal of Microbiology 26(5): 622-9.  ISSN: 0008-4166.

            NAL Call Number:  448.8 C162

            Descriptors:  ducks microbiology, influenza A virus avian isolation and purification, paramyxoviridae isolation and purification, Alberta, antigens, viral, ducks classification, avian classification, avian immunology, paramyxoviridae classification, paramyxoviridae immunology.

Ho, M.S. and I.J. Su (2004). Preparing to prevent severe acute respiratory syndrome and other respiratory infections. Lancet Infectious Diseases 4(11): 684-9.  ISSN: 1473-3099.

            Abstract:  Globalisation and its effect on human development has rendered an environment that is conducive for the rapid international spread of severe acute respiratory syndrome (SARS), and other new infectious diseases yet to emerge. After the unprecedented multi-country outbreak of avian influenza with human cases in the winter of 2003-2004, an influenza pandemic is a current threat. A critical review of problems and solutions encountered during the 2003-2004 SARS epidemics will serve as the basis for considering national preparedness steps that can be taken to facilitate the early detection of avian influenza, and a rapid response to an influenza pandemic should it occur.

            Descriptors:  communicable disease control methods, disease outbreaks prevention and control, severe acute respiratory syndrome epidemiology, severe acute respiratory syndrome prevention and control, China epidemiology, influenza epidemiology, influenza prevention and control.

Hoey, J. (1998). Avian influenza. CMAJ Canadian Medical Association Journal; Journal De L'Association Medicale Canadienne 158(3): 369.  ISSN: 0820-3946.

            NAL Call Number:  R11.C3

            Descriptors:  disease outbreaks, fowl plague transmission, influenza epidemiology, influenza A virus avian immunology, avian isolation and purification, avian pathogenicity, pneumonia, viral transmission, zoonoses, adolescent, adult, chickens virology, child, child, preschool, fowl plague epidemiology, fowl plague prevention and control, Hong Kong epidemiology, incidence, influenza prevention and control, middle aged, pneumonia, viral epidemiology, pneumonia, viral prevention and control, trachea virology.

Hollamby, S., J.G. Sikarskie, and J. Stuht (2003). Survey of peafowl (Pavo cristatus) for potential pathogens at three Michigan zoos. Journal of Zoo and Wildlife Medicine Official Publication of the American Association of Zoo Veterinarians 34(4): 375-379.  ISSN: 1042-7260.

            NAL Call Number:  SF601.J6

            Descriptors:  peafowl, Pavo cristatus, Bordetella avium infection, Capillaria sp. infection, Clostridium perfringens type A infection, Escherichia coli infection, Goniodes gigas infestation, Mycoplasma meleagridis infection, Mycoplasma synoviae infection, diagnostic techniques, serum plate agglutination test, antibody titer, zoo, Michigan.

Holmes, E.C. (2004). Virology. 1918 and all that. Science 303(5665): 1787-8.  ISSN: 1095-9203.

            NAL Call Number:  470 Sci2

            Descriptors:  hemagglutinin glycoproteins, influenza virus chemistry, hemagglutinin glycoproteins, influenza virus metabolism, influenza history, influenza virology, influenza A virus, human immunology, binding sites, birds, carbohydrate conformation, crystallography, x-ray, disease outbreaks history, history, 20th century, influenza epidemiology, avian immunology, avian metabolism, human metabolism, human pathogenicity, membrane glycoproteins chemistry, membrane glycoproteins metabolism, protein conformation, RNA, viral chemistry, viral genetics, viral isolation and purification, receptors, virus chemistry, receptors, virus metabolism, sialic acids metabolism, virulence.

Homme, P.J. and B.C. Easterday (1970). Avian influenza virus infections. 3. Antibody response by turkeys to influenza A-turkey-Wisconsin-1966 virus. Avian Diseases 14(2): 277-84.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Descriptors:  antibodies analysis, influenza veterinary, orthomyxoviridae immunology, turkeys, aerosols, cold, hemagglutination inhibition tests, hemagglutination tests, poultry diseases immunology, Wisconsin.

Homme, P.J. and B.C. Easterday (1970). Avian influenza virus infections. I. Characteristics of influenza A-turkey-Wisconsin-1966 virus. Avian Diseases 14(1): 66-74.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Descriptors:  orthomyxoviridae growth and development, orthomyxoviridae pathogenicity, chick embryo, hemagglutinins viral analysis, orthomyxoviridae infections, poultry diseases, temperature, tissue culture, turkeys, virus cultivation.

Homme, P.J. and B.C. Easterday (1970). Avian influenza virus infections. IV. Response of pheasants, ducks, and geese to influenza A-turkey-Wisconsin-1966 virus. Avian Diseases 14(2): 285-90.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Descriptors:  ducks, geese, influenza veterinary, orthomyxoviridae isolation and purification, poultry diseases microbiology, aerosols, antibodies analysis, disease outbreaks veterinary, hemagglutination inhibition tests, orthomyxoviridae immunology, orthomyxoviridae pathogenicity, turkeys.

Homme, P.J., B.C. Easterday, and D.P. Anderson ( 1970). Avian influenza virus infections. II. Experimental epizootiology of influenza A-turkey-Wisconsin-1966 virus in turkeys. Avian Diseases 14(2): 240-7.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Descriptors:  influenza veterinary, orthomyxoviridae isolation and purification, poultry diseases microbiology, turkeys, disease outbreaks veterinary, hemagglutination inhibition tests, influenza epidemiology, influenza immunology, influenza pathology, orthomyxoviridae pathogenicity, Wisconsin.

Hooper, P.T., G.W. Russell, P.W. Selleck, and W.L. Stanislawek (1995). Observations on the relationship in chickens between the virulence of some avian influenza viruses and their pathogenicity for various organs. Avian Diseases 39(3): 458-464.  ISSN: 0005-2086.

            NAL Call Number:  41.8 Av5

            Abstract:  Comparative histological and immunocytochemical studies were conducted on formalin-fixed tissues from chickens infected with avian influenza viruses of varying virulence. Results showed a distinct pattern of disease that depended on the virulence of the virus and the susceptibility of the birds. At 3 days post-intranasal inoculation with a highly virulent H7N7 virus, all 6-to-8-week-old specific-pathogen-free (SPF) birds were affected, and all developed pancreatic necrosis and encephalitis associated with specific immunoperoxidase staining. Other same-aged SPF birds were only occasionally affected 6 to 8 days after intravenous inoculation with almost avirulent H4N4, H6N2, or H3N8 virus. Specific lesions and immunoperoxidase staining were noted in the kidneys only. The H7N7 virus in older commercial birds and an H7N3 virus in young SPF and older commercial birds caused intermediate mortality rates at 4 to 11 days postinoculation, and there was a broad range of lesions and specific immunoperoxidase staining in the pancreas, brain, kidney, heart, and skeletal muscle. Two exceptional birds had immunostaining of small blood vessels throughout their bodies with or without lesions or staining in the tissues, which may have represented a transitory pre-localizing phase occurring in many birds. There was necrosis without virus antigen detection in the bursae, thymuses, and cecal tonsils, possibly secondary to stress or only transitory infection of virus. These data indicate that rapid, retrospective diagnosis of avian influenza in fixed tissues is possible by using an immunoperoxidase test on pancreas, brain, and kidney.

            Descriptors:  chickens, avian influenza virus, pathogenicity, disease resistance, body parts, animal tissues, antigens, histopathology, immunology, biological properties, birds, body parts, domestic animals, domesticated birds, Galliformes, immunological factors, influenza virus, livestock, microbial properties, orthomyxoviridae, pathology, poultry, resistance to injurious factors, useful animals, viruses, susceptibility, viral antigens, immunocytochemistry.

Hopkins, B.A., J.K. Skeeles, G.E. Houghten, D. Slagle, and K. Gardner (1990). A survey of infectious diseases in wild turkeys (Meleagridis gallopavo silvestris) from Arkansas. Journal of Wildlife Diseases 26(4): 468-72.  ISSN: 0090-3558.

            NAL Call Number:  41.9 W64B

            Abstract:  Wild turkeys (Meleagridis gallopavo silvestris) trapped as part of a relocation program by the Arkansas Game and Fish Commission were tested for selected infectious diseases and parasites. The 45 birds were trapped at four locations in Pope, Scott, and Montgomery counties (Arkansas, USA). Forty-four blood samples for serology, 27 blood smears and 12 fecal samples were collected. Of the serum samples tested, 20 of 44 (45%) were positive for Pasteurella multocida by enzyme-linked immunosorbent assay (ELISA), 42 of 44 (95%) were positive for Bordetella avium by ELISA, and 15 of 44 (34%) were positive for Newcastle disease virus antibody by the hemagglutination inhibition test. All serum samples were negative for Mycoplasma gallisepticum, Mycoplasma synoviae, avian paramyxovirus 3, avian influenza, hemorrhagic enteritis, Marek's disease, avian encephalomyelitis, laryngotracheitis, Salmonella pullorum and Salmonella gallinarum. Haemoproteus meleagridis was found in eight of 27 (30%) and  Leucocytozoon smithi in nine of 27 (33%) blood smears; all smears were negative for Plasmodium hermani. Enteric parasites included Ascaridia dissimilis, Heterakis gallinarum, Eimeria dispersa and Raillietina spp. This study was an attempt to document the health status and disease exposure of wild turkeys in Arkansas to aid in managing and preventing the spread of disease agents to wild turkeys and other species of birds.