22/9/84 (Item 33 from file: 73)

Anesthesia‑associated depression of peripheral node lymphocyte traffic and antibody production in sheep accompanied by elevations in arachidonic acid metabolites in efferent lymph

Spruck C.H.; Moore T.C.

Transplantation Proceedings ( TRANSPLANT. PROC. ) ( United States )

1988 , 20/6 (1169‑1174)

The present study extends earlier observations of prostaglandin Einf 2 (PGEinf 2) involvement in depression in lymphocyte traffic and accompanying alterations in immune response factors, including involvement of other arachidonic acid metabolites and changes in lymphocyte types and subtypes. Prior studies of arachidonic acid metabolites have involved the use of both barbiturate‑halothane and ketamine‑xylazine general anesthesias.

Manufacturer Names: parke davis/United States; miles laboratories/United

States

Drug Descriptors:

* prostaglandin e2; *ketamine‑‑pharmacology‑‑pd; *xylazine‑‑pharmacology‑‑pd

Medical Descriptors: * anesthesia; *antibody production; *arachidonic acid metabolism; *lymph node sheep; nonhuman; intramuscular drug administration; priority journal; complication

CAS Registry Number: 363‑24‑6 (prostaglandin e2); 1867‑66‑9, 6740‑88‑1, 81771‑21‑3 (ketamine); 23076‑35‑9, 7361‑61‑7 (xylazine)

22/9/118 (Item 67 from file: 73)

01701380 EMBASE No: 1980069626

alpha‑ and beta‑adrenergic stimulation of arachidonic acid metabolism in cells in culture

Levine L.; Moskowitz M.A.

Proceedings of the National Academy of Sciences of the United States of America 1979 ,

76/12 (6632‑6636)

Drug Descriptors:

* alpha adrenergic receptor blocking agent; *alpha adrenergic receptor; *

arachidonic acid; *beta adrenergic receptor; *bromocriptine; *dibenamine;

* dihydroergotamine; *ergocryptine; *ergotamine; *noradrenalin; *

phenoxybenzamine; *phentolamine; *phospholipid; *propranolol;

*prostacyclin ; *prostaglandin; *prostaglandin d2; *prostaglandin e2;

*prostaglandin f2 alpha; *thromboxane a2; *tolazoline; *yohimbine

colchicine; cycloheximide; cytochalasin b

Medical Descriptors:

* kidney cell; *lymphoma

kidney; in vitro study; animal experiment; dog; mouse; drug analysis;

drug comparison

CAS Registry Number: 506‑32‑1, 6610‑25‑9, 7771‑44‑0 (arachidonic acid);

25614‑03‑3 ( bromocriptine); 51‑50‑3, 55‑43‑6 (dibenamine); 511‑12‑6

(dihydroergotamine) ; 511‑09‑1 (ergocryptine); 113‑15‑5, 52949‑35‑6

(ergotamine); 1407‑84‑7, 51‑41‑2 (noradrenalin); 59‑96‑1, 63‑92‑3

(phenoxybenzamine); 50‑60‑2, 73‑05‑2 (phentolamine); 13013‑17‑7,

318‑98‑9, 3506‑09‑0, 4199‑09‑1, 525‑66‑6 (propranolol); 35121‑78‑9,

61849‑14‑7 (prostacyclin); 41598‑07‑6 ( prostaglandin d2); 363‑24‑6

(prostaglandin e2); 551‑11‑1 (prostaglandin f2 alpha); 57576‑52‑0

(thromboxane a2); 59‑97‑2, 59‑98‑3 (tolazoline); 146‑48‑5, 65‑19‑0

(yohimbine); 64‑86‑8 (colchicine); 642‑81‑9, 66‑81‑9 ( cycloheximide);

14930‑96‑2 (cytochalasin b)

22/9/133 (Item 3 from file: 5)

A role for arachidonic acid in general anesthetic action.

Author: Denson D D(a); Eaton D C

Journal: Society for Neuroscience Abstracts 21 ( 1‑3 ): p 1833 1995

Conference/Meeting: 25th Annual Meeting of the Society for Neuroscience

San Diego, California, USA November 11‑16, 1995

Registry Numbers: 506‑32‑1: ARACHIDONIC ACID; 6740‑88‑1: KETAMINE;

7440‑09‑7: POTASSIUM; 9001‑84‑7: PHOSPHOLIPASE A‑2

Descriptors:

Major Concepts: Cell Biology; Enzymology (Biochemistry and Molecular

Biophysics); Membranes (Cell Biology); Metabolism; Nervous System (Neural

Coordination); Pharmacology

Biosystematic Names: Muridae‑‑Rodentia, Mammalia, Vertebrata, Chordata,

Animalia; Vertebrata‑Unspecified‑‑Vertebrata, Chordata, Animalia

Organisms: GH3 (Muridae)‑‑cell line; Vertebrata (Vertebrata ‑

Unspecified)

Biosystematic Classification (super Taxa): animals; chordates; mammals;

nonhuman mammals; nonhuman vertebrates; rodents; vertebrates

Chemicals & Biochemicals: ARACHIDONIC ACID; KETAMINE; POTASSIUM;

PHOSPHOLIPASE A‑2

Miscellaneous Terms: KETAMINE; MEETING ABSTRACT; MEETING POSTER;

PHOSPHOLIPASE A‑2; POTASSIUM CHANNEL