Contents

• About the Animal Welfare Information Center Newsletter

• Validation of In Vitro Methods: Regulatory Issues
  • Introduction
  • The FDA Mission
  • Drugs, Cosmetics, and Devices Defined
  • Regulations and Animal Use
  • Regulation of Cosmetics vs. Drugs and Medical Devices
  • Methods for Hazard/Safety Determination
  • Current Utility of In Vitro Methods
  • In Vitro Testing Methods and Regulatory Acceptance
  • In Vivo "Replacement"
  • The Tiered Approach to Substance Testing
  • Components of Methods Evaluation
  • Summary
  • References

• Congress In Session

  H.R. 4091	S. 1915	H.R. 3575	H.R. 4044	Public Law 103-182
  H.R. 4008	S. 2100	S. 2142	H.R. 4289	H.R. 3978
  H.R. 3987	H.R. 3997	H.R. 3954	S. 1831	H.R. 3526

• The Cotton Rat in Biomedical Research
  • [Introduction]
  • Natural History
  • The Cotton Rat as a Model of Human Disease
    • Polio
    • Typhus
    • Filariasis
    • Respiratory Syncytial Virus
    • Adenoviruses and Genetic Therapy
  • Care and Handling
  • Experimental Manipulation

• New and Updated Files From the AWIC Electronic Library

• Marine Mammal Welfare: The Role of USDA, APHIS
  • The Past
  • The Present
  • The Future

• Marine Mammal Protection Act Amendments of 1994
  P.L. 103-238

• The Importance of Animals in Biomedical and Behavioral Research

• Announcements...
  • Animal Care Symposium Proceedings Published
  • New Publications From The Universities Federation For Animal Welfare
  • Laboratory Animal Anesthesia Workshop
  • NIH Animal Welfare Education Workshops
  • SCAW To Sponsor Seminar At National AALAS On "The Husbandry And Care Of Birds In The Laboratory
  • SCAW And University Of Texas Health Science Center At San Antonio Co-sponsor Conference
  • Laboratory Rat And Mouse Housing Publication Available
  • The Shape Of Equipment

• Grants From The Small Business Innovation Research Program

• Upcoming Meetings

The Animal Welfare Information Center
U.S. Department of Agriculture
Agricultural Research Service
National Agricultural Library
10301 Baltimore Ave.
Beltsville, MD 20705-2351

Phone: (301) 504-6212
FAX: (301) 504-7125
E-mail: awic@nal.usda.gov

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