Table 1: Qualifying Pain/Distress/Suffering

Body Weight Changes 
1< 10 percent weight loss
210-15 percent weight loss
3> 20 percent weight loss
Physical Appearance 
1Lack of grooming
2Rough coat, nasal/ocular discharge
3Very rough coat, abnormal posture, enlarged pupils
Measurable Clinical Signs 
1Small changes of potential significance
2Temperature change of 1-2oC, cardiac and respiratory rates increased up to 30 percent
3Temperature change of > 2oC, cardiac and respiratory rates increased up to 50 percent, or markedly reduced
Unprovoked Behavior 
1Minor changes
2Abnormal, reduced mobility, decreased alertness, inactive
3Unsolicited vocalizations, self mutilation, either very restless or immobile
Behavioral Responses to External Stimuli 
1Minor depression/exaggeration of response
2Moderately abnormal responses
3Violent reactions, or comatose

Adapted from: Morton, D.B. and P.H.M. Griffiths (1985). Veterinary Record 116: 431-436.

This table was referenced in: Olfert, Ernest D. "Defining an Acceptable Endpoint in Invasive Experiments," Animal Welfare Information Center Newsletter, 6(1):3-7, Spring 1995.

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December 30, 1997
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