- Rapid weight loss (15-20 percent within a few days)
- Extended period of weight loss (progressing to emaciated state)
- Spreading area of alopecia caused by disease
- Rough hair coat, hunched posture, distended abdomen, or lethargy, especially if debilitating or prolinged (3 days)
- Diarrhea, especially if debilitating or prolonged (3 days)
- Coughing, rales, wheezing, and nasal discharge
- Distinct icterus and/or anemia
- Rapid growth of mass or masses, or clinical signs of neoplasia
- Central nervous system signs such as head tilt, tremors, spasticity, seizures, circling, or paralysis or paresis, especially if associated with anorexia
- Frank bleeding from any orifice
- Markedly discolored urine, polyuria, or anuria
- Persistent self-induced trauma
- Lesions interfering with eating or drinking
- Clinical signs of suspected infectious disease requiring necropsy for diagnosis
- Other clinical signs judged by experienced technical staff to be indicative of moribund condition
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