Graczyk, S., a. Wieliczko, a. Pliszczak Krol, and B. Janaczyk (2006). Humoral and cellular response of pheasants vaccinated against newcastle disease and haentorrhagic enteritis. Acta Veterinaria Brno 75(3): 379-386. ISSN: 0001-7213.
Descriptors: pheasants, cellular response, humoral response, vaccinated, newcastle disease, hemorrhagic enteritis.
Hou, J.M., J.Y. Liu, L. Yang, X. Zhao, L. Tian, Z.Y. Ding, Y.J. Wen, T. Niu, F. Xiao, Y.Y. Lou, G.H. Tan, H.X. Deng, J. Li, J.L. Yang, Y.Q. Mao, B. Kan, Y. Wu, Q. Li, and Y.Q. Wei (2005). Combination of low-dose gemcitabine and recombinant quail vascular endothelial growth factor receptor-2 as a vaccine induces synergistic antitumor activities. Oncology 69(1): 81-7. ISSN: 0923-7534.
Abstract: Vascular endothelial growth factor receptor-2 (VEGFR-2) has been shown to play a major role in inducing the full spectrum of VEGF biological response which is essential for tumor angiogenesis. We have demonstrated that immunotherapy of tumors with a vaccine based on quail homologous VEGFR-2 (qVEGFR) was effective in providing both protective and therapeutic antitumor immunity in several tumor models in mice. The purpose of this study was to determine whether the combination therapy of low-dose gemcitabine with qVEGFR as a vaccine could inhibit tumor growth to a greater extent. To test this concept, H22 hepatoma and Lewis lung carcinoma models were established in BALB/c mice and C57BL/6 mice, respectively. Mice were treated with either qVEGFR as a protein vaccine, gemcitabine, or both agents together. qVEGFR or low-dose chemotherapy treatment individually resulted in tumor inhibition to a certain extent.Remarkably, the combination therapy resulted in synergistic antitumor activity. Histological examination revealed that there was endothelial deposition of immunoglobulins within tumor tissues from mice treated with vaccine or combination therapy, especially intratumor angiogenesis was suppressed more significantly for the combination group. Also, ELISPOT analysis showed that mice treated with either qVEGFR alone or in combination with low-dose chemotherapy produced similar amount of anti-VEGFR antibody-producing B cells, which suggested that low-dose gemcitabine did not suppress the host's immune response, but potentiated the antitumor activity of the qVEGFR vaccine. Furthermore, TUNEL staining demonstrated a significant increase in the number of TUNEL-positive cells in the combination group compared with those of other groups. The observations may provide a new bio-chemotherapeutic approach for cancer.
Descriptors: antineoplastic combined chemotherapy protocols, therapeutic use, cancer vaccines therapeutic use, carcinoma, lewis lung drug therapy, deoxycytidine analogs, derivatives, liver neoplasms, experimental drug therapy, vascular endothelial growth factor receptor 2, therapeutic use, antimetabolites, antineoplastic administration, dosage, deoxycytidine administration, dosage, drug administration schedule, drug synergism, mice, inbred Balb c inbred C57BL, quail, vaccines, synthetic therapeutic use.
Novak, I.L., M. Simpraga, and H. Mazija (2004). Humoral immune reaction of ostriches vaccinated against Newcstale disease by different routes. Proceedings of the 11th Ostrich World Congress, Island Great Brijun, Croatia, 15 17 October 2004 82-88
Descriptors: ostriches, vaccinated, Newcastle disease, humoral immune reaction, different routes, spraying, drinking, conference proceedings.
Notes: Meeting Information: Proceedings of the 11th Ostrich World Congress, Island Great Brijun, Croatia, 15-17 October 2004.
Raukar, J., M. Simpraga, R. Zadro, and J. Lukac (2006). Immunological status in one-day old ostriches: preliminary results. Journal of Ornithology 147(5, Suppl. 1): 236. ISSN: 0021-8375.
Descriptors: ostriches, one day old, immunological status, preliminary results, meeting.
Notes: Meeting Information: 24th International Ornithological Congress, Hamburg, GERMANY; 2006.
Roberts, M.L., K.L. Buchanan, D. Hasselquist, and M.R. Evans (2007). Effects of testosterone and corticosterone on immunocompetence in the zebra finch. Hormones and Behavior 51(1): 126-34. ISSN: 0018-506X.
Abstract: The original immunocompetence handicap hypothesis (ICHH) suggested that testosterone has a handicapping effect in males by both promoting the development of sexual signals and suppressing immune function. A modified version, the stress-linked ICHH, has recently proposed that testosterone is immunosuppressive indirectly by increasing production of corticosterone. To test both the original and stress-mediated versions of the ICHH, we implanted male zebra finches taken from lines selected for divergent maximum stress-induced levels of corticosterone (high, low and control) with either empty or testosterone-filled implants. Their humoral and cell-mediated immune responses were then assessed by challenge with diphtheria:tetanus vaccine and phytohemagglutinin respectively. We found no effect of the hormone manipulations on either PHA or tetanus antibody responses, but found a significant interaction between titers of both testosterone and corticosterone on diphtheria secondary antibody response; antibody response was greatest in individuals with high levels of both hormones. There was also a significant interactive effect between testosterone treatment group and corticosterone titer on body mass; the body mass of males in the elevated testosterone treatment group decreased with increasing corticosterone titer. These results suggest that, contrary to the assumption of the stress-mediated version of the ICHH, high plasma levels of corticosterone are not immunosuppressive, but are in fact immuno-enhancing in the presence of high levels of plasma testosterone. Equally, the central assumption of the ICHH that testosterone is obligately immunosuppressive is also not supported. The same individuals with the highest levels of both hormones and consequently the most robust antibody response also possessed the lowest body mass.
Descriptors: zebra finches, corticosterone, blood, immunology, immunocompetence, testosterone, antibody formation, body weight, immunity, cellular.
Sakai, K., G. Sakabe, O. Tani, M. Nakamura, and K. Takehara (2006). Antibody responses in ostriches (Struthio camelus) vaccinated with commercial live and killed Newcastle disease vaccines. Journal of Veterinary Medical Science the Japanese Society of Veterinary Science 68(6): 627-9. ISSN: 0916-7250.
Abstract: Three ostriches (Struthio camelus) were immunized with commercially available live and killed Newcastle disease (ND) vaccines for chickens and the antibody responses to the ND vaccines were evaluated by a virus-neutralization (VN) test. Primary vaccination with the live vaccine, B1, by eye drop was followed with two shots of alum-precipitated killed vaccine via subcutaneous injection in the neck. As a final booster, another live vaccine, Clone 30, was used by eye drop. A VN antibody titer, more than 1:10 was observed for 6 months. This is the first report on the use of a live vaccine by eye drop as a booster in ostriches as well as evaluating responses to ND vaccines using the VN test in this avian species.
Descriptors: ostriches, antibody responses, Newcastle disease vaccines, live, killed, immunology, viral vaccines immunology, newcastle disease prevention, control, ophthalmic solutions, viral vaccines, administration, dosage.
Snoeijs, T., T. Dauwe, R. Pinxten, V.M. Darras, L. Arckens, and M. Eens (2005). The combined effect of lead exposure and high or low dietary calcium on health and immunocompetence in the zebra finch (Taeniopygia guttata). Environmental Pollution 134(1): 123-132. ISSN: 0269-7491.
Descriptors: zebra finch, pollutants, lead, dietary calcium, heavy metals, immunocompetence, bioaccumulation, wild birds, Passeriformes, uptake mechanisms.