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Information Resources on the Care and Welfare of Cats
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Aguirre, A., A. Escobar, V. Ferreira, M.C. Molina, A. Ferreira, and J.C. Aguillon (2003). An anti-human recombinant tumor necrosis factor alpha (TNF alpha) monoclonal antibody recognizes an epitope in feline TNF alpha. Veterinary Research 34(2): 177-184. ISSN: 0928-4249.
NAL Call Number: SF602 .A5
Abstract: It is likely that the murine response to human recombinant TNF alpha (hrTNF alpha) may generate antibodies (Ab) to epitopes present in TNF alpha from other species. Here, we demonstrate that F5 anti-hrTNF alpha monoclonal antibody (mAb) recognizes feline TNF alpha while E8 anti-hrTNF alpha mAb failed to do so. In order to demonstrate that E8 and F5 mAb recognize different epitopes in the hrTNF alpha molecule, a constant concentration of E8 and variable concentrations of F5 were incubated with solid phase bound hrTNF alpha. Binding of E8 and F5 to hrTNF alpha was determined with anti-mu and gamma chain specific Ab. F5 bound equally to hrTNF alpha in the presence or absence of E8 and the same amount of E8 bound to hrTNF alpha, in spite of the presence of F5. When using the E8 and F5 mAb for capturing the TNF alpha from the equine, canine, feline and bovine species, in supernatants of an ex vivo lipopolysaccharide (LPS)-stimulated whole blood cell culture, we only detected the feline TNF alpha by F5 mAb (p = 0.001). By a cytotoxic assay on L929 fibroblasts, we indeed demonstrated the feline TNF alpha production after the LPS stimulus. In an inhibition assay, the human and feline cytokines competed for F5, although the inhibition of native human TNF alpha binding to F5 was significant but only about 20% (p = 0.001). In conclusion, most likely the F5 anti-hrTNF alpha mAb recognizes an epitope in feline TNF alpha. Its immunomodulatory potential in the feline model remains to be studied.
Descriptors: monoclonal antibodies, cross reactions, epitopes, tumor necrosis factor alpha, cats, cattle, cell line, dogs, horses, mice, radioimmunoassay, recombinant proteins, species-specificity, tumor necrosis factor alpha analysis.

Albarellos, G.A., R.R. Bonafine, V.E. Kreil, L.A. Ambros, L. Montoya, and R.E. Hallu (2003). A non-surgical jugular catheterization technique for multiple blood sampling in cats. Laboratory Animal 37(3): 188-192. ISSN: 0093-7355.
NAL Call Number: QL55.A1L33
Abstract: In order to perform pharmacokinetic studies involving multiple blood sampling, repeated at variable intervals of time, a simple and reliable non-surgical jugular catheterization technique was developed. Six cats were catheterized 48 times using an indwelling through-the-needle type catheter (22G and 20.3 cm) placed into the jugular vein through an over-the-needle type (20G and 32 mm). Catheters remained in place for 1-13 days (median 3 days) without loss of patency until removal. Each jugular was catheterized a range of 2-6 times, with a total indwelling time of 4-33 days. No clinical signs of phlebitis, thrombosis or sepsis were observed either during or after the studies. This technique allows an easy, non-painful, non-stressful blood withdrawal during extended sampling periods, with minimal damage of the veins.
Descriptors: blood specimen collection, catheterization, cats, jugular veins, specimen collection, catheterization.

Alef, M. and G. Oechtering (1995). Nichtinvasive Patientenueberwachung in der Tiermedizin: Pulsoxymetrie und Kapnographie. Teil 2: Kapnographie [Non-invasive monitoring in veterinary medicine: Pulse oximetry and capnography. Part 2: Capnography]. Tieraerztliche Praxis 23(1): 1-6. ISSN: 0303-6286.
NAL Call Number: SF603 .V4
Descriptors: horses, dogs, cats, surgical operations, anesthesia, monitoring, breathing, functional disorders, measurement, carbon dioxide, anoxia, disorders , equidae , functional disorders, gas exchange, oxides , perissodactyla , physiological functions, respiratory disorders.
Language of Text: German; Summaries in German and English.

Alix, C., F. Koehren, J.P. Martin, A. Kirn, and J. Braunwald (1998). A thermoresistant strain of feline immunodeficiency virus (FIV) with an altered cytopathic effect and a restricted cell tropism. Archives of Virology 143(11): 2093-2107. ISSN: 0304-8608.
NAL Call Number: 448.3 Ar23
Descriptors: env gene, envelope glycoproteins, nucleotide sequences, amino acids, genbank, y10614 .

American College of Veterinary Radiaology (2001). Annual Meeting of the American College of Veterinary Radiology. Veterinary Radiology and Ultrasound 42(6): 576-593. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: MRI, osteoarthritis, diagnosis, tumor treatment, neoplasms, CAT.

Amzica, F., M. Massimini, and A. Manfridi (2002). Spatial buffering during slow and paroxysmal sleep oscillations in cortical networks of glial cells in vivo. The Journal of Neuroscience 22(3): 1042-1053. ISSN: 0270-6474.
Abstract: The ability of neuroglia to buffer local increases of extracellular K(+) has been known from in vitro studies. This property may confer on these cells an active role in the modulation and spreading of cortical oscillatory activities. We addressed the question of the spatial buffering in vivo by performing single and double intraglial recordings, together with measures of the extracellular K(+) and Ca(2+) concentrations ([K(+)](out) and [Ca(2+)](out)) in the cerebral cortex of cats under ketamine and xylazine anesthesia during patterns of slow sleep oscillations and spike-wave seizures. In addition, we estimated the fluctuations of intraglial K(+) concentrations ([K(+)](in)). Measurements obtained during the slow oscillation indicated that glial cells phasically take up part of the extracellular K(+) extruded by neurons during the depolarizing phase of the slow oscillation. During this condition, the redistribution of K(+) appeared to be local. Large steady increases of [K(+)](out) and phasic potassium accumulations were measured during spike-wave seizures. In this condition, [K(+)](in) rose before [K(+)](out) if the glial cells were located at some distance from the epileptic focus, suggesting faster K(+) diffusion through the interglial syncytium. The simultaneously recorded [Ca(2+)](out) dropped steadily during the seizures to levels incompatible with efficient synaptic transmission, but also displayed periodic oscillations, in phase with the intraseizure spike-wave complexes. In view of this fact, and considering the capability of K(+) to modulate neuronal excitability both at the presynaptic and postsynaptic levels, we suggest that the K(+) long-range spatial buffering operated by glia is a parallel synchronizing and/or spreading mechanism during paroxysmal oscillations.
Descriptors: biological clocks, cerebral cortex, egtazic acid, nerve net, neuroglia, sleep, action potentials, action potentials, anesthesia, calcium, cats, cerebral cortex, chelating agents, egtazic acid, electroencephalography, membrane potentials, neuroglia, neurons, neurons, potassium, seizures, signal processing, computer assisted.

Andersen, P.R., T.P. O'connor, and Q.J. Tonelli (1997). Polypeptides of feline t-cell lymphotrophic lentivirus. Official Gazette of the United States Patent and Trademark Office Patents 1201(2): 1335. ISSN: 0098-1133.
NAL Call Number: T223. A21
Descriptors: biochemistry and molecular biophysics, general life studies, microbiology , biotechnology, lentivius, polypeptides, feline, patents .

Andolina, I.M., H.E. Jones, and a.M. Sillito (1998). Pop-out processing at the sub-cortical level of the feline visual pathway. Society for Neuroscience Abstracts 24(1-2): 139. ISSN: 0190-5295.
NAL Call Number: QP351. S6
Descriptors: nervous system, neural coordination, vision pathway, feline.

Antzelevitch, C. and A.C. Zygmunt (2001). Experimental models to assess the role of heterogeneous repolarization in arrhythmogenesis. In: Myocardial Repolarization: From Gene to Bedside, Futura Publishing Company Inc. Armonk, New York, USA, p. 89-116. ISBN: 0879934778.
Descriptors: cardiovascular medicine, membranes, cell biology, molecular, Brugada syndrome, heart disease model, electorcardiography, physiological method, arrhythmogenesis, myocardial repolarization.

Armbrust L .J., Hoskinson J. J., and Michiels L.M. and Milliken G. A. (2003). Gastric emptying in cats using foods varying in fiber content and kibble shapes. Veterinary Radiology and Ultrasound (3): 339-343. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Abstract: The purpose of this study is to evaluate the influence of kibble shape and fiber content of commercial dry foods on gastric emptying in healthy cats. Eight healthy cats were used to evaluate four different diets which varied in shape of kibble (round versus triangle) or fiber content (low versus high). Diets were labeled with 99mTc-mebrofenin and gastric emptying was evaluated with nuclear scintigraphy. There was a significant difference between the kibble shapes at both T50 and T20. The triangle shaped kibble required significantly longer time than the round kibble to reach T50 (P +AD0- 0.02) and T20 (P +AD0- 0.001). Diet fiber content did not have a significant influence on T50, and T20. The influence of caloric and water intake was assessed with division of cats into high, medium, and low intake groups. The caloric intake had its main effect at T50 with the lowest quartile of caloric intake requiring significantly less time to reach T50 than the middle group and upper quartile (P +AD0- 0.05). Water intake did not have a significant effect on gastric emptying in this study. There was no relationship or correlation between the surface area of the food (cm2/kg) and T90, T50, and T20.
Descriptors: animal feed, cats, dietary fiber analysis, gastric emptying, reference values, stomach radionuclide imaging, technetium tc 99m disofenin diagnostic use.

Balasubramanian, S. and D. Kuppuswamy (2003). Rgd-containing peptides activate s6k1 through beta3 integrin in adult cardiac muscle cells. Journal of Biological Chemistry 278(43): 42214-42224. ISSN: 0021-9258.
NAL Call Number: 381
Descriptors: cardiovascular system, feline cardiomyocytes, integrins, cell growth, endocytic vesicles, cardiac hypertropHy, enzyme, p706S6 kinase, beta 3 integrin, beta 1 integrin, rapamycin.

Ballevre, O.P., J. Ambrose, C. Piguet, H. Schierbeek, and F. Chauffard (1996). Energy expenditure of adult cats estimated using the doubly-labelled-water method, indirect calorimetry and activity monitoring. Proceedings of the Nutrition Society 55(1): 129A. ISSN: 0029-6651.
NAL Call Number: 389.9 N953
Descriptors: metabolism , techniques, non invasive method, energy expenditure measurements, cats, doubly labelled water, indirect calorimetry, activity monitoring, meeting abstract.

Bandyopadhyay, S., C. Rajkhowa, and U.K. Hazarika (1996). A computer programme for identification of parasite eggs and larvae. Journal of Veterinary Parasitology 10(2): 197-199. ISSN: 0304-4017.
NAL Call Number: SF810.V4
Descriptors: helminths, helminth ova, oocysts, nematode larvae, poultry, domestic animals, livestock, morphology, keys, parasites, identification, computer software, protozoa, sheep, goats, cattle, dogs, pigs, man.

Banerji, N., X. Li, J.S. Klausner, V. Kapur, and S. Kanjilal (2002). Evaluation of in vitro chemosensitivity of vaccine-associated feline sarcoma cell lines to vincristine and paclitaxel. American Journal of Veterinary Research 63(5): 728-732. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: vincristine, antineoplastic agents, sarcoma, cell lines, in vitro culture, viability, susceptibility.

Barger, A.M. (2003). The complete blood cell count: A powerful diagnostic tool. Veterinary Clinics of North America, Small Animal Practice 33(6): 1207-1222. ISSN: 0195-5616.
NAL Call Number: SF601 .V523
Descriptors: blood disorders, diagnosis, diagnostic techniques, erythrocytes, hematology, leukocytes, platelets, cats.

Barnes, K.V., G. Cheng, M.M. Dawson, and D.R. Menick (1997). Cloning of cardiac, kidney, and brain promoters of the feline ncx1 gene. Journal of Biological Chemistry 272(17): 11510-11517. ISSN: 0021-9258.
Descriptors: cardiovascular system, feline ncx1 gene, molecular, biochemistry and molecular biophysics, urinary system, homeostasis, alpha adrenergic stimulation, calcium efflux, calcium homeostasis, cardiac hypertropHy, circulatory system, cloning , excretory system, exons , heart , heart disease, kidney , brain, mRNA , ncx1 gene promoters, nervous system, sodium calcium exchanger, tissue specific promoters.

Bartlett, M.S., M.P. Goheen, C.H. Lee, M.M. Shaw, M.M. Durkin, and J.W. Smith (1994). Close association of Pneumocystis carinii from infected rat lung with culture cells as shown by light and electron microscopy. Parasitology Research 80(3): 208-15. ISSN: 0932-0113.
NAL Call Number: QL757 P377
Abstract: Studies of the association of rat-origin Pneumocystis carinii with culture cells were performed both to learn more about the role of cells in P. carinii culture and to evaluate additional cell lines in an effort to improve culture methods. Proliferation of trophozoites of P. carinii from rat lung in cultures with six lung cell lines was demonstrated by light microscopic evaluations of both Giemsa-stained and immune-specific-stained culture samples. Scanning electron microscopy and transmission electron microscopy were used to study the organism's interaction with culture cells and demonstrated a close association of P. carinii with cells in cell lines that supported growth. Proliferation with the MVILU line was suboptimal and there was less organism interaction with these cells than with other cell lines that allowed proliferation. Two cell lines evaluated, Chinese Hamster ovary CHOKI and CHOLEKI, did not allow proliferation and had no association of P. carinii with cells. Scanning and transmission electron micrographs demonstrated the close association of organisms with rat fetal lung (RFL), human embryonic lung (HEL), human diploid lung (HFL), and feline embryonic lung (AKD) culture cells. It appears that the association of rat-origin P. carinii with cells is essential for parasite proliferation in short-term culture.
Descriptors: lung microbiology, pneumocystis growth and development, pneumonia, pneumocystis microbiology, cell line, cells, cultured, cricetulus, hamsters, lung ultrastructure, electron microscopy, electron microscopy, scanning transmission, pneumocystis ultrastructure, rats, feline cells.

Baumann, J.G., W.H. Guenzburg, and B. Salmons (1998). Crfk feline kidney cells produce an rd114-like endogenous virus that can package murine leukemia virus-based vectors. Journal of Virology 72(9): 7685-7687. ISSN: 0022-538X.
NAL Call Number: QR360. J6
Descriptors: feline kidney cell line CrFK, molecular, cell culture, molecular biophysics, viral factors, viral infectivity, viral vector packaging, RD114 like endogenous virus production, murine leukemia.

Beaumont, S.L., D.J. Maggs, and H.E. Clarke (2003). Effects of bovine lactoferrin on in vitro replication of feline herpesvirus. Veterinary Ophthalmology 6(3): 245-250. ISSN: 1463-5216.
NAL Call Number: SF891 .V47
Descriptors: in vitro culture, lactoferrin, viral replication, cats, feline herpesvirus.

Besso, J. (1996). Imagerie medicale. Le contraste abdominal [Diagnostic imaging. The abdominal contrast]. Le Point Veterinaire 28(177): 83-87. ISSN: 0303-4997.
NAL Call Number: SF602.P6
Descriptors: cats, abdomen, radiography, analytical, body parts, body regions.
Language of Text: French.

Binns, S.H., D.D. Sisson, D.A. Buoscio, and D.J. Schaeffer (1995). Doppler ultrasonographic, oscillometric sphygmomanometric, and photoplethysmographic techniques for noninvasive blood pressure measurement in anesthetized cats. Journal of Veterinary Internal Medicine 9(6): 405-14. ISSN: 0891-6640.
NAL Call Number: SF601 .J65
Abstract: Blood pressure (BP) measurements obtained using 3 indirect BP measuring instruments, a Doppler ultrasonic flowmeter, an oscillometric device, and a photoplethysmograph, were compared with direct arterial pressure measurements in 11 anesthetized cats. The standard deviation of the differences (SDD) between direct and indirect pressure measurements were not significantly different from each other (P < .01), and ranged from 10.82 to 24.32 mm Hg. The high SDD values indicate that indirect BP estimates obtained with all these devices must be interpreted cautiously in individual patients. The mean errors (calculated as the sum of the differences between direct and indirect pressure measurements divided by the number of observations) of the 3 indirect devices were significantly different for systolic (SAP), diastolic (DAP), and mean (MAP) arterial pressures (P < .05). The Doppler and photoplethysmographic devices had the highest overall accuracy, as indicated by mean error values of less than 10 mm Hg. Correlation coefficients varied from .88 to .96 for the Doppler flowmeter, and from .85 to .94 for the photoplethysmograph; for both devices, the regression line slopes were close to unity. The Doppler flowmeter detected a pulse under all experimental conditions. The photoplethysmograph was also efficient in obtaining BP measurements, obtaining over 90% of SAP, DAP, and MAP readings attempted. The oscillometric device was the least accurate, with mean error values varying from 10 to 22 mm Hg. Correlation coefficients were high (.90 to .94) for this device, but the slopes of the regression lines were 0.7 to 0.8, indicating a trend for increased error at higher BP. The oscillometric device tended to underestimate BP by increasing amounts as the BP increased. The oscillometric device was the least efficient device for obtaining BP measurements (P < .01).
Descriptors: anesthesia, pressure, cats, analysis of variance, bias epidemiology, oscillometry, photoplethysmography, regression analysis, ultrasonography, doppler.

Blackwood, L., P.J. O'shaughnessy, S.W.J. Reid, and D.J. Argyle (2001). E. Coli nitroreductase/cb1954: in vitro studies into a potential system for feline cancer gene therapy. Veterinary Journal 161(3): 269-279. ISSN: 1090-0233.
NAL Call Number: SF601.V484
Descriptors: cancer, feline thyroid disease, feline neoplasia, treatment, gene therapy, therapeutic method, transfection , molecular genetic method, nitroreductase, in vitro, feline cells, prodrug, CB1954, feline thyroglobulin, E Coli nitroreductase.

Blackwood, L., D.E. Onions, and D.J. Argyle (2001). Characterization of the feline thyroglobulin promoter. Domestic Animal Endocrinology 20(3): 185-201. ISSN: 0739-7240.
NAL Call Number: QL868 .D6
Descriptors: polymerase chain reaction, DNA amplification, feline thyroglobulin promoter, sequencing techniques, analytical method, feline thyroid disease, somatic gene therapy.

Bond, R., L. Wren, and D.H. Lloyd (2000). Adherence of Malassezia pachydermatis and Malassezia sympodialis to canine, feline and human corneocytes in vitro. Veterinary Record 147(16): 454-455. ISSN: 0042-4900.
NAL Call Number: 41.8 V641
Descriptors: feline, corneocytes, M. pachyderatis, in vitro, M. sympodialis.

Borras, T., C.R. Brandt, R. Nickells, and R. Ritch (2002). Gene therapy for glaucoma: treating a multifaceted, chronic disease. Investigative Ophthalmology and Visual Science 43(8): 2513-2518. ISSN: 0146-0404.
Descriptors: glaucoma , eye disease, gene therapy, recombinant gene expression, tissue culture, gene expression, intraocular pressure.

Brackett, B.G. (2001). Advances in animal in vitro fertilization. In: Contemporary Endocrinology: Assisted Fertilization and Nuclear Transfer in Mammals, IX edition, Humana Press Inc. Totowa, New Jersey, USA, p. 21-52. ISBN: 0896036634.
NAL Call Number: QP273.A87
Descriptors: methods, techniques, reproduction , medical sciences, in vitro fertilization, artificial reproduction, animal breeding, endangered species preservation.

Brown, I.E., D.H. Kim, and G.E. Loeb (1998). The effect of sarcomere length on triad location in intact feline caudofemoralis muscle fibres. Journal of Muscle Research and Cell Motility 19(5): 473-477. ISSN: 0142-4319.
NAL Call Number: QP321.J59
Descriptors: muscular system, skeletal muscle sarcomere, A I junction, feline muscle, caudofemoralis, Z band.

Calia, C.M., S.E. Kirschner, K.E. Baer, and J.D. Stefanacci (1994). The use of computed tomography scan for the evaluation of orbital disease in cats and dogs. Veterinary and Comparative Ophthalmology 4(1): 24-30. ISSN: 1076-4607.
NAL Call Number: SF891 .P78
Descriptors: cats, dogs, eye diseases, etiology, radiography, neoplasms, infectious diseases, inflammation, analytical, animal morphology.

Chaudhary, K.W., X. Chen, E.I. Rossman, D. Harris, B. Mathew, V. Piacentino, J. Gaughan, and S.R. Houser (2002). The positive inotropic effects of et-1 on feline ventricular myocytes are mediated through na+/h+, na+/ca2+ exchange, and l-type ca2+ current. Biophysical Journal 82(1 Part 2): 654a. ISSN: 0006-3495.
NAL Call Number: 442.8 B5238
Descriptors: cardiovascular system, transport, circulation, cell biology, feline ventricular myocytes, positive inotropic effect, sodium, calcium exchange.

Cheng, E.J., I.E. Brown, and G.E. Loeb (2000). Virtual muscle: a computational approach to understanding the effects of muscle properties on motor control. Journal of Neuroscience Methods 101(2): 117-30. ISSN: 0165-0270.
NAL Call Number: RC346
Abstract: This paper describes a computational approach to modeling the complex mechanical properties of muscles and tendons under physiological conditions of recruitment and kinematics. It is embodied as a software package for use with Matlab and Simulink that allows the creation of realistic musculotendon elements for use in motor control simulations. The software employs graphic user interfaces (GUI) and dynamic data exchange (DDE) to facilitate building custom muscle model blocks and linking them to kinetic analyses of complete musculoskeletal systems. It is scalable in complexity and accuracy. The model is based on recently published data on muscle and tendon properties measured in feline slow- and fast-twitch muscle, and incorporates a novel approach to simulating recruitment and f requency modulation of different fiber-types in mixed muscles.
Descriptors: computational biology, models, neurological, motor activity, muscle, skeletal, software standards, user computer interface, biomechanics, cell size, central nervous system, electromyogrphy, muscle fibers classification, muscle fibers, muscle fibers, muscle, skeletal, muscle, skeletal innervation, tendons, tendons.

Chetboul, V., N. Athanassiadis, C. Carlos, A.P. Nicolle, R. Tissier, J.L. Pouchelon, D. Concordet, and H.P. Lefebvre (2004). Quantification, repeatability, and reproducibility of feline radial and longitudinal left ventricular velocities by tissue Doppler imaging. American Journal of Veterinary Research 65(5): 566-572. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: analytical, flow, cardiomyopathy, diagnostic techniques, diagnostic value, heart diseases, imagery, muscle contraction, myocardium, quantitative analysis, techniques, velocity, ventricles, cats.

Choi, i.S., S.M. Hash, B.J. Winslow, and E.W. Collisson (2000). Sequence analyses of feline b7 costimulatory molecules. Veterinary Immunology and Immunopathology 73(3-4): 219-231. ISSN: 0165-2427.
NAL Call Number: SF757.2. V38
Descriptors: immune system, chemical coordination, homeostasis, feline mononuclear cells, reverse transcriptase polymerase chain reaction amplification, RT PCR amplification, sequence analysis, analytical method, amino acid sequence.

Clark, A., W. Herzog, and T. Leonard (2000). Contact area and pressure distribution in the feline patellofemoral joint under physiological loading conditions. Archives of Physiology and Biochemistry 108(1-2): 173. ISSN: 1381-3455.
NAL Call Number: QP1.A7
Descriptors: computational biology, skeletal system, model, movement, support, biomechanics, feline patellofemoral joint .
Notes: Meeting Information: XIth Congress of the Canadian Society for Biomechanics, Montreal, Quebec, Canada; August 23-26, 2000.

Clark, A.L., W. Herzog, and T.R. Leonard (2002). Contact area and pressure distribution in the feline patellofemoral joint under physiologically meaningful loading conditions. Journal of Biomechanics 35(1): 53-60. ISSN: 0021-9290.
NAL Call Number: TA166. J6
Descriptors: models, simulations, computational biology, skeletal system, micro indentation transducer, physiological method, biomechanics, feline patellofemoral joint.

Clark, W.a., M.L. Decker, M. Behnke Barclay, D.M. Janes, and R.S. Decker (1998). Cell contact as an independent factor modulating cardiac myocyte hypertrophy and survival in long-term primary culture. Journal of Molecular and Cellular Cardiology 30(1): 139-155. ISSN: 0022-2828.
Descriptors: cell culture, beta adrenergic agonists, cardiac myocyte, hypertrophy, heart disease, electron microscopy, long term primary myocyte culture, cell contact, contractile force, myocyte survival, morphology.

Couillard, S., W. Herzog, and V. Pery (2000). In situ cartilage deformation resulting from physiological loading of the feline patello-femoral joint. Archives of Physiology and Biochemistry 108(1-2): 179. ISSN: 1381-3455.
NAL Call Number: QP1.A7
Descriptors: skeletal system, feline patello femeral joint, biomechanics, in situ cartilage deformation.

Cox, C.L., B.A. Summers, D.F. Kelly, and M.T. Cheeseman (1997). Heterotopic neural tissue in the pharynx of a 7-week-old kitten. Journal of Comparative Pathology 117(1): 95-98. ISSN: 0021-9975.
NAL Call Number: 41.8 J82
Descriptors: kittens, pharynx, nerve tissue, abnormalities, case reports.

Cruz, A.C., C.A. Sutton, and R.J. Avery (1999). The role of apoptosis in cytopathic killing of tissue culture cells by feline immunodeficiency virus. Abstracts of the General Meeting of the American Society for Microbiology 99: 628. ISSN: 1060-2011.
NAL Call Number: QR1.A5
Descriptors: infection , AIDS, acquired immunodeficiency syndrome, immune system disease, viral disease, apoptosis, tissue culture, cells, feline immunodeficiency virus .

Darkes, M.J.M., S.M.A. Davies, and J.P. Bradshaw (1999). Membrane-thinning by the feline leukemia virus fusion peptide. Biophysical Journal 76(1 PART 2): A439. ISSN: 0006-3495.
NAL Call Number: 442.8 B5238
Descriptors: cell biology, feline leukemia virus, fusion peptide, membrane thinning .

Day, M.J. and R.K. Sellon (1999). Immunity & Disease: The T.G. Hungerford Refresher Course for Veterinarians, Post Graduate Foundation in Veterinary Science: Sydney, New South Wales, Australia, 350 p.
Descriptors: veterinary, immunologic diseases in animals.

de Bittencourt, R.H., J.C. da Costa, S.K. da Salim, E.M. da Costa, and G.R. Galvao (1999). Uso dos raios-x e da ultra-sonografia na avaliacao do trato urinario e prostata de caes e gatos. [Use of X-rays and ultrasound imaging to evaluate the uribary tract and prostate glande of cats and dogs] . Revista De Ciencias Agrarias( 31): 101-114. ISSN: 1517-591X.
NAL Call Number: S192 .P3E8
Descriptors: dogs, cats, radiography, x rays, ultrasonics, urinary tract, analytical, body parts, radiation , sound , urogenital system.
Language of Text: Portuguese with summaries in English and Portuguese.

De Vos, J.P., A.G. Burm, and B.P. Focker (2004). Results from the treatment of advanced stage squamous cell carcinoma of the nasal planum in cats, using a combination of intralesional carboplatin and superficial radiotherapy: A pilot study. Veterinary and Comparative Oncology 2(2): 75-81. ISSN: 1476-5810.
NAL Call Number: SF910.T8 V484
Descriptors: carcinoma, combination therapy, disease control, neoplasms, nose, radiotherapy, therapy, cats.

Decker, M.L., D.M. Janes, M.M. Barclay, L. Harger, and R.S. Decker (1997). Regulation of adult cardiocyte growth: effects of active and passive mechanical loading. American Journal of Physiology 272(6 PART 2): H2902-H2918. ISSN: 0002-9513.
NAL Call Number: 447.8 Am3
Descriptors: cell culture, cell biology, costameres, adult, cardiocyte, cardiovascular system, circulatory system, development, hemodynamic load.

Decker, R.S., D.M. Janes, and M.L. Decker (1997). Protein degradation modulates load-dependent growth of cultured adult cardiac myocytes. Journal of Molecular and Cellular Cardiology 29(6): A160. ISSN: 0022-2828.
Descriptors: cardiovascular system, cell biology, feline cardiac myocytes, circulatory system, contractile, creatine kinase, cell culture, degradation , load dependent growth, myosin heavy chain, protein .

Dennis, R. (2000). Use of magnetic resonance imaging for the investigation of orbital disease in small animals. Journal of Small Animal Practice 41(4): 145-155. ISSN: 0022-4510.
NAL Call Number: 41.8 J8292
Descriptors: dogs, cats, diagnostic techniques, imagery, eye diseases, diagnostic value, ultrasonography, radiography, neoplasms, inflammation, foreign bodies.

Dennis, R. (1998). Magnetic resonance imaging and its applications in small animals. In Practice 20(3): 117-124.
Descriptors: dogs, cats, nervous system diseases, nmr spectroscopy, analytical, organic diseases, spectrometry , magnetic resonance imaging, brain diseases, nuclear magnetic resonance.

Dial, E.J. and L.M. Lichtenberger (2002). Effect of lactoferrin on Helicobacter felis induced gastritis. Biochemistry and Cell Biology; Biochimie Et Biologie Cellulaire 80(1): 113-7. ISSN: 1208-6002.
NAL Call Number: QP501.B642
Abstract: Lactoferrin possesses antibiotic, antiinflammatory, and immune-modulating properties that may be active against the gastritis-, ulcer- and cancer-inducing bacterium Helicobacter pylori. In vitro testing of bovine and human lactoferrin by several laboratories has shown significant bacteriostatic and bactericidal activity. Subsequent in vivo testing of bovine lactoferrin in animal models of H. pylori infection has shown beneficial effects of this agent. Our laboratory has utilized a mouse model that is infected with the feline strain of this bacterium, H. felis. The resulting gastritis that develops in this model and the effects of bovine lactoferrin and recombinant human lactoferrin (from Aspergillus niger var. awamori, Agennix Inc., Houston, Tex.) treatment were assessed by various measures. Infected animals treated with orally administered lactoferrin showed reversals in all parameters. In addition, when recombinant human lactoferrin was used in combination with low doses of amoxicillin or tetracycline, there was an enhancement in gastritis-reducing activity. Possible mechanisms for these effects of lactoferrin are discussed. Lactoferrin has significant, orally active in vivo actions and should be further investigated for clinical situations involving Helicobacter infections where it may have utility when administered alone and also when given in combination with established antibiotic agents.
Descriptors: gastritis, helicobacter, helicobacter infections, lactoferrin, lactoferrin, anti bacterial agents, anti bacterial agents, cell division, clinical trials, animal disease models, helicobacter pathogenicity.

Dias Pereira, P., J. Carvalheira, and F. Gartner (2004). Cell proliferation in feline normal, hyperplastic and neoplastic mammary tissue - an immunohistochemical study. Veterinary Journal 168(2): 180-185. ISSN: 1090-0233.
NAL Call Number: SF601.V484
Descriptors: feline, cell growth, hyperplastic, neoplastic, mammary.

Dillmann, R.U. (2003). Diagnosis of arrhythmias in cats - a study to improve arrhythmia diagnosis in cats with computer-assisted ECG registration and analysis methods (PC-EKG) [Arrhythmieerkennung bei der Katze - eine Studie zur verbesserten Diagnose von Herzrhythmusstorungen unter Anwendung von computergestutzten]. Aufzeichnungs Und Analysemethoden 108
Descriptors: arrhythmia, cardiac rhythm, diagnosis, diagnostic techniques, electrocardiograms, heart, cats.
Language of Text: German; Summary in English.

Doppenberg, E.M.R., A. Zauner, J.C. Watson, and R. Bullock (1998). Determination of the ischemic threshold for brain oxygen tension. Acta Neurochirurgica 71(Suppl.): 166-169. ISSN: 0065-1419.
Abstract: Special Supplement on intracranial pressure and neuromonitoring in brain injury
Descriptors: cardiovascular system, nervous system, neural coordination, Craniocerebral Trauma, middle cerebral artery occlusion, Arterial Occlusive Diseases, nervous system disease, vascular disease, cerebral flow, cats.
Notes: Meeting Information: Proceedings of the Tenth International ICP Symposium, Williamsburg, Virginia, USA; May 25-29, 1997.

Dunham, S.P. and J. Bruce (2004). Isolation, expression and bioactivity of feline granulocyte-macrophage colony-stimulating factor. Gene 332(May 12): 97-106. ISSN: 0378-1119.
NAL Call Number: QH442 .A1G4
Descriptors: dendritic cells, cell biology, feline immunopathology, vaccine adjuvant, immune system, feline granulocyte macropHage colony stimulating factor, reverse transcriptase polymerase chain reaction, feline bone marrow cell culture.

Duong, T.Q., S.C. Ngan, K. Ugurbil, and S.G. Kim (2002). Functional magnetic resonance imaging of the retina. Investigative Ophthalmology and Visual Science 43(4): 1176-1181. ISSN: 0146-0404.
Abstract: PURPOSE: This study explored the feasibility of mapping the retina's responses to visual stimuli noninvasively, by using functional magnetic resonance imaging (fMRI). METHODS: fMRI was performed on a 9.4-Tesla scanner to map activity-evoked signal changes of the retina-choroid complex associated with visual stimulation in anesthetized cats (n = 6). Three to 12 1-mm slices were acquired in a single shot using inversion-recovery, echo-planar imaging with a nominal in-plane resolution of 468 x 468 microm(2). Visual stimuli were presented to the full visual field and to the upper and lower visual fields. The stimuli were drifting or stationary gratings, which were compared with the dark condition. Activation maps were computed using cross-correlation analysis and overlaid on anatomic images. Multislice activation maps were reconstructed and flattened onto a two-dimensional surface. RESULTS: fMRI activation maps showed robust increased activity in the retina-choroid complex after visual stimulation. The average stimulus-evoked fMRI signal increase associated with drifting-grating stimulus was 1.7% +/- 0.5% (P < 10(-4), n = 6) compared with dark. Multislice functional images of the retina flattened onto a two-dimensional surface showed relatively uniform activation. No statistically significant activation was observed in and around the optic nerve head. Hemifield stimulation studies demonstrated that stimuli presented to the upper half of the visual field activated the lower part of the retina, and stimuli presented to the lower half of the visual field activated the upper part of the retina, as expected. Signal changes evoked by the stationary gratings compared with the dark basal condition were positive but were approximately half that evoked by the drifting gratings (1.0% +/- 0.1% versus 2.1% +/- 0.3%, P < 10(-4)). CONCLUSIONS: To the best of our knowledge, this is the first fMRI study of the retina, demonstrating its feasibility in imaging retinal function dynamically in a noninvasive manner and at relatively high spatial resolution.
Descriptors: magnetic resonance imaging, retina, cats, choroid, photic stimulation, visual fields.

Durymanov, A.G. and A.M. Shestopalov (1999). A new continuous feline kidney cell culture (fk-91) promising for reproduction of the carnivore parvoviruses. Biotekhnologiya(6): 42-44. ISSN: 0234-2758.
Descriptors: continuous feline kidney cell line 91, cell culture, laboratory equipment, continuous microbial reproduction, parvovirus.
Language of Text: Russian.

Durymanov, A.G. and A.M. Shestopalov (1999). A promising continuous feline kidney cell culture (FK-91) for reproduction of parvoviruses. Biotekhnologiya 15(6): 42-44. ISSN: 0234-2758.
Descriptors: cell lines, in vitro, viral diseases, dog diseases, Parvoviridae, mink, cats.
Language of Text: Russian; Summary in English.

Ebermaier, C. (1999). Vergleichende Untersuchung zur konventionellen und digitalen Radiogrphie bei Hund and Katze [Comparative examination of conventional and digital radiography in dogs and cats]. Dissertation, Tierarztliche Hochschule Hannover: Hannover, Germany. 147 p.
NAL Call Number: DISS F1999060
Descriptors: conventional radiography, digital radiography, cats.
Language of Text: German with a summary in English.

Eilts, B.E., D.L. Paccamonti and C. Pinto (2003). Artificial insemination in the dog. In: M.V. Root Kustritz Small Animal Theriogenology, Butterworth Heinemann: St. Louis, USA, p. 61-95. ISBN: 0750674083.
Descriptors: artificial insemination, conception rate, frozen semen, handling, insemination, semen, cats.

Eken, E.G.M. (2002). The influence of stomach volume on the liver topography in cats. Anatomia, Histologia, Embryologia 31(2): 99-104. ISSN: 0340-2096.
NAL Call Number: SF761.A1G4
Abstract: The aim of this study has been to describe the effect of varying degrees of fullness of the stomach on liver topography in cats by means of the sectional anatomy of the abdominal cavity. Twenty-four adult healthy cats of both sexes and of different ages were used. The cats were divided into two groups. The first group had empty stomachs and the second group had filled stomachs. Eight cats were dissected. The remaining cats were frozen at - 20 degrees C, eight of these were then sectioned paramedially and the other eight were sectioned transversely. In the dissection and sections, it was observed that the liver shifted considerably to the right and craniodorsally in cats with full stomachs. In this article, the topographical anatomy of the liver according to varying stomach volumes is described in a manner that is useful to veterinary surgeons and clinicians. The sectional findings obtained from the paramedial and transverse sections provide information for computed tomography and magnetic resonance imaging.
Descriptors: cats, liver, stomach, abdomen, cats, dissection, dissection, liver, stomach.

Engelmann, R., J.M. Crook, and S. Lowel (2002). Optical imaging of orientation and ocular dominance maps in area 17 of cats with convergent strabismus. Visual Neuroscience 19(1): 39-49. ISSN: 0952-5238.
Abstract: Strabismus (or squint) is both a well-established model for developmental plasticity of the brain and a frequent clinical symptom. While the layout and topographic relationship of functional domains in area 17 of divergently squinting cats has been analyzed extensively in recent years (e.g. Lowel et al., 1998), functional maps in convergently squinting animals have so far not been visualized with comparable detail. We have therefore investigated the functional organization of area 17 in adult cats with a surgically induced convergent squint angle. In these animals, visual acuity was determined by both behavioral tests and recordings of visual evoked potentials, and animals with comparable acuities in both eyes were selected for further experiments. The functional layout of area 17 was visualized using optical imaging of intrinsic signals. Monocular iso-orientation domains had a patchy appearance and their layout was different for left and right eye stimulation, so that segregated ocular dominance domains could be visualized. Iso-orientation domains exhibited a pinwheel-like organization, as previously described for normal and divergently squinting cats. Mean pinwheel density was the same in the experimental and control animals (3.4 pinwheel centers per mm2 cortical surface), but significantly (P < 0.00001) higher than that reported previously for normal and divergently squinting cats (2.7/mm2). A comparison of orientation with ocular dominance maps revealed that iso-orientation domains were continuous across the borders of ocular dominance domains and tended to intersect these borders at steep angles. However, in contrast to previous reports in normally raised cats, orientation pinwheel centers showed no consistent topographical relationship to the peaks of ocular dominance domains. Taken together, these observations indicate an overall similarity between the functional layout of orientation and ocular dominance maps in area 17 of convergently and divergently squinting cats. The higher pinwheel densities compared with previous reports suggest that animals from different gene pools might generally differ in this parameter and therefore also in the space constants of their cortical orientation maps.
Descriptors: ocular dominance, esotropia, visual evoked potentials, orientation, visual cortex, cats, visual acuity.

Feng XiaoChuan and M. Milhausen (1999). Location of Toxoplasma gondii in feline intestinal tissue using PCR. Journal of Parasitology 85(6): 1041-1046. ISSN: 0022-3395.
NAL Call Number: 448. J824
Descriptors: collection, processing, intestines, detection, DNA, polymerase chain reaction, tubulin, techniques, parasites, Toxoplasma gondii, cats, protozoa.

Fernandes, P.J., J.F. Modiano, J. Wojcieszyn, J.S. Thomas, P.A. Benson, R.I. Smith, A.C. Avery, R.C. Burnett, L.I. Boone, M.C. Johnson, and K.R. Pierce (2002). Use of the Cell-Dyn 3500 to predict leukemic cell lineage in peripheral blood of dogs and cats. Veterinary Clinical Pathology 31(4): 167-182. ISSN: 0275-6382.
NAL Call Number: SF601 .A54
Descriptors: analytical, diagnosis, diagnostic techniques, flow cytometry, leukemia, leukocytes, cats, dogs.

Friedman, C.D., P.D. Costantino, S. Takagi, and L.C. Chow (1998). Bonesource hydroxyapatite cement: a novel biomaterial for craniofacial skeletal tissue engineering and reconstruction. Journal of Biomedical Materials Research 43(4): 428-432. ISSN: 0021-9304.
Descriptors: biomaterials, cranial defect repair, cats, therapeutic method, bonesource hydroxyapatite cement, biocompatibility, self-setting calcium phosphate cement .

Friedrich, H. (2002). Entwicklung eines computerbasierten Informationssystems zum Thema Ektoparasiten bei Hund und Katze [Development of a computer-based information system on the subject Ectoparasites of Dogs and Cats]. Dissertation, Freie Universitat Berlin,Berlin, Germany: 88 p.
Descriptors: diagnosis, ectoparasites, epidemiology, information systems, internet, life cycle, morphology, symptoms, cats.
Language of Text: German, LS=English.

Fritz, D., C.L. Hopfner, and J.C. Guilhot Chretien (2004). Systemic mast cell diseases in cats, retrospective study of seven cases, benefits of bone marrow biopsy, comparative aspects. Revue De Medecine Veterinaire 155(7): 362-370. ISSN: 0035-1555.
NAL Call Number: 41.8 R32
Descriptors: biopsy, disorders, bone marrow, clinical aspects, diagnosis, dysplasia, fibrosis, hematology, histopathology, leukaemia, mast cells, renal failure, splenomegaly, cats.
Language of Text: English with summary in French.

Fuentealba, P., I. Timofeev, and M. Steriade (2004). Prolonged hyperpolarizing potentials precede spindle oscillations in the thalamic reticular nucleus. Proceedings of the National Academy of Sciences of the United States of America 101(26): 9816-21. ISSN: 0027-8424.
NAL Call Number: 500 N21P
Abstract: The thalamic reticular (RE) nucleus is a key structure in the generation of spindles, a hallmark bioelectrical oscillation during early stages of sleep. Intracellular recordings of RE neurons in vivo revealed the presence of prolonged hyperpolarizing potentials preceding spindles in a subgroup (30%) of neurons. These hyperpolarizations (6-10 mV) lasted for 200-300 ms and were present just before the onset of spontaneously occurring spindle waves. Corticothalamic volleys also were effective in generating such hyperpolarizations followed by spindles in RE neurons. A drop of up to 40% in the apparent input resistance (R(in)) was associated with these hyperpolarizing potentials, suggesting an active process rather than disfacilitation. Accordingly, the reversal potential was approximately -100 mV for both spontaneous and cortically elicited hyperpolarizations, consistent with the activation of slow K(+) conductances. QX-314 in the recording pipettes decreased both the amplitude and incidence of prolonged hyperpolarizations, suggesting the participation of G protein-dependent K(+) currents in the generation of hyperpolarizations. Simultaneous extracellular and intracellular recordings in the RE nucleus demonstrated that some RE neurons discharged during the hyperpolarizations and, thus, may be implicated in their generation. The prolonged hyperpolarizations preceding spindles may play a role in the transition from tonic to bursting firing of RE neurons within a range of membrane potential (-60 to -65 mV) at which they set favorable conditions for the generation of low-threshold spike bursts that initiate spindle sequences. These data are further arguments for the generation of spindles within the thalamic RE nucleus.
Descriptors: action potentials, neurons, thalamic nuclei, thalamic nuclei, aging, anesthesia, cats, electric conductivity, excitatory postsynaptic potentials, ion transport, potassium, sleep, sodium.

Gaughan, J.P. and S.R. Houser (2004). Negative inotropic effects of pkc activation in human and feline cardiac myocytes. Biophysical Journal 86(1): 65a-66a. ISSN: 0006-3495.
NAL Call Number: 442.8 B5238
Descriptors: congestive heart failure, CHF, cardiovascular system, heart disease, contractility, muscular system.
Notes: Meeting Information: 48th Annual Meeting of the Biophysical Society, Baltimore, MD, USA; February 14-18, 2004.

Gavaghan, B.J., M.D. Kittleson, K.J. Fisher, P.H. Kass, and M.A. Gavaghan (1999). Quantitative of left ventricular diastolic wall motion by Doppler tissue imaging in healthy cats and cats with cardiomyopathy. American Journal of Veterinary Research 60(12): 1478-1486. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: cats, cardiomyopathy, ultrasonography, ventricles, physiological functions, heart rate.

Gavaghan, B.J., M.D. Kittleson, K.J. Fisher, P.H. Kass, and M.A. Gavaghan (1999). Quantification of left ventricular diastolic wall motion by Doppler tissue imaging in healthy cats and cats with cardiomyopathy. American Journal of Veterinary Research 60(12): 1478-1486. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: cardiomyopathy, haemodynamics, diagnostic techniques, heart diseases, cats.

Gavrilin, M.A. and M. Podell (2001). Methamphetamine enhances FIV-MD replication in feline astrocytes. Society for Neuroscience Abstracts 27(1): 613. ISSN: 0190-5295.
NAL Call Number: QP351. S6
Descriptors: infection, toxicology, meeting abstract.

Gehrke, C., J. Steinmann, and P. Goroncy Bermes (2004). Inactivation of feline calicivirus, a surrogate of norovirus (formerly norwalk-like viruses), by different types of alcohol in vitro and in vivo. Journal of Hospital Infection 56(1): 49-55. ISSN: 0195-6701.
Descriptors: infection, sanitation, quantitative suspension assay, bioassay techniques, laboratory techniques, hand disinfection.

Geiselhart, V., P. Bastone, T. Kempf, M. Schnoelzer, and M. Loechelt (2004). Furin-mediated cleavage of the feline foamy virus Env leader protein. Journal of Virology 78(24): 13573-13581. ISSN: 0022-538X.
NAL Call Number: QR360. J6
Descriptors: feline foamy virus, Env leader protein, retrovirus infection, viral diseases, Retroviridae, FFV.

Gengozian, N., R.E. Hall, and C.E. Whitehurst (2002). Erythrocyte-rosetting properties of feline blood lymphocytes and their relationship to monoclonal antibodies to t lymphocytes. Journal of the Federation of American Societies for Experimental Biology 16(4): A720. ISSN: 0892-6638.
NAL Call Number: QH301. F3
Descriptors: feline T lymphocytes, erythrocyte rosetting properties, guinea pigs, T supressor cells, CD4 antibody, CD8 antibody, immune system, cell culture, homeostasis.
Notes: Meeting Information: Annual Meeting of the Professional Research Scientists on Experimental Biology, New Orleans, Louisiana, USA; April 20-24, 2002.

Gidlewski, J. and J.P. Petrie (2003). Pericardiocentesis and principles of echocardiographic imaging in the patient with cardiac neoplasia. Clinical Techniques in Small Animal Practice 18(2): 131-134. ISSN: 1096-2867.
NAL Call Number: SF911 .S45
Descriptors: dogs, cats, neoplasms, heart, ultrasonography, diagnostic techniques, pericardium, echocardiograpHy , pericardiocentesis .

Ginovart, N., A.A. Wilson, S. Houle, and S. Kapur (2004). Amphetamine pretreatment induces a change in both D2-Receptor density and apparent affinity: a +AFs-11C+AF0-raclopride positron emission tomography study in cats. Biological Psychiatry 55(12): 1188-1194. ISSN: 0006-3223.
Descriptors: amphetamine, dopamine antagonists, dopamine uptake inhibitors, raclopride, dopamine d2 receptors, competitive binding, pressure, cats, intravenous injections, neostriatum, radiopharmaceuticals, emission computed tomography.

Good, M.S., V. Krebsbach, N. Loewen, E.M. Poeschla, and D.H. Johnson (2001). Transduction of retinal ganglion cells in culture using feline immunodeficiency virus. Investigative Ophthalmology and Visual Science 42(4): S411. ISSN: 0146-0404.
Descriptors: apoptosis, feline immunodeficiency virus, cell culture, retinal ganglion cell, transduction.

Govindasamy, L., K. Hueffer, C.R. Parrish, and M. Agbandje Mckenna (2003). Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants. Journal of Virology 77(22): 12211-12221. ISSN: 0022-538X.
NAL Call Number: QR360. J6
Descriptors: infection , molecular, crystallography, laboratory techniques, feline panleukopenia virus, capsid structure, virus cell interaction, asparagine, arginine.

Graham, L.H. and J.L. Brown (1997). Nicht-invasive Bestimmung der Gonaden- und Adrenocortisonfunktion mittels faekaler Steroidanalyse bei Katzen [Non-invasive assessment of gonadal and adrenocortical function in felid species via faecal steroid analysis]. Zeitschrift Fuer Saeugetierkunde 62(Suppl. 2): 78-82. ISSN: 0044-3468.
NAL Call Number: QL700. Z4
Descriptors: cats, lions, leopards, tigers, cheetahs, estrogens, progesterone, testosterone, glucocorticoids, feces, monitoring, measurement, adrenal cortex hormones, androgens , corpus luteum hormones, corticoids , excreta , hormones , isoprenoids , progestational hormones, sex hormones, steroids .
Language of Text: German; Summary in English.
Notes: Meeting Information: National Zoological Park, Front Royal, Virginia (USA). Smithsonian Institution. Conservation and Research Center. 1st International Symposium on Physiology and Ethology of Wild Zoo Animals. September 18-21, 1996.

Guaguere, E., T. Olivry, A. Delverdier Poujade, P. Denerolle, J.P. Pages, and J.P. Magnol (1999). Demodex cati infestation in association with feline cutaneous squamous cell carcinoma in situ: a report of five cases. Veterinary Dermatology 10(1): 61-67. ISSN: 0959-4493.
NAL Call Number: SF901 .V47
Descriptors: carcinoma, demodex, lesions, skin diseases, ova, larvae, adults, developmental stages, histopathology, diagnosis, lentivirus, immunosuppression, papovaviridae, disorders, pathogenesis, acarina , animal developmental stages, arachnida , cells , demodicidae , developmental stages, gametes , immunotherapy , neoplasms , organic diseases, prostigmata , retroviridae , therapy , viruses , demodex cati, feline immunodeficiency virus, papillomavirus , dysplasia , opportunistic infections, mixed infections.

Gueguen, S., V. Martin, L. Maynard, and B. Lebreux (2002). In vitro antiviral effect of a recombinant feline omega interferon on a feline leukaemia retrovirus (felv). Journal of Interferon and Cytokine Research 22(Supplement 1): S-163. ISSN: 1079-9907.
Descriptors: cell biology, feline leukemia retrovirus, recombinant feline omega interferon, neoplastic disease, viral disease.

Gunaseelan, L., N.D.J. Chandran, K. Kumanan, J. Ramkrishna, and R. Manickam (1997). Propagation and isolation of canine parvovirus in crandell feline kidney cell line. Indian Journal of Animal Sciences 67(8): 679-682. ISSN: 0367-8318.
NAL Call Number: 41.8 IN22
Descriptors: cell biology, immune system, infection , radiation biology, urinary system, crandell feline kidney cells, digestive systemfeces, indirect fluorescent antibody technique, infection , isolation method, pathogen, propagation, urinary system.

Hatama, S., K. Otake, M. Ohta, M. Kobayashi, K. Imakawa, A. Ikemoto, H. Okuyama, M. Mochizuki, T. Miyazawa, and Y. Tohya (2001). Reactivation of feline foamy virus from a chronically infected feline renal cell line by trichostatin A. Virology 283(2): 315-323. ISSN: 0042-6822.
NAL Call Number: 448.8 V81
Descriptors: chronic infections, feline renal cell line, trichostatin A, feline foamy virus, FFV.

Heckman, C., M.D. Johnson, A. Hyngstrom, E.J. Perreault, and V. Ravichandran (2003). Three - dimensional sensory convergence onto spinal interneurons from functionally complex muscles. In: Society for Neuroscience Abstract Viewer and Itinerary Planner: 33rd Annual Meeting of the Society of Neuroscience, November 8, 2003-November 12, 2003, New Orleans, LA, USA, Vol. 2003, p. Abstract No. 186.18.
NAL Call Number: QP351. S6
Descriptors: muscular system, feline lumbar spinal interneurons, nervous system, computer model, mathematical and computer techniques, principle component analysis, robotic arm, sensory convergence, hind limb muscles.

Henderson, L.A., P.M. Macey, C.A. Richard, M.L. Runquist, and R.M. Harper (2004). Functional magnetic resonance imaging during hypotension in the developing animal. Journal of Applied Physiology 97(6): 2248-2257. ISSN: 8750-7587.
NAL Call Number: 447.8 J825
Descriptors: kittens, magnetic resonance imaging, isoflurane, hypotension, blood pressure, cats.

Hisasue, M., S. Neo, R. Tuchiya, and T. Yamada (2004). Successful therapy with a vitamin k2 analog (menatetrenone) in feline myelodysplastic syndromes. Journal of Veterinary Internal Medicine 18(3): 440. ISSN: 0891-6640.
NAL Call Number: SF601. J65
Descriptors: pharmacology , medicine, myelodysplastic syndrome, and lymphatic disease, neoplastic disease, therapy, vitamin K2 analog, menatetronone .

Hoffmann, A., S. Vieths, and D. Haustein (1997). Biologic allergen assay for in vivo test allergens with an in vitro model of the murine type I reaction. Journal of Allergy and Clinical Immunology 99(2): 227-232. ISSN: 0091-6749.
NAL Call Number: 448.8 J8236
Descriptors: in vitro, allergens, bioassays, IgE, techniques, analytical, cats.

Hogan, D.F. and M.P. Ward (2004). Effect of clopidogrel on tissue-plasminogen activator-induced in vitro thrombolysis of feline whole blood thrombi. American Journal of Veterinary Research 65(6): 715-719. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: blood, plasminogen activator, thrombolysis, thrombosis, cats.

Hohdatsu, T., J. Tokunaga, and H. Koyama (1994). The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages. Archives of Virology 139(3/4): 273-285. ISSN: 0304-8608.
NAL Call Number: 448.3 Ar23
Abstract: Antibody-dependent enhancement (ADE) of feline infectious peritonitis virus (FIPV) infection was studied in feline alveolar macrophages and human monocyte cell line U937 using mouse neutralizing monoclonal antibodies (MAbs) directed to the spike protein of FIPV. Even among the MAbs that have been shown to recognize the same antigenic site, IgG 2a MAbs enhanced FIPV infection strongly, whereas IgG 1 MAbs did not. These IgG 2a MAbs enhanced the infection even when macrophages pretreated with the MAb were washed and then inoculated with the virus. Immunofluorescence flow cytometric analysis of the macrophages treated with each of the MAbs showed that the IgG 2a MAbs but not the IgG 1 MAbs bound to feline alveolar macrophages. Treatment of the IgG 2a MAb with protein A decreased the binding to the macrophages and, in parallel, diminished the ADE activity. Although no infection was observed by inoculation of FIPV to human monocyte cell line U937 cells, FIPV complexed with either the IgG 2a MAb or the IgG 1 MAb caused infection in U937 cells which are shown to express Fc gamma receptor (Fc gamma R) I and II that can bind mouse IgG 2a and IgG 1, respectively. These results suggest that the enhancing activity of MAb is closely correlated with IgG subclass and that the correlation is involved in binding of MAb to Fc gamma R on feline macrophage.
Descriptors: feline peritonitis virus, monoclonal antibodies, acute course, macrophages, binding, igg, virus neutralization, flow cytometry.

Hosie, M.J., N. Broere, J. Hesselgesser, J.D. Turner, J.A. Hoxie, J.C. Neil, and B.J. Willett (1998). Modulation of feline immunodeficiency virus infection by stromal cell-derived factor. Journal of Virology 72(3): 2097-2104. ISSN: 0022-538X.
NAL Call Number: QR360. J6
Descriptors: feline immunodeficiency, cats.

Ichimura, N., M. Shimojima, Y. Nishimura, Y. Tohya, and H. Akashi (2004). Molecular cloning and sequencing of feline cd7. Journal of Veterinary Medical Science 66(10): 1255-1258. ISSN: 0916-7250.
NAL Call Number: SF604. J342
Descriptors: immune system, human CD7 molecule, T cell, molecular, feline CD7, molecular biophysics, gene sequencing, immunofluorescence assay, histidine, immunologic techniques, molecular cloning, genetic techniques .

Ikeda, Y., K. Tomonaga, M. Kawaguchi, M. Kohmoto, Y. Inoshima, Y. Tohya, T. Miyazawa, C. Kai, and T. Mikami (1996). Feline immunodeficiency virus can infect a human cell line (MOLT-4) but establishes a state of latency in the cells. Journal of General Virology 77(pt.8): 1623-1630. ISSN: 0022-1317.
NAL Call Number: QR360. A1J6
Abstract: Infectivity of feline immunodeficiency virus (FIV) in feline and human lymphoblastoid cell lines was examined using homogeneous populations of FIV derived from infectious molecular clones of strains TM2 and Petaluma, and two recombinant chimeric clones carrying gag, pol, vif and ORF-A from the heterologous virus. FIV from the clones with the env region of the Pataluma strain was shown to infect and establish provirus in a human lymphoid coil line (MOLT-4), although the FIV-infected cells did not produce any infectious viruses. By treatment of the infected MOLT-4 cells with a phorbol ester, infectious virus was rescued. To examine which stage of the life-cycle of FIV is blocked in these coils, we analysed transcription of FIV-14 in the cells by RT-PCR. FIV-specific RNA expression could not be detected. These results strongly suggest that latency of the virus in MOLT-4 cells is due to a failure in transcription.
Descriptors: feline immunodeficiency virus, infection, man, lymphocytes, cell lines, latent infections, infectivity, proviruses, transcription, replication, life cycle, lymphoblastoid cell lines.

Ikeda, Y., J. Shinozuka, T. Miyazawa, K. Kurosawa, Y. Izumiya, Y. Nishimura, K. Nakamura, J. Cai, K. Fujita, K. Doi, and T. Mikami (1998). Apoptosis in feline panleukopenia virus-infected lymphocytes. Journal of Virology 72(8): 6932-6936. ISSN: 0022-538X.
NAL Call Number: QR360. J6
Descriptors: cell biology, infection, feline panleukopenia virus, apoptosis, pathophysiology, interleukin 2 receptor alpha .

Imamura, T., H. Maeda, T. Fujiyasu, Y. Imagawa, and S. Tokiyoshi (2003). Feline cytokine protein. Official Gazette of the United States Patent and Trademark Office Patents 1267(2) ISSN: 0098-1133.
NAL Call Number: T223. A21
Descriptors: immune system, feline cytokine protein, feline infectious diseases, infectious disease, viral disease, feline cytotoxic T lymphocytes, heteologus dimer, FLAF p35, FLAF p40, cytotoxic activity, expression vector.

Itoh, Y., D. Uematsu, N. Araki, K. Muramatsu, S. Watanabe, and Y. Fukuuchi (1998). Fluorometric measurement of intracellular pH in vivo in feline cerebral cortex during ischemia and reperfusion. Keio Journal of Medicine 47(1): 37-41. ISSN: 0022-9717.
Descriptors: feline cerebral cortex, cerebral ischemia, nervous system disease, vascular disease, intracellular acidosis, neuronal damage, intracellular pH, hypoxemia, in vivo, 2,7 biscarboxyethyl carboxyfliorescein, pH probe, transit time, hemodilution curve.

Jankowska, E., D.J. Maxwell, S. Dolk, and A. Dahlstrom (1997). A confocal and electron microscopic study of contacts between 5-HT fibres and feline dorsal horn interneurons in pathways from muscle afferents. Journal of Comparative Neurology 387(3): 430-438. ISSN: 0021-9967.
Descriptors: analytical method, confocal microscopy, feline dorsal horn interneurons, electron microscopy, 5HT fibres, nervous system, serotonin, serotonin fibers, synaptic cell contacts, immunocytochemistry, muscle afferents, horseradish peroxidase, soma, dendrites.

Johnson, C.M., D.W. Selleseth, M.N. Ellis, T.A. Childers, M.B. Tompkins, and W.A.F. Tompkins (1994). Feline lymphoid tissues engrafted into scid mice maintain morphologic structure and produce feline immunoglobulin. Laboratory Animal Science 44(4): 313-318. ISSN: 0023-6764.
NAL Call Number: 410.9 P94
Abstract: To adapt the feline immune system to a small laboratory animal host, severe combined immunodeficient (scid) mice were engrafted with neonatal feline lymphoid tissues, including lymph node, thymus, spleen, and bone marrow. Lymph node and thymus tissue were implanted subcutaneously within the mammary fat pad, and a single-cell suspension of spleen, thymus, and bone marrow was inoculated intraperitoneally (IP). Seven groups of mice (three mice per group) were engrafted on day 0, and members of one group were euthanatized weekly from 2 to 8 weeks after engraftment. For each mouse, graft morphology was evaluated by light microscopy, feline DNA was detected in peripheral blood by polymerase chain reaction (PCR) amplification of feline-specific DNA sequences, and serum feline IgG concentration was measured by ELISA. Ten of 13 feline grafts evaluated histologically between 3 and 8 weeks after engraftment contained large focal aggregates of lymphocytes bordered by plasma cells. Of 14 thymus grafts evaluated histologically during the same period, 5 were characterized by dense accumulations of small lymphocytes surrounding thymic epithelial cells. Two of these thymus grafts were indistinguishable from age-matched feline thymus. At 2 weeks after engraftment, feline lymph node and thymus contained extensive central necrosis bordered by a narrow zone of lymphocytes and small-caliber blood vessels. Feline DNA, as detected by PCR amplification of the feline c-fes proto-oncogene from peripheral blood lysates, was detected in the peripheral blood of 9 of 18 mice. All mice evaluated at 3, 7, and 8 weeks after engraftment had detectable levels of feline DNA. Feline IgG was detected in all engrafted mice, with concentration.
Descriptors: mice, immunological deficiency, kittens, lymph nodes, thymus gland, spleen, bone marrow cells, xenografts, morphology, DNA, IgG, histology, lymphocytes, proto oncogenes, animal models, severe combined immunodeficiency, c fes proto oncogene.

Johnsson, H., P. Heldin, G. Sedin, and L.C. Laurent (1997). Hyaluronan production in vitro by fetal lung fibroblasts and epithelial cells exposed to surfactants of n-acetylcysteine. Upsala Journal of Medical Sciences 102(3): 199-209. ISSN: 0300-9734.
Descriptors: feline lung epithelial cells, infant respiratory distress syndrome, hyaluronan, N acetylcysteine, cell culture.

Jordan, K., S.J. O' Brien, K.H. Johnson, and T.D. O' Brien (1995). Assignment of islet amyloid polypeptide (IAPP) gene to feline chromosome B4 using the polymerase chain reaction technique on feline-rodent hybrid cell lines. Veterinary Pathology 32(2): 195-197. ISSN: 0300-9858.
NAL Call Number: 41.8 P27
Descriptors: diabetes, diabetes mellitus, genes, polymerase chain reaction, cell lines, chromosomes, polypeptides, DNA, DNA hybridization, gene mapping, biotechnology, cats.

Joshi, M.S., E.D. Crouser, M.W. Julian, B.L. Schanbacher, and J.A. Bauer (2000). Digital imaging analysis for the study of endotoxin-induced mitochondrial ultrastructure injury. Analytical Cellular Pathology 21(1): 41-48. ISSN: 0921-8912.
Descriptors: cell biology, infection, endotoxin induced mitochondrial ultrastructure injury, toxicity, sepsis, bacterial disease, digital imaging analysis, analytical method.

Kano, R., A. Kubota, Y. Nakamura, S. Watanabe, and A. Hasegawa (2001). Feline ubiquitin fusion protein genes. Veterinary Research Communications 25(8): 615-622. ISSN: 0165-7380.
NAL Call Number: SF601. V38
Descriptors: DNA amplification, in situ recombinant gene expression detection, feline ubiquitin fusion proteins, molecular genetic method, reverse transcriptase polymerase chain reaction, molecular genetic method, polymerase chain reaction, heat shock, immunoblot assay, homology .

Karle, P., M. Renner, B. Salmons, and W.H. Gunzburg (2001). Necrotic, rather than apoptotic, cell death caused by cytochrome p450-activated ifosfamide. Cancer Gene Therapy 8(3): 220-230. ISSN: 0929-1903.
Descriptors: tumor biology, cytochrome p450 2b1, antitumorigenic prodrug, ifosfamide, cyp2b1 detection assay, gene therapy, genetic method, recombinant gene expression applications, therapeutic method, cell death, necrotic mechanism.

Kashiwase, H., T. Katsube, T. Kimura, T. Nishigaki, and M. Yamashita (2000). 8-difluoromethoxy-4-quinolone derivatives as anti-feline immunodeficiency virus (FIV) agents: important structural features for inhibitory activity of FIV replication. Journal of Veterinary Medical Science 62(5): 499-504. ISSN: 0916-7250.
NAL Call Number: SF604. J342
Descriptors: infection, cell culture, Feline Acquired Immunodeficiency Syndrome, immune system disease, viral disease, virus replication.

Katayama, R., M.K. Huelsmeyer, D.M. Vail, I.D. Kurzman, and E.G. Macewen (2002). Selective inhibition of platelet-derived growth factor receptor activity in feline vaccine-associated sarcoma. 93rd Annual Meeting of the American Association for Cancer Research, Proceedings of the American Association for Cancer Research: the official organ of the American Association for Cancer Research , April 06-10, 2002, San Francisco, California, USA, Vol. 43: p. 600-601.
NAL Call Number: RC261.A4
Descriptors: pharmacology, tumor biology, feline, vaccine associated sarcoma, neoplastic disease, platlet growth factor.

Kawabata, S., H. Komori, K. Mochida, O. Harunobu, and K. Shinomiya (2002). Visualization of conductive spinal cord activity using a biomagnetometer. Spine 27(5): 475-9. ISSN: 0362-2436.
Abstract: STUDY DESIGN: The authors measured conductive cervical spinal cord evoked magnetic fields (SCEFs) after thoracic spinal cord stimulation in cats and visualized spinal cord activities. OBJECTIVE: To evaluate the usefulness of magnetic field measurement. SUMMARY OF BACKGROUND DATA: Magnetic field measurement has several theoretical advantages compared with electric potential measurement. Although biomagnetometers for the brain and heart are already on the market and are widely used, methods for magnetic field measurement of the spinal cord have not been established. METHOD: Cervical laminectomy was performed on adult cats under anesthesia and the dural tube was exposed. Electrical stimuli were applied to the lower thoracic spinal cord by a catheter epidural electrode. SCEFs were recorded using a biomagnetometer specially designed for recording spinal cord action potentials. SCEFs were measured at 35 different points over the cervical spine and isomagnetic field maps of SCEFs were constructed. Thereafter, the spinal cord was transected completely at C5 and SCEFs were measured again. RESULTS: The detected SCEFs showed a clear biphasic configuration. The first deflection of the magnetic fields from the left side was directed outward, but the right-side deflection was directed inward. The second deflection showed reversed polarity. The isomagnetic field maps of SCEFs clearly demonstrated the quadrupolar pattern and propagated at a conduction velocity of 80-120 m/s. After spinal cord transection, the propagation of SCEFs stopped at the transection site, and the SCEFs could not be obtained above the site. CONCLUSIONS: The authors concluded that magnetic field measurement is useful for evaluation of spinal cord function. Moreover, it was apparent that SCEFs could indicate conduction block in the spinal cord.
Descriptors: magnetics instrumentation, neural conduction, spinal cord, action potentials, axotomy, cats, electric stimulation, evoked potentials, laminectomy, neck, predictive value of tests, reproducibility of results, sensitivity and specificity.

Kennedy, M.A., V.S. Mellon, G. Caldwell, and L.N.D. Potgieter (1995). Virucidal efficacy of the newer quaternary ammonium compounds. American Animal Hospital Association 31(3): 254-258. ISSN: 0587-2871.
NAL Call Number: SF601 .A5
Descriptors: quateRNAry ammonium compounds, antiviral agents, feline calicivirus, herpetoviridae, parvoviridae, cell culture, disinfectants, ammonium compounds, antimicrobials , caliciviridae , culture techniques, in vitro culture, viruses , feline herpesvirus, canine parvovirus, labeling.

Kim, H.J., C.H. Lee, S.H. Lee, B.M. Cho, H.K. Kim, B.R. Park, S.Y. Ye, G.R. Jeon, and K.H. Chang (2001). Early development of vasogenic edema in experimental cerebral fat embolism in cats: correlation with MRI and electron microscopic findings. Investigative Radiology 36(8): 460-469. ISSN: 0020-9996.
Abstract: RATIONALE AND OBJECTIVES: To evaluate the magnetic resonance imaging and electron microscopic findings of the hyperacute stage of cerebral fat embolism in cats and the time needed for the development of vasogenic edema. METHODS: Magnetic resonance imaging was performed at 30 minutes (group 1, n = 9) and at 30 minutes and 1, 2, 4, and 6 hours after embolization with triolein (group 2, n = 10). As a control for group 2, the same acquisition was obtained after embolization with polyvinyl alcohol particles (group 3, n = 5). Magnetic resonance images were analyzed qualitatively and quantitatively. Electron microscopic examination was done in all cats. RESULTS: In group 1, the lesions were iso- or slightly hyperintense on T2-weighted (T2W) and diffusion-weighted (DWIs) images, hypointense on the apparent diffusion coefficient (ADC) map image, and markedly enhanced on the gadolinium-enhanced T1-weighted images (Gd-T1WIs). In group 2 at 30 minutes, the lesions were similar to those in group 1. Thereafter, the lesions became more hyperintense on T2WIs and DWIs and more hypointense on the ADC map image. The lesions were enhanced on Gd-T1WIs at all acquisition times. In group 3, the lesions showed mild hyperintensity on T2WIs at 6 hours but hypointensity on the ADC map image from 30 minutes, with a tendency toward a greater decrease over time. The lesions were not enhanced on Gd-T1WIs at any time point. Electron microscopic findings revealed discontinuity of the capillary endothelial wall, perivascular and interstitial edema, and swelling of glial and neuronal cells in groups 1 and 2. Cellular swelling and interstitial edema were more prominent in group 2. In group 3, interstitial edema was seen; however, discontinuity of the endothelial wall was absent. CONCLUSIONS: The lesions were hyperintense on T2WIs and DWIs, hypointense on the ADC map image, and enhanced on Gd-T1WIs. On electron microscopy, the lesions showed cytotoxic and vasogenic edema with disruption of the blood-brain barrier. Vasogenic edema seems to develop within 30 minutes in cerebral fat embolism in cats.
Descriptors: brain edema, brain edema, embolism, fat, embolism, fat, intracranial embolism, intracranial embolism, magnetic resonance imaging, electron microscopy, cats, contrast media, animal disease models, gadolinium diagnostic use.

Kim, S.G. and K. Ugurbil (2003). High-resolution functional magnetic resonance imaging of the animal brain. Methods 30(1): 28-41. ISSN: 1046-2023.
Abstract: To fully understand brain function, one must look beyond the level of a single neuron. By elucidating the spatial properties of the columnar and laminar functional architectures, information regarding the neural processing in the brain can be gained. To map these fine functional structures noninvasively and repeatedly, functional magnetic resonance imaging (fMRI) can be employed. In this article the basic principles of fMRI are introduced, including specific hardware requirements and the equipment necessary for animal magnetic resonance research. Since fMRI measures a change in secondary hemodynamic responses induced by neural activity, it is critical to understand the principles and potential pitfalls of fMRI techniques. Thus, the underlying physics of conventional blood oxygenation, cerebral blood flow, and cerebral blood volume-based fMRI techniques are extensively discussed. Tissue-specific signal change is close to the site of neural activity, while signals from large vessels can be distant from the actual active site. Thus, methods to minimize large vessel contributions and to maximize tissue signals are described. The fundamental limitation of fMRI spatial resolution is the intrinsic hemodynamic response. Based on our high-resolution fMRI studies, the hemodynamic response is regulated at submillimeter functional domains and thus spatial resolution can be achieved to an order of 100 microm. Since hemodynamic responses are sluggish, it is difficult to obtain very high temporal resolution. By using an approach with multiple experiments with different stimulus conditions, temporal resolution can be improved on the order of 100 ms. With current fMRI technologies, submillimeter columnar- and laminar-specific specific functional images can be obtained from animal brains.
Descriptors: brain, magnetic resonance imaging instrumentation, magnetic resonance imaging, brain supply, cats, cerebrovascular circulation.

Kirbach, B., K. Schober, G. Oechtering, and H. Aupperle (2000). Diagnostik von Herzmuskelschaden bei Katzen mit stumpfen Thoraxtraumen uber biochemische Parameter im Blut [Diagnosis of myocardial cell injuries in cats with blunt thoracic trauma using circulating biochemical markers]. Tierarztliche Praxis 28(1): 25-33. ISSN: 1434-1220.
NAL Call Number: SF603 .V43
Descriptors: biochemical markers, ECG abnormalities, thoracic trauma, creatine kinase, isoenzymes, diagnosis, electorcardiography, myocardium, heart diseases, cats.
Language of Text: German with a summary in English.

Klaser, D.A., N.J. Reine, and A.E. Hohenhaus (2005). Red blood cell transfusions in cats: 126 cases (1999). Journal of the American Veterinary Medical Association 226(6): 920-923. ISSN: 0003-1488.
NAL Call Number: 41.8 Am3
Descriptors: adverse effects, anemia, transfusion, case reports, diagnosis, erythrocytes, cats.

Klein, M.K. (2003). Multimodality therapy for head and neck cancer. Veterinary Clinics of North America, Small Animal Practice 33(3): 615-628. ISSN: 0195-5616.
NAL Call Number: SF601 .V523
Abstract: The refinement of radiation therapy techniques should result in a decrease in morbidity in canine and feline nasal carcinoma patients and should further allow for the addition of adjuvant therapies. Patients with large oral tumors that are incompletely excised should have radiation therapy added to their treatment regimen. Tumors with significant metastatic potential, such as melanoma, should be considered for addition of chemotherapy. Carboplatin has activity in melanomas and is being added at several institutions, but trial results are not yet available. Chemoradiation has become the treatment of choice for human head and neck squamous cell carcinomas but remains largely unexplored in veterinary medicine. Hopefully, development of chemoradiation will benefit feline squamous cell carcinoma patients, because current treatment regimens are largely ineffective. Immunotherapy agents and targeted biologic therapeutics seem to hold promise for the future.
Descriptors: dog diseases, head and neck neoplasms, combined modality therapy, dogs.

Klopp, L.S., J.T. Hathcock, and D.C. Sorjonen (2000). Magnetic resonance imaging features of brain stem abscessation in two cats. Veterinary Radiology and Ultrasound 41(4): 300-307. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: cats, brain stem, abscesses, nuclear magnetic resonance, imagery, disease course, differential diagnosis.

Koch, R., H. Schroder, and H. Waibl (2002). Zur Topographie und bildlichen Darstellung (Rontgen und CT) der Nasennebenhohlen der Katze [Topography and imaging methods (X-rays and computer tomography) on the paranasal sinuses of cats]. Kleintierpraxis 47(4): 213-219. ISSN: 0023-2076.
NAL Call Number: 41.8 K67
Descriptors: analytical, animal anatomy, computed tomography, paranasal sinuses, sex differences, topograpHy, cats.
Language of Text: German; Summary in English.

Koffas, H., J. Dukes McEwan, B.M. Corcoran, C.M. Moran, A. French, V. Sboros, T. Anderson, P. Smith, K. Simpson, and W.N. McDicken (2003). Peak mean myocardial velocities and velocity gradients measured by color M-mode tissue Doppler imaging in healthy cats. Journal of Veterinary Internal Medicine 17(4): 510-524. ISSN: 0891-6640.
NAL Call Number: SF601. J65
Descriptors: age differences, heart, heart rate, heart sounds, myocardium, pulsation, ultrasonography, cats.

Koga, L., Y. Kobayashi, M. Yazawa, S. Maeda, K. Masuda, K. Ohno, and H. Tsujimoto (2002). Nucleotide sequence and expression of the feline vascular endothelial growth factor. Journal of Veterinary Medical Science 64(5): 453-456. ISSN: 0916-7250.
NAL Call Number: SF604. J342
Descriptors: endocrine system, feline lymphoid tumor cell line, feline vascular endothelial growth factor, human VEGF165 molecular, reverse transcriptase polymerase chain reaction, RT PCR, glycosylation, mRNA.

Kopelovich, L. (Inventor) De novo induction of cells exhibiting characteristics of macrophages utilizing feline sarcoma virus. 1997). Official Gazette of the United States Patent and Trademark Office Patents, 1202 (5): 3842. ISSN: 0098-1133
NAL Call Number: T223. A21
Descriptors: blood and lymphatics, feline sarcoma virus, infection, skeletal system, analytical techniques, biotechnology, cell culture, de novo conversion, expression, human fibroblasts.

Kording, K.P., C. Kayser, B.Y. Betsch, and Konig P. (2001). Non-contact eye-tracking on cats. Journal of Neuroscience Methods 110(1-2): 103-111. ISSN: 0165-0270.
NAL Call Number: RC346
Abstract: The objective of visual systems neuroscience has shifted over the past few years from determining the receptive fields of cells towards the understanding of higher level cognition in awake animals viewing natural stimuli. In experiments with awake animals it is important to control the relevant aspects of behavior. Most important for vision science is the control of the direction of gaze. Here we present Dual Purkinje eye-tracking on cats, which--as a non-contact method--brings a number of advantages. Along with the presented methods for calibration and for synchronization to off-the-shelf video presentation hardware, this method allows high precision experiments to be performed on cats freely viewing videos of natural scenes.
Descriptors: automatic data processing, cats, eye movements, computer assisted image processing, neurophysiology, electrodes, implanted, neurophysiology instrumentation, photic stimulation, video recording.

Kostopoulos, G.K. (2000). Spike-and-wave discharges of absence seizures as a transformation of sleep spindles: the continuing development of a hypothesis. Clinical Neurophysiology 111(Suppl. 2): S27-S38. ISSN: 1388-2457.
Descriptors: nervous system, feline penicillin epilepsy, nervous system disease, seizures, digital EEG , electroencephalography , sleep spindles, spike and wave discharges, thalamocortical volleys, animal models, cortical neurons, computer models.

Kramer, M., M. Gerwing, U. Michele, E. Schimke, and S. Kindler (2001). Ultrasonographic examination of injuries to the achilles tendon in dogs and cats. The Journal of Small Animal Practice 42(11): 531-535. ISSN: 0022-4510.
NAL Call Number: 41.8 J8292
Abstract: The value of ultrasonography in the diagnosis of lesions of the Achilles tendon was Investigated in 42 dogs and seven cats. A standardised four-part ultrasonographic examination was established. Linear transducers with a frequency of more than 7.5 MHz were used. Ultrasonography allowed identification and differentiation of total ruptures and the differentiation of partial ruptures into deep or superficial ruptures, or those comprising muscular tears. The healing process could be monitored and imaged using this technique. Suture material was readily visible in surgically treated cases. Displacement of the superficial digital flexor tendon could be identified. In such cases, the tendon tissue was seen either medially or laterally to the calcaneus. The healing process of the Achilles tendon could also be documented using ultrasonography. However, it was not possible to determine the age of the injury and the exact end of the healing process. Ultrasonography therefore proved to be an excellent diagnostic method for imaging lesions of the Achilles tendon and associated injuries in dogs and cats. After physical examination, the technique should be the next logical step in the evaluation of a suspected injury to the Achilles tendon.
Descriptors: achilles tendon injuries, cats, dogs, diagnosis, differential, physical examination, sensitivity and specificity, ultrasonography, wounds and injuries .

Kreutz, L.C., B.S. Seal, and W.L. Mengeling (1994). Early interaction of feline calicivirus with cells in culture. Archives of Virology 136(1/2): 19-34. ISSN: 0304-8608.
NAL Call Number: 448.3 Ar23
Abstract: The kinetics and biochemical properties of feline calicivirus (FCV) attachment to Crandell-Reese feline kidney cells were determined. Maximum binding was observed at pH 6.5. Cells in suspension at 4 degrees C bound virus more efficiently than cells in monolayers at 4 degrees C or 37 degrees C. High initial binding rate was observed in monolayers or cells in suspension and proceeded to a maximum at 90 min, although half maximal binding was observed as early as 15 min. Binding was specific and competitively blocked by serotypically homologous or heterologous FCV as well as by San Miguel sea lion virus. Treatment of cells with proteases increased FCV binding, whereas phospholipase had no effect on virus attachment. Conversely, cells treated with neuraminidase followed by O-glycanase treatment showed a decreased binding ability. Cells of feline origin bound FCV very efficiently, and non-permissive cells showed a poor binding ability. Following transfection of viral RNA, infectious virus could be recovered from all non-permissive cells, except from Madin-Darby canine kidney cells. These results suggest that FCV binds to a receptor in which carbohydrates may be an important component and that FCV replication in nonpermissive cells is primarily restricted by the absence of appropriate receptors on the cell surface.
Descriptors: feline calicivirus, kidneys, cell cultures, receptors, proteinases, binding site, phospholipase a.

Kyles, A.E., E.M. Hardie, M. Mehl, and C.R. Gregory (2002). Evaluation of ameroid ring constrictors for the management of single extrahepatic portosystemic shunts in cats: 23 cases (1996-2001). Journal of the American Veterinary Medical Association 220(9): 1341-1347. ISSN: 0003-1488.
NAL Call Number: 41.8 Am3
Abstract: OBJECTIVE: To document the signalment; history; clinical signs; clinicopathologic, diagnostic imaging, and surgical findings; perioperative complications; and long-term clinical results of ameroid ring constrictor (ARC) placement on single extrahepatic portosystemic shunts (PSS) in cats. DESIGN: Retrospective study. ANIMALS: 23 cats treated with an ARC on a single extrahepatic PSS. PROCEDURE: An ARC was placed surgically around the PSS. Portal pressure was measured prior to ARC placement, with complete temporary PSS occlusion, and after ARC placement. Cats were scheduled for recheck transcolonic portal scintigraphy 8 to 10 weeks after surgery. Follow-up information was obtained by telephone interview with the owners. RESULTS: An ARC was successfully placed in 22 of 23 cats. Intraoperative complications, consisting of PSS hemorrhage, occurred in 2 cats. Mean (+/- SD) portal pressure (n = 15) was 6.7+/-2.9 mm Hg before PSS manipulation, 18.6+/-7.7 mm Hg with complete temporary PSS occlusion, and 6.9+/-2.7 mm Hg after ARC placement. Postoperative complications developed in 77% (17 of 22) of cats after ARC placement, and included central blindness, hyperthermia, frantic behavior, and generalized motor seizures. Perioperative mortality rate was 4.3% (1 of 23). Persistent shunting was identified in 8 of 14 cats. Overall, 75% (15 of 20) of cats had an excellent long-term outcome. CONCLUSIONS AND CLINICAL RELEVANCE: Placement of an ARC on single extrahepatic PSS in cats resulted in low surgical complication and perioperative mortality rates, but most cats did have substantial postoperative complications. Persistent shunting was common, although many cats with persistent shunting were clinically normal.
Descriptors: ameroid ring, extrahepatic shunt, cats, scintigraphy, surgery.

Lauten, S.D., N.R. Cox, G.H. Baker, D.J. Painter, N.E. Morrison, and H.J. Baker (2000). Body composition of growing and adult cats as measured by use of dual energy x-ray absorptiometry. Comparative Medicine 50(2): 175-183. ISSN: 0023-6764.
NAL Call Number: SF77 .C65
Abstract: Background and Purpose: Total body scans were performed on 89 domestic cats of various ages, using dual energy x-ray absorptiometry (DEXA) to determine body composition, including fat, lean, and bone mineral content. Bone mineral density results from scans also are presented. Methods: This cross sectional study included data for cats from a closed colony and from privately owned cats. Data were grouped by age and were analyzed by sex and reproductive status to provide information as to the rate of growth of the individual components of body composition. Results: The results indicate that the rate of accretion of bone mineral, fat, and lean tissue differs throughout maturation and by sex. Regressions are provided to highlight age- and sex-related differences. Conclusions: The results of this study emphasize the benefits of examining the growth of each component of body composition when studying the effects of nutrition, disease processes, or therapeutic interventions.
Descriptors: cats, laboratory animals, age differences, body weight, radiography, bone density, bone mineralization, body composition, sex differences.

Lee, R. (1995). British Small Animal Veterinary Association Manual of Small Animal Diagnostic Imaging, 2nd edition, British Small Animal Veterinary Association: Cheltenham, 200 p. ISBN: 0905214269 .
NAL Call Number: SF757.8.M3
Descriptors: dogs, cats, disease diagnosis, diagnostic imaging.
Notes: Previous edition published as: Manual of radiography and radiology in small animal practice, 1989.

Lee, R. (1995). Manual of Small Animal Diagnostic Imaging, 2nd edition, British Small Animal Veterinary Association.: Shurdington, Cheltenham, UK, 200 p. ISBN: 0905214269.
NAL Call Number: SF757.8.M3
Descriptors: dogs, diagnosis, ultrasonics, nimal diseases, cats, radiography, analytical, small animal practice.

Lee, R. (Editor) (1995). BSAVA Manual of Small Animal Diagnostic Imaging: Manual of Radiography and Radiology in Small Animal Practice, 2nd edition, British Small Animal Veterinary Association (BSAVA): Cheltenham, uk, 200 p. ISBN: 0905214269 .
NAL Call Number: SF757.8.M3
Descriptors: dogs, cats, disease diagnosis, medicine, diagnostic imaging.

Lemire, T.D. (2000). Microwave irradiated canine and feline tissues: part 1. Morphologic evaluation. Journal of Histotechnology 23(2): 113-120. ISSN: 0147-8885.
Descriptors: cell biology, endoscopic, wedge biopsy procedures, invasive, surgical techniques, eosin staining, preparatory techniques, staining method, formalin fixation, hematoxylin staining, microwave irradiation, irradiation method, necropsy, surgical method, paraffin embedding, histological appearance, temperature, PBS, Klotz solution.

Lemire, T.D. and J.C. Duffy (2000). Microwave irradiated canine and feline tissues: part 2. Immunohistochemical and histochemical staining. Journal of Histotechnology 23(2): 123-131. ISSN: 0147-8885.
Descriptors: histochemical staining, detection, feline tissues, labeling techniques, staining method, immunohistochemical staining, detection, labeling techniques, microwave irradiation, preparatory laboratory techniques, necropsy, invasive, surgical techniques, surgical method, staining intensity.

Lilliehook, I. and B. Larsson (1998). Utvardering av Cell-Dyn 3500. Hematologiinstrument anpassat till prover fran djur [Evaluation of Cell-Dyn 3500, a haematological instrument adapted for testing animal samples]. Svensk Veterinartidning 50(14): 643-648. ISSN: 0346-2250.
NAL Call Number: 41.9 SV23
Descriptors: hematology, instruments, cells, cell counting, platelets, medicine, haemoglobin, leukocytes, erythrocytes, horses, cattle, sheep, cats.
Language of Text: Swedish with a summary in English.

Luvoni, G.C., P. Testa, and P.A. Biondi (2001). Intracellular glutathione content in feline oocytes matured in vitro in presence of l-cysteine. Theriogenology 55(1): 483. ISSN: 0093-691X.
NAL Call Number: QP251.A1T5
Descriptors: cell biology, oocytes, cats, L-cysteine, reproductive system, meeting abstract.

Maggs, D.J., B.K. Collins, J.G. Thorne, and M.P. Nasisse (2000). Effects of L-lysine and L-arganine on in vitro replication of feline herpesvirus type-1. American Journal of Veterinary Research 61(12): 1474-1478. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: feline herpesvirus, viral replication, lysine, arginine, culture media, in vitro, growth rate.

Mai, W. (1998). Imagerie medicale: Particularites de la radiographie du squelette appendiculaire chez le jeune. 2. Affections traumatiques, metaboliques, inflammatoires, idiopathiques [Diagnostic imaging: Particularities in radiography of young animals appendicular skeleton. 2. Traumatic, metabolic, inflammatory, idiopathic affections. ]. Le Point Veterinaire 29(191): 83-87. ISSN: 0303-4997.
Descriptors: dogs, cats, young animals, bones, limbs, radiography, metabolic disorders, inflammation, bone diseases, analytical, body parts, body regions.
Language of Text: French.

Mai, W. and D. Begon (1998). Imagerie medicale. Echographie de la rate. 2. Etude speciale. [Diagnostic imaging. Spleen ultrasonography. 2. Special study.]. Le Point Veterinaire 29(188): 73-76. ISSN: 0303-4997.
Descriptors: dogs, cats, spleen, echography, lesions, diagnosis, body parts, cardiovascular system .
Language of Text: French.

Manrique, M.L., S.A. Gonzalez, and J.L. Affranchino (2004). Functional relationship between the matrix proteins of feline and simian immunodeficiency viruses. Virology 329(1): 157-167. ISSN: 0042-6822.
NAL Call Number: 448.8 V81
Descriptors: feline immunodeficiency virus, simian immunodeficiency virus, matrix proteins, chimerism analysis, provirus, functional homology, remotely related lentiviruses, genetic techniques, laboratory techniques, virion production, wild type kinetics.

Martin, D.R., N.R. Cox, G.P. Niemeyer, N.E. Morrison, and H.J. Baker (2002). Bone marrow stromal cells as therapeutic vehicles for feline GM1 gangliosidosis. Developmental Brain Research 134(1-2): A45. ISSN: 0165-3806.
Descriptors: cell biology, development, nervous system, neural coordination, feline GM1 gangliosidosis, genetic disease, metabolic disease, transplantation , therapeutic method.

Martin de las Mulas, J., C. Reymundo, A. Espinosa de los Monteros, Y. Millan, and J. Ordas (2004). Calponin expression and myoepithelial cell differentiation in canine, feline and human mammary simple carcinomas. Veterinary and Comparative Oncology 2(1): 24-35. ISSN: 1476-5810.
NAL Call Number: SF910.T8 V484
Descriptors: carcinoma, human diseases, mammary gland neoplasms, neoplasms, prognosis, proteins, cats.

Matheson, J.S., R.T. O'Brien, and F. Delaney (2003). Tissue harmonic ultrasound for imaging normal abdominal organs in dogs and cats. Veterinary Radiology and Ultrasound 44(2): 205-208. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Abstract: Normal cats (n = 38) and dogs (n = 40) were imaged with fundamental ultrasound and tissue harmonic ultrasound. Images of the liver, gall bladder, spleen, left kidney, urinary bladder, and jejunum were collected in all animals. Images of the left adrenal gland were collected in all dogs. All normal cats and dogs had improved imaging with tissue harmonic ultrasound. The number of organs with improved conspicuity ranged from one to all organs imaged. The most common organ to have improved conspicuity was the jejunum (100% of dogs and 89% of cats). Significant improvement by tissue harmonic ultrasound was seen in images of gall bladder (p = .05) and left adrenal gland (p = .02) in dogs, and spleen, urinary bladder, and intestinal images (p = .01) in cats. Significant improvement was seen in tissue harmonic ultrasound images of the gall bladder in dogs weighing greater than 16 kilograms (p = .03) and in the images of the urinary bladder of dogs weighing less than 16 kilograms (p = .02). These data suggest that image quality improvement of normal organs using tissue harmonic ultrasound is consistent but not predictable. The exception was the jejunum, where improvement was seen in all dogs. Sonographers should be cognizant of the potential benefits of tissue harmonic ultrasound.
Descriptors: abdomen ultrasonography, cats, dogs.

Matsuda, M., N. Matsuda, A. Watanabe, R. Fujisawa, K. Yamamoto, and M. Masuda (2003). Cell cycle arrest induction by an adenoviral vector expressing hiv-1 vpr in bovine and feline cells. Biochemical and Biophysical Research Communications 311(3): 748-753. ISSN: 0006-291X.
NAL Call Number: 442.8
Descriptors: cell biology, feline cells, western blot, genetic techniques, flow cytometry, histology and techniques, cell cycle arrest, induction, Western blot .

Maxwell, I.H., J. Chapman, F. Maxwell, and J. Corsini (1999). Introduction of integrin binding motifs into recombinant feline parvovirus for re-targeting to human melanoma cells. Journal of Investigative Dermatology 112(4): 591. ISSN: 0022-202X.
Descriptors: molecular, tumor biology, melanoma , neoplastic disease, gene therapy, in vitro cell study, feline parvovirus, dermatology.

Maxwell, I.H., J.T. Chapman, L.C. Scherrer, a.L. Spitzer, S. Leptihn, F. Maxwell, and J.a. Corsini (2001). Expansion of tropism of a feline parvovirus to target a human tumor cell line by display of an alphav integrin binding peptide on the capsid. Gene Therapy 8(4): 324-331. ISSN: 0969-7128.
Descriptors: molecular, tumor biology, feline panleukopenia virus, feline cells, oncolytic properties, luciferase, rhabdomyosarcoma, muscle disease, neoplastic disease.

McCann, K.B., A. Lee, J. Wan, H. Roginski, and M.J. Coventry (2003). The effect of bovine lactoferrin and lactoferricin B on the ability of feline calicivirus (a norovirus surrogate) and poliovirus to infect cell cultures. Journal of Applied Microbiology 95(5): 1026-1033. ISSN: 1364-5072.
NAL Call Number: QR1.J687
Descriptors: cell cultures, culture media, disease models, human diseases, lactoferrin, milk proteins, pathogenesis, peptides, feline calicivirus, polioviruses.

McEntee, M.C. (2004). A survey of veterinary radiation facilities in the United States during 2001. Veterinary Radiology and Ultrasound 45(5): 476-479. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: mast cells, neoplasms, radiotherapy, equipment, practice.

McSharry, J.J. (1994). Uses of flow cytometry in virology. Clinical Microbiology Reviews 7(4): 576-604. ISSN: 1098-6618.
Abstract: This article reviews some of the published applications of flow cytometry for in vitro and in vivo detection and enumeration of virus-infected cells. Sample preparation, fixation, and permeabilization techniques for a number of virus-cell systems are evaluated. The use of flow cytometry for multiparameter analysis of virus-cell interactions for simian virus 40, herpes simplex viruses, human cytomegalovirus, and human immunodeficiency virus and its use for determining the effect of antiviral compounds on these virus-infected cells are reviewed. This is followed by a brief description of the use of flow cytometry for the analysis of several virus-infected cell systems, including blue tongue virus, hepatitis C virus, avian reticuloendotheliosis virus, African swine fever virus, woodchuck hepatitis virus, bovine viral diarrhea virus, feline leukemia virus, Epstein-Barr virus, Autographa californica nuclear polyhedrosis virus, and Friend murine leukemia virus. Finally, the use of flow cytometry for the rapid diagnosis of human cytomegalovirus and human immunodeficiency virus in peripheral blood cells of acutely infected patients and the use of this technology to monitor patients on antiviral therapy are reviewed. Future prospects for the rapid diagnosis of in vivo viral and bacterial infections by flow cytometry are discussed.
Descriptors: flow cytometry, viral, viruses, antibodies, viral analysis, antibodies, viral, viral antigens, forecasting, specimen handling, staining and labeling, methods, viruses.

Mehock, J.R., C.E. Greene, F.C. Gherardini, T.W. Hahn, and D.C. Krause (1998). Bartonella henselae invasion of feline erythrocytes in vitro. Infection and Immunology 66(7): 3462-3466. ISSN: 0019-9567.
NAL Call Number: QR1.I57
Descriptors: cat, infection, erythrocytes, B. henselae, in vitro, cell culture.

Mellema, L.M., V.F. Samii, K.M. Vernau, and R.A. LeCouteur (2002). Meningeal enhancement on magnetic resonance imaging in 15 dogs and 3 cats. Veterinary Radiology and Ultrasound 43(1): 10-15. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: dogs, cats, meninges, nuclear magnetic resonance, imagery, contrast media, diagnostic value, diagnosis, pia mater, dura mater.

Miles, K. (1997). Imaging abdominal masses. Veterinary Clinics of North America: Small Animal Practice 27(6): 1403-1431. ISSN: 0195-5616.
NAL Call Number: SF601 .V523
Descriptors: dogs, cats, geriatrics.

Miles, K. (1995). Imaging pregnant dogs and cats. Compendium on Continuing Education for the Practicing Veterinarian 17(10): 1217-1220, 1224-1227. ISSN: 0193-1903.
NAL Call Number: SF601 .C66
Descriptors: cats, dogs, pregnancy, radiography, diagnosis, litter size, embryonic development, ionizing radiation, analytical, animal performance, biological development, physiological functions, radiation , reproduction , reproductive performance, sexual reproduction, ultrasonography , fetal development, fetal growth.

Minihan, A.C., J. Berg, and K.L. Evans (2004). Chronic diaphragmatic hernia in 34 dogs and 16 cats. Journal of the American Animal Hospital Association 40(1): 51-63. ISSN: 0587-2871.
NAL Call Number: SF601 .A5
Abstract: Medical records of 34 dogs and 16 cats undergoing surgical repair of diaphragmatic hernia of >2 weeks' duration were reviewed, and long-term follow-up information was obtained. The most common clinical signs were dyspnea and vomiting; however, many of the animals were presented for nonspecific signs such as anorexia, lethargy, and weight loss. Thoracic radiographs revealed evidence of diaphragmatic hernia in only 66% of the animals, and additional imaging tests were often needed to confirm the diagnosis. Thirty-six hernias were repaired through a midline laparotomy; 14 required a median sternotomy combined with a laparotomy. In 14 animals, division of mature adhesions of the lungs or diaphragm to the herniated organs was necessary to permit reduction of the hernia. Fourteen animals required resection of portions of the lungs, liver, or intestine. All hernias were sutured primarily without the use of tissue flaps or mesh implants. Twenty-one of the animals developed transient complications in the postoperative period; the most common of these was pneumothorax. The mortality rate was 14%. Thirty-four (79%) of the animals that were discharged from the hospital had complete resolution of clinical signs, and none developed evidence of recurrent diaphragmatic hernia during the follow-up period. Nine were lost to follow-up.
Descriptors: Cats, hernia, diaphragm, radiographs, surgery, laparotomy, pneumothorax.

Mischke, R., A. Deniz, and J. Weiss (1995). Untersuchung zur automatischen Zellzahlung aus Katzenblut. [Automatic cell counting in blood samples from cats]. Deutsche Tierarztliche Wochenschrift 102(11): 435-440. ISSN: 0341-6593.
NAL Call Number: 41.8 D482
Descriptors: cell counting, evaluation, automation, hematology, diagnostic techniques, cats.
Language of Text: German; Summary in English.

Mishina, M., T. Watanabe, K. Fujii, H. Maeda, Y. Wakao, and M. Takahashi (1998). Non-invasive blood pressure measurements in cats: Clinical significance of hypertension associated with chronic renal failure. Journal of Veterinary Medical Science 60(7): 805-808. ISSN: 0916-7250.
NAL Call Number: SF604 .J342
Descriptors: cats, pressure, hypertension, heart rate, kidney diseases, mineralocorticoids, adrenal cortex hormones, circulation, cardiovascular diseases, corticoids, hormones, organic diseases, physiological functions, urinary tract diseases, vascular diseases.
Language of Text: Japanese; Summary in English.

Mitchener, K.L. (2004). Mast cell tumours: Unraveling the mysteries of this common disease. In: Ontario Veterinary Medical Association Conference Proceedings, February 5, 2004-February 7, 2004, Ottawa, Canada, Ontario Veterinary Medical Association: Milton, Canada , p. 101-104.
Descriptors: blood, bone marrow, cimetidine, clinical aspects, diagnosis, diagnostic techniques, hematology, histopathology, lymph nodes, mast cells, neoplasms, prednisolone, prednisone, prognosis, radiotherapy, splenectomy, sucralfate, surgery, synthetic glucocorticoids, urine analysis, vinblastine, cats.

Miyamoto, K. (1998). Computer analysis of inulin plasma clearance curve in conscious cats. Journal of the Japan Veterinary Medical Association 51(9): 511-515. ISSN: 0446-6454.
NAL Call Number: 41.9 J275
Descriptors: filtration, glomerular filtration rate, renal function tests, normal values, cats.
Language of Text: Japanese with a summary in English.

Molotchnikoff, S., J. Aitoubah, F. Bretzner, S. Shumikhina, Y.F. Tan, and J.P. Guillemot (2001). Comparative computations of spike synchronization in visual cortex of cats. Brain Research/ Brain Research Protocols 6(3): 148-158. ISSN: 1385-299X.
Abstract: In recent years it has been proposed that synchronous activity between neurons is a putative mechanism to bind together various trigger features of an image. Thus the measure of synchronization becomes an important issue since it may be an electrophysiological sign of visual perception. This paper describes and compares six techniques of computing synchronization strength, that is, the central peak of a cross-correlogram. Data were obtained in anesthetized cats prepared for electrophysiological recordings in a conventional fashion. Results indicate that: (1) eye fits are misleading. Visual inspection of cross-correlograms, may be interesting if one needs to estimate approximately synchronization strength and the presence of oscillations in the cross-correlograms, however it may be misleading if one wants to compare different cross-correlograms; (2) regression analysis to compare one method against the others yields a relatively poor correlation suggesting that methods are not directly comparable; (3) the sensitivity of each computational method is unequal. The results may indicate that some functional connections are either under- or over-evaluated depending upon the strategy employed to measure synchronization.
Descriptors: cortical synchronization, visual cortex, artifacts, cats, regression analysis.

Morcillo, E.J. and J. Cortijo (1999). Species differences in the responses of pulmonary vascular preparations to 5-hydroxytryptamine. Therapie 54(1): 93-97. ISSN: 0040-5957.
Descriptors: pulmonary hypertension, 5 Hydroxytryptamine, vasoconstriction, isolated feline pulmonary arteries, in vitro .

Morita, T., A. Shimada, T. Ishibashi, K. Kimura, M. Haritani, and T. Umemura (2002). Congenital spongiform change in the brain stem nuclei of a domestic kitten. Journal of Comparative Pathology 126(2/3): 212-215. ISSN: 0021-9975.
NAL Call Number: 41.8 J82
Descriptors: kittens, medulla oblongata, spongiform encephalopathy, nuclei, symptoms, histopathology, vacuoles, neutrophils, cytoplasm, neurons, tissue ultrastructure.

Mortola, E., Y. Endo, M. Risso, and E. Gimeno (2000). Estudio comparativo de los efectos antivirales de agentes antioxidantes: n-acetilcisteina y acido ascorbico e inmunosupresores: ciclosporina a y tacrolimus en celulas cronicamente infectadas con el virus de la inmunodeficiencia felina [Comparative study of the antiviral effects of antioxidants, n-acetylcysteine and ascorbic acid and two immunosuppressive agents, cyclosporin a and tracrolimus in a feline cell line chronically infected with feline immunodeficiency virus]. Veterinaria Mexico 31(4): 271-277. ISSN: 0301-5092.
NAL Call Number: SF604 .V485
Descriptors: cell biology, feline fibroblastic cells, infection, feline immunodeficiency virus, antioxidants, apoptosis, immunosuppressive drugs, in vitro .
Language of Text: Spanish.

Muleya, J.S., M. Nakaichi, Y. Taura, R. Yamaguchi, and S. Nakama (1999). In-vitro anti-proliferative effects of some anti-tumour drugs on feline mammary tumour cell lines. Research in Veterinary Science 66(3): 169-174. ISSN: 0034-5288.
NAL Call Number: 41.8 R312
Descriptors: tumor biology, mammary adenocarcinoma cells, recombinant feline interferon gamma, doxorubicin, mitoxantrone, vincristine, cisplatin, in vitro, neoplasms.

Muller, J.G., Y. Isomatsu, S.V. Koushik, M. O'quinn, L. Xu, C.S. Kappler, E. Hapke, M.R. Zile, S.J. Conway, and D.R. Menick (2002). Cardiac-specific expression and hypertrophic upregulation of the feline na+-ca2+ exchanger gene h1-promoter in a transgenic mouse model. Circulation Research 90(2): 158-164. ISSN: 0009-7330.
NAL Call Number: RC681 .A1A57137
Descriptors: feline cation exchanger gene, heart, kidney, brain, molecular, luciferase reporter gene, upregulation, feline NCX1 gene.

Munana, K.R., N.J. Olby, N.J.H. Sharp, and T.M. Skeen (2001). Intervertebral disk disease in 10 cats. Journal of the American Animal Hospital Association 37(4): 384-389. ISSN: 0587-2871.
NAL Call Number: SF601 .A5
Descriptors: cats, intervertebral discs, spinal diseases, hernia, age, clinical aspects, diagnosis, radiography, computed tomography, surgical operations, prognosis, myelography , surgical decompression.

Munday, H.S., D. Booles, P. Anderson, D.W. Poore, and K.E. Earle (1994). The repeatability of body composition measurements in dogs and cats using dual energy X-ray absorptiometry. Journal of Nutrition 124(12S): 2619S-2621S. ISSN: 0022-3166.
NAL Call Number: 389.8 J82
Descriptors: dogs, cats, x radiation, body composition, body weight, bone density, body fat, body lean mass, bones, mineral content, prediction, accuracy.

Mundina Weilenmann, C., L. Vittone, G. Rinaldi, M. Said, G.C. De Cingolani, and A. Mattiazzi (2000). Endoplasmic reticulum contribution to the relaxant effect of cgmp- and camp-elevating agents in feline aorta. American Journal of Physiology 278(6 Part 2): H1856-H1865. ISSN: 0002-9513.
NAL Call Number: 447.8 Am3
Descriptors: cell biology, cardiovascular system, sodium nitroprusside, endoplasmic reticulum, phosphoalamban, forskolin, feline aorta, tetraethylammonium, Serl6, protein kinase G.

Murakami, T., H. Fujita, T. Fujihara, M. Nakamura, and K. Nakata (2002). Novel noninvasive sensitive determination of tear volume changes in normal cats. Ophthalmic Research 34(6): 371-374. ISSN: 0030-3747.
Descriptors: ophthalmological diagnostic techniques, polyphosphates, tears secretion, uracil nucleotides, cats, conjunctiva, conjunctiva secretion, fluorescein diagnostic use, fluorophotometry, tibial menisci, ophthalmic solutions, sensitivity and specificity, time factors.

Nath, M.D. and D.L. Peterson (2001). In vitro assembly of feline immunodeficiency virus capsid protein: biological role of conserved cysteines. Archives of Biochemistry and Biophysics 392(2): 287-294. ISSN: 0003-9861.
NAL Call Number: 381 Ar2
Descriptors: In vitro, cysteine, capsid, FIV.

Ni, Y., S. Dymarkowski, F. Chen, J. Bogaert, and G. Marchal (2002). Occlusive myocardial infarction enhanced or not enhanced with necrosis-avid contrast agents at MR imaging. Radiology 225(2): 603-605; Author Reply 605-606. ISSN: 0033-8419.
Descriptors: contrast media, magnetic resonance imaging, mesoporphyrins diagnostic use, metalloporphyrins diagnostic use, myocardial infarction diagnosis, myocardium, cats, dose response relationship, drug, image enhancement, necrosis.

Nishimura, T. (1997). The intrinsic oscillator regulates neuronal excitability in feline colonic parasympathetic ganglia. Journal of the Autonomic Nervous System 65(2-3): 126. ISSN: 0165-1838.
Descriptors: cell biology, nervous system, animal model, feline colonic parasympathetic ganglia, depolarizing membrane oscillation, digestive system, dmo, enkephalin receptors, muscarinic receptors, nervous system, neuronal excitability, norepinephrine receptors, somatostatin receptors.

Nishimura, T. and T. Tokimasa (1997). Comparative study of parasympathetic neurons in the rabbit and feline pelvic ganglia. Society for Neuroscience Abstracts 23(1-2): 2284. ISSN: 0190-5295.
NAL Call Number: QP351. S6
Descriptors: cell biology, nervous system, urinary system, chemical coordination, epsps, excitatory postsynaptic potentials, excretory system, nervous system, parasympathetic neurons, feline pelvic ganglia, urinary bladder.

Nishimura, Y., T. Miyazawa, Y. Ikeda, Y. Izumiya, K. Nakamura, J.S. Cai, E. Sato, M. Kohmoto, and T. Mikami (1998). Molecular cloning and sequencing of feline stromal cell-derived factor-1alpha and beta. European Journal of Immunogenetics 25(4): 303-305. ISSN: 0960-7420.
NAL Call Number: QR184 .J62
Descriptors: immune system, molecular, biochemistry and molecular biophysics, feline stromal cell, cloning, cDNA, feline immunodeficiency virus.

Norman, E.J., R.C.J. Barron, A.S. Nash, and R.B. Clampitt (2001). Evaluation of a citrate-based anticoagulant with platelet inhibitory activity for feline blood cell counts. Veterinary Clinical Pathology 30(3): 124-132. ISSN: 0275-6382.
NAL Call Number: SF601 .A54
Descriptors: anticoagulants, cells, citrates, EDTA, hematology, leukocyte count, leukocytes, platelets, cats.

Nuanualsuwan, S., T. Mariam, S. Himathongkham, and D.O. Cliver (2002). Ultraviolet inactivation of feline calicivirus, human enteric viruses and coliphages. Photochemistry and Photobiology 76(4): 406-410. ISSN: 0031-8655.
NAL Call Number: 382 P56
Abstract: Norwalk and Norwalk-like viruses (NLV) are major causes of food- and water-related disease in the United States. There is no host cell line in which the NLV can be tested for infectivity. Feline calicivirus (FCV) and NLV both belong to the family Caliciviridae. FCV can be assayed for infectivity in the Crandell Reese feline kidney cell line, so FCV serves as a surrogate for NLV. This study is the first report of UV inactivation of FCV and also of using the plaque technique, in contrast to the 50% tissue culture infectious dose end point technique, to determine the FCV infectivity titer. The infectivity titers (log10 plaque-forming units/mL) of UV-inactivated FCV, hepatitis A virus (HAV), poliovirus type 1 (PV1) and two small, round coliphages were plotted as a function of UV dose and analyzed by regression analysis and analysis of variance. These fitted straight-line curves represent exponential inactivation, so UV inactivation can be said to show "one-hit kinetics." The decimal inactivation doses of UV for FCV, HAV, PV1, MS2 and phiX174 were 47.85, 36.50, 24.10, 23.04 and 15.48 mW s/cm2, respectively. FCV appears to be the most UV resistant among the tested viruses.
Descriptors: feline calicivirus, coliphages, ultraviolet rays, calicivirus, calicivirus, cell line, coliphages growth and development, coliphages pathogenicity, Macaca mulatta, Norwalk virus growth and development, plaque assay, virulence.

Ny, L., K. Waldeck, E. Carlemalm, and K.E. Andersson (1997). Alpha-latrotoxin-induced transmitter release in feline oesophageal smooth muscle: focus on nitric oxide and vasoactive intestinal peptide. British Journal of Pharmacology 120(1): 31-38. ISSN: 0007-1188.
Descriptors: cell biology, digestive system, endocrine system, morphology, muscular system, nervous system, toxicology, acetylcholine, alpha latrotoxin, cyclic amp, cyclic gmp, cyclic nucleotide, digestive system, lower esophageal spHincter, muscle tone, muscular system, n g nitro l arginine, nitric oxide, resting membrane potential, ultrastructure, vasoactive intestinal peptide.

Oakley, R., A. Shores, R. Walshaw, D. Rosenstein, and R. Perry (1995). Computed tomography as an aid to diagnosing vertebral osteomyelitis. Progress in Veterinary Neurology 6(3): 95-99. ISSN: 1061-575X.
NAL Call Number: SF895 .P76
Descriptors: cats, dogs, osteomyelitis, radiography, spine, diagnosis, case studies, foreign bodies, biopsy, antibiotics, analytical, biological analysis, body parts, bone diseases, bones , musculoskeletal diseases, pollutants .

Odening, K., K. Frolich, B. Kirsch, and I. Bockhardt (1997). Sarcocystis: development of sporocysts in cell culture. Journal of Protozoology Research 7(1): 9-16. ISSN: 0917-4427.
NAL Call Number: QL366 .J68
Descriptors: parasitology, cell culture, sporocysts, Sarcocystis hofmanni, Cervus albirostris, S. gracilis, S. sibirica, feline kidney cell lines, in vitro gamogony, sporogony, S. cuniculorum, Sarcocystis .

Ogilvie, G.K. (1995). Hematopoietic growth factors: Frontiers for cure. Veterinary Clinics of North America, Small Animal Practice 25(6): 1441-1456. ISSN: 0195-5616.
NAL Call Number: SF601 .V523
Descriptors: immunological factors, cytokinins, growth, hormones, haematopoiesis, erythropoietin, interleukins, biological development, composition, proteins, glycoproteins , hormones , immunological factors, physiological functions, plant growth substances, proteins, stem cell factor, cytokines , hematopoiesis , colony stimulating factor.
Notes: In the series: Canine and feline transfusion medicine, edited by A.T. Kristensen and B.F. Feldman.

Okabayashi, K., R. Kano, K. Sirouzu, T. Yanai, M. Mizuno, H. Yamamura, S. Saegusa, and A. Hasegawa (2003). Detection of cap59 gene in 2 feline cases of systemic cryptococcosis. Journal of Veterinary Medical Science 65(8): 953-955. ISSN: 0916-7250.
NAL Call Number: SF604 .J342
Descriptors: infection, molecular, systemic cryptococcosis, fungal disease, infectious disease, gene detection, genetic techniques, laboratory techniques, polymerase chain reaction, pcr, genetic techniques, feline, Cryptococcus neoformans, teleomorph, Filobasidiella.

Okuno, S., H. Nakase, and T. Sakaki (2001). Comparative study of 2,3,5-triphenyltetrazolium chloride (TTC) and hematoxylin-eosin staining for quantification of early brain ischemic injury in cats. Neurological Research 23(6): 657-661. ISSN: 0161-6412.
Abstract: There are no staining methods that can reliably and unequivocally detect final infarcts in the acute stage of experimental ischemia. In most instances, 2,3,5-triphenyltetrazolium chloride (TTC) and hematoxylin and eosin (HE) stainings are accepted for this purpose, but neither is perfect. We performed a comparative study of the TTC immersion method and HE staining for quantification of early brain ischemic injury in cats, focussing on the reproducibility associated with planimetry. Focal brain ischemia was produced by middle cerebral artery (MCA) occlusion via the transorbital approach in 14 cats. After 6 h of occlusion, two slices of 3 mm thickness, passing through the optic chiasma and mammillary body, were selected for pathological examination. TTC immersion and HE staining were both used for planimetric study of the surface of the same slice. The area of the injury was traced manually with the aid of computerized digital planimetry and expressed as a percentage of the area of the contralateral hemisphere. The area of hemispheric injury and the area of gray matter injury were separately calculated in the TTC specimens, and each was compared with the area of gray matter injury in the HE-stained specimens. Measurements were repeated twice on each slice to estimate errors associated with manual tracing of the boundary of the area of injury. The mean percentage values of the area of injury in the TTC-immersed gray matter specimens were lower than those detected by HE staining, although there was a very significant correlation between the two. The differences between each two measurements of TTC-determined gray matter injury were significantly less than those between each two measurements of HE-determined gray matter injury. The differences between each two measurements of TTC-determined hemispheric injury were slightly less than those between each two measurements of TTC-determined gray matter injury, although there was no significant difference between them. For quantifying ischemic injury after 6 h of MCA occlusion in cats, the TTC immersion method is more reproducible and simpler in manner than HE staining, but the results of both are significantly correlated.
Descriptors: brain infarction, brain ischemia, dyes diagnostic use, eosine yellowish diagnostic use, hematoxylin diagnostic use, staining and labeling, tetrazolium salts diagnostic use, cats, neurons, telencepHalon.

Osborne, C.A., J.P. Lulich, and L.K. Unger (1997). Non-surgical retrieval of uroliths for mineral analysis. 19(1): s37-s39. ISSN: 0165-2176.
NAL Call Number: SF601. V46
Descriptors: diagnostic techniques, diagnosis, urinary tract diseases, urolithiasis, cats.

Pacchiana, P.D., R.S. Gilley, L.J. Wallace, D.W. Hayden, D.A. Feeney, C.R. Jessen, and B. Aird (2004). Absolute and relative cell counts for synovial fluid from clinically normal shoulder and stifle joints in cats. Journal of the American Veterinary Medical Association 225(12): 1866-1870. ISSN: 0003-1488.
NAL Call Number: 41.8 Am3
Descriptors: arthrocentesis, body weight, diagnosis, histology, joints animal, leukocyte count, morphology, neutrophils, osteoarthritis, shoulders, stifle, synovial fluid, cats.

Partington, B.P. and D.S. Biller (1995). Hepatic imaging with radiology and ultrasound. Veterinary Clinics of North America, Small Animal Practice 25(2): 305-335. ISSN: 0195-5616.
NAL Call Number: SF601 .V523
Descriptors: dogs, cats, liver, radiography, ultrasonics, optical properties, liver diseases, gall bladder, vascular diseases, analytical, body parts, cardiovascular diseases, chemicophysical properties, digestive system, liver , organic diseases, radiations , sound , cholecystography , position , contrast media, opacity , gall bladder diseases.
Notes: In the series analytic: Liver disease, edited by Donna S. Dimski.

Phadke, A.P., I.S. Choi, Z.X. Li, E. Weaver, and E.W. Collisson (2004). The role of inducer cells in mediating in vitro suppression of feline immunodeficiency virus replication. Virology 320(1): 63-74. ISSN: 0042-6822.
NAL Call Number: 448.8 V81
Descriptors: lymphocytes, fibroblasts, viral replication, cats, feline immunodeficiency virus.

Piacentino, V.I., J.P. Gaughan, and S.R. Houser (1999). Calcium current, not depolarization, induces contraction in feline ventricular myocytes. Biophysical Journal 76(1 PART 2): A457. ISSN: 0006-3495.
NAL Call Number: 442.8 B5238
Descriptors: molecular biophysics, cardiovascular system, feline vetricular myocytes, transport and circulation, cell biology, calcium current, contraction.

Piacentino, V.I., D. Harris, and S.R. Houser (2002). Defective diastolic ca handling can be induced in normal feline ventricular myocytes by inhibition of the sr caatpase. Biophysical Journal 82(1 Part 2): 598a. ISSN: 0006-3495.
NAL Call Number: 442.8 B5238
Descriptors: cardiovascular system, transport and circulation, biochemistry and molecular biophysics, cell biology, heart failure, heart disease, action potential, sodium, calcium exchange, feline ventricular myocytes.

Piirsalu, K., R. McLean, R. Zuber, K. Bannister, S. Penglist, J. Bellen, and R. Bais (1994). Role of I-123 serum amyloid protein in the detection of familial amyloidosis in Oriental cats. Journal of Small Animal Practice 35(11): 581-586. ISSN: 0022-4510.
NAL Call Number: 41.8 J8292
Descriptors: cats, amyloidosis, breeds, amyloid, liver, diagnostic value, scintigraphy.

Qureshi, M.A. and R.A. Ali (1996). Spirulina platensis exposure enhances macrophage phagocytic function in cats. Immunopharmacology and Immunotoxicology 18(3): 457-463. ISSN: 0892-3973.
NAL Call Number: RM370 .I55
Descriptors: macropHage, cats , cell biology, immune system, infection, bronchoalveolar lavage, cytotoxicity, immune response, Spirulina platensis, disease resistance, Escherichia coli, cell culture .

Ray, N.B., C. Power, W.P. Lynch, L.C. Ewalt, and D.L. Lodmell (1997). Rabies viruses infect primary cultures of murine, feline, and human microglia and astrocytes. Archives of Virology 142(5): 1011-1019. ISSN: 0304-8608.
NAL Call Number: 448.3 Ar23
Abstract: Recent studies have reported the detection of rabies viral antigens and virions in astrocytes and microglia of rabies-infected animals. As a first step toward understanding whether these glial cells may be involved in rabies virus replication, persistence, and/or pathogenesis, we explored their potential to be infected in vitro. Primary cultures of murine, feline, and human microglia and astrocytes were infected with several different rabies viruses: two unpassaged street virus isolates, a cell culture-adapted strain, and a mouse brain-passaged strain. Infection, as determined by immunofluorescence, was detected in 15 of the 16 (94%) virus-glial cell combinations. Replication of infectious virus, determined by infectivity assay, was detected in 7 of the 8 (88%) virus-cell combinations. These results show that astrocytes and microglia can be infected by rabies viruses, suggesting that they may have a potential role in disease, perhaps contributing to viral spread, persistence and/or neuronal dysfunction.
Descriptors: rabies virus, brain, cell cultures, infections, in vitro.

Reichke, J.K., S.P. DiBartola, and R. Leveille (2002). Renal ultrasonographic and computed tomographic appearance, volume, and function of cats with autosomal dominant polycystic kidney disease. Veterinary Radiology and Ultrasound 43(4): 368-373. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: cats, kidney diseases, genetic disorders, renal failure, cysts, volume determination, ultrasonography, computed tomography, glomerular filtration rate, kidneys, scintigraphy, neuroleptics.

Reinhart, G.A. (1996). Review of omega-3 fatty acids and dietary influences on tissue concentrations. In: Recent Advances in Canine and Feline Nutritional Research: Proceedings of the 1996 Iams International Nutrition Symposium, Orange Frazer Press: Wilmington, Ohio, p. 235-242. ISBN: 1882203097.
NAL Call Number: SF427.4.I26
Descriptors: dogs, essential fatty acids, eicosanoids, inflammation, arachidonic acid, eicosapentaenoic acid, dietary fat, linoleic acid, skin diseases, therapeutic diets, pruritus.
Notes: Paper presented at the "Iams International Nutrition Symposium" held April 17-20, 1996, in Boca Raton, Florida.

Risselada, M., M. Kramer, H. de Rooster, O. Taeymans, P. Verleyen, and H. Van Bree (2005). Ultrasonographic and radiographic assessment of uncomplicated secondary fracture healing of long bones in dogs and cats. Veterinary Surgery 34(2): 99-107. ISSN: 0161-3499.
NAL Call Number: SF911. V43
Abstract: Objectives-To evaluate the use of ultrasonography (US) to detect bone healing in uncomplicated diaphyseal fractures of dogs and cats, and to compare these observations with detection of healing by radiography (RG). Study Design-Clinical study. Animals-Dogs (33) and cats (11). Methods-RG and brightness mode US were used to follow uncomplicated secondary fracture healing. Fractures were examined at admission and then every 2-4 weeks until healed or implant removal. Temporal differences in definitive detection of healed fracture by imaging technique were examined by species, patient age, bone, and fracture type. Results-US images obtained during uncomplicated secondary fracture healing were consistent with images of fracture healing described in humans. Mean time to US diagnosis of a healed fracture (mean 46 days) was significantly shorter than by RG (mean 66 days). Mean time until diagnosis of a healed fracture (US and RG) did not differ significantly between open and closed treatment. Patients </=7 months (n=9) healed significantly faster (P<.05) than animals aged 7-36 months (n=24) and animals >36 months (n=11), but there was no significant difference between the latter 2 groups. Diagnosis of a healed simple fracture by US was significantly quicker than for a comminuted fracture (P<.05), but no difference was noted when using RG. Conclusions-US can be used to evaluate secondary fracture healing in biologically treated fractures in dogs and cats. US permits detection of a healed fracture earlier than RG. Clinical Relevance-Earlier diagnosis of a healed fracture by US can prevent unnecessarily long limb immobilization and allow earlier dynamization.
Descriptors: cats, ultrasound, bone healing, fractures, X-ray, long limb.

Roberts, L.O., N. Al Molawi, M.J. Carter and G.E.N. Kass (2004). Apoptosis in cultured cells infected with feline calicivirus. In: Apoptosis: From Signaling Pathways to Therapeutic Tools, Vol. 1010, New York Academy of Sciences: New York, New York, USA, p. 587-590. ISBN: 1573314757.
Descriptors: cell biology, infection, apoptosis, cell damage mechanism, chromatin condensation.

Saint Andre Marchal, I., C. Dezutter Dambuyant, B.J. Willett, J.C. Woo, P.F. Moore, J.P. Magnol, D. Schmitt, and T. Marchal (1997). Immunophenotypic characterization of feline Langerhans cells. Veterinary Immunology and Immunopathology 58(1): 1-16. ISSN: 0165-2427.
NAL Call Number: SF757.2. V38
Abstract: To carry out the characterization of feline Langerhans cells (LC), first described in 1994, we used a panel of monoclonal antibodies (MAb) known to react with human, canine and feline leukocyte membrane antigens (Ag). The immunolabeling was performed, at light microscope level, on frozen sections of feline skin and labial mucosa using an avidin-biotin-peroxidase technique, and at electron microscope level on epidermal cell suspensions using an immunogold technique. Out of the 52 MAb tested, six labeled basal or suprabasal DC cells in the frozen sections, either in epidermis or lip epithelium: MHM23 (anti-human CD18), CVS20 and vpg3 (respectively anti-canine and feline-major histocompatibility complex class II molecules), vpg5 (anti-feline leukocytes), vpg39 (anti-feline CD4) and Fel5F4 (anti-feline CD1a). These six MAb were used on suspensions, and labeled cells which showed no desmosomes or melanosomes, but contained 'zipper-like' structures similar to Birbeck granules (BG) in their cytoplasm, revealing they were LC. Consequently, feline LC are CD18-positive (CD18+), major histocompatibility complex class II-positive (Class II+), CD1a-positive (CD1a+), vpg5-positive (vg5+) and CD4-positive (CD4+). This immunophenotypic and ultrastructural characterization demonstrates that feline LC share many characteristics with their human counterparts, a fact that will allow us to study the role of feline LC in certain feline diseases such as Feline Immunodeficiency Virus (FIV) infection, since it has been shown that human LC cells are HIV-permissive, and to establish an animal model for human AIDS.
Descriptors: cats, langerhans cells ultrastructure, antibodies, monoclonal, CD1 antigens, CD1 antigens8, antigens, cd4, cell separation, cytoplasmic granules ultrastructure, dogs, epidermis, frozen sections, histocompatibility antigens class ii, lip, microscopy, immunoelectron, phenotype.

Salvadori, C., M. Modenato, D.S. Corlazzoli, M. Arispici, and C. Cantile (2005). Clinicopathological features of globoid cell leucodystrophy in cats. Journal of Comparative Pathology 132(4): 350-356. ISSN: 0021-9975.
NAL Call Number: 41.8 J82
Descriptors: animal, case reports, clinical aspects, histopathology, lesions, metabolic disorders, nervous system diseases, peripheral nerves, cats.

Sarli, G., C. Benazzi, R. Preziosi, L. Della Salda, G. Bettini, and P.S. Marcato (1999). Evaluating mitotic activity in canine and feline solid tumors: standardizing the parameter. Biotechnic and Histochemistry 74(2): 64-76. ISSN: 1052-0295.
NAL Call Number: QH613 .B56
Descriptors: tumor biology, feline solid tumors, neoplastic disease, histochemistry, immunohistochemical, immunocytochemical techniques, analytical method, image analysis, analysis, characterization techniques, image analyzer, cytometrica, laboratory equipment; immunohistochemistry, silver NOR, staining, visualization, toluidine, cell proliferation, mitoses, area, mitosis, mitotic count, mitotic index.

Sasaki, N., H. Shibata, T. Honjoh, K. Kimura, M. Saito, and I. Ohishi (2001). cDNA cloning of feline leptin and its mRNA expression in adipose tissue. Journal of Veterinary Medical Science 63(10): 1115-1120. ISSN: 0916-7250.
NAL Call Number: SF604 .J342
Descriptors: adipose tissue, amino acid sequences, DNA cloning, DNA sequencing, gene expression, leptin, messenger RNA, nucleotide sequences, polymerase chain reaction, reverse transcription, tissue distribution, cats.

Sato, A.F. and M. Solano (2004). Ultrasonography findings in abdominal mast cell disease: a retrospective study of 19 patients. Veterinary Radiology and Ultrasound 45(1): 51-57. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: abdomen, diagnosis, digestive tract, histopathology, kidneys, liver, lymph nodes, mast cells, neoplasms, spleen, ultrasonography, cats, dogs.

Schatz, S.P.R. (2001). Measurement of faecal cortisol metabolites in cats and dogs: a non-invasive method for evaluating adrenocortical function. Veterinary Research Communications 25(4): 271-287. ISSN: 0165-7380.
NAL Call Number: SF601. V38
Abstract: The aim of this comparative study was to gain more information about the metabolism and excretion of glucocorticoids in cats and dogs in order to establish non-invasive methods for evaluating stressful conditions. Therefore, in a first experiment, [14C]cortisol was administered intravenously to 8 animals (two of each sex and species). Over a period of 6 days, faeces and urine were collected immediately after spontaneous defecation and urination. Marked species differences were found, as cats mainly excreted cortisol in the faeces (82% +/- 4% of the total recovered radioactivity), whereas in dogs only a small portion was found there (23% +/- 4%). The highest urinary radioactivity was observed after 9 +/- 3 h in cats and 3 +/- 1 h in dogs. Peak concentrations in the faeces occurred after 22 +/- 6 h in cats and after 24 +/- 4 h in dogs. Most of the radioactivity was not extractable with diethyl ether, indicating that the metabolites excreted in urine and faeces were mainly of the conjugated or polar unconjugated types. This was confirmed by RP-HPLC, which also revealed marked differences between cats and dogs concerning the metabolites formed. In addition, the immunoreactivity of the metabolites was tested in cortisol, corticosterone and 11-oxoaetiocholanolone EIAs. The latter, measuring 11,17-dioxoandrostanes (11,17-DOA) detected the highest quantities of immunoreactive metabolites in cats, but not in dogs. In a second experiment, the adrenal cortex of both species was stimulated by ACTH and, three weeks later, suppressed by dexamethasone. In this study, only faeces were collected over a period of 7 days. In both species, inter-animal variability in the basal and maximal/minimal faecal cortisol metabolite concentrations and the time course was observed. The 11-oxoaetiocholanolone EIA in cats and the cortisol EIA in dogs proved best suited for monitoring changes in adrenocortical activity. ACTH injections resulted in an increase above baseline values of 355%, (median) in 11,17-DOA concentrations in cats and of 702% in the concentrations of cortisol equivalents in dogs by about 25 h and 22 h (median) after injection, respectively. Minimal concentrations after dexamethasone administration were about 17% in cats and 31% in dogs (in relation to baseline values) and were reached in 66 h and 72 h, respectively. It was concluded that measuring cortisol metabolites in faeces should be a useful non-invasive tool for monitoring stress in carnivores.
Descriptors: adrenal cortex, cats, dogs, feces, hydrocortisone, adrenal cortex, cats, chromatography, high pressure liquid, corticotropin, dexamethasone, dogs, glucocorticoids, hydrocortisone analysis, hydrocortisone urine, immunoenzyme techniques, nonparametric statistics.

Schijns, V.E. and W.G. Bradley (1997). Cytokines in Veterinary Medicine. Feline Cytokines, Vol. 251-256, CAB International: Wallingford, England, UKISBN: 0851992099.
NAL Call Number: SF757.25.C997
Descriptors: immune system, molecular, biochemistry and molecular biophysics, feline cytokines.

Schiller, A. (1998). Topographische und angewandte Anatomie des Auges und Ohres der Katze unter besonderer Berucksichtigung moderner bilgebender Verfahren (CT und MRT) [Topographical and applied anatomy of the eyes and ears of cats, examined by computer tomography and magnetic resonance imaging]. Dissertation, Fachbereich Veterinärmedizin, Freie Universität: Berlin. 141 p.
Descriptors: anatomy, eyes, computed tomography, magnetic resonance imaging, cats.
Language of Text: German; Summary in English.

Schober, K.E., V.L. Fuentes, and J.D. Bonagura (2003). Comparison between invasive hemodynamic measurements and noninvasive assessment of left ventricular diastolic function by use of Doppler echocardiography in healthy anesthetized cats. American Journal of Veterinary Research 64(1): 93-103. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: beta blockers, flow, cardiac output, cardiovascular agents, echocardiograpHy, haemodynamics, heart, heart rate, methodology, ventricles, cats.

Schoster, J.V., L. Wickman, and C. Stuhr (1995). The use of ultrasonic pachymetry and computer enhancement to illustrate the collective corneal thickness profile of 25 cats. Veterinary Comparative Ophtalmology 5(2): 68-73. ISSN: 1076-4607.
NAL Call Number: SF891 .P78
Descriptors: cats, cornea, ultrasonography, thickness, computer techniques.

Scrivani, P.V., R.M. Bednarski, C.W. Myer, and N.L. Dykes (1996). Restraint methods for radiography in dogs and cats. Compendium of Continuing Education for the Practicing Veterinarian 18(8): 899-915. ISSN: 0193-1903.
NAL Call Number: SF601 .C66
Descriptors: dogs, cats, restraint of animals, radiography, neuroleptics, anesthesia, contrast media.

Seitz, S.E., J.M. Losonsky, and S.M. Marretta (1996). Computed tomographic appearance of inflammatory polyps in three cats. Veterinary Radiology and Ultrasound 37(2): 99-104. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: cats, ears, inflammation, nose, case studies, radiography, analytical, body parts, disorders , respiratory system, sense organs, computed tomography.

Shikamoto, Y., S. Shibusawa, I. Okuyama, and T. Morita (1997). Characterization of membrane-associated prothrombin activator in normal and injured murine tissues. Federation of European Biochemistry Societies Letters 412(3): 526-30. ISSN: 0014-5793.
Abstract: Thrombin is a multifunctional enzyme involved in coagulation, cell modulation and inflammation. We recently reported a novel membrane-associated prothrombin activator, abbreviated as MAPA, found in cultured fibroblasts and glial cell lines. In this study, we examined the physiological role of this enzyme. MAPA-like activity was detected in the liver, kidney, lung and heart but not in the spleen or brain in normal mice. To examine whether MAPA participates in biological reactions, hepatic and renal injury were induced by administration of CCl4 and HgCl2, respectively. MAPA-like activity was specifically increased in the injured tissues: the activity was elevated by about 100-fold in 48 h in the liver and increased by about 5-fold in 12 h in the kidney. Their enzymatic properties were the same as those of MAPA in 8C feline kidney fibroblast cells. Phospholipids are required for activation of prothrombin by MAPA obtained from both 8C cells and tissues. These results suggest that MAPA activates prothrombin on the cell surface in injured tissue and participates in inflammation and regeneration associated with tissue injury.
Descriptors: kidney, liver, membrane proteins, prothrombin, coagulation, carbon tetrachloride, cell line, injections, intraperitoneal, injections, subcutaneous, kidney, kidney, liver, liver, membrane proteins, mercuric chloride, mice, phospholipids, prothrombin.

Shimada, Y., M. Kiyosawa, T. Nariai, K. Oda, H. Toyama, K. Ono, M. Senda, and K. Ishiwata (2003). Quantitative in vivo measurement of central benzodiazepine receptors in the brain of cats by use of positron-emission tomography and [11C]flumazenil. American Journal of Veterinary Research 64(8): 999-1002. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Abstract: OBJECTIVE: To map central benzodiazepine receptors (BZRs) in the brain of cats by use of positron-emission tomography (PET) and [11C]flumazenil. ANIMALS: 6 male cats that weighed between 2.0 and 3.6 kg. PROCEDURE: Brain images obtained by PET evaluation of [11C]flumazenil were superimposed on T2-weighted magnetic-resonance imaging (MRI) scans of the same cats. Detailed anatomic regions, such as the cerebral cortex, striatum, thalamus, midbrain, and cerebellum, on the PET images were evident by PET-MRI registration. Regional binding of [11C]flumazenil to BZRs was quantitatively measured by use of a model with 2 tissue compartments and 4 variables. RESULTS: The highest value for distribution volume was observed in the cerebral cortex, and the lowest value was found in the midbrain of cats. CONCLUSIONS AND CLINICAL RELEVANCE: Binding of [11C]flumazenil to BZRs in the brain of cats can be quantitatively measured by use of PET with the aid of PET-MRI registration. It is difficult to diagnose changes in these neuroreceptors within the field of current veterinary science. In the future, PET should prove useful for investigating and diagnosing brain disorders in animals in clinical settings.
Descriptors: brain, cats, flumazenil , gaba modulators, gaba a receptors, emission computed of tomography, brain, carbon radioisotopes, flumazenil, gaba modulators.

Shimojima, M., Y. Nishimura, T. Miyazawa, K. Kato, K. Nakamura, Y. Izumiya, H. Akashi, and Y. Tohya (2002). A feline CD2 homologue interacts with human red blood cells. Immunology 105(3): 360-366. ISSN: 0019-2805.
NAL Call Number: 448.3 IM6
Descriptors: feline, immune system, T lymphocytes, human CD2, monocytes, cultured lymphoid cells, human red cells, rosette formation.

Shimura, S. (2001). Extracellular ATP regulation of airway secretion. Drug Development Research 52(1-2): 170-177. ISSN: 0272-4391.
Descriptors: feline trachea, respiratory system, northern blot, analytical method, immunohistochemistry, patch clamp technique, submucosal glands, airway secretion, ATP, epithelium.

Sin, J.I. and S. Specter (1996). The role of interferon-gamma in antiretroviral activity of methionine enkephalin and AZT in a murine cell culture. The Journal of Pharmacology and Experimental Therapeutics 279(3): 1268-73. ISSN: 0022-3565.
NAL Call Number: 396.8 J82
Abstract: The ability of spleen cells treated with methionine enkephalin (Met-ENK) in the presence of 3'-azido-3'-deoxythymidine (AZT) to produce cytokines and inhibit Friend leukemia virus (FLV) replication in Mus dunni cell cultures was investigated. In the presence of murine spleen cells, combination treatments using AZT plus Met-ENK or concanavalin A reduced FLV replication by 63% and 84%, respectively, as compared with 47% for AZT alone. When interleukin (IL)-2, IL-4 and interferon (IFN gamma) levels were measured in FLV-infected cell cultures, both AZT and Met-ENK treatments induced a higher production of IFN gamma and a slight increase in IL-2 and IL-4, as compared with either treatment alone. Subsequent treatment of FLV-infected cells with concanavalin A-stimulated cell supernatants, containing approximately 10 U/ml each of IFN gamma and IL-2, resulted in inhibition of viral replication. Thus, in the absence of spleen cells, IFN gamma was added to cell cultures to determine whether this cytokine contributed to combination antiviral effects. Results show that addition of IFN gamma alone results in a slight suppression of FLV expression, whereas treatment with both AZT and IFN gamma inhibits FLV replication significantly. Subsequently, addition of anti-IFN gamma antibody to cell cultures treated with Met-ENK blocked antiviral effects due to this neuropeptide. Thus anti-FLV effects of spleen cells treated with Met-ENK in combination with AZT are mediated to a large degree by IFN gamma.
Descriptors: antiviral agents, enkephalin, methionine, zidovudine, cells, cultured, concanavalin a, drug synergism, interferon type II biosynthesis, interleukin 2 biosynthesis, interleukin 4 biosynthesis, leukemia virus, feline, leukemia virus, feline, mice, mice, inbred balb C, spleen, spleen, virus replication.

Smith, S.A., D.S. Biller, S.L. Kraft, J.M. Goggin, and J.J. Hoskinson (1998). Diagnostic imaging of biliary obstruction. Compendium on Continuing Education for the Practicing Veterinarian 20(11): 1225-1234. ISSN: 0193-1903.
NAL Call Number: SF601 .C66
Descriptors: dogs, cats, jaundice, digestive system diseases, radiography, gall bladder, ultrasonics, echography, scintigraphy, bile ducts, bile, analytical, body fluids, body parts, digestive system, liver , liver diseases, organic diseases, radiation , sound , tracer techniques, cholangiograpHy , cholestasis , cholelithiasis , ultrasonography .

Snyder, L.A., E.R. Bertone, R.M. Jakowski, M.S. Dooner, J. Jennings Ritchie, and A.S. Moore (2004). p53 expression and environmental tobacco smoke exposure in feline oral squamous cell carcinoma. Veterinary Pathology 41(3): 209-214. ISSN: 0300-9858.
NAL Call Number: 41.8 P27
Descriptors: carcinogenesis, gene expression, genes, mouth, neoplasms, predisposition, questionnaires, risk factors, tobacco smoking, cats.

Sosnovtsev, S.V., E.A. Prikhod'ko, G. Belliot, J.I. Cohen, and K.Y. Green (2003). Feline calicivirus replication induces apoptosis in cultured cells. Virus Research 94(1): 1-10. ISSN: 0168-1702.
NAL Call Number: QR375. V6
Descriptors: infection, feline calicivirus infection, viral disease, feline kidney cells, apoptosis, chromatin condensation, viral replication, de novo synthesis.

Specke, V., S.J. Tacke, K. Boller, J. Schwendemann, and J. Denner (2001). Porcine endogenous retroviruses: in vitro host range and attempts to establish small animal models. Journal of General Virology 82(4): 837-844. ISSN: 0022-1317.
NAL Call Number: QR360. A1J6
Descriptors: infection, reverse transcriptase polymerase chain reaction, polymerase chain reaction, in vitro infection studies, analytical method.

Steriade, M., F. Amzica, and D. Contreras (1994). Cortical and thalamic cellular correlates of electroencephalographic burst-suppression. Electroencephalography and Clinical Neurophysiology 90(1): 1-16. ISSN: 0013-4694.
Abstract: This experimental study on anesthetized cats used intracellular recordings of cortical, thalamocortical and reticular thalamic neurons (n = 54), as well as multi-site extracellular recordings (n = 36), to investigate the cellular correlates of EEG burst-suppression patterns, defined as alternating wave bursts and periods of electrical silence. Burst-suppression was elicited by the administration of the same or other anesthetic agents upon the background of an already synchronized EEG activity. About 95% of cortical cells entered burst-suppression, in close time-relation with EEG activity, displaying sequences of phasic depolarizing events associated with bursts of EEG waves and an electrical silence of the neuronal membrane during flat EEG epochs. The membrane potential (Vm) hyperpolarized by approximately 10 mV prior to any EEG change and the slow rhythms reflecting deep stages of anesthesia progressively disorganized with transition to burst-suppression. During flat EEG epochs, the apparent input resistance (tested through short hyperpolarizing current pulses) decreased (range 12-60%) and neuronal responsiveness to orthodromic volleys (tested by thalamic and cortical evoked excitatory postsynaptic potentials) was dramatically reduced. It is proposed that the decreased input resistance is mainly due to an increase in K+ conductances. At variance with cortical neurons, only 60-70% of thalamic cells ceased firing before overt EEG burst-suppression and were completely silent during flat periods of EEG activity. The remaining 30-40% of thalamic cells discharged rhythmic (1-4 Hz) spike bursts during periods of EEG silence. This rhythm, within the frequency range of delta waves, is generated in thalamic cells by the interplay between two of their intrinsic currents at critical levels of Vm hyperpolarization. However, with the deepening of burst-suppression, when silent EEG periods became longer than 30 sec, thalamic cells also ceased firing. The assumption that full-blown burst-suppression is achieved through virtually complete disconnection in brain circuits implicated in the genesis of the EEG is corroborated by the revival of normal cellular and EEG activities after volleys setting into action thalamic and cortical networks.
Descriptors: cerebral cortex, electroencephalography, thalamus, cats, membrane potentials, synapses.

Steyn, P.F., D. Twedt, and W. Toombs (1996). The scintigraphic evaluation of solid phase gastric emptying in normal cats. Veterinary Radiology and Ultrasound 36(4): 327-331. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: cats, digestion, analytical, computer applications, digestive system, technetium, radioisotopes, stomach, body parts, digestive system, elements , isotopes , metallic elements, physiological functions, transition elements, scintigraphy , computer techniques, transit time, stomach emptying.

Sweeney, D.J., K.L. Riggs, R.L. Johnson, D.E. Kiehl, J.O. Clark, and S.A. Wrighton (2004). In vitro metabolism of macrolide antibiotics using feline, canine, and phenobarbital-induced canine microsomes. Drug Metabolism Reviews 36(Suppl. 1): 206. ISSN: 0360-2532.
NAL Call Number: RM301.D73
Descriptors: metabolism, macrolide antibiotics, feline microsomes, n demethylation, food producing animal.

Takagi, S. (2000). A basic study on the possible application of differentiation therapy for feline mammary carcinoma. The Japanese Journal of Veterinary Research 48(1): 77. ISSN: 0047-1917.
NAL Call Number: 41.8 V6446
Descriptors: pharmacology, reproduction, tumor biology, feline mammary carcinoma, neoplastic disease, reproductive system disease, female, treatment, differentiation therapy, application , therapeutic method.

Tanaka, A., Y. Takagi, K. Nakagawa, Y. Fujimoto, T. Hori, and T. Tsutsui (2000). Artificial intravaginal insemination using fresh semen in cats. Journal of Veterinary Medical Science 62(11): 1163-1167. ISSN: 0916-7250.
NAL Call Number: SF604 .J342
Descriptors: artificial insemination, conception rate, HCG, ovulation, semen, spermatozoa, cats.

Tateyama, S., B.P. Priosoeryanto, R. Yamaguchi, K. Uchida, K. Ogiwara, and A.T. Suchiya (1995). In vitro growth inhibition activities of recombinant feline interferon on all lines derived from canine tumours. Research in Veterinary Science 59(3): 275-277. ISSN: 0034-5288.
NAL Call Number: 41.8 R312
Abstract: To evaluate the anti-tumour effect of recombinant feline interferon (rFeIFN) against canine neoplastic cells, the antiproliferation and anti-colony-forming activities of rFeIFN were investigated in vitro, using four cell lines derived from canine tumours; oral acanthomatous epulis (MCA-B1), mammary benign mixed tumour (MCM-B2), squamous cell carcinoma (CSCC), and malignant melanoma (CMC-1). The rFeIFN had a dose-dependent inhibitory effect on the cell growth and colony formation of all the cell lines, although the degree of inhibition was lower than that in the feline cell lines used as a positive control, and the sensitivity of the cells to rFeIFN differed.
Descriptors: interferon, cell lines, neoplasms, dogs, in vitro, inhibition, antineoplastic agents.

Tidwell, A.S., M. Solano, and S.H. Schelling (1994). Pediatric neuroimaging. Seminars in Veterinary Medicine and Surgery Small Animal 9(2): 68-85. ISSN: 0882-0511.
NAL Call Number: SF911 .S45
Descriptors: puppies, kittens, radiography, diagnosis, nervous system, nervous system diseases, young animals, animal diseases, analytical, animal morphology, cats , dogs , organic diseases, young animals, magnetic resonance, ultrasonography , computed tomography, literature reviews.

Torre Amione, G., S. Kapadia, J. Lee, R.D. Bies, R. Lebovitz, and D.L. Mann (1995). Expression and functional significance of tumor necrosis factor receptors in human myocardium. Circulation 92(6): 1487-93. ISSN: 0009-7322.
NAL Call Number: RC681 .A1C8
Abstract: BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine with potent negative inotropic properties, is elaborated in septic shock, acute myocarditis, reperfusion injury, and congestive heart failure. TNF-alpha acts by binding to two specific receptors: TNFR1 and TNFR2. However, neither the presence nor the significance of TNF receptors has been studied in the adult mammalian heart. METHODS AND RESULTS: In the present study, we showed that the adult heart expresses mRNA and receptor proteins for TNFR1 and TNFR2. Moreover, immunohistochemical staining studies localized TNFR1 and TNFR2 to the cardiac myocyte, providing a potential signaling pathway for the deleterious effects of TNF-alpha. The functional significance of the expression of TNFR1 and TNFR2 was explored with the use of a simple cell motion assay in which we assessed the effect(s) of TNF-alpha mutants known to bind selectively to human TNFR1 and TNFR2. We showed that the negative inotropic effect of wild-type TNF-alpha in isolated feline cardiac myocytes was mimicked by the TNF mutant that binds to TNFR1, whereas the TNF mutant that binds to TNFR2 had no significant effect on cell motion. CONCLUSIONS: Results of the present study show that the adult human heart expresses both mRNA and receptor proteins for TNFR1 and TNFR2; moreover, the negative inotropic effects of TNF-alpha in adult cardiac myocytes appear to be initiated by activation of TNFR1.
Descriptors: myocardium, receptors, tumor necrosis factor analysis, adolescent, adult, enzyme linked immunosorbent assay, middle aged, RNA, messenger analysis, receptors, tumor necrosis factor, receptors, tumor necrosis factor, tumor necrosis factor alpha.

Triolo, A.J. and K.G. Miles (1995). Renal imaging techniques in dogs and cats. Veterinary Medicine 90(10): 959-960, 962-966. ISSN: 8750-7943.
NAL Call Number: 41.8 M69
Descriptors: dogs, cats, radiography, kidneys, diagnosis, analytical, kidney diseases, analytical, body parts, organic diseases, urinary tract, urinary tract diseases, urogenital system, ultrasonography , scintigraphy .

Trouliaris, S., A. Hadwier Fangmeier, M. Heimann, and T. Tamura (1995). Influence of tyrosine residues Y705 and Y807 on the transforming potency of the v-fms oncogene product of feline sarcoma virus. Archives of Virology 140(1): 179-186. ISSN: 0304-8608.
NAL Call Number: 448.3 Ar23
Abstract: Cell transformation is characterized by overt changes in growth control and cell morphology. To study the role of tyrosine residues Y705 and Y807 of v-Fms of the McDonough strain of feline sarcoma virus in cell transformation we replaced them individually with phenylalanine residues. Cells expressing the mutant genes showed mitogenic properties similar to wild-type v-Fms transformed cells. However, the morphology of cells expressing the Y807F mutant remained the same as nontransformed cells. Four phosphoproteins of 190, 120, 55 and 50 kDa were detected in cells expressing the wild-type but were absent in cells expressing the mutant Y807F-v-fms gene.
Descriptors: feline oncovirus, binding site, binding proteins, kinases, tyrosine, phenylalanine, induced mutations, phosphorylation, transformation.

Tsutsui, T., M. Wada, M. Anzai, and T. Hori (2003). Artificial insemination with frozen epididymal sperm in cats. Journal of Veterinary Medical Science 65(3): 397-399. ISSN: 0916-7250.
NAL Call Number: SF604 .J342
Descriptors: artificial insemination, conception rate, male fertility, semen, spermatozoa, cats.

Tudor, N., C. Vlagioiu, A. Lungu, P. Tudor, and A. Comarzan (2004). The imaging diagnosis of the genetics osteopathies in cats. In: Clinica veterinaria 2004: Proceedings of the Sixth International Symposium in Animal Clinical Pathology and Therapy, June 14, 2004-June 18, 2004, Budva (Serbia and Montenegro), Faculty of Veterinary Medicine.: Belgrade (Serbia and Montenegro). 292 p. ISBN: 8681043196.
Abstract: In this article this presented two cases of genetic anomalies of the limbs and spine in cats. After radiological examinations we established the diagnosis of the block vertebra in one case, bilateral agenesis of radius and ulna and hypoagenesis of the femur, tibia and calcaneus of the second case. The cases described in this study represent the first contribute in this field from the Clinic of Radiology at the Faculty of Veterinary Medicine in Bucharest (Romania).
Descriptors: radiology, cats, vertebrae, radius, femur, tibia, genetic anomalies.
Language of Text: Romanian with a summary in English.

Tuxworth, W.J.Jr., H. Wada, Y. Ishibashi, and P.J. Mcdermott (1999). Role of load in regulating eif-4f complex formation in adult feline cardiocytes. American Journal of Physiology 277(4 PART 2): H1273-H1282. ISSN: 0002-9513.
NAL Call Number: 447.8 Am3
Descriptors: molecular biophysics, cell biology, cardiovascular system, feline cardiocytes, in vitro, 2,3 butanedione, rapamycin, insulin, pHorbol ester, electrical stimulation.

Uchiyama, T., H. Johansson, and U. Windhorst (2003). Static and dynamic input-output relations of the feline medial gastrocnemius motoneuron-muscle system subjected to recurrent inhibition: a model study. Biological Cybernetics 89(4): 264-273. ISSN: 0340-1200.
Descriptors: models and simulations, computational biology, muscular system, nervous system, computer simulation, mathematical and computer techniques, spinal recurrent inhibition, feline gastrocnemius muscle.

Van Vuuren, M., E. Stylianides (Nee De Klerk), S.A. Kania, E.E. Zuckerman, and W.D.J. Hardy (2003). Evaluation of an indirect enzyme-linked immunosorbent assay for the detection of feline lentivirus-reactive antibodies in wild felids, employing a puma lentivirus-derived synthetic peptide antigen. Onderstepoort Journal of Veterinary Research 70(1): 1-6. ISSN: 0030-2465.
NAL Call Number: 41.8 ON1
Descriptors: infection, medicine, feline immunodeficiency virus infection, immune system disease, viral disease, diagnosis, lentivirus infection, western blot, genetic techniques, indirect elisa, immunologic techniques.

Vanzetta, I. and A. Grinvald (2001). Evidence and lack of evidence for the initial dip in the anesthetized rat: implications for human functional brain imaging. NeuroImage 13(6 Pt 1): 959-967. ISSN: 1053-8119.
Descriptors: arousal, brain supply, energy, magnetic resonance imaging, magnetic resonance spectroscopy, oxygen consumption, cats, haplorhini, rats, regional flow, species specificity.

Vignoli, M., S. Ohlerth, F. Rossi, L. Pozzi, R. Terragni, D. Corlazzoli, and B. Kaser Hotz (2004). Computed tomography-guided fine-needle aspiration and tissue-core biopsy of bone lesions in small animals. Veterinary Radiology and Ultrasound 45(2): 125-130. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: aspiration, biopsy, bone diseases, computed tomography, diagnosis, diagnostic techniques, infectious diseases, lesions, neoplasms, cats, dogs.

Vink, C., K.H.v.d. Linden, and R.H.A. Plasterk (1994). Activites of the feline immunodeficiency virus integrase protein produced in Escherichia coli. Journal of Virology 68(3): 1468-14747. ISSN: 0022-538X.
NAL Call Number: QR360. J6
Abstract: Retroviral DNA integration requires the activity of at least one viral protein, the integrase (IN) protein. We cloned and expressed the integrase gene of feline immunodeficiency virus (FIV) in Escherichia coli as a fusion to the male gene and purified the IN fusion protein by affinity chromatography. The protein is active in site-specific cleavage of the viral DNA ends, DNA strand transfer, and disintegration. FIV IN has a relaxed viral DNA substrate requirement: it cleaves and integrates FIV DNA termini, human immunodeficiency virus DNA ends, and Moloney murine leukemia virus DNA ends with high efficiencies. In the cleavage reaction, IN exposes a specific phosphodiester bond near the viral DNA end to nucleophilic attack. In vitro, either H2O, glycerol, or the 3' OH group of the viral DNA terminus can serve as nucleophile in this reaction. We found that FIV IN preferentially uses the 3' OH ends of the viral DNA as nucleophile, whereas HIV IN protein preferentially uses H2O and glycerol as nucleophiles.
Descriptors: feline immunodeficiency virus, Escherichia coli, DNA binding proteins, viral proteins, DNA modification, structural genes, gene transfer, recombinant DNA, site specific DNA cleavage, DNA strand transfer.

Waly, N., T.J. Gruffydd-Jones, C.R. Stokes, and M.J. Day (2001). The distribution of leucocyte subsets in the small intestine of healthy cats. Journal of Comparative Pathology 124(2-3): 172-182. ISSN: 0021-9975.
NAL Call Number: 41.8 J82
Abstract: The aim of this study was to investigate the distribution of leucocyte subsets in the small intestine of healthy adult cats (n=16). Immunohistochemical methods were used to identify leucocyte subsets within the mucosa of the duodenum, jejunum and ileum. Computer-aided morphometry was used to enumerate cells within the epithelial compartment, villous lamina propria and lamina propria adjacent to upper and lower crypt. Throughout the small intestine, IgA+ and IgM+ plasma cells were more prominent in the lamina propria adjacent to the lower crypt than in the villus, whereas IgG+ plasma cells were present in equal numbers in the crypt and villous regions. Overall, IgA+ plasma cells predominated and IgM+ plasma cells were higher in number than IgG+ plasma cells at each of the three anatomical locations. By contrast, T cells (CD3+) and T-cell subsets (CD4+ and CD8+) were present in greater numbers in the villous lamina propria than in the lamina adjacent to the crypts. Intraepithelial lymphocytes (IELs) were also characterized phenotypically, the majority being CD8+ T lymphocytes. Lamina propria macrophages and dendritic cells were characterized by expression of L1 and major histocompatibility complex (MHC) class II, and MHC class II expression by enterocytes overlying Peyer's patches, although rare, was also shown. The qualitative and quantitative data from this study provide a basis for comparison with cats with inflammatory enteropathies.
Descriptors: cats, intestine, small, t lymphocyte subsets, antigens, CD3 analysis, CD4 positive t lymphocytes, CD4 positive t lymphocytes, CD4 positive t lymphocytes, CD8 positive t lymphocytes, CD8 positive t lymphocytes, CD8 positive t lymphocytes, fluorescent antibody technique, indirect, histocompatibility antigens class ii analysis, computer assisted image processing, immunoglobulin a analysis, immunoglobulin m analysis, immunopHenotyping, intestinal mucosa, intestinal mucosa, intestine, small, leukocyte l1 antigen complex, membrane glycoproteins analysis, neural cell adhesion molecules analysis, plasma cells, plasma cells, plasma cells, t lymphocyte subsets, t lymphocyte subsets.

Waly, N.E., C.R. Stokes, T.J. Gruffydd Jones, and M.J. Day (2004). Immune cell populations in the duodenal mucosa of cats with inflammatory bowel disease. Journal of Veterinary Internal Medicine 18(6): 816-825. ISSN: 0891-6640.
NAL Call Number: SF601 .J65
Descriptors: disease markers, duodenum, IgA, IgG, immunoglobulins, immunohistochemistry, intestinal diseases, intestinal mucosa, leukocytes, major histocompatibility complex, T lymphocytes, villi, cats.

Wang, F., Y. Seta, G. Baumgarten, and D.L. Mann (1998). Expression of leukemia inhibitory factor in the adult mammalian heart: dynamic regulation and functional significance. Circulation 98(17 SUPPL.): I247-I248. ISSN: 0009-7322.
NAL Call Number: RC681 .A1C8
Descriptors: cardiovascular system, transport and circulation, feline heart, leukemia inhibitory factor, hemodynamic overloading.

Webb, C., S. Dow, M. Lappin, A. Guth, and D. Twedt (2004). Determination of glutathione and lipid peroxidation in feline peripheral blood cells using flow cytometry. Journal of Veterinary Internal Medicine 18(3): 430. ISSN: 0891-6640.
NAL Call Number: SF601 .J65
Descriptors: blood and lymphatics, feline cells, glutathione, medicine, flow cytometry, histology, lipid peroxidation.

Weiss, D.J. (2001). Determination of differential cell counts in feline bone marrow by use of flow cytometry. American Journal of Veterinary Research 62(4): 474-478. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: bone marrow cells, cell counting, erythrocytes, flow cytometry, hematology, lymphocytes, cats.

Weisser Thomas, J., V.I. Piacentino, J.P. Gaughan, K. Margulies, and S.R. Houser (2003). Calcium entry via na/ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes. Cardiovascular Research 57(4): 974-985. ISSN: 0008-6363.
Descriptors: molecular biophysics, cardiovascular system, transport and circulation, feline heart, cell biology, heart failure, sarcoplasmic reticulum, heart disease, Na Ca exchanger, feline myocytes, cyclopiazonic acid, nifedipine.

Wesseling, B. and L. Kopelovich (1997). Differentiation of human fibroblasts to tissue macrophages by the snyder-theilen feline sarcoma virus (st:fesv): growth modulation of human tumor cell lines in agar. AntiCancer Research: the Official Organ of the American Association for Cancer Research 17(4A): 2599-2602. ISSN: 0250-7005.
Descriptors: cell biology, clinical endocrinology, oncology, ccl 121 cell line, differentiation , du 145 cell line, fibroblasts, growth modulation, human breast adenocarcinoma cells, human colon adenocarcinoma cells, human fibrosarcoma cells, human fibrous histiocytoma cells, human leiomyosarcoma cells, human malignant melanoma cells, human prostate adenocarcinoma cells, immune system, mcf 7 cell line, mur cell line, pflug cell line, feline sarcoma virus, tib 223 cell line, tissue macrophages, tumor biology, tumor cells.

Widmer, W.R. and L. Guptill (1995). Imaging techniques for facilitating diagnosis of hyperadrenocorticism in dogs and cats. Journal of the American Veterinary Medical Association 206(12): 1857-1864. ISSN: 0003-1488.
NAL Call Number: 41.8 Am3
Descriptors: dogs, cats, endocrine diseases, diagnosis, radiography, adrenal glands, nmr spectroscopy, analytical, animal glands, body parts, endocrine glands, organic diseases, spectrometry , endocrine tests, cushing' s syndrome, diagnostic techniques, ultrasonography , computed tomography, nuclear magnetic resonance.

Williams, J., R. Leveille, and C.W. Myer (1998). Imaging modalities used to confirm diaphragmatic hernia in small animals. Compendium of Continuing Education for the Practicing Veterinarian 20(11): 1199-1210. ISSN: 0193-1903.
NAL Call Number: SF601 .C66
Descriptors: dogs, cats, hernia, symptoms, radiography, contrast media, ultrasonography.

Wisniewski, S. (1999). Kisallatok koponyamegbetegedeseinek vizsgalata komputertomografiaval [Computed tomography in the examination of cranial disorders in small animals]. Magyar Allatorvosok Lapja 121(3): p.153-160. ISSN: 0025-004X.
Abstract: This study deals with the evaluation of the use of computer tomography (CT) for the diagnosis of cranial disorders in 128 patients.Compared to conventional diagnostic techniques, with CT one is able to gather more information, especielly about diseases of the facial cranium and central nervous system.Indications for the use of CT typically include symptoms like nasal discharge, exophthalmos, mastication disturbance, abnormal neurologic status, epileptiform seizures and conditions and diseases such as head trauma and otitis media.
Descriptors: dogs, cats, skull, radiography, diagnosis, encephalitis, nervous system diseases, analytical, body parts, bones.
Language of Text: Hungarian; Summary in English.

Wong, C.J., R.L. Peiffer, S. Oglesbee, and C. Osborne (1996). Feline ocular epithelial response to growth factors in vitro. American Journal of Veterinary Research 57(12): 1748-1752. ISSN: 0002-9645.
NAL Call Number: 41.8 Am3A
Descriptors: in vitro, cell culture, epithelium, epidermal growth factor, transforming growth factor, insulin, eye lens, retina, sarcoma, growth factors, eyes, cats.

Xu, L., J.G. Muller, P.R. Withers, C. Kappler, W. Jiang, and D.R. Menick (2002). Role of map kinases in the NA+/CA2+ exchanger gene expression in feline adult cardiocytes. In: Cellular and molecular physiology of sodium-calcium exchange: Proceedings of the IVth International Conference on Cellular and Molecular Physiology of Sodium-Calcium Exchange, October 10, 2001-October 14, 2001, Banff, Alberta, Canada, New York Academy of Sciences: New York, New York, p. 285-287. ISBN: 1573313866 .
Descriptors: cardiovascular, circulation, membranes, cell biology, molecular, molecular biophysics, cardiac hypertropHy, heart disease, signal transduction.

Yamamoto, J.K. (Inventor) Feline derived t-cell lines for producing fiv. 1998). Official Gazette of the United States Patent and Trademark Office Patents, 1217 (2): 1576. ISSN: 0098-1133
NAL Call Number: T223. A21
Descriptors: cell biology, infection, atcc accession no: crl 11968, biotechnology, feline derived t cell line, fet 1c, feline immunodeficiency virus.

Yazawa, M., M. Okuda, R. Uyama, T. Nakagawa, N. Kanaya, R. Nishimura, N. Sasaki, K. Masuda, K. Ohno, and H. Tsujimoto (2003). Molecular cloning of the feline telomerase reverse transcriptase (TERT) gene and its expression in cell lines and normal tissues. Journal of Veterinary Medical Science 65(5): 573-577. ISSN: 0916-7250.
NAL Call Number: SF604 .J342
Descriptors: adrenal glands, amino acid sequences, animal tissues, bladder, bone marrow, brain, cell lines, complementary DNA, DNA cloning, gene expression, genes, liver, lungs, lymph nodes, messenger RNA, neoplasms, nucleotide sequences, pancreas, reverse transcriptase, spleen, stomach, testes, thymus gland.

Zeidner, N.S., D.L. Belasco, M.J. Dreitz, G.R. Frank, and W.R. Usinger (1995). Gliding bacterial adjuvant stimulates feline cytokines in vitro and antigen-specific IgG in vivo. Vaccine 13(14): 1294-1299. ISSN: 0264-410X.
NAL Call Number: QR189.V32
Descriptors: immunoglobulins, IgG, vaccines, adjuvants, cytokines, immunization, recombinant vaccines, parasites, helminths, Dirofilaria immitis, cats.

Zekas, L.J., J.T. Crawford, and R.T. O' Brien (2005). Computed tomography-guided fine-needle aspirate and tissue-core biopsy of intrathoracic lesions in thirty dogs and cats. Veterinary Radiology and Ultrasound 46(3): 200-204. ISSN: 1058-8183.
NAL Call Number: SF757.8 .A4
Descriptors: biopsy, computed tomography, diagnosis, diagnostic techniques, fine needle aspiration, lesions, neoplasms, pneumothorax, respiratory diseases, thorax, cats, dogs, Felis concolor.

Zhan, X. and T. Shou (2002). Anatomical evidence of subcortical contributions to the orientation selectivity and columns of the cat's primary visual cortex. Neuroscience Letters 324(3): 247-251. ISSN: 0304-3940.
NAL Call Number: QP351.N3
Abstract: Physiological studies have demonstrated a subcortical origin for orientation selectivity and the orientation columns of the primary visual cortex. However, there are no anatomical data showing how subcortical cells contribute to this important property. Optical imaging, combined with 1,1'-dioctadecyl-3,3,3,3'-tetramethylin-docarbocyanine perchlolate (DiI) and biocytin retrograde tracing, reveals that relay cells projecting to a single orientation column representing the horizontal meridian were clustered within 300 microm in the dorsal lateral geniculate nucleus (LGN). Interestingly, some labeled cells were located on a line parallel to an iso-elevation line in the LGN. Thus, according to the quantitative projection of the visual field to the LGN (J. Comp. Neurol. 143 (1971) 101), their receptive fields must distribute horizontally in alignment in the visual field providing the first anatomical evidence for Hubel and Wiesel's model of simple cell receptive fields (J. Physiol. 160 (1962) 106).
Descriptors: geniculate bodies, lysine, neurons, orientation, pattern recognition, visual, visual cortex, visual fields, visual pathways, action potentials, brain mapping, carbocyanines diagnostic use, cats, fluorescent dyes diagnostic use, geniculate bodies, lysine diagnostic use, neurons, photic stimulation, visual cortex, visual pathways.


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