Animal Welfare Information Center
United States Department of Agriculture
National Agricultural Library
United States Department of Agriculture
National Agricultural Library
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Animal Welfare Information Center United States Department of Agriculture National Agricultural Library |
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Information Resources on the Care and Welfare of Rodents |
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Alban, L., P.J. Dahl, A.K. Hansen, K.C. Hejgarrd, A.L. Jensen, M. Kragh, P. Thomsen, and P. Steensgaard (2001). The welfare impact of increased gavaging doses in rats. Animal Welfare 10(3): 303-314. ISSN: 0962-7286.
NAL Call Number: HV4701.A557
Abstract: Textbook recommendations for gavaging rats vary between 1-5 ml for an adult rat. This study indicates that high doses (i.e. doses up to 10 ml for a 250 g rat) might be safe to use; however, if an adverse impact on the rat is to be avoided, use of much lower doses should be considered - for example, doses that do not enforce opening of the pyloric sphincter in any rat. This would be less than 4 ml kg-1 in a 250 g rat.
Descriptors: rats, laboratory mammals, body weight, dosage effects, volume, stomach, stomach emptying, barium sulfate, radiography, body temperature, restraint of animals, animal behavior, animal welfare.
Bondy, G.S., C.A.M. Suzuki, S.M. Fernie, C.L. Armstrong, S.L. Hierlihy, M.E. Savard, and M.G. Barker (1997). Toxicity of fumonisin B1 to B6C3F1 mice: a 14-day gavage study. Food and Chemical Toxicology 35(10-11): 981-989. ISSN: 0278-6915.
NAL Call Number: 391.8 F73
Descriptors: toxicity, mice, fumonisins, mycotoxins, poisoning, pathology, mammals, mycotoxins, Rodentia, toxic substances, toxins.
Bondy, G.S., C.A.M. Suzuki, R.W. Mueller, S.M. Fernie, C.L. Armstrong, S.L. Hierlihy, M.E. Savard, and M.G. Barker (1998). Gavage administration of the fungal toxin fumonisin B1 to female Sprague-Dawley rats. Journal of Toxicology and Environmental Health 53(2): 135-151.
Descriptors: rats, fumonisins, mycotoxins, poisoning, females, toxicity, kidneys, bone marrow, liver, pathology, histopathology, cholesterol, sex, biological differences, body parts, cardiovascular system, digestive system, isoprenoids, mammals, mycotoxins, pathology, Rodentia, sex, steroids, sterols, toxic substances, toxins, urinary tract, urogenital system.
Brown, A.P., N. Dinger, and B.S. Levine (2000). Stress produced by gavage administration in the rat. Contemporary Topics in Laboratory Animal Science 39(1): 17-21. ISSN: 1060-0558.
NAL Call Number: SF405.5.A23
Descriptors: stress, rat, gavage, administration.
Cooke, G.M., H. Tryphonas, O. Puliod, D. Caldwell, G.S. Bondy, and D. Forsyth (2004). Oral (gavage), in utero and postnatal exposure of Sprague Dawley rats to low doses of tributyltin chloride. 1. Toxicology, histopathology and clinical chemistry. Food and Chemical Toxicology 42(2): 221-235. ISSN: 0278-6915.
NAL Call Number: 391.8 F73
Descriptors: oral gavage, in utero, rats, low doses, Sprague Dawley, toxicology.
Craig, M.A. and J.F. Elliott (1999). Mice fed radiolabeled protein by gavage show sporadic passage of large quantities of intact material into the blood, an artifact not associated with voluntary feeding. Contemporary Topics in Laboratory Animal Science 38(5): 18-23. ISSN: 1060-0558.
NAL Call Number: SF405.5.A23
Descriptors: mice, radiolabeled protein, gavage, blood, feeding, passage, voluntary feeding.
Kim, J.C., B.H. Kang, C.C. Shin, Y.B. Kim, H.S. Lee, C.Y. Kim, J. Han, K.S. Kim, D.W. Chung, and M.K. Chung (2002). Subchronic toxicity of plant sterol esters administered by gavage to Sprague-Dawley rats. Food and Chemical Toxicology 40(11): 1569-1580. ISSN: 0278-6915.
NAL Call Number: 391.8 F73
Descriptors: Sprague Dawley rats, subchronic toxicity, plant sterol esters, gavage, daily, male, female, target organ.
Liao, J.W., S.J. Tsai, S.C. Wang, and J.S. Hwang (2003). Safety evaluation of turmeric (Curcuma longa L.) powder via oral gavage for 28 days in rats. Plant Protection Bulletin (Taipei ) 45(3): 237-255. ISSN: 0577-750X.
Descriptors: rats, oral gavage, safety evaluation, tumeric, antioxident effect, hepatic disorders, cancer, toxicity.
Liao, J.W., S.C. Wang, S.Y. Liu, and J.S. Hwang (2002). Safety evaluation of feeding yam tuber powder to rats by gavage for 28 days. Plant Protection Bulletin (Taipei ) 44(2): 75-88. ISSN: 0577-750X.
Descriptors: Sprague Dawley rats, yam tuber powder, feeding toxicity, gavage, safety evaluation.
Masanes, R.M., I. Rafecas, and X. Remesar (2001). Absorption of a protein gavage in Zucker lean rats. Influence of protein content in the diet. Archives of Physiology and Biochemistry 109(2): 168-174. ISSN: 1381-3455.
Descriptors: Zucker lean rats, protein gavage, diet, protein content, absorption, blood, labelled proteins, tissue proteins.
Tryphonas, H., G. Cooke, D. Caldwell, G. Bondy, M. Parenteau, S. Haywood, and O. Pulido (2004). Oral (gavage), in utero and post-natal exposure of Sprague Dawley rats to low doses of tributyltin chloride. II. Effects on the immune system. Food and Chemical Toxicology 42(2): 221-235. ISSN: 0278-6915.
NAL Call Number: 391.8 F73
Descriptors: oral gavage, rats, in utero, Sprague Dawley, effects, immune system.
Wheatley, J.L. (2002). A gavage dosing apparatus with flexible catheter provides a less stressful gavage technique in the rat. Lab Animal 31(7): 53-56. ISSN: 0093-7355.
NAL Call Number: QL55.A1L33
Descriptors: rats, laboratory animals, animal use refinement, distress, catheters, aggression, animal stress, dosage, restraint of animals, training people, animal technicians, laboratory equipment, measuring devices, mice, scruffing.