Animal Welfare Information Center

Johne's Disease--Mycobacterium avium subsp. paratuberculosis: A Debilitating Enteric Disease of Ruminants


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2002


Adaska, J.M.; Munoz-Zanzi, C.A.; Hietala, S.K.  Evaluation of result variability with a commercial Johne's disease enzyme-linked immunosorbent assay kit and repeat testing of samples.  Journal of Veterinary Diagnostic Investigation.  2002; 14(5): 423-426.  ISSN:  1040-6387.  
NAL Call No.:  SF774.J68
Descriptors:  cattle, dairy cows, Johne’s disease, Mycobacterium avium subsp. paratuberculosis, serum sampling, 201 individual animals, antibody testing, diagnosis, diagnostic techniques, immunodiagnosis, ELISA kit, test kit variability, optical density variation, inconsistency of results complicates management decisions.

Amadori, M.; Lyashchenko, K.P.; Gennaro, M.L.; Pollock, J.M.; Zerbini, I.  Use of recombinant proteins in antibody tests for bovine tuberculosis.  Veterinary Microbiology.  2002; 85(4): 379-389.  ISSN:  0378-1135.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5190&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=7e99acb030d8f79b52d4e03a1c31a5f8NAL Call No.:  SF601.V44
Descriptors:  cattle, calves, Mycobacterium avium, Mycobacterium avium subsp. paratuberculosis, Mycobacterium bovis, ELISA, analytical diagnostic methods, diagnostic test reliability and sensitivity, antibody testing, antigens, immune response, interferon, paratuberculosis, recombinant proteins, tuberculosis, zoonoses.

Australia New South Wales Agriculture.  Ovine Johne's Disease Possible Trading and Control Options Available in the Residual Zone.  NSW Agriculture.  Australia.  2002; 4 p.
Descriptors:  sheep flocks, strategies, management, options to reduce impact of Johne’s, Mycobacterium avium subsp. paratuberculosis, disease control and prevention, immunization with vaccination, New South Wales, Australia.

Baba, A.I.; Catoi, C.; Denes, C.  Histopathological aspects of avian tuberculosis.  Buletinul Universitatii de Stiinte Agricole si Medicina Veterinara Cluj Napoca, Seria Medicina Veterinara.  2002; 58: 583-586.  ISSN:  1454-2382.  Note:  In English with a Rumanian summary.
Descriptors:  14,000 birds necropsied, hens, pigeons, turkeys, disease survey, Mycobacterium avium, Mycobacterium avium subsp. paratuberculosis, many tissues sampled, amyloid in liver and spleen, Romania.

Bakker, D. Keynote: Johne's disease in the Netherlands. Research in Veterinary Science. April 2002; 72(Suppl. A): 28-29. ISSN: 0034-5288. Note: 56th Annual Conference of the Association of Veterinary Teachers and Research Workers on Current Topics in Veterinary Science, Scarborough, England, UK, March 25-27, 2002.
NAL Call No.: 41.8 R312
Descriptors: epidemiology, Mycobacterium avium subsp. paratuberculosis, cattle, The Netherlands, Johne’s disease.

Ball, R.L.; Burton, M.; Leger, J.S.; Dumonceaux, G.; Olsen, J.H.  Changes in calcium metabolism in nyala (Tragelaphus angassi) on a forage only diet.  Advances in Ethology.  2002; 37: 107.  ISSN:  0931-4202.  Note:  4th International Symposium on Physiology and Behaviour of Wild and Zoo Animals, Berlin, Germany; September 29-October 02, 2002.  
Descriptors:  captive zoo animal, nyala, Tragelaphus angassi, forage diet, calcium metabolism changes, excretion, phosphorus, potassium, sodium, Johne’s disease, Mycobacterium avium subsp. paratuberculosis.

Ballarini, G.; Martelli, P.  Paratubercolosi bovina: importanza della profilassi nel vitello.  [Bovine paratuberculosis: importance of prevention in calves.]  Obiettivi e Documenti Veterinari. 2002; 23(2): 5-8.  ISSN:  0392-1913.  Note:  In Italian.  
Descriptors:  calves, Mycobacterium avium subsp. paratuberculosis, importance of disease prevention, reviews.

Bannantine, J.P.; Baechler, E.; Zhang, Q.; Li, L.L.; Kapur, V.  Genome scale comparison of Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium reveals potential diagnostic sequences.  Journal of Clinical Microbiology.  2002; 40(4): 1303-1310.  ISSN:  0095-1137.
URL:  http://www.pubmedcentral.gov/articlerender.fcgi?artid=140397
Descriptors:  Mycobacterium avium, Mycobacterium avium subsp. paratuberculosis, Mycobacterium avium subsp. avium, genes, genetic comparisons, genome analysis, nucleotide sequences, codons, diagnosis, diagnostic techniques, analytical methods.

Bannantine, John P.; Stabel, Judith R. Killing of Mycobacterium avium subspecies paratuberculosis within macrophages. BMC Microbiology. January 30, 2002; 2(2 Cited May 17, 2002): 1-7. ISSN: 1471-2180.
Article URL: http://www.biomedcentral.com/content/pdf/1471-2180-2-2.pdf [cited July 16, 2002]
URL: http://www.biomedcentral.com/1471-2180
Descriptors: ruminant animal pathogen, cultured macrophages, interplay between bacterium and host, replication time, immunogold labeling of infected macrophages with antibodies, using transmission electron microscopy and viability counts.

Blackburn, C. de W.; McClure, P.J. [Editors]  Foodborne Pathogens: Hazards, Risk Analysis and Control.  Woodhead Publishing Ltd., Cambridge, UK.  2002; xvii + 521.  ISBN:  1855734540. Note:  20 chapters on a variety of topics regarding foodborne disease organisms.  
NAL Call No.:  RA601.5.F659  2002
Descriptors:  effective detection measures, control measures and application to individual pathogens, HACCP systems implementation, safe handling at every stage, Escherichia coli, Salmonella, Listeria monocytogenes, Campylobacter and Arcobacter, viruses, parasites, Mycobacterium avium subsp. paratuberculosis, many additional organisms addressed.

Borody, T. J.; Leis, S.; Warren, E. F.; Surace, R. Treatment of severe Crohn's disease using antimycobacterial triple therapy: Approaching a cure? Digestive and Liver Disease. January 2002; 34(1): 29-38. ISSN: 1590-8658.
Descriptors: causal role, Mycobacterium avium subsp. paratuberculosis, Crohn’s disease, triple macrolide-based anti-mycobacterial therapy, rifabutin (450 mg/d), clarithromycin (750 mg/d) and clofazimine (2 mg/kg/d), anti microbial treatment.

Burton, L.; Voges, H. Control of Johne's disease in dairy cattle. Proceedings of the New Zealand Society of Animal Production. 2002; 62: 299-302. ISSN: 0370-2731.
NAL Call No.: 49.9 N483
Descriptors: dairy cattle, Mycobacterium avium subsp. paratuberculosis, Crohn’s disease, contaminated milk products, infection level data, economic impacts, possible control measures, vaccines, management practices, breeding for genetic resistance, New Zealand.

Catton, B.A.  Paucibacillary paratuberculosis in a goat.  Canadian Veterinary Journal.  2002; 43(10): 787-788.  ISSN:  0008-5286.  Note:  In English with a French summary.
URL:  http://www.pubmedcentral.nih.gov/tocrender.fcgi?action=archive&journal=202
NAL Call No.:  41.8 R3224
Descriptors:  goats, Mycobacterium avium subsp. paratuberculosis, etiology, clinical aspects, pathogenesis, case report.

Cerri, D.; Cantile, C.; Ebani, V. V.; Montagnese, M.; Voltini, B.; Arispici, M. Diagnosis of paratuberculosis in naturally infected goats. Microbiologica. April 2002; 25(2): 131-137. ISSN: 1121-7138.
NAL Call No.: QR1 M57
Descriptors: goats, immunohistochemical method, agar gel immunodiffusion (AGID), diagnosis, Mycobacterium avium subsp. paratuberculosis, pathology, isolated from various organs, intestines, mesenteric lymph nodes, macrophages.

Chi, Junwook; Van Leeuwen, John A.; Weersink, Alfons; Keefe, Gregory P.  Direct production losses and treatment costs from bovine viral diarrhoea virus, bovine leukosis virus, Mycobacterium avium subspecies paratuberculosis, and Neospora caninum.  Preventive Veterinary Medicine. 2002; 55(2): 137-153.  ISSN:  0167-5877.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5145&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=c5bc3d9e1bb66468352ae1f5475d522f
NAL Call No.:  SF601.P7
Descriptors:  cattle, production losses, production costs, animal diseases, milk losses, premature culling, reduced slaughter, mortality, abortion and reproductive losses, veterinary services, drug therapy, medication costs, extra farm labor, partial-budget model, 50 cow herd, viral diarrhea virus, bovine leucosis virus, Neospora canium, Mycobacterium avium subsp. paratuberculosis, milk yield effects, Maritime provinces, New Brunswick, Nova Scotia, Prince Edward Island, Canada.

Chi Junwook; Weersink, A.; Van Leeuwen, J.A.; Keefe, G.P.  The economics of controlling infectious diseases on dairy farms.  Canadian Journal of Agricultural Economics.  2002; 50(3): 237-256.  ISSN:  0008-3976.  Note:  In English with a French summary.
NAL Call No.:  281.8 C16
Descriptors:  livestock diseases, empirical model, optimal set of control strategies, 4 cattle diseases, bovine viral diarrhea (BVD), enzootic bovine leukosis (EBL), Johne's disease,  neosporosis, direct production losses and control expenditures for each disease, new animal screening, vaccination protection.

Chi, Junwook; Van Leeuwen, J.A.; Weersink, A.; Keefe, G.P.  Management factors related to seroprevalences to bovine viral-diarrhoea virus, bovine-leukosis virus, Mycobacterium avium subspecies paratuberculosis, and Neospora caninum in dairy herds in the Canadian Maritimes.  Preventive Veterinary Medicine. 2002; 55(1): 57-68.  ISSN: 0167-5877.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5145&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=c5bc3d9e1bb66468352ae1f5475d522f
NAL Call No.:  SF601.P7
Descriptors:  dairy cattle, on farm productivity lowered by diseases, bovine diarrhea virus, bovine leukemia virus, Mycobacterium avium subsp. paratuberculosis, Neospora caninum, epidemiology, disease prevalence, risk assessment, animal husbandry, seroprevalence, disease control, vaccination, hygiene, Prince Edward Island, Nova Scotia, New Brunswick, Canada.

Cliver, D.O.  Infrequent microbial infections.  In: Cliver, D.O.; Riemann, H.P. [Editors]  Foodborne Diseases.  2nd edition. Academic Press. London, UK.  2002;  151-159.  ISBN:  0121765598. 
NAL Call No.:  QR201.F62 F67 2002
Descriptors:  food borne diseases described, zoonotic diseases, historic agents, occasionally transmitted agents, agents that can affect susceptible people, emerging foodborne pathogens, Escherichia coli O157:H7, Bacillus cereus, Mycobacterium avium subsp. paratuberculosis, Listeria monocytogenes, Giardia duodenalis, prions causing variant Creutzfeldt-Jakob disease.

Cocito, Carlo; Coene, Marc; De Kesel, Myriam; Gilot, Philippe. Polypeptides from Mycrobacterium paratuberculosis. Official Gazette of the United States Patent and Trademark Office Patents. [e-file] May 14, 2002; 1258(2): No Pagination. ISSN: 0098-1133.
NAL Call No.: T223.A21
Descriptors: Johne’s disease, bacterial pathogen, 101 amino acids of FIG 8, Mycobacterium bovis, Mycobacterium avium, Mycobacterium phlei, Mycobacterium tuberculosis, and possibly against Mycobacterium leprae, Mycobacterium intracellulare, Mycobacterium scrofulaceum, Mycobacterium fortuitum, Mycobacterium gordonae and Mycobacterium smegmatis, Johne’s positive cattle sera.

Collins, D.M.; de Zoete, M.; Cavaignac, S.M.  Mycobacterium avium subsp. paratuberculosis strains from cattle and sheep can be distinguished by a PCR test based on a novel DNA sequence difference.  Journal of Clinical Microbiology.  2002; 40(12): 4760-4762.  ISSN:  0095-1137.
URL:  http://www.pubmedcentral.gov/articlerender.fcgi?artid=154624
NAL Call No.:  QR46.J6
Descriptors:  Mycobacterium avium subsp. paratuberculosis, strain differences, identifying sheep types and cattle types, DNA sequences, PCR.

Collins, M.T.  Interpretation of a commercial bovine paratuberculosis enzyme-linked immunosorbent assay by using likelihood ratios.  Clinical and Diagnostic Laboratory Immunology.  2002; 9(6): 1367-1371.  ISSN:  1071-412X.
URL:  http://www.pubmedcentral.gov/articlerender.fcgi?artid=130105
Descriptors:  143 infected diary cattle, 2974 free of Johne’s disease, sera testing for Mycobacterium avium subsp. paratuberculosis, commercial ELISA, diagnosis, disease control.

Corti, Sabrina; Stephan, Roger. Detection of Mycobacterium avium subsp. paratuberculosis specific IS900 insertion sequences in bulk-tank milk samples obtained from different regions throughout Switzerland. BMC Microbiology. June 26, 2002; 2(15 Cited August 6, 2002): No Pagination. ISSN: 1471-2180.
URL: http://www.biomedcentral.com/1471-2180
Descriptors: possible relationship of Mycobacterium avium subsp. paratuberculosis to Crohn’s disease etiology, possible hazards of raw milk, bulk tank milk sampling, dairy stock subclinical infections, Switzerland.

Coussens, P.M.; Colvin, C.J.; Wiersma, K.; Abouzied, A.; Sipkovsky, S.  Gene expression profiling of peripheral blood mononuclear cells from cattle infected with Mycobacterium paratuberculosis.  Infection and Immunology.  2002; 70(10): 5494-5502.  ISSN: 0019-9567.
URL:  http://www.pubmedcentral.gov/articlerender.fcgi?artid=128350
NAL Call No.:  QR1.I57
Abstract:  A bovine-specific cDNA microarray system containing 721 unique leukocyte expressed sequence tags (ESTs) and amplicons representing known genes was used to compare gene expression profiles of peripheral blood mononuclear cells (PBMCs) from clinical and subclinical Johne's disease-positive Holstein cows (n = 2 per group).  Stimulation of PBMCs from clinically infected cows with Mycobacterium paratuberculosis tended to decrease expression of 83 genes (fold change, >1.5).  Of these 83 genes, 16 displayed significant down regulation across both clinical cows (P < 0.1), including genes encoding microspherule protein 1, fibroblast growth factor, and the Lyn B protein kinase.  Only eight genes from PBMCs of clinically infected cows exhibited a modest up regulation following stimulation with M. paratuberculosis, including those encoding bovine CD40L, gamma interferon, interleukin-10 (IL-10), and tissue inhibitor of matrix metalloproteinases (TIMP) 4.  In contrast, stimulation of PBMCs from subclinically infected cows with M. paratuberculosis tended to up regulate expression of 71 genes representing 68 unique transcripts.  Of these, 11 genes showed significant up regulation (fold change, >1.5; P < 0.1) across both animals, including those encoding bovine CD40L, several matrix metalloproteinases, and SPARC (secreted protein, acidic and rich in cystine).  Repression of gene expression was also observed in PBMCs from the subclinical cows, with 16 genes being significantly down regulated (fold change, >1.5; P < 0.1) across both animals, including those encoding the bovine orthologs of cytochrome oxidase subunit III, IL-1 receptor type I, and fibrinogen-like 2 protein.  Only one clone, representing an unknown bovine EST, was similarly down regulated in PBMCs from both the clinical and subclinical cows.  Thus, the most prominent change induced by exposure of PBMCs from clinical cows to M. paratuberculosis in vitro tended to be repression of gene expression, while changes in similarly treated PBMCs from subclinical cows was balanced between gene activation and repression. Comparison of gene expression profiles between PBMCs from clinical and uninfected (control) cows stimulated with the general mitogen concanavalin A were highly similar (overall r = 0.84), suggesting that M. paratuberculosis-induced gene repression in clinically infected cow PBMCs was not due to a general failure of the immune response in these animals.
Descriptors:  messenger RNA. leukocytes, leukocyte tags, gene expression profiles, peripheral blood mononuclear cells, clinical and subclinical Johne’s disease, Holstein cows, in vitro exposure, Mycobacterium paratuberculosis, immune responses.

Cvetnic, Z.; Brlek, K.; Trstenjak, J.; Ocepek, M.; Spicic, S.; Mitak, M.; Krt, B.  Gospodarska vaznost paratuberkuloze u uzgoju mlijecnih goveda.  [Economic importance of paratuberculosis in a breeding herd of dairy cows in Croatia.]  Veterinarska Stanica.  2002; 33(3): 133-139.  ISSN:  0350-7149.  Note:  In Croatian with an English summary.  
Descriptors:  dairy cattle, reasons for culling/slaughtering 1056 cows, 1995-2000, various conditions and diseases found, 19.7% clinical Johne’s, Mycobacterium avium subsp. paratuberculosis, Croatia.

Cvetnic, Z.  Paratuberkuloza ovaca i koza u Republici Hrvatskoj.  [Paratuberculosis in sheep and goats in the Republic of Croatia.]  Praxis Veterinaria Zagreb.  2002; 50(3): 255-260.  ISSN:  0350-4441.  Note:  In Croatian with an English summary.  
Descriptors:  sheep, goats, Mycobacterium avium subsp. paratuberculosis, disease prevalence, disease surveys, seroprevalence, 7058 sera samples, percentages of positives given, complement fixation tests, immunoenzyme techniques, ELISA, paratuberculosis, seroprevalence, Republic of Croatia.

Daniels, M.J.; Hutchings, M.R.; Allcroft, D.J.; Mckendrick I.J.; Greig A.  Risk factors for Johne's disease in Scotland--the results of a survey of farmers.  Veterinary Record.  2002; 150(5): 135-139.  ISSN: 0042-4900.
URL:  http://veterinaryrecord.bvapublications.com/
NAL Call No.:  41.8 V641
Descriptors:  farm surveys mailed to 127 farms, risk factors for Johne’s disease, Mycobacterium avium subsp. paratuberculosis, paratuberculosis, wildlife and farm management practices, large numbers of livestock and rabbits, access of wildlife to feed stores clearest and most consistent risks, application of manure to grazing pasture, type of water supply for cattle, numbers of cows, cattle, cattle husbandry, disease prevalence, disease control, feeds, manures, drinking water, Corvus, East Scotland.

Davies, P.R. Is Crohn's disease caused by M. avium subsp. paratuberculosis? Proceedings of the New Zealand Society of Animal Production. 2002; 62: 290-293. ISSN: 0370-2731.
NAL Call No.: 49.9 N483
Descriptors: Johne’s disease, role of disease in Crohn’s disease, discussion of possible zoonotic aspects of Mycobacterium avium subsp. paratuberculosis.

de Lisle, G.W.  Johne's disease in New Zealand: the past, present and a glimpse into the future.  New Zealand Veterinary Journal.  2002; 50(3 Suppl.): 53-56.  ISSN:  0048-0169.
NAL Call No.:  41.8 N483
Descriptors:  ruminants, deer, sheep, cattle, Johne’s disease, disease control, Mycobacterium avium subsp. paratuberculosis, New Zealand.

D'Haese, Eva; Nelis, Hans J. Rapid detection of single cell bacteria as a novel approach in food microbiology. Journal of AOAC International. July-August 2002; 85(4): 979-983. ISSN: 1060-3271.
NAL Call No.: S583.A7
Descriptors: solid phase cytometry, food sampling, slow growing bacteria detection, of Mycobacterium avium subsp. paratuberculosis, model example of a slow-growing bacterium in milk.

Douart, A.; Maillard, R.  Eziologia ed epidemiologia della paratubercolosi bovina.  [Etiology and epidemiology of bovine paratuberculosis.]  Summa.  2002; 19(8): 37-42.  Note:  In Italian with an English summary.
Descriptors:  cattle, Johne’s disease, epidemiology, Mycobacterium avium subsp. paratuberculosis, etiology, fecal sampling, intestinal infection, disease transmission, environment.

Douart, A.; Maillard, R.  Le controle de la paratuberculose bovine.  [Monitoring of bovine paratuberculosis.]  Point Veterinaire.  2002; 33(222): 34-37.  ISSN:  0335-4997.  Note:  In French with an English summary.
Descriptors:  cattle, Johne’s disease, diagnosis, disease control, feces, paratuberculosis, Mycobacterium avium subsp. paratuberculosis.

Drennan, M.  Important factors in suckler beef production and influence of calving season on income.  Irish Grassland Association Journal.  2002; 36: 129-136.  ISSN:  0322-0588.
Descriptors:  beef cattle, beef production, suckler herds, beef cattle health, beef quality, calving, calving season, cost benefit analysis, economic analysis, profitability, profits, Ireland.    

Dumonceaux, G.A.; Burton, M.S.; Olsen, J.H.; Ball, R.L.  Johne's disease in zoological collections.  Proceedings of the North American Veterinary Conference.  2002; 16: 993-994.  Note:  In the volume: Small Animal and Exotics.  Part of a three volume set. Meeting held January 12-16, 2002, Orlando, FL.
NAL Call No.:  SF605.N672
Descriptors:  zoo animals, Johne’s disease, Mycobacterium bovis, Mycobacterium avium subsp. paratuberculosis.

Englund, Stina; Bolske, Goran; Johansson, Karl Erik. An IS900-like sequence found in a Mycobacterium sp. other than Mycobacterium avium subsp. paratuberculosis. FEMS Microbiology Letters. April, 9 2002; 209(2): 267-271. ISSN: 0378-1097.
URL: http://www.elsevier.com/locate/femslett
NAL Call No.: QR1.F44
Descriptors: IS 900, specificity, dairy cows, Mycobacterium cookii, recommendations of gene other than IS900 for detection.

Fang, Y.; Wu, W.H.; Pepper, J.L.; Larsen, J.L.; Marras, S.A.E.; Nelson, E.A.; Epperson, W.B.; Christopher-Hennings, J.  Comparison of real-time, quantitative PCR with molecular beacons to nested PCR and culture methods for detection of Mycobacterium avium subsp. paratuberculosis in bovine fecal samples.  Journal of Clinical Microbiology.  2002; 40(1): 287-291.  ISSN:  0095-1137.
URL:  http://www.pubmedcentral.gov/articlerender.fcgi?artid=120117
NAL Call No.:  QR46.J6
Descriptors:  bovine fecal sampling, detection methods for Mycobacterium avium subsp. paratuberculosis, automated PCR with fluorescent probes, sensitivity and specificity compared to fecal cultures, minimum quantity of 1.7x10-4 pg of DNA, correlating to 1 to 8 CFU, was detected.

Ferreira, R.; Fonseca, L.S.; Lilenbaum, W. Agar gel immunodiffusion test (AGID) evaluation for detection of bovine paratuberculosis in Rio de Janeiro, Brazil. Letters in Applied Microbiology. 2002; 35(3):173-175. ISSN: 0266-8254.
NAL Call No.: QR1.L47
Descriptors: epidemiology, immune response, bacterial infection, Mycobacterium paratuberculosis, diagnostic screening method, agarose gel immunodiffusion test, cattle sera, Brazilian herds, subclinical herd infections.

Ferreira, R.; Fonseca, L.; Lilenbaum, W.  Comparison between a commercial and an in-house ELISA for anti-Mycobacterium avium paratuberculosis antibodies detection in dairy herds in Rio de Janeiro, Brazil.  Revista Latinoamericana de Microbiologia.  2002; 44(3/4): 129-132.  ISSN:  0034-9771.  Note:  In English with a Spanish summary.
Descriptors:  dairy cows, Mycobacterium avium subsp. paratuberculosis, diagnosis, diagnostic techniques comparison study, 179 sera samples, PPA ELISA (protoplasmic paratuberculosis antigen and monoclonal anti-bive IgG conjugated to alkaline phosphatase), HerdChek Mpt (IDEXX), the PPA ELISA useful for collective herd test, Rio do Janeiro, Brazil.

Flebbe, U.  15 Jahre Paratuberkulosebekampfung. Erfahrungen der Niedersachsischen Tierseuchenkasse.  [15 years of paratuberculosis eradication programs in Lower Saxony. Experiences from the Niedersaechsische Tierseuchenkasse.]  Deutsche Tierarztliche Wochenschrift.  2002; 109(12): 520-523.  ISSN:  0341-6593.  Note:  In German with an English summary.
NAL Call No.:  41.8 D482
Descriptors:  Mycobacterium avium subsp. paratuberculosis, disease eradication and control programs, diagnostic techniques, program results, Lower Saxony, Germany.

Forbes, P.; Kingham, L.  Played for it, got it. Experiences of OJD extension.  Wool and Sheepmeat Services Program Annual Conference, Tocal Agricultural Centre, Paterson, NSW, Australia, December 3-5, 2002.  NSW Agriculture. Orange, Australia.  2002; 139-144.
Descriptors:  sheep, Johne’s disease, Mycobacterium avium subsp. paratuberculosis, extension services to farmers, mycobacterial diseases, strategies for control and prevention, Australia

Fujita, Hiroshi; Eishi, Yoshinobu; Ishige, Ikuo; Saitoh, Kiyoshi; Takizawa, Touichirou; Arima, Terukatsu; Koike, Morio. Quantitative analysis of bacterial DNA from Mycobacteria spp., Bacteroides vulgatus, and Escherichia coli in tissue samples from patients with inflammatory bowel diseases. Journal of Gastroenterology. July 2002; 37(7): 509-516. ISSN: 0944-1174.
Descriptors: possible role of Mycobacterium, bowel diseases in humans.

Gerlach, G.F.  Paratuberkulose: Erreger und Uebertragungswege.  [Paratuberculosis: The pathogen and routes of infection.]  DTW (Deutsche Tieraerztliche Wochenschrift).  2002; 109(12): 504-506.  ISSN:  0341-6593.  Note:  In German with an English summary.  
NAL Call No.:  41.8 D482
Descriptors:  cattle, Mycobacterium avium subsp. paratuberculosis, disease control programs, disease prevalence, paratuberculosis, North Rhine Westphalia, Germany.

Glanemann, B.; Hoelzle, L.E.; Wittenbrink, M.M.  Bakteriologische Untersuchungen zur Paratuberkulose in Rinderbestaenden in der Schweiz.  [Bacteriological investigations about paratuberculosis in dairy herds in Switzerland.]  DTW (Deutsche Tieraerztliche Wochenschrift). 2002; 109(12): 528-529.  ISSN:  0341-6593.  Note:  In German.  
NAL Call No.:  41.8 D482
Descriptors:  cattle, antibodies, disease prevalence, paratuberculosis, Johne’s disease, fecal sampling, blood sera, ELISA assay, Mycobacterium avium subsp. paratuberculosis, Mycobacterium hassiacum, Mycobacterium thermoresistibile, genes, Switzerland.

Gomes, M.J.P.; Driemeier, D.; Ribeiro, V.R.; Wunder Junior, E.A.; Asanome, W.; Lanzon, L.F.; Wald, V.B. Doenca de Johne: isolamento do Mycobacterium avium subsp. paratuberculosis (MAP) em um rebanho leiteiro infectado na Regiao sul do Brasil.  [Johne's disease: isolation of Mycobacterium avium subsp. paratuberculosis (MAP) from an infected dairy herd in Southern Brazil.]  Acta Scientiae Veterinariae.  2002; 30(2): 113-118.  ISSN:  1678-0345.  Note:  In Portuguese with an English summary.
Descriptors:  8 Holstein cows, other animals, disease prevalence of Mycobacterium avium subsp. paratuberculosis, epidemiology, isolated and identified strains of MAP in bovine tissues, intestinal and lymph node, animals with and without clinical signs, culture in HEYM, estimate prevalence in infected herds using absorbed and non-absorbed ELISA, AGID assay, disease levels warrant a control program, Rio Grande do Sul, Brazil.

Grant, Irene R.; Hitchings, Edward I.; McCartney, Alan; Ferguson, Fiona; Rowe, Michael T. Effect of commercial-scale high-temperature, short-time pasteurization on the viability of Mycobacterium paratuberculosis in naturally infected cows' milk. Applied and Environmental Microbiology. February 2002; 68(2): 602-607. ISSN: 0099-2240.
NAL Call No.: 448.3 Ap5
URL: http://www.journals.asm.org
Descriptors: milk contamination control, APV HXP commercial scale pasteurizer, 4 different treatments, immunomagnetic separation PCR detection method, effects of homogenization, levels of contamination.

Grant, I.R.; Ball, H.J.; Rowe, M.T. Effectiveness of milk pasteurization in relation to Mycobacterium paratuberculosis. Research in Veterinary Science. April 2002; 72(Suppl. A): 29. ISSN: 0034-5288. Note: 56th Annual Conference of the Association of Veterinary Teachers and Research Workers on Current Topics in Veterinary Science, Scarborough, England, UK, March 25-27, 2002.
NAL Call No.: 41.8 R312
Descriptors: epidemiology, Mycobacterium avium subsp. paratuberculosis, contamination control, milk pasteurization treatments, Crohn’s disease, Johne’s disease.

Grant, Irene R.; Ball, Hywel J.; Rowe, Michael T. Incidence of Mycobacterium paratuberculosis in bulk raw and commercially pasteurized cows' milk from approved dairy processing establishments in the United Kingdom. Applied and Environmental Microbiology. May 2002; 68(5): 2428-2435. ISSN: 0099-2240.
URL: http://www.journals.asm.org
NAL Call No.: 448.3 Ap5
Descriptors: milk sampling, Mycobacterium avium subsp. paratuberculosis, immunomagnetic PCR, cell culture, low levels of Mycobacterium avium subsp. paratuberculosis, commercially pasteurized cows' milk, United Kingdom.

Greig, A.; Beard, P.; Daniels, M. J.; Henderson, D.; Hutchings, M.R.; Stevenson, K. The potential role of wildlife in the epidemiology of paratuberculosis in domestic animals. Research in Veterinary Science. April 2002; 72(Suppl. A): 30. ISSN: 0034-5288. Note: 56th Annual Conference of the Association of Veterinary Teachers and Research Workers on Current Topics in Veterinary Science, Scarborough, England, UK, March 25-27, 2002.
NAL Call No.: 41.8 R312
Descriptors: epidemiology, Mycobacterium avium subsp. paratuberculosis, wildlife as a disease reservoir, fox, rabbit, stoat, weasel, dairy cattle industry, Johne’s disease, transmission, United Kingdom.

Groenendaal, H.; Nielen, M.; Jalvingh, A.W.; Horst, S.H.; Galligan, D.T.; Hesselink, J.W.  A simulation of Johne's disease control.  Preventive Veterinary Medicine.  2002; 54(3): 225-245.  ISSN: 0167-5877.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5145&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=c5bc3d9e1bb66468352ae1f5475d522f
NAL Call No.:  SF601.P7
Descriptors:  dairy cows, Mycobacterium avium subsp. paratuberculosis, simulation models, disease control, bacterial diseases, epidemiology, economic analysis, infections, culling, calves, vaccination, milk yield, diagnosis, treatment, case reports, disease prevalence.

Guo, Hongyan; Naser, Saleh A; Ghobrial, George; Phanstiel, Otto IV. Synthesis and biological evaluation of new citrate-based siderophores as potential probes for the mechanism of iron uptake in mycobacteria. Journal of Medicinal Chemistry. May 9, 2002; 45(10): 2056-2063. ISSN: 0022-2623.
NAL Call No.: RS403.A1J6
URL: http://pubs.acs.org/jmc
Descriptors: bacterial pathogen, Mycobacterium avium subsp. paratuberculosis, iron uptake, mycobactin J, deferrioxamine B, acinetoferrin, nannochelin A, trans 2 octenoyl motif, trans cinnamoyl groups, iron binding ligands (C5), growth index values, at 2.4 muM a trans 2 octenoylated, citrate containing imide 6.

Gwozdz, J. M.; Thompson, K. G. Antigen-induced production of interferon-gamma in samples of peripheral lymph nodes from sheep experimentally inoculated with Mycobacterium avium subsp. paratuberculosis. Veterinary Microbiology. January 23, 2002; 84(3): 243-252. ISSN: 0378-1135.
NAL Call No.: SF601.V44
Descriptors: sheep, IFN-gamma, experimental oral inoculation, blood sampling, complement fixation test (CFT), agar gel diffusion test (AGID), enzyme-linked immunosorbent assay (ELISA), IFN-gamma test.

Halldorsdottir, Stefania; Englund, Stina; Nilsen, Sigrun Fredsvold; Olsaker, Ingrid. Detection of Mycobacterium avium subsp. paratuberculosis by buoyant density centrifugation, sequence capture PCR and dot blot hybridisation. Veterinary Microbiology. July 22, 2002; 87(4): 327-340. ISSN: 0378-1135.
URL: http://www.elsevier.com/locate/vetmic
NAL Call No.: SF601.V44
Descriptors: detection methods, bovine fecal samples, Percoll and IS900, alternative to bacterial culture.

Hammer, P.; Kiesner, C.; Walte, H.G.; Knappstein, K.; Teufel, P.  Heat resistance of Mycobacterium avium ssp. paratuberculosis in raw milk tested in a pilot plant pasteurizer.  Kieler Milchwirtschaftliche Forschungsberichte.  2002; 54(4): 275-297.  ISSN:  0023-1347.  Note:  In English with summaries in German and French.  
NAL Call No.:  44.9 K542
Descriptors:  raw milk, Mycobacterium avium subsp. paratuberculosis, pasteurization, time and temperature combination experiments, pathogen survival, heat treatment, heat resistance, macrophages, phagocytosis.

Hancox, M. Bovine tuberculosis: Milk and meat safety. Lancet North American Edition. February 23, 2002; 359(9307): 706-707. ISSN: 0099-5355.
NAL Call No.: 448.8 L22
Descriptors: bovine based food product safety, human health risks, Mycobacterium avium subsp. paratuberculosis, Campylobacter spp, bacterial disease contamination.

Harris, N. B.; Zinniel, D. K.; Hsieh, M. K.; Cirillo, J. D.; Barletta, R. G. Cell sorting of formalin-treated pathogenic Mycobacterium paratuberculosis expressing GFP. Biotechniques. March 2002; 32(3): 522-527. ISSN: 0736-6205.
NAL Call No.: RB37.A1B56
Descriptors: Mycobacterium avium subsp. paratuberculosis, occupational safety, laboratory employees, pathogenic organisms, GFP fluorophore, safe handling without biosafety level II and III equipment.

Hasvold, H.J.; Valheim, M.; Berntsen, G.; Storset, A.K.  In vitro responses to purified protein derivate of caprine T lymphocytes following vaccination with live strains of Mycobacterium avium subsp. paratuberculosis.  Veterinary Immunology and Immunopathology.  2002; 90(1-2): 79-89.  ISSN:  0165-2427.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5189&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=f5f60e05fe0e447c7311059c14754776
NAL Call No.:  SF757.2.V38
Descriptors:  goats, goat kids, Mycobacterium avium subsp. paratuberculosis, Johne’s disease, live vaccines, vaccine development, T lymphocytes, immune response, immunity, immunology, interferon, interleukin-2. 

Hermon, Taylor John; Bull, Tim. Crohn's disease caused by Mycobacterium avium subspecies paratuberculosis: A public health tragedy whose resolution is long overdue. Journal of Medical Microbiology. January, 2002; 51 (1): 3-6. ISSN: 0022-2615
NAL Call No.: QR1.J62
Descriptors: animal and human pathogen, zoonotic aspects, human health risks, contaminated animal products.

Hermon, Taylor J.; Bull, T.; Boumedine, K.; McMinn, E.; Skull, A. Keynote: Mycobacterium avium subsp. paratuberculosis in animals, food and water supplies, and its impact on human health. Research in Veterinary Science. April 2002; 72(Suppl. A): 28. ISSN: 0034-5288. Note: 56th Annual Conference of the Association of Veterinary Teachers and Research Workers on Current Topics in Veterinary Science, Scarborough, England, UK, March 25-27, 2002.
NAL Call No.: 41.8 R312
Descriptors: epidemiology, Mycobacterium avium subsp. paratuberculosis, cattle, humans, rabbits, sheep, human health risks, Johne’s disease.

Hermon, Taylor J. Treatment with drugs active against Mycobacterium avium subsp. paratuberculosis can heal Crohn's disease: More evidence for a neglected public health tragedy. Digestive and Liver Disease. January 2002; 34(1): 9-12. ISSN: 1590-8658.
Descriptors: clinical immunology, bacterial infection, Mycobacterium avium subsp. paratuberculosis, pathogens, clarithromycin, clofazimine, rifabutin, Crohn's disease, therapy.

Herva, T.  Turvallinen kumppani - hanke selvittaa elaintautien esiintymista.  [Safe company - plan for solving the disease situation.]  Suomen Elainlaakarilehti.  2002; 108(9): 507-510.  ISSN:  0039-5501.  Note:  In Finnish.
NAL Call No.:  41.8 F49
Descriptors:  cattle, disease prevention and control, diseases of concern, bovine diarrhea virus, Mycobacterium avium subsp. paratuberculosis, Trichophyton verrucosum, Finland.

Hirst, Heather L.; Garry, Franklyn B.; Salman, M.D. Assessment of test results when using a commercial enzyme-linked immunosorbent assay for diagnosis of paratuberculosis in repeated samples collected from adult dairy cattle. Journal of the American Veterinary Medical Association. June 1, 2002; 220(11): 1685-1689. ISSN: 0003-1488.
URL: http://www.avma.org
NAL Call No.: 41.8 Am3
Descriptors: dairy cows, cattle, ELISA, antibody detection, Mycobacterium avium subsp. paratuberculosis, serum samples, 2 sampling times, control measures.

Homuth, M. Diagnostik der Paratuberkulose.  [Diagnostics for paratuberculosis.]  DTW (Deutsche Tieraerztliche Wochenschrift).  2002; 109(12): 516-519.  ISSN:  0341-6593.
NAL Call No.:  41.8 D482
Descriptors:  Mycobacterium avium subsp. paratuberculosis, Johne’s disease, diagnostic techniques, control programs, paratuberculosis, various diagnostic approaches, advantages and disadvantages of methods, review article.

Hostetter, Jesse M.; Steadham, Edward M.; Haynes, Joseph S.; Bailey, Theodore B.; Cheville, Norman F.  Cytokine effects on maturation of the phagosomes containing Mycobacteria avium subspecies paratuberculosis in J774 cells.  FEMS Immunology and Medical Microbiology.  2002; 34(2): 127-134.  ISSN:  0928-8244.  
Descriptors:  Mycobacterium avium subsp. paratuberculosis, J774 cell lines, cytokines, interferon, lipopolysaccharides, lysosomes, macrophage activation, paratuberculosis.

Hutchings, M.R.; Daniels, M.J.; Henderson, D.; Greig, A. Wildlife to ruminant transmission routes for M. a. paratuberculosis. Research in Veterinary Science. April 2002; 72(Suppl. A): 30. ISSN: 0034-5288. Note: 56th Annual Conference of the Association of Veterinary Teachers and Research Workers on Current Topics in Veterinary Science, Scarborough, England, UK, March 25-27, 2002.
NAL Call No.: 41.8 R312
Descriptors: epidemiology, Mycobacterium avium subsp. paratuberculosis, wildlife as a disease reservoir, cattle, rabbit, rodents, dairy cattle industry, Johne’s disease, transmission, United Kingdom.

Jones, P.H.; Farver, T.B.; Beaman, B.L.; Cetinkaya, B.; Morgan, K. L. Chronic gastrointestinal diseases in dairy farmers in England and the Welsh borders: Is there an association between Crohn's disease and bovine paratuberculosis? Research in Veterinary Science. April 2002; 72(Suppl. A): 30-31. ISSN: 0034-5288. Note: 56th Annual Conference of the Association of Veterinary Teachers and Research Workers on Current Topics in Veterinary Science, Scarborough, England, UK, March 25-27, 2002.
NAL Call No.: 41.8 R312
Descriptors: epidemiology, potential for zoonotic disease, Mycobacterium avium subsp. paratuberculosis, possible work related illness, dairy cattle industry, dairy farmers, Johne’s disease, United Kingdom.

Jungersen, G.; Huda, A.; Hansen, J.J.; Lind, P.  Interpretation of the gamma interferon test for diagnosis of subclinical paratuberculosis in cattle.  Clinical and Diagnostic Laboratory Immunology.  2002; 9(2): 453-460.  ISSN:  1071-412X.
URL:  http://www.pubmedcentral.gov/tocrender.fcgi?action=archive&journal=84
Descriptors:  Kongeaa project, 252 cattle with no signs of Johne’s in 10 infected herds, 117 cattle in 5 herds no Johne’s, whole blood stimulated with bovine, avian and johnin purified protein derivative, checked for IFN gamma release, specificity data, false positives noted, cross reactions, Denmark.

Kalis, C.H.J.; Barkema, H.W.; Hesselink, J.W.; van Maanen, C.; Collins, M.T.  Evaluation of two absorbed enzyme-linked immunosorbent assays and a complement fixation test as replacements for fecal culture in the detection of cows shedding Mycobacterium avium subspecies paratuberculosis.  Journal of Veterinary Diagnostic Investigation.  2002; 14(3): 219-224.  ISSN:  1040-6387.
NAL Call No.:  SF774.J68
Descriptors:  dairy cattle, Johne’s disease, Mycobacterium avium subsp. paratuberculosis, prevention of disease from cows to calves, disease control with management strategies, 2 different ELISAs and a complement fixation test compared, carrier state, diagnosis, diagnostic techniques, diagnostic value, level of pathogen shedding.

Kavanagh, N.  Milk borne zoonotic infections.  Cattle Practice.  2002; 10(1): 15-18.  ISSN:  0969-1251.
NAL Call No.:  SF961.C37
Descriptors:  food borne illness, raw milk, other milk products, salmonellosis, Salmonella typhimurium DT104, E. coli 0157, Campylobacter, Mycobacterium avium subsp. paratuberculosis, Crohn’s disease, bovine tuberculosis, United Kingdom, Republic of Ireland.

Kim Doo; Jeon KwanJoon; Kim JongTaek; Shin KwangSoon; Shin MyungKyun; Chang GukHyun; Kim JeungKi; Kim OchSung; Jung JaeYoung.  Prevalence of paratuberculosis of dairy cattle in Kangwon area.  Korean Journal of Veterinary Research.  2002; 42(1): 81-88.  ISSN:  1225-0198.  Note:  In Korean with an English summary.
Descriptors:  2261 dairy cows, 162 herds, serotesting, ELISA, immunoblotting with recombinant 43 KDa protein of Mycobacterium avium subsp. paratuberculosis, fecal culture, HEYM with mycobactin J, PCR, sensitivity and specificity for each method, Korean Republic.

Kim, S.G.; Shin, S.J.; Jacobson, R.H.; Miller, L.J.; Harpending, P.R.; Stehman, S.M.; Rossiter, C.A.; Lein, D.A.  Development and application of quantitative polymerase chain reaction assay based on the ABI 7700 system (TaqMan) for detection and quantification of Mycobacterium avium subsp. paratuberculosis.  Journal of Veterinary Diagnostic Investigation.  2002; 14(2): 126-131.  ISSN:  1040-6387.
NAL Call No.:  SF774.J68
Descriptors:  development and application of diagnostic techniques, Johne’s disease, nucleotide sequences, PCR, IS900 TaqMan, useful in determining viable cell numbers over the incubation period, Mycobacterium strain differences, Mycobacterium avium subsp. paratuberculosis ATCC 19698, Mycobacterium fortuitum, Mycobacterium intracellulare, Mycobacterium kansasii, Mycobacterium marinum, Mycobacterium phlei, Mycobacterium smegmatis, Mycobacterium terrae, Mycobacterium ulcerans, Mycobacterium asiaticum, Mycobacterium simiae, Mycobacterium abscessus, Mycobacterium avium subsp. avium, Mycobacterium bovis, Mycobacterium fortuitum subsp. fortuitum, Mycobacterium scrofulaceum, Mycobacterium ulcerans, 9 non-mycobacterial species, Borrelia burgdorferi, Chlamydia psittaci, Ehrlichia canis, Ehrlichia equi, Ehrlichis risticii, Escherichia coli, Escherichia coli O157:H7, Streptococcus equi, Streptococcus zooepidemicus.

Klawonn, W.; Cussler, K.; Draeger, K. G.; Gyra, H.; Koehler, H.; Zimmer, K.; Hess, R.G.  Zur Bedeutung von allergischem Hauttest mit Johnin, Antikoerper-ELISA, kultureller Kotuntersuchung sowie der Impfung fuer die Sanierung dreier chronisch Paratuberkulose-infizierter Milchviehherden in Rheinland-Pfalz.  [Evaluation of intradermal test with Johnin, antibody ELISA, microbial culture and vaccination for sanitation of three chronically paratuberculosis infected dairy herds in Rhineland-Palatinate.]  DTW (Deutsche Tieraerztliche Wochenschrift).  2002; 109(12): 510-516.  ISSN:  0341-6593.  Note:  In German with an English summary.  
NAL Call No.:  41.8 D482
Descriptors:  cattle, calves, culling sick animals, Mycobacterium avium subsp. paratuberculosis, antibodies, diagnostic techniques, disease control, granuloma, immunization, paratuberculosis, sanitation, skin tests, vaccination, Rhineland Palatinate, Germany.

Koets, Ad; Rutten, Victor; Hoek, Aad; van Mil, Frans; Muller, Kerstin; Bakker, Douwe; Gruys, Erik; van Eden,Willem. Progressive bovine paratuberculosis is associated with local loss of CD4+ T cells, increased frequency of gammadelta T cells, and related changes in T cell function. Infection and Immunity. July 2002; 70(7): 3856-3864. ISSN: 0019-9567.
NAL Call No.: QR1.I57
Descriptors: Mycobacterium avium subsp. paratuberculosis, loss of cell mediated response, immune reactivity of intestine, cows, etiology.

Krayc, B.; Schonthaler, D. [Editors]  Tagungsbericht 1. Fachtagung fur Ziegenzuchter und -halter zum Thema Ziegenzucht und Ziegenhaltung, 12. November und 13. November 2002, BAL Gumpenstein, Irdning, Austria[Conference report. 1. Specialist Conference for Goat Breeders and Keepers on the Theme of Goat Breeding and Management.  12-13 November, 2002 at BAL Gumpenstein, Austria.]  Published by Bundesanstalt fur Alpenlandische Landwirtschaft Gumpenstein.  Irdning, Austria.  2002; 50.  Note:  In German.
Descriptors:  12 papers, goats, breeding, nutritional value of goat products, improving goats milk, milk protein variations, grazing in alpine regions, feeding and feeds, inbreeding, tuberculosis and Johne’s disease, other diseases, mastitis, Austria.

Langelaar, M.; Koets, A.; Muller, K.; van Eden, W.; Noordhuizen, J.; Howard, C.; Hope, J.; Rutten, V. Mycobacterium paratuberculosis heat shock protein 70 as a tool in control of paratuberculosis. Veterinary Immunology and Immunopathology. September 10, 2002; 87(3-4): 239-244. ISSN: 0165-2427.
NAL Call No.: SF757.2.V38
URL: http://www.elsevier.com/locate/vetimm
Descriptors: Mycobacterium avium subsp. paratuberculosis, cattle, antibody titers, rHsp 70, shuttle antigen, interaction between APC and Fitc-labelled rHsp70, FACS analysis, uptake.

Leid, J.G.; Hunter, D.; Speer, C.A.  Early diagnosis of Johne's disease in the American bison by monoclonal antibodies directed against antigen 85.  In:  Gibbs, E. P. J.; Bokma, B.H. [Editors].  The Domestic Animal/Wildlife Interface: Issues for Disease Control, Conservation, Sustainable Food Production, and Emerging Diseases Conference and Workshop Organised by the Society for Tropical Veterinary Medicine and the Wildlife Diseases Association Wildlife and Livestock, Disease and Sustainability: What Makes Sense?  Pilanesberg National Park, South Africa, 22-27 July, 2001.  New York Academy of Sciences, New York.  2002; 66-72.  ISBN:  1573314382
NAL Call No.:  500 N484 v. 969
Descriptors:  American bison, experimental infection with Mycobacterium avium subsp. paratuberculosis, diagnostic monoclonal antibodies, mice hybridomas, Mycobacterium bovis antigen 85, sera from 100 inoculated bison, indicate monoclonal antibodies can be reliable diagnostic test.

Leine, N.  Friskare geiter" - eit smittesaneringsprosjekt: med malsetting a sanere sjukdommane CAE, byllesjuke og paratuberkulose i norske geitebuskapar.   ['Healthy goats' - a project for the eradication of infectious diseases.]  Norsk Veterinaertidsskrift.  2002; 114(3): 313-315.  ISSN:  0332-5741.  Note:  In Norwegian.  
Descriptors:  goat herds, 20 farms tested, disease elimination, caprine arthritis encephalitis, Johne's disease, Mycobacterium avium subsp. paratuberculosis, and caseous lymphadenitis Corynebacterium pseudotuberculosis, information dissemination, establishing a base line of infections, serological survey, Norway.

Lewis, C.  Developing a healthy flock.  In Practice.  2002; 24(1): 12-16.  ISSN:  0263-841X.
NAL Call No.:  SF601.I4
Descriptors:  sheep, husbandry, management, replacement rates, abortion, many diseases mentioned, toxicities, pyrethroid insecticides, organophosphate insecticides, vaccination, transport of animals, nematodes, avermectins, scrapie, various bacterial diseases including Mycobacterium avium subsp. paratuberculosis, viral diseases, external and internal parasites, disease prevention.

Links, I.J.; Evers, M.; Denholm, L.J.  Progress with Ovine Johne's Disease Control in New South Wales - update November 2002.  Wool and Sheepmeat Services Program Annual Conference, Tocal Agricultural Centre Paterson, NSW, Australia, 3-5 December 2002.  NSW Agriculture.  Orange, Australia.  2002; 85-87.  
Descriptors:  sheep, lambs, Johne’s disease, mycobacterial diseases, Mycobacterium avium subsp. paratuberculosis, disease prevalence, epidemiology, diagnosis, disease control, immunity, immunization, vaccination, vaccine development, New South Wales, Australia.

Lund, Barbara M.; Gould, Grahame W.; Rampling, Anita M. Pasteurization of milk and the heat resistance of Mycobacterium avium subsp. paratuberculosis: A critical review of the data. International Journal of Food Microbiology. July 25, 2002; 77(1-2): 135-145. ISSN: 0168-1605.
URL: http://www.elsevier.com/locate/ijfood,icro
NAL Call No.: QR115.I57
Descriptors: Mycobacterium avium subsp. paratuberculosis, heat resistance, Johne’s disease, Crohn’s disease, heat treatment parameters, performance criterian, human health risks, post-pasteurization contamination control.

Luyven, G.; Vom Schloss, A.; Sasserath, M.  Paratuberkulosesanierung in Nordrhein-Westfalen.  [Paratuberculosis eradication programs in North Rhine, Westfalia.]  DTW (Deutsche Tierarztliche Wochenschrift).  2002; 109(12): 524-527.  ISSN:  0341-6593.  Note:  In German with an English summary.  
NAL Call No.:  41.8 D482
Descriptors:  Mycobacterium avium subsp. paratuberculosis, Johne’s control programs, testing, herd management, North Rhine, Westphalia, Germany.

Mackintosh, C. G. Johne's disease in deer: Prospects for control. Proceedings of the New Zealand Society of Animal Production. 2002; 62: 303-306. ISSN: 0370-2731.
NAL Call No.: 49.9 N483
Descriptors: farmed deer, disease prevention and control, Mycobacterium avium subsp. paratuberculosis, clinical picture, detection of subclinical infections, culling, depopulation, restocking, New Zealand.

Magnano, G.; Schneider, M.; Carranza, A.; Bergamo, E.; Henriquez, M.B.; Giraudo, J.A.  Evaluacion serologica de paratuberculosis en el sudoeste de la provincia de Cordoba, Argentina.  [Serologic evaluation of paratuberculosis in the southernwest area of Cordoba province, Argentina.]  Veterinaria Argentina.  2002; 19(190): 741-746.  ISSN:  0326-4629.  Note:  In Spanish with an English summary.  
NAL Call No.:  SF604.V463
Descriptors:  beef cattle herds, 19 farms, serological survey, ELISA, low percentages for Mycobacterium avium subsp. paratuberculosis, Cordoba province, Argentina.

Mahavir Singh; Siddiqui, M.Z.; Singh, R.P.  Intra-species mice hybridomas against a recombinant protein of Mycobacterium avium paratuberculosis.  Journal of Applied Animal Research.  2002; 22(1): 137-144.  ISSN:  0971-2119.  Note:  In English with a Hindi summary.
NAL Call No.:  SF55.I4J68
Descriptors:  mice, intra-species mice hybridomas, 35kDa antibodies of Mycobacterium avium subsp. paratuberculosis primed splenocytes of Swiss white mice with BALB/c derived myeloma cells, DNA cloning, hybridomas, IgG, immune response, monoclonal antibodies, recombinant proteins, macrophages, immunoblots.  

Mahmoud, O. M.; Haroun, E. M.; Elfaki, M. G.; Abbas, B. Pigmented paratuberculosis granulomata in the liver of sheep. Small Ruminant Research. March 2002; 43(3): 211-217. ISSN: 0921-4488.
URL: http://www.elsevier.com/locate/smallrumres
NAL Call No.: SF380.I52
Descriptors: Johne’s disease, sheep, description of granulomata, epitheloid cells, basophilic granules, fibrous capsule, intestinal lesions, ileum, rectum, mesenteric lymph nodes, acid fast bacteria, Mycobacterium avium subsp. paratuberculosis, yellowish orange pigment.

Mainali, C.  Alberta's Johne's disease control program.  Advanced Dairy Technology.  2002.  14: 77-82.  ISSN: 1184-0684. Note:  Paper presented at the Western Canadian Dairy Seminar, March 5-8, 2002, Red Deer, Alberta.
NAL Call No.:  SF223.W478
Descriptors:  dairy cows, Mycobacterium avium subsp. paratuberculosis, Johnes’ disease control program, Alberta, Canada.  

Manjurano, A.; Karimuribo, E.D.; Mdegela, R.H.; Kusiluka, L.I.M.; Kipanyula, M.I.; Kambarage, D.M.  Prevalence of Mycobacterium avium subspecies paratuberculosis infection in cattle in the southern highlands of Tanzania.  In:  Kazwala, R.R.; Mbaga, S.H.; Kusiluka, L.J.M.; Laswai, G.  [Editors].  Proceedings of the Joint 17th Scientific Conference of the Tanzania Society for Animal Production and the 20th Scientific Conference of the Tanzania Veterinary Association held at AICC Arusha, Tanzania, 3-5 December 2002.  Published by Tanzania Society of Animal Production, Morogoro, Tanzania.  2002; 351-359.  
Descriptors:  dairy cattle, dairy herds, Johne’s disease, disease prevalence, Mycobacterium avium subsp. paratuberculosis, disease prevalence, fecal sampling, age differences, disease surveys, epidemiology, paratuberculosis, Tanzania.

Marco, Ignasi; Ruiz, Maria; Juste, Ramon; Garrido, Juan Manuel; Lavin, Santiago.  Paratuberculosis in free-ranging fallow deer in Spain.  Journal of Wildlife Diseases.  2002; 38(3): 629-632.  ISSN:  0090-3558.
URL:  http://www.jwildlifedis.org/
NAL Call No.:  41.9 W64B
Descriptors:  fallow deer, Dama dama, gross lesions, post mortem examination and histopathology, PCR, indirect ELISA, immunodiffusion tests, sera testing, Mycobacterium avium subsp. paratuberculosis, Regional Hunting Reserve of El Sueve, Asturias, Spain.

McClure, P.J.  Microbiological hazard identification in the meat industry.  Kerry, J.; Kerry, J.; Ledward, D. [Editors]  Meat Processing: Improving Quality.  Woodhead Publishing Ltd.  Cambridge, UK.  2002; 217-236.  ISBN:  1855735830.
Descriptors:  microbial hazards of meat and meat products, foodborne illnesses, zoonotic diseases, analytical detecting methods, Salmonella, Escherichia coli, Campylobacter jejuni, Yersinia enterocolitica, Staphylococcus aureus, Listeria monocytogenes, Clostridium perfringens, Clostridium botulinum, Mycobacterium avium subsp. paratuberculosis, other bacteria, parasites, prions, viruses.

Mehta, B.M.; Mehta, F.M.; Borkhatriya, V.N.  Mycobacterium avium ssp. paratuberculosis: an overview.  Indian Dairyman.  2002; 54(11): 63-68.  ISSN:  0019-4603.
NAL Call No.:  44.8 IN282
Descriptors:  cattle, Johne’s disease, Mycobacterium avium subsp. paratuberculosis, diagnosis, disease transmission, public health, zoonoses, India.

Menzies, F.D.; Reid, S.W.J. [Editors]  Society for Veterinary Epidemiology and Preventive Medicine. Twentieth Anniversary Proceedings of a Meeting Held at University of Cambridge, UK, 3rd-5th April, 2002.  Published by the Society.  Roslin, UK.  2002; 220 p.  ISBN:  0948073543.
Descriptors:  sheep, horses, pigs, cattle, epidemiology, preventative medicine, risk factors, mathematical models for analysis, impact of housing systems, methods for assessing sensitivity and specificity of diagnostic techniques, equine influenza, foot and mouth disease, Johne's disease, salmonellosis, encephalomyocarditis, toxoplasmosis, helminthoses, colic, lameness, fetal death, isoflurane and halothane toxicity.

Mori, Yasuyuki; Kikuma, Reiko; Muneta, Yoshihiro; Yoshihara, Kazuhiro; Hikono, Hirokazu; Momotani, Eiichi.  Studies on the diagnostic methods for bovine paratuberculosis.  Bulletin of the National Institute of Animal Health.  2002; (109): 33-42.  ISSN:  1347-2542.  Note: In Japanese.
Descriptors:  Mycobacterium avium subsp. paratuberculosis, diagnostic methods, cytokines, diagnosis, interferon, monoclonal antibodies, monocytes, paratuberculosis, pathogenesis, tuberculin, fecal testing, PCR test with internal control DNA is accurate, sensitive and rapid, interferon gamma (IFN-gamma) assay using johnin purified protein derivative (J-PPD), bovine tuberculin PPD and concanavalin A (Con A), IFN-gamma responses against J-PPD highest in affected animals.

Mullerad, J.; Hovav, A.; Fishman, Y.; Barletta, R.G.; Bercovier, H.  Antigenicity of Mycobacterium paratuberculosis superoxide dismutase in mice.  FEMS Immunology and Medical Microbiology.  2002; 34(1): 81-88.  ISSN:  0928-8244.
URL:  http://www.blackwellsynergy.com/servlet/useragent?func=showIssues&code=fim
NAL Call No.:  QR180.F46
Descriptors:  mice, cattle disease, Mycobacterium avium subsp. paratuberculosis, effective control needed, acellular vaccine, immunized mice with MPT superoxide dismutase alone or adjuvanted by Ribi, purified antigen in E. coli, results indicate exploring antigen for future acellular vaccine. 

Mullerad, Jacob; Michal, Israel; Fishman, Yolanta; Hovav, Avi Hai; Barletta Raul, G.; Bercovier, Herve. The immunogenicity of Mycobacterium paratuberculosis 85B antigen. Medical Microbiology and Immunology. March 2002; 190(4): 179-187. ISSN: 0300-8584.
Descriptors: Mycobacterium avium subsp. paratuberculosis, mouse model, laboratory experiment, immune response, recombinant MPT 85B in Ribi adjuvant, anti-85B antibody production of all classes tested, IgG1/IgG2a ratio, cellular vaccine candidate.

Murray, Dupont C. Vaccination against Johne's disease. Proceedings of the New Zealand Society of Animal Production. 2002; 62: 288-289. ISSN: 0370-2731.
NAL Call No.: 49.9 N483
Descriptors: control, immunogenic cell surface associated and secreted proteins, New Zealand field isolate, Mycobacterium avium subsp. paratuberculosis, possible subunit vaccine, adverse effects of vaccination, TB testing.

Muskens, J.; van Zijderveld, F.; Eger, A.; Bakker, D. Evaluation of the long-term immune response in cattle after vaccination against paratuberculosis in two Dutch dairy herds. Veterinary Microbiology. May 1, 2002; 86(3): 269-278. ISSN: 0378-1135.
URL: http://www.elsevier.com/locate/vetmic
NAL Call No.: SF601.V44
Descriptors: vaccination, paratuberculosis, tuberculosis, herd health, serological screening, cattle 3 years old, vaccine testing, heat killed paratuberculosis vaccine, 12-14 year study, 2 herds, The Netherlands, effect of vaccination on both cellular and humoral immune responses, paratuberculosis antigen, bovine tuberculosis antigen, long lasting interference, Mycobacterium avium subsp. paratuberculosis.

Mutwiri, George K.; Rosendal, Soren; Kosecka, Ula; Yager, Julie A.; Perdue, Mary; Snider, Denis; Butler, Daniel G. Adoptive transfer of BALB/c mouse splenocytes reduces lesion severity and induces intestinal pathophysiologic changes in the Mycobacterium avium subspecies paratuberculosis beige/scid mouse model. Comparative Medicine. August 2002; 52(4): 332-341. ISSN: 1532-0820.
NAL Call No.: SF77. C65
Descriptors: mouse model, beige/scid strain, resistance, introperitoneal inoculation, immune reconstruction.

Nettles, Victor F.; Quist, Charlotte F.; Lopez, Roel R.; Wilmers, Tom J.; Frank, Phil; Roberts, Wayne; Chitwood, Sharon; Davidson, William R.  Morbidity and mortality factors in Key deer (Odocoileus virginianus clavium).  Journal of Wildlife Diseases.  2002; 38(4): 685-692.  ISSN:  0090-3558.
URL:  http://www.jwildlifedis.org/
NAL Call No.:  41.9 W64B
Descriptors:  Key deer, Odocoileus virginianus clavium, wild animals, endangered species, protected species, population levels, causes of death, morbidity, mortality, nature reserves, postmortem examinations, pathogens, salmonellosis, Arcanobacterium pyogenes, Haemonchus contortus, Mycobacterium avium subsp. paratuberculosis, Johne’s disease, Salmonella, Florida, United States.

New South Wales Agriculture.  Ovine Johne's Disease in New South Wales Quarterly Disease Surveillance Report. 2002.  Note:  Quarterly reports are at the website below.
URL:  http://www.dpi.nsw.gov.au/agriculture
Descriptors:  sheep, Johne’s disease, Mycobacterium avium subsp. paratuberculosis, disease surveys, disease control, monitoring disease distribution and prevalence, epidemiology, New South Wales, Australia.

New Zealand Society of Animal Production.  62nd Conference, Massey University, New Zealand, 24-26 June 2002.  Proceedings of the New Zealand Society of Animal Production.  2002; 62: 388.  ISSN:  0370-2731.  Note:  A compilation of 92 scientific articles from a conference on dairy, sheep, and beef production.
NAL Call No.:  49.9 N483
Descriptors:  cattle, sheep, production systems, wool, milk, meat, nutrition, forages, Johne’s disease, reproduction, breeding, animal welfare, New Zealand.

Nielsen, Soren S.; Gronbaek, Carsten; Agger, Jens F.; Houe, Hans. Maximum-likelihood estimation of sensitivity and specificity of ELISAs and faecal culture for diagnosis of paratuberculosis. Preventive Veterinary Medicine. March 14, 2002; 53(3): 191-204. ISSN: 0167-5877.
NAL Call No.: SF601.P7
Descriptors: Mycobacterium bovis, Mycobacterium avium subsp. paratuberculosis, 3 diagnostic tests, 2 ELISA’s, fecal cultures, use of tests for screening and for confirmation, discussion of test selection.

Nielsen, Soren S.; Enevoldsen, Carsten; Grohn, Yrjo T. The Mycobacterium avium subsp. paratuberculosis ELISA response by parity and stage of lactation. Preventive Veterinary Medicine. May 30, 2002; 54(1): 1-10. ISSN: 0167-5877.
URL: http://www.elsevier.com/locate/prevetmed
NAL Call No.: SF601.P7
Descriptors: ELISA, Johne’s disease, cows, milk samples, serum samples, antibody detection, interpretation, detection, tentative diagnosis.

Nielsen, S. S.; Grohn Y. T.; Quaas, R.L; Agger, J. F. Paratuberculosis in dairy cattle: Variation of the antibody response in offspring attributable to the dam. Journal of Dairy Science. February 2002; 85(2): 406-412. ISSN: 0022-0302.
URL: http://www.ADSA.org/jds
NAL Call No.: 44.8 J822
Descriptors: transmission factors, Mycobacterium avium subsp. paratuberculosis, dairy cattle, ELISA antibody testing, contribution from parents, heritability of susceptibility and vertical transmission, control programs, etiology, epidemiology.

Nielsen, K.K.; Ahrens, P.  Putative in vitro expressed gene fragments unique to Mycobacterium avium subspecies paratuberculosis.  FEMS  Microbiology Letters.  2002; 214(2): 199-203.  ISSN: 0378-1097.
URL:  http://www.blackwell-synergy.com/servlet/useragent?func=showIssues&code=fml
NAL Call No.:  QR1.F44
Abstract:  By a suppression subtractive hybridization based method, nine novel Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) fragments of between 318 and 596 bp have been identified and characterized.  Database search revealed little or no similarity with other mycobacteria.  The uniqueness and diagnostic potential of seven of these fragments in relation to M. paratuberculosis closest relative Mycobacterium avium subsp. avium (M. avium) was confirmed by species-specific PCR and Southern blot.  Furthermore, RT-PCR indicated that eight of the nine fragments originate from areas of the genome that are expressed in vitro.
Descriptors:  Mycobacterium paratuberculosis, nucleotide sequences, Mycobacterium avium subsp. paratuberculosis.

Nielsen, S.S.  Variance components of an enzyme-linked immunosorbent assay for detection of IgG antibodies in milk samples to Mycobacterium avium subspecies paratuberculosis in dairy cattle.  Journal of Veterinary Medicine Series B.  2002; 49(8): 384-387.  ISSN:  0931-1793.
URL:  http://www.blackwellpublishing.com/journal.asp?ref=0931-1793&site=1
NAL Call No.:  41.8 Z52
Descriptors:  cattle, 120 cows, ELISA anitibody testing, Johne’s diagnosis, variance components, mixed model theory, milk sampling, Mycobacterium avium subsp. paratuberculosis, IgG, laboratory variability.

Nielsen, S.S.; Grohn, Y.T.; Enevoldsen, C.  Variation of the milk antibody response to paratuberculosis in naturally infected dairy cows.  Journal of Dairy Science.  2002; 85(11): 2795-2802.  ISSN:  0022-0302.
URL:  http://www.adsa.org/jds/abs/2002/d02B2795.htm
NAL Call No.:  44.8 J822
Descriptors:  812 dairy cows, milk antibody response, fecal culture, Mycobacterium avium subsp. paratuberculosis, asymptomatic infection, antibody formation, diagnostic methods, ELISA, longitudinal study, 4289 observations, model controlled for effect of herd, breed, laboratory effects, age of calving, effect over time of lactation.

Nsengwa, G.; Massele, R.M.; Udoba, C.N.A.  Further confirmation of Johne's disease at Kitulo Dairy Farm in southern highlands of Tanzania and its economic implication.  In:  Kazwala, R.R.; Mbaga, S.H.; Kusiluka, L.J.M.; Laswai, G.  Proceedings of the Joint 17th Scientific Conference of the Tanzania Society for Animal Production and the 20th Scientific Conference of the Tanzania Veterinary Association held at AICC Arusha, Tanzania, 3-5 December 2002.  Tanzania Society of Animal Production, Morogoro, Tanzania.  2002; 332-339.  
Descriptors:  dairy cows, dairy farms, Johne’s disease, case reports, Mycobacterium avium subsp. paratuberculosis, clinical aspects, post mortem examination, lesions, histopathology, economics, epidemiology, paratuberculosis, Tanzania.

Ocepek, M.; Krt, B.; Pate, M.; Pogacnik, M.  Seroprevalence of paratuberculosis in Slovenia between 1999 and 2001.  Slovenian Veterinary Research.  2002; 39(3/4): 179-185.  ISSN:  1580-4003.  Note:  In English with a Swedish summary.
Descriptors: 38,469 cattle serum samples, 12,578 sheep and goats serum samples Mycobacterium avium subsp. paratuberculosis, disease survey, disease prevalence, diagnostic techniques, antibody testing kits, ELISA, immunodiagnosis, movement of animals transmits disease, Slovenia.

O'Doherty, A.; O' Grady, D.; Smith, T.; Egan, J. Mycobacterium avium subsp. paratuberculosis in pasteurised and unpasteurised milk in the Republic of Ireland. Irish Journal of Agricultural and Food Research. June 2002; 41(1): 117-121. ISSN: 0791-6833.
NAL Call No.: S539.5.I74
Descriptors: milk samples, unpasteurized, bulk sampling, cattle, goats, retail pasteurized milk sampling, decontamination with hexadecyl pyridinium chloride, cultured for Mycobacterium avium subsp. paratuberculosis, Bactec B12B and Herrold's Egg Yolk medium.

O'Doherty, A.; O'Grady, D.; O'Farrell, K.; Smith, T.; Egan, J.  Survey of Johne's disease in imported animals in the Republic of Ireland.  Veterinary Record.  2002; 150(20): 634-636.  ISSN:  0042-4900.
URL:  http://veterinaryrecord.bvapublications.com/
NAL Call No.:  41.8 V641
Descriptors:  224 imported animals, 36 herd health, carriers of Mycobacterium avium subsp. paratuberculosis, serum testing, ELISA assay failed to detect animals in early stages of disease, feces, disease prevalence, data from disease survey, Denmark, France, Irish Republic, The Netherlands.

Olsen, I.; Siguroardottir, O. G.; Djonne, B. Paratuberculosis with special reference to cattle. A review. Veterinary Quarterly. February 2002; 24(1): 12-28. ISSN: 0165-2176.
NAL Call No.: SF601 V46
Descriptors: cattle disease, description, symptoms, world-wide economic effects, control, clinical importance, pathology, immunology, properties of infectious agent, identification of subclinical infections, diagnostic methods evaluated, Mycobacterium avium subsp. paratuberculosis.

O'Mahony, J.; Hill, C.  A real time PCR assay for the detection and quantitation of Mycobacterium avium subsp. paratuberculosis using SYBR Green and the Light Cycler. Journal of Microbiological Methods.  2002; 51(3): 283-293.  ISSN:  0167-7012.
URL:  http://www.elsevier.com/cdweb/views/article.htt?jnl=01677012&iss=3&vol=51&pii=S016770120200098
NAL Call No.:  QR65.J68
Descriptors:  Mycobacterium avium subsp. paratuberculosis, Johne’s disease, Crohn’s disease, rapid detection methods, rapid real time PCR assay to detect and quantify, SYBR Gree and Lightcycler, P90, P91 primers, which amplify a 400-bp region of the IS900 element, can detect as few as 20 copies.

Pang, Victor Fei; Lee, Chia Hao; Chueh, Ling Ling; Liu, Chen Hsuan; Cheng, Chiung Hsian; Chiou, Huey Ing; Chang, Chih Cheng; Fu, Yng Bin; Chang, Chih Hua; Lee, Shu Hwae; Chen, Mei Ing; Shiau, Chung Jung; Chang, Chao Fu; Chi, Chau Haw; Jeng, Chian-Ren. Diagnosis and differentiation of mycobacterial infection in formalin-fixed and paraffin-embedded tissues of zoo animals by polymerase chain reaction. Taiwan Veterinary Journal. March 2002; 28(1): 80-87. ISSN: 1682-6485. Note: In Chinese.
NAL Call No.: SF604 C54
Descriptors: zoo animals, Mycobacterium, diagnosis of species of Mycobacterium tuberculosis, polymerase chain reaction (PCR) based method, non-radioactive labeled Southern blot hybridization, DNA fragment, 65 kD mycobacterial surface antigen of Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium subsp. avium, Mycobacterium avium subsp. paratuberculosis, and Mycobacterium fortuitum, 38 kd protein antigen b of Mycobacterium tuberculosis and Mycobacterium bovis, in formalin-fixed and paraffin-embedded tissues.

Pillai, S.R.; Jayarao, B.M. Application of IS900 PCR for detection of Mycobacterium avium subsp. paratuberculosis directly from raw milk. Journal of Dairy Science. May, 2002; 85(5): 1052-1057. ISSN: 0022-0302.
URL: http://www.ADSA.org/jds
NAL Call No.: 44.8 J822
Descriptors: polymerase chain reaction-based assay, sequence 900, raw bulk milk samples, experimental inoculation, cattle milk sampling, Johne’s disease, sensitivity of assay.

Pitt, D.J.; Pinch, D.S.; Janmaat, A.; Condron, R.J.  An estimate of specificity for a Johne's disease absorbed ELISA in northern Australian cattle.  Australian Veterinary Journal.  2002; 80(1-2): 57-60.  ISSN:  0005-0423.
URL:  http://www.ava.com.au/avjpast.php?journalid=9&plink=avj03.htm
NAL Call No.:  41.8 AU72
Descriptors:  mature, beef cattle,  dairy cattle, blood sampling, Mycobacterium avium subsp. paratuberculosis, Johne’s disease, bacterial diseases, beef cattle, dairy cattle, absorbed ELISA kit, tissue and fecal sampling, paratuberculosis, regional variations, Queensland, Northern Territory, Western Australia.

Quist, Charlotte F.; Nettles, Victor F.; Manning, Elizabeth J.B.; Hall, D.Greg; Gaydos, Joseph K.; Wilmers, Tom J.; Lopez, Roel R.  Paratuberculosis in Key deer (Odocoileus virginianus clavium).  Journal of Wildlife Diseases.  2002; 38(4): 729-737.  ISSN:  0090-3558.
URL:  http://www.jwildlifedis.org/
NAL Call No.:  41.9 W64B
Descriptors:  Key deer, Odocoileus virginianus clavium, Mycobacterium avium subsp. paratuberculosis, Johne’s disease, disease surveys, fecal culture, serology, epidemiology, paratuberculosis, low prevalence, Florida, United States.

Radunz, B.  Johne's disease.  Agnote Northern Territory of Australia.  2002; (K30): 3.  ISSN:  0157-8243.
Descriptors:  cattle, goats, deer, Mycobacterium avium subsp. paratuberculosis, disease symptoms, clinical aspects, epidemiology, diagnosis, pathogenesis, disease transmission, Northern Territory, Australia.

Richter, Elvira; Wessling, Johannes; Luegering, Norbert; Domschke, Wolfram; Ruesch, Gerdes Sabine. Mycobacterium avium subsp. paratuberculosis infection in a patient with HIV, Germany. Emerging Infectious Diseases. July 2002; 8(7): 729-731. ISSN: 1080-6040.
NAL Call No.: RA648.5.E46
Descriptors: confirmed diagnosis, human, zoonotic disease, impared immune system, Germany.

Robbi, C.; Rossi, I.; Nardelli, S.; Rossi, E.; Toson, M.; Marangon, S.; Cestaro, F.; Vicenzoni, G.  Diagnosi della paratubercolosi bovina: studio sull'utilizzo di test multipli.  [Serological diagnosis of paratuberculosis by means of multiple tests.]  Atti della Societa Italiana di Buiatria.  2002; 34: 277-282.  Note:  In Italian with an English summary.
Descriptors:  cattle, serological testing, Mycobacterium avium subsp. paratuberculosis, disease control and prevention, accuracy of diagnostic tests, 2 different ELISA’s in a series, 1 for first screening, 1 to confirm positives from first test.

Robbi, C.; Rossi, I.; Nardelli, S.; Rossi, E.; Toson, M.; Marangon, S.; Vincenzi, G.; Vicenzoni, G.  Prevalenza di Paratubercolosi (Johnes disease) nella popolazione di bovine da latte della Regione Veneto.  [Prevalence of paratuberculosis (Johne's disease) in dairy farms of the Veneto Region.]  Atti della Societa Italiana di Buiatria.  2002; 34: 283-288.  Note:  In Italian with an English summary.  
Descriptors:  dairy cattle, dairy farms, Johne’s disease survey, serological monitoring for Mycobacterium avium subsp. paratuberculosis, seroprevalence, disease distribution, disease prevalence, disease surveys, ELISA, epidemiology, paratuberculosis, Veneto region, Italy

Samarineanu, M.; Medeanu, R.; Sarca, M.; Cismileanu, A.  ELISA kit for bovine paratuberculosis diagnosis.  Buletinul Universitatii de Stiinte Agricole si Medicina Veterinara Cluj Napoca, Seria Medicina Veterinara.  2002; 58: 426-434.  ISSN:  1454-2382.  
Descriptors:  antigen based on lipoarabinomannan from cultures of Mycobacterium avium subsp. paratuberculosis, used as a capture antigen in ELISA kit, diagnostic test, sera testing, PARACHEK, CST Australia, diagnostic value tested, Romania.

Secott, T.E.; Lin, T. L.; Wu, C. C. Fibronectin attachment protein is necessary for efficient attachment and invasion of epithelial cells by Mycobacterium avium subsp. paratuberculosis.
Infection and Immunity. May, 2002; 70(5): 2670-2675. ISSN: 0019-9567.
NAL Call No.: QR1.I57
Descriptors: Mycobacterium avium subsp. paratuberculosis, attachment, ingestion, 2 epithelial cells, effect of soluble fibromectin, disruption of FAP-P expression T-24 and Caco-2 calls.

Sergeant, E.S.G.; Baldock, F.C.  The estimated prevalence of Johne's disease infected sheep flocks in Australia.  Australian Veterinary Journal.  2002; 80(12): 762-768.  ISSN:  0005-0423.
URL:  http://www.ava.com.au/avjpast.php?journalid=9&plink=avj03.htm
NAL Call No.:  41.8 AU72
Descriptors:  ovine Johne’s disease, slaughter house surveillance, prevalence of infected flocks, Bayesian approach, cluster distribution shown, 3 regions of Australia.

Sergeant, E. S. G.; Whittington, R. J.; More, S. J. Sensitivity and specificity of pooled faecal culture and serology as flock-screening tests for detection of ovine paratuberculosis in Australia. Preventive Veterinary Medicine. January 22, 2002; 52(3-4): 199-211. ISSN: 0167-5877.
NAL Call No.: SF601.P7
Descriptors: sheep, pooled fecal culture, serological testing AGID, Johnes’s infected flocks, test sensitivity and reliability for flock health testing, surveillance and assurance programs, Australia.

Shafran, I.; Kugler, L.; El Zaatari, F. A. K.; Naser, S. A.; Sandoval, J. Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease. Digestive and Liver Disease. January 2002; 34(1): 22-28. ISSN: 1590-8658.
Descriptors: humans, Crohn's disease, etiology of Mycobacterium avium subsp. paratuberculosis, rifabutin and clarithromycin anti-Mycobacterium avium subsp. paratuberculosis treatment, evaluation of patient responses.

Simpson, V.R.  Wild animals as reservoirs of infectious diseases in the UK.  Veterinary Journal.  2002; 163(2): 128-146.  ISSN: 1090-0233.
URL:  http://journals.harcourt-international.com/wbs/tvj
NAL Call No.:  SF601.V484
Abstract:  This review aims to illustrate the extent to which wildlife act as reservoirs of infectious agents that cause disease in domestic stock, pet and captive animals and humans.  More than 40 agents are described.  In the case of some of these, e.g. Cryptosporidium spp., Escherichia coli O157 and malignant catarrhal fever, the current evidence is that wildlife either does not act as a reservoir or is of limited importance.  However, in the case of many important diseases, including bovine tuberculosis, Weil's disease, Lyme disease, avian influenza, duck virus enteritis and louping ill, wild animals are considered to be the principal source of infection.  Wildlife may be involved in the epidemiology of other major diseases, such as neosporosis, Johne's disease, mucosal disease and foot and mouth disease, but further studies are needed.  The UK would benefit from a more positive approach to the study of wildlife and the infections they harbour.
Descriptors:  wild animals, disease reservoir hosts, bacterial diseases, Johne’s disease, viral diseases, parasitoses, livestock, epidemiology, disease transmission, pathogens, literature reviews, United Kingdom.

Singh, Mahavir; Siddiqui, Mahtab Z.; Singh, R.P.  Intra-species mice hybridomas against a recombinant protein of Mycobacterium avium paratuberculosis.  Journal of Applied Animal Research.  2002; 22(1): 137-144.  ISSN:  0971-2119.
NAL Call No.:  SF55.I4J68
Descriptors:  35 kDa recombinant protein, Mycobacterium avium subsp. paratuberculosis primed Swiss white mice splenocytes with BALB/c derived myeloma cells, intra species mice hybridomas, peritoneal macrophages as feeder layer, 5 monoclonal antibodies, 1AG2, 2BD2, 2BG2, 1DE8, IgG2b, immunoblots.

Skjerve, E.  Emerging pathogenic bacteria of special interest; epidemiological concerns.  In:  Smulders, F.J.M.; Collins, J.D. [Editors].  Food Safety Assurance and Veterinary Public Health. Vol.1. Food Safety Assurance in the Pre harvest Phase.  Wageningen Academic Publishers.  Wageningen, Netherlands.  2002; 141-152.  ISBN:  9076998051.
Descriptors:  animal health, food production, food safety, foodborne illnesses, food contamination, drug resistance, epidemiology, public health, risk assessment, zoonoses, salmonellosis, Salmonella enteritidis, tuberculosis, Bacillus cereus, Escherichia coli, Mycobacterium avium subsp. paratuberculosis, Salmonella typhimurium.

Smith, D.R.  Epidemiologic tools for biosecurity and biocontainment.  Veterinary Clinics of North America, Food Animal Practice.  2002; 18(1): 157-175.  ISSN:  0749-0720.
NAL Call No.:  SF601.V535
Descriptors:  cattle, Johne’s disease, biosecurity concerns, etiology, diagnosis, disease prevention and control, epidemiology, probabilistic mathematical models.  

Soons, R.; Heuer, C.; Jackson, R.; Groenendaal. Computer simulation of Johne's disease in New Zealand dairy cattle. Proceedings of the New Zealand Society of Animal Production. 2002; 62: 294-298. ISSN: 0370-2731.
NAL Call No.: 49.9 N483
Descriptors: disease control, dairy herds, Mycobacterium avium subsp. paratuberculosis, review, models, the model 'JohneSSim', control measures, test and cull, contract heifer rearing, colostrum management, seasonal calving, risk factors, possible application to New Zealand.

Soto, J.P.; Kruze, J.; Leiva, S.  Aislamiento de Mycobacterium avium subsp. paratuberculosis de fecas en rebanos lecheros infectados mediante el Metodo de Cornell modificado.  [Isolation of Mycobacterium avium subsp. paratuberculosis from bovine feces of infected dairy herds by the Cornell's method modified.]  Archivos de Medicina Veterinaria.  2002; 34(2): 275-282.  ISSN:  0301-732X.  Note:  In Spanish with an English summary.
URL:  http://www.scielo.cl/scielo.php?script=sci_issues&pid=0301-732X&lng=en&nrm=iso
NAL Call No.:  SF604.A75
Descriptors: cattle, 14 dairy herds infected with Mycobacterium avium subsp. paratuberculosis, asymptomatic infections, fecal culture procedure, decontamination solution of hexadecylpiridinium chloride, antibiotic solution containing amphotericin B, vancomycin, and nalidixic acid, HEYM and mycobactin J with antibiotics used above as culture media, isolates testes with PCR with primer P90 and P91, low rates of contamination with high specificity makes it a good diagnostic techniques, Chile.

Soto, J.P.; Kruze, J.; Leiva, S.  Comparacion de tres metodos de diagnostico de Paratuberculosis bovina en rebanos lecheros infectados.  [Comparison of three different methods for the diagnosis of bovine paratuberculosis in infected dairy herds.]  Archivos de Medicina Veterinaria.  2002; 34(2): 265-273.  ISSN:  0301-732X.  Note:  In Spanish with an English summary.
NAL Call No.:  SF604.A75
Descriptors:  250 animals, 14 infected dairy herds, cattle, Mycobacterium avium subsp. paratuberculosis, asymptomatic infections, diagnosis, diagnostic techniques, feces, direct microscopic examination, fecal culture with Modified Herrold’s Medium, and serological testing with ELISA, 2 bacteriological methods, isolated culture identified with PCR, serological testing with ELISA IDEXX test kit, combination of fecal and sera testing seems most effective for infected asymptomatic animals.

Stabel, J. R.; Wells, S. J.; Wagner, B. A. Relationships between fecal culture, ELISA, and bulk tank milk test results for Johne's disease in US dairy herds. Journal of Dairy Science. March 2002; 85(3): 525-531. ISSN: 0022-0302.
URL: http://www.ADSA.org/jds
NAL Call No.: 44.8 J822
Descriptors: cows, estimate percentages of seropositive herds, Mycobacterium paratuberculosis in feces and milk, estimate of sensitivity, specificity, and predictive value, ELISA compared to fecal culture.

Stabel, J.R.; Ackermann, M.R.  Temporal Mycobacterium paratuberculosis infection in T-cell receptor (TCR)-alpha and TCR-delta-deficient mice.  Veterinary Immunology and Immunopathology.  2002; 89(3-4): 127-132.  ISSN:  0165-2427.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5189&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=f5f60e05fe0e447c7311059c14754776
NAL Call No.:  SF757.2.V38
Descriptors:  Mycobacterium avium subsp. paratuberculosis, clinical aspects, Johne’s disease, cell mediated immunity, mice, disease models, laboratory animals, experimental infections, pathogenesis, strain differences, T lymphocytes.

Steadham, E.M.; Martin, B.M.; Thoen, C.O.  Production of a Mycobacterium avium ssp. paratuberculosis purified protein derivative (PPD) and evaluation of potency in guinea pigs.  Biologicals.  2002; 30(2): 93-95.  ISSN:  1045-1056.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=6718&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=2c72079aa9cb5ae63c632d6d5dfb5966
Descriptors:  guinea pigs, laboratory animal models, Mycobacterium avium subsp. paratuberculosis, purified protein derivative, bacterial antigens, delayed type hypersensitivity, T lymphocytes.

Stephan, R.; Buhler, K.; Corti, S.  Incidence of Mycobacterium avium subspecies paratuberculosis in bulk-tank milk samples from different regions in Switzerland.  Veterinary Record.  2002; 150(7): 214-215.  ISSN:  0042-4900.   http://veterinaryrecord.bvapublications.com/
NAL Call No.:  41.8 V641
Descriptors:  501 raw milk samples, screened for Mycobacterium avium subsp. paratuberculosis, pathogen prevalence data shows variation in geographic regions, northeast, central and northwest regions of Switzerland.

Stevenson, K.; Hughes, V,M. ; De Juan, L.; Inglis, N.F.; Wright, F.; Sharp, J.M. Molecular characterisation of pigmented and non-pigmented isolates of Mycobacterium avium subsp. paratuberculosis. Research in Veterinary Science. April 2002; 72(Suppl. A): 29. ISSN: 0034-5288. Note: 56th Annual Conference of the Association of Veterinary Teachers and Research Workers on Current Topics in Veterinary Science, Scarborough, England, UK, March 25-27, 2002.
NAL Call No.: 41.8 R312
Descriptors: epidemiology, Mycobacterium avium subsp. paratuberculosis, non-pigmented isolates, pigmented isolates, sheep.

Stratmann, J.; Strommenger, B.; Stevenson, K.; Gerlach, G.F.  Development of a peptide-mediated capture PCR for detection of Mycobacterium avium subsp. paratuberculosis in milk.  Journal of Clinical Microbiology.  2002; 40(11): 4244-4250.  ISSN:  0095-1137.   http://www.pubmedcentral.gov/articlerender.fcgi?artid=139712
NAL Call No.:  QR46.J6
Descriptors:  dairy herds, naturally infected with Mycobacterium avium subsp. paratuberculosis, bulk milk testing, diagnostic method, recombinant bacteriophages isolated, phage peptides, one peptide sequence NYVIHDVPRHPA, designated aMP3, chemically synthesized, put on paramagnetic beads captured MAP, potential value as a screening tool. 

Surujballi, Om P.; Romanowska, Anna; Sugden, Edward A.; Turcotte, Claude; Jolley, Michael E. A fluorescence polarization assay for the detection of antibodies to Mycobacterium bovis in cattle sera. Veterinary Microbiology. [print] June 20, 2002; 87(2): 149-157. ISSN: 0378-1135.
URL: http://www.elsevier.com/locate/vetmic
NAL Call No.: SF601.V44
Descriptors: cattle, sera, fluorescence polarization assay, fluorescein-labelled MPB70 protein antigen, Mycobacterium bovis, accuracy of indicator test, lack of cross reaction.

Svastova, P.; Pavlik, I.; Bartos, M.  Rapid differentiation of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. paratuberculosis by amplification of insertion element IS901.  Veterinarni Medicina.  2002; 47(5): 117-121.  ISSN:  0375-8427.  http://vetmed.vri.cz/
NAL Call No.:  41.9 C333
Descriptors:  Mycobacterium avium, Mycobacterium avium subsp. paratuberculosis, strain differences, Mycobacterium intracellulare, IS901, amplicons, DNA sequencing, transposable elements.

Swalve, H.H.; von Lengerken, G.  Beitrag der Tierzucht zur Lebensmittelsicherheit.  [Impact of animal breeding on food safety.]  Zuchtungskunde.  2002; 74(6): 403-412.  ISSN:  0044-5401.  Note:  In German with an English summary.
NAL Call No.:  49 Z8
Descriptors:  animal production, animal health, breeding for disease resistance and reduction zoonotic diseases, meat, milk, eggs, TSE, mastitis, E. coli, Mycobacterium avium subsp. paratuberculosis, stress susceptibility, role of gene identification and selection. 

Taragel, C.  Johne's disease zoning for goats.  Agnote NSW Agriculture.  2002; (DAI/100 (2nd edition)): 4 p.  ISSN:  1034-6848.  
Descriptors:  goats, Mycobacterium avium subsp. paratuberculosis, disease control, disease transmission, epidemiology, regulations, concerns regarding transport of animals, zoning, New South Wales, Australia.

Thompson, K. G.; West, D. M.; Anderson, P.V.A.; Burnham, D.L. Subclinical Johne's disease in sheep. Proceedings of the New Zealand Society of Animal Production. 2002; 62: 284-287. ISSN: 0370-2731.
NAL Call No.: 49.9 N483
Descriptors: sheep, subclinical infection, 5 year study, disease impact on productivity, vaccines, Mycobacterium avium subsp. paratuberculosis, Neoparasec, Gudair, experimental design.

Thornton, C.G.; MacLellan, K.M.; Stabel, J.R.; Carothers, C.; Whitlock, R.H.; Passen, S.  Application of the C18-carboxypropylbetaine specimen processing method to recovery of Mycobacterium avium subsp. paratuberculosis from ruminant tissue specimens.  Journal of Clinical Microbiology.  2002; 40(5): 1783-1790.  ISSN:  0095-1137.
URL:  http://www.pubmedcentral.gov/articlerender.fcgi?artid=130914
NAL Call No.:  QR46.J6
Descriptors:  tissue specimen processing method, bovine and bison tissues infected with Mycobacterium avium subsp. paratuberculosis, C18-carboxypropylbetaine (CB-18) treatment, lytic enzyme decontamination, ruminant tissues, BACTEC 12B liquid culture system supplemented with egg yolk emulsion, mycobactin J, pyruvate (12B/EMP), vancomycin, amphotericin B, nalidixic acid.

Tooker, B. C.; Burton, J. L.; Coussens, P. M. Survival tactics of M. paratuberculosis in bovine macrophage cells. Veterinary Immunology and Immunopathology. September 10, 2002; 87(3-4): 429-437. ISSN: 0165-2427.
URL: http://www.elsevier.com/locate/vetimm
NAL Call No.: SF757.2.V38
Descriptors: Mycobacterium avium subsp. paratuberculosis, vesicles of macrophage cells, 3 theories of survival, affects on host protein expression, interference with macrophage activation, entry avoids, macrophage activation, DDRT-PCR, gene expression comparison to E coli.

Tripathi, B.N.; Munjal, S.K.; Paliwal, O.P.  An overview of paratuberculosis (Johne's disease) in animals.  Indian Journal of Veterinary Pathology.  2002; 26(1/2): 1-10.  ISSN:  0250-4758.  Note:  A review.
Descriptors:  animal bacterial disease, disease surveys, Mycobacterium avium subsp. paratuberculosis, Johne’s disease, diagnosis, diagnostic techniques, disease control and prevention, disease transmission, immunopathology, pathogenesis, physiopathology.

Vagnozzi, A.  Paratuberculosis: una revision bibliografica.  [Paratuberculosis: a bibliographic revision.]  Revista de Medicina Veterinaria Buenos Aires.  2002; 83(1): 9-13.  ISSN:  0325-6391.  Note:  In Spanish with an English summary.
Descriptors:  Mycobacterium avium subsp. paratuberculosis, diagnosis, disease control, epidemiology, immune response.

Valentin-Weigand, P. Pathomechanismen und Immunreaktionen bei der Paratuberkulose.  [Pathogenesis and immunology of paratuberculosis.]  DTW (Deutsche Tieraerztliche Wochenschrift).  2002; 109(12): 507-509.  ISSN:  0341-6593.  Note:  In German with an English summary. 
NAL Call No.:  41.8 D482
Descriptors:  Mycobacterium avium subsp. paratuberculosis, factors regarding understanding pathogenesis, slow growth, taxonomy, limited molecular techniques, long incubation periods of natural infection, lack of laboratory model, role of macrophage in immune response, immunology.

Valentin-Weigand, P.  Tagung der Fachgruppe "Bakteriologie und Mykologie" der DVG vom 22. bis 25. Mai 2002 in Hannover, Germany.  [Meeting of the expert group on bacteriology and mycology of the German Veterinary Association, Hannover, 22-25 May 2002.]  Berliner und Munchener Tierarztliche Wochenschrift.  2002; 115(9/10): 321-350.  ISSN:  0005-9366.  Note: In German.  
NAL Call No.:  41.8 B45
Descriptors:  collection of 35 papers, diagnosis, diagnostic techniques for domestic animal diseases, characteristics of 3 important bacteria, Escherichia coli, Mycobacterium avium subsp. paratuberculosis, Yersinia.

Valheim, M.; Storset, A.K.; Aleksandersen, M.; Brun-Hansen, H.; Press, C.M.  Lesions in subclinical paratuberculosis of goats are associated with persistent gut-associated lymphoid tissue.  Journal of Comparative Pathology.  2002; 127(2/3): 194-202.  ISSN:  0021-9975.
URL:  http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=6861&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=6091bef4d15aae1adbceffba708c6eb8 NAL Call No.:  41.8 J82
Descriptors:  ruminants, goat kids, Peyer patches (PP) described, morphology, site of Mycobacterium avium subsp. paratuberculosis lesions, experimental infection effects after 2 years, subclinical stage finding described, persistent organized lymphoid tissue in jejunum PP (JPPs) and ileocaecal-valve PP (ICVPP), but not involuted ileal PP (IPP), sustains the development of granulomatous inflammation.

Valheim, M.; Hasvold, H.J.; Storset, A.K.; Larsen, H.J.S.; Press, C.McL.  Localisation of CD25+ cells and MHCII+ cells in lymph nodes draining Mycobacterium avium subsp. paratuberculosis vaccination granuloma and the presence of a systemic immune response.  Research in Veterinary Science.  2002; 73(1): 77-85.  ISSN:  0034-5288.
URL: http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=7137&_auth=y&_acct=C000052423&_version=1&_urlVersion=0&_userid=4250348&md5=de976ce390543b0c4a1081aa5ff3686f NAL Call No.:  41.8 R312
Descriptors:  goats, vaccination of goat kids, Mycobacterium avium subsp. paratuberculosis, systemic cellular response, peripheral blood cells, interferon gamma production, expression of interleukin 2 receptor, granuloma, immune-response, interferon, lymph nodes, MHCII+ cells, CD4+T cells, major histocompatibility complex, paratuberculosis, T lymphocytes, CD25+ lymphocytes.

Van Leeuwen, J. A.; Keefe, G. P.; Tiwari, A Seroprevalence and productivity effects of infection with bovine leukemia virus, Mycobacterium avium subspecies paratuberculosis, and Neospora caninum in Maritime Canadian dairy cattle. Bovine Practitioner. June 2002; 36(2): 86-91. ISSN: 0524-1685.
NAL Call No.: SF779.5.A1B6
Descriptors: 90 dairy cattle herds, subclinical infection effects, milk production, serum sampling, ELISA antibody testing, Canada.

Veerabadran Dheenadhayalan; Shin, K.S.; Chang, C.F.; Chang, C.D.; Wang, S.J.; McDonough, S.; McDonough, P.; Stehman, S.; Shin, S.; Torres, A.; Chang, Y.F.  Cloning and characterization of the genes coding for antigen 85A, 85B and 85C of Mycobacterium avium subsp. paratuberculosisDNA Sequence.  2002; 13(5): 287-294.  ISSN:  1042-5179.
DNA Sequence:  GenBank Accession no.:  AF280067, AF280068, AF219121
Descriptors:  cattle, Mycobacterium avium subsp. paratuberculosis, antigens, genes, molecular genetics, genetic analysis, DNA cloning, binding proteins, fibronectins.

Vialard, J.  La paratubercolosi caprina.  Caprine paratuberculosis.  Summa.  2002; 19(4): 39-45.  Note:  In Italian with an English summary.  
Descriptors:  goats, Mycobacterium avium subsp. paratuberculosis, clinical aspects, diagnosis.  

Vihan, V.S.  Evaluation of ELISA using wild type species-specific sonicated antigen for diagnosis of Mycobacterium paratuberculosis in goats.  Indian Journal of Veterinary Medicine.  2002; 22(1): 21-24.  ISSN:  0970-051X.
Descriptors:  121 goats, sera samples, diagnosis of Johne’s disease, Mycobacterium avium subsp. paratuberculosis, wild purified sonicated antigen from ileum mucosa of infected goats, antigen preparation, ELISA, checked against fecal culture, sensitivity and specificity were high with low false positives.

Waldner, C.L.; Cunningham, G.L.; Janzen, E.D.; Campbell, J.R.  Survey of Mycobacterium avium subspecies paratuberculosis serological status in beef herds on community pastures in Saskatchewan.  Canadian Veterinary Journal.  2002; 43(7): 542-546.  ISSN:  0008-5286.  Note:  In English with a French summary.
URL:  http://www.pubmedcentral.nih.gov/tocrender.fcgi?action=archive&journal=202
NAL Call No.:  41.8 R3224
Descriptors:  beef herds, commercial cow-calf operations, community pastures, disease prevalence, disease control, blood sampling of 1799 animals, sera testing, ELISA, Mycobacterium avium subsp. paratuberculosis, low prevalence found, future research, identify risk factors and control points, target problem herds, utilize a case-control study design, Saskatchewan, Canada.

Walravens, K.; Marche, S.; Rosseels, V.; Wellemans, V.; Boelaert, F.; Huygen, K.; Godfroid, J. IFN-gamma diagnostic tests in the context of bovine mycobacterial infections in Belgium. Veterinary Immunology and Immunopathology. September 10, 2002; 87(3-4): 401-406. ISSN: 0165-2427.
URL: http://www.elsevier.com/locate/vetimm
NAL Call No.: SF757.2.V38
Descriptors: cattle tuberculosis, Mycobacterium bovis, Mycobacterium avium subsp. paratuberculosis, testing strategies, differentiation between species, IFN-gamma responses of animals, experimental infection.

Waters, W. R.; Sacco, R. E.; Fach, S. J.; Palmer, M. V.; Olsen, S. C.; Kreeger, T. J. Analysis of mitogen-stimulated lymphocyte subset proliferation and nitric oxide production by peripheral blood mononuclear cells of captive elk (Cervus elaphus). Journal of Wildlife Diseases. April 2002; 38(2): 344-351. ISSN: 0090-3558.
NAL Call No.: 41.9 W64B
Descriptors: elk, animal reservoirs, Brucella abortus, Mycobacterium bovis, Mycobacterium avium subsp. paratuberculosis, immune responses, peripheral blood mononuclear cells, gammadelta TCR+ cells, pokeweed mitogen (PWM) stimulation, nitric oxide production, sIgM+ cells co-expressed MHC class II and B-B4, a B cell lineage marker.

Weber, M.F.; Groenendaal, H.; van Roermund, H.J.W.; Nielen, M.  Simulation of alternative for the Dutch Johne's disease certification programme.  In:  Menzies, F.D.; Reid, S.W.J.  Society for Veterinary Epidemiology and Preventive Medicine Twentieth Anniversary Proceedings of a Meeting Held at University of Cambridge, UK, 3-5 April, 2002.  Published by the Society.  Roslin, UK.  2002; 178-188.  ISBN:  0948073543.
NAL Call No.:  SF780.9.S63
Descriptors:  dairy cattle herds, Mycobacterium avium subsp. paratuberculosis, Johne’s disease, animal health certification, disease surveys, disease control, disease prevalence, economic impact, stochastic models, The Netherlands.

Weersink, A.; Van Leeuwen, J.A.; Chi, J.; Keefe, G.P.  Direct production losses and treatment costs due to four dairy cattle diseases.  Advances in Dairy Technology.  2002; 14: 55-75.  ISSN: 1184-0684.  Note:  Paper presented at the Western Canadian Dairy Seminar, March 5-8, 2002, Red Deer, Alberta.
NAL Call No.:  SF223.W478
Descriptors:  dairy cows, bovine diarrhea virus, bovine leucosis, paratuberculosis, Mycobacterium avium subsp. paratuberculosis, yield losses, Johne's disease, Maritime Provinces, Canada.

Weiss, D.J.; Evanson, O.A.; Moritz, A.; Deng, M.Q.; Abrahamsen, M.S.  Differential responses of bovine macrophages to Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium.  Infection and Immunology.  2002.  70(10): 5556-5561.  ISSN: 0019-9567.
URL:  http://www.pubmedcentral.gov/articlerender.fcgi?artid=128321
NAL Call No.:  QR1.I57
Abstract:  Mycobacterium avium subsp. paratuberculosis and Mycobacterium avium subsp. avium are antigenically and genetically similar organisms; however, they differ in their virulence for cattle.  M. avium subsp. paratuberculosis causes a chronic intestinal infection leading to a chronic wasting disease termed paratuberculosis or Johne's disease, whereas M. avium subsp. avium causes only a transient infection.  We compared the response of bovine monocyte-derived macrophages to ingestion of M. avium subsp. paratuberculosis and M. avium subsp. avium organisms by determining organism survival, superoxide and nitric oxide production, and expression of the cytokines tumor necrosis factor alpha (TNF-alpha), gamma interferon (IFN-gamma), interleukin-8 (IL-8), IL-10, IL-12, and granulocyte-monocyte colony-stimulating factor (GM-CSF).  Unlike M. avium subsp. paratuberculosis, macrophages were able to kill approximately half of the M. avium subsp. avium organisms after 96 h of incubation.  This difference in killing efficiency was not related to differences in nitric oxide or superoxide production.  Compared to macrophages activated with IFN-gamma and lipopolysaccharide, macrophages incubated with M. avium subsp. paratuberculosis showed greater expression of IL-10 and GM-CSF (all time points) and IL-8 (72 h) and less expression of IL-12 (72 h), IFN-gamma (6 h), and TNF-alpha (6 h).  When cytokine expression by macrophages incubated with M. avium subsp. paratuberculosis was compared to those of macrophages incubated with M. avium subsp. avium, M. avium subsp. paratuberculosis-infected cells showed greater expression of IL-10 (6 and 24 h) and less expression of TNF-alpha (6 h).  Therefore, the combination of inherent resistance to intracellular degradation and suppression of macrophage activation through oversecretion of IL-10 may contribute to the virulence of M. avium subsp. paratuberculosis in cattle.
Descriptors:  cattle, virulence differences, bovine macrophages, killing efficiency, cell survival Mycobacterium avium subsp. paratuberculosis, Johne’s disease, Mycobacterium avium subsp. avium, cytokines, immunopathology.

Wells, S.J.; Dee, S.; Godden, S.  Biosecurity for gastrointestinal diseases of adult dairy cattle.  Veterinary Clinics of North America, Food Animal Practice.  2002; 18(1): 35-55.  ISSN:  0749-0720.
NAL Call No.:  SF601.V535
Descriptors:  dairy cattle, dairy herds, adult animals, Mycobacterium avium subsp. paratuberculosis, Salmonella, animal health, biosecurity concerns, Johne’s disease, disease control, disease transmission, gastrointestinal diseases, risk assessment.

Wells, Scott J.; Whitlock, Robert H.; Lindeman, Cynthia J. ; Fyock, Terry Evaluation of bacteriologic culture of pooled fecal samples for detection of Mycobacterium paratuberculosis. American Journal of Veterinary Research. August 2002; 63(8): 1207-1211. ISSN: 0002-9645.
NAL Call No.: 41.8 Am3A
Descriptors: cattle, concentration of organisms, detection sensitivity, methods recommended to survey disease levels of cattle herds, Mycobacterium avium subsp. paratuberculosis.

Wells, Scott J.; Whitlock, Robert H.; Wagner, Bruce A.; Collins, James; Garry, Franklyn; Hirst, Heather; Lawrence, John; Saville, William J. A.; Naugle, Alecia L. Larew. Sensitivity of test strategies used in the Voluntary Johne's Disease Herd Status Program for detection of Mycobacterium paratuberculosis infection in dairy cattle herds. Journal of the American Veterinary Medical Association. April 1, 2002; 220(7): 1053-1057. ISSN: 0003-1488.
URL: http://www.avma.org
NAL Call No.: 41.8 Am3
Descriptors: dairy cattle herd evaluation, reliability of the Voluntary Johne's Disease Herd Status Program (VJDHSP), 64 dairy herds from Pennsylvania, Minnesota, Colorado, Ohio, and Wisconsin, serum testing for antibodies to Mycobacterium avium subsp. paratuberculosis, fecal testing.

West, D. M. Johne's disease: Why Johne's disease is so difficult to control. Proceedings of the New Zealand Society of Animal Production. 2002; 62: 282-283. ISSN: 0370-2731.
NAL Call No.: 49.9 N483
Descriptors: Mycobacterium avium subsp. paratuberculosis, cattle, sheep, goats, deer, control issues, incubation periods, pathogen survival, subclinical infection shedding, unreliability of diagnostic tests, control comparisons between New Zealand and Australia.

Wilson, P.R.  Bacterial infections reported in New Zealand farmed deer.  Surveillance Wellington.  2002; 29(3): 13-16.  ISSN:  0112-4927.
NAL Call No.:  SF604.63.N455S87
Descriptors:  farmed deer, bacterial diseases, disease prevalence, epidemiology, clinical aspects, Actinobacillus, Arcanobacterium pyogenes, Brucella ovis, Campylobacter fetus, Clostridium, Dermatophilus congolensis; Dichelobacter nodosus, Escherichia coli, Fusobacterium necrophorum, Leptospira, Listeria monocytogenes, Mycobacterium avium subsp. paratuberculosis, Mycobacterium bovis, Pasteurella multocida, Salmonella typhimurium, Yersinia pseudotuberculosis, New Zealand.

Winterhoff, C.; Beyerbach, M.; Homuth, M.; Strutzberg, K.; Gerlach, G. F. Etablierung und Evaluation eines ELISA zum Nachweis von Antikoerpern gegen Mycobacterium avium sub-species paratuberculosis in Milch. [Evaluation of an ELISA for the detection of Mycobacterium avium subsp. paratuberculosis-specific antibodies in milk.] Deutsche Tieraerztliche Wochenschrift. Mai 2002; 109(5): 230-234. ISSN: 0341-6593. Note: In German.
NAL Call No.: 41.8 D482
Descriptors: dairy farms, economically viable diagnostic method, antibody detection, Svanovir(R) ELISA, milk testing.

Zwick, L.S.; Walsh, T.F.; Barbiers, R.; Collins, M.T.; Kinsel, M.J.; Murnane, R.D.  Paratuberculosis in a mandrill (Papio sphinx).  Journal of Veterinary Diagnostic Investigation. 2002; 14(4): 326-328.  ISSN:  1040-6387.
NAL Call No.:  SF774.J68
Descriptors:  mandrill, Mandrillus sphinx, Papio sphinx, zoo animal, amyloidosis, lymphadentis, enterocolitis, Mycobacterium avium subsp. paratuberculosis, histopathology, clinical aspects, case report, Illinois, United States.


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