Animal Models in Biomedical Research: SwineProvided by the Animal Welfare
Information Center
|
United States Department of Agriculture
National Agricultural Library
10301 Baltimore Blvd.
Beltsville, Maryland 20705-2351
Cynthia Petrie Smith
Animal Welfare Information Center
Published in cooperation with the Virginia-Maryland Regional College
of Veterinary Medicine
December 1993
National Agricultural Library cataloging Record:
Smith, Cynthia Petrie
Animal models in biomedical research : swine.
(Special reference briefs ; 94-01)
1. Swine as laboratory animals--Bibliography. 2. Animal
models in research--Bibliography. I. Title.
aS21.D27S64 no.94-01
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INTRODUCTION
Swine have been utilized as a biomedical research model
in a wide variety of disciplines; the most notable being
cardiovascular research. Swine exhibit many similarities to
man in cardiovascular anatomy and physiology including: a
comparable heart to body size ratio, spontaneous development
of atherosclerosis, coronary arterial anatomy, lipoprotein
structure, propensity towards obesity, and susceptibility to a
variety of stressors. Pigs are nonruminant omnivores and
exhibit similarities to man in digestive physiology. Piglets
and human infants share similar nutrient requirements and a
susceptibility to a host of gastrointestinal pathogens.
The pig has been used as a model for diabetes, alcoholism, peptic ulcers, and liver transplant studies. Swine have multilobar kidneys similar in size, number, and structure to human kidneys, which makes the pig an excellent model for kidney obstruction and reflux neuropathies. In the field of dermatology, swine have been utilized to study wound healing, plastic surgery procedures, the formation of human melanomas, and the effects of photoaging. Swine also have been utilized as models in skeletal research, toxicology, and pharmacology.
Advantages to using swine as animal models include: relatively low cost, availability, and the ability of swine to produce large litters of hardy newborns. In addition, a great wealth of agricultural literature has been produced that may have applications in biomedical research--particularly in the areas of nutrition, reproduction, and behavior.
Pigs are an intelligent and versatile species that can adapt to a variety of experimental conditions, provided their environmental and behavioral needs are met (533, 537, 539). As swine continue to gain popularity as a biomedical research model, there is a need for more information on the management, handling, care, and welfare of swine in laboratory settings.
This Special Reference Brief is a general reference tool for individuals interested in the use of swine as biomedical models. It is not meant to be a complete review of all literature existing on swine in biomedical research, but rather a sampling of the current literature. Individuals interested in using swine for a specific model, should consult with their librarian and have a literature search tailored to meet their specific needs. A variety of biological, medical and agricultural literature databases including MEDLINE, TOXLINE, EMBASE, BIOSIS, AGRICOLA, and CAB Abstracts, contain excellent references on the use of swine as biomedical models.
The following Special Reference Brief, contains bibliographic citations of articles and books obtained from a variety of scientific and agricultural sources dating from January 1980 to September 1990. Citations from materials that are present in the collection of the National Agricultural Library have been assigned an NAL call number. Citations are arranged in chronological order from the most to the least recent.
The author wishes to acknowledge M. Michael Swindle, D.V.M. for his expert review of this document. Dr. Swindle is well known for his many writings and presentations on the use of swine as surgical models. The author also extends her appreciation to Catherine Shull, for her tireless enthusiasm and diligence while working on the update of this document.
GENERAL REVIEW
1
Swine as Models in Biomedical Research M.M. Swindle, D.C.
Moody, and L.D. Phillips (eds.), Iowa State University Press,
IA; 1992, 312p.
NAL call number: RB125 S79
Descriptors: miniature swine, pancreatic beta-cell
transplantation, renal transplantation, liver transplantation,
pediatric surgery, peritoneal dialysis, vascular pharmacology,
anesthetics, hypercholesterolemia, myocardial ischemia,
congenital cardiovascular disease, hemorrhagic shock,
intraperitoneal sepsis, wound-healing, hypertension.
2
"MHC-homozygous miniature swine." D.H. Sachs. In: Swine as
Models in Biomedical Research M.M. Swindle, D.C. Moody, and
L.D. Phillips (eds.), Iowa State University Press, IA; 1992,
pp. 3-15. NAL call number: RB 125 S79
Descriptors: genetics, inbreeding, transplant immunity, graft
survival.
3
A Colour Atlas of Diseases and Disorders of the Pig W.J.
Smith, D.J. Taylor, and R.H.C. Penny. Wolfe Publishing Ltd,
Ipswich, England; 1990, 192p.
NAL call number: SF971 S59
Descriptors: developmental abnormalities, nutritional
disorders, trauma disorders, parasites, bacteria, viruses,
behavioral problems, vices.
4
"Normal physiological values for conscious pigs used in
biomedical research." J.P. Hannon, C.A. Bossone, and C.E.
Wade. Laboratory Animal Science 40(3):293-298(May 1990). NAL
call number: 410.9 P94
Descriptors: acid base equilibrium, blood gas monitoring,
transcutaneous, electrolytes, hemoglobins, hormones, kidney
physiology, oxygen consumption, respiratory function tests.
5
"Animal models: The pig." J. Rapacz and J. Hasler-Rapacz. In:
Monographs in Human Genetics, Vol 12. Genetic Factors in
Atherosclerosis: Approaches and Model Systems A.J. Lusis and
R.S. Sparkes (eds.), Karger Ag, Basel, Switzerland, New York,
NY; 1989, pp139-169.
Descriptors: lipoprotein, polymorphism, hereditary aspects,
hypercholesterolemia, atherosclerosis.
6
Research Utilization of Miniature Swine Charles River
Laboratories, MA; 1989, 83p. NAL call number: Z6658.R47
Descriptors: bibliography, models, atherosclerosis,
dermatology, gastrointestinal function, breeds, handling,
housing, hematology, nephrology, nervous system, parasitology,
perinatology, reproduction, surgery.
7
Experimental Surgery and Physiology: Induced Animal Models of
Human Disease M.M. Swindle and R.J. Adams. Williams and
Wilkins, Baltimore, MD; 1988, 350p.
NAL call number:RB 125 E9
Descriptors: animal models, wound healing, musculoskeletal
system, urogenital system, cardiovascular system, pulmonary
system, ophthalmic system, otology, laryngology, oral surgery,
pancreas, alimentary tract, liver, endocrine system, nervous
system, organ transplantation, neonatal surgery,
interventional radiology, anesthesia.
8
"Swine as models in experimental surgery." M.M. Swindle, A.C.
Smith, and B.J. Hepburn. Journal of Investigative Surgery
1(1):65-79(1988).
Descriptors: anesthetic selection, housing, anatomic and
physiologic characteristics.
9
"The minipig as a model in gnotobiology." L. Mandel and J.
Travnicek. Nahrung 31(5-6):613-618(1987). NAL call number:
389.8 N142
Descriptors: germ free life, diet, radiation, immunity.
10
"The use of animals in biomedical research and testing."
Foundation for Biomedical Research. Clinical Research
Practices and Drug Regulatory Affairs 4-5:265-282(1987).
Descriptors: economic aspects, social aspects, animal models,
monkey, cattle, swine, sheep, cat, dog, mouse, rat.
11
"Characteristics of swine as biomedical research subjects."
M.E. Tumbleson. Laboratory Animal Science 36(5):555-556(1986).
NAL call number: 410.9 P94
Descriptors: abstract, nutrition, reproduction,
atherosclerosis.
12
"Pigs: From B.C. to 2000 A.D.: From outhouse to penthouse."
L.K. Bustad and V.G. Horstman. In: Swine in Biomedical
Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York,
NY; 1986, pp. 3-15. NAL call number: RB125.C68 1985.
Descriptors: history, medical research, husbandry, miniature
swine, intelligence, behavior, socialization.
13
"Swine in biomedical research." L.M. Panepinto and M.M.
Swindle (eds.) Laboratory Animal Science 36(4):343-433(August
1986).
NAL call number: 410.9 P94
Descriptors: Yucatan miniature pig, myocardial ischemia,
exercise, cardiopulmonary surgery, anesthetics, reproductive
and thermoregulatory behavior, stress, handling, housing,
endotoxemia, immunology, interstitial radiation studies,
herpes encephalitis, fetal calcium homeostasis, liver
transplantation, plastic surgery, blood sampling methods.
14
Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1-3.
Plenum Press, New York; 1986, 1988p. NAL call number:
RB125.C68 1985.
Descriptors: history, models, management, nutrition,
immunology, hematology, cardiovascular studies, perinatology,
renal functioning, medicine.
15
Basic Surgical Exercises Using Swine M.M. Swindle. Praeger
Publishers, New York, NY; 1983, 277p. NAL call number: RD29.5
S94S94
Descriptors: anesthesia, euthanasia, instrumentation,
operative procedures, sterile surgery, suture materials and
techniques.
16
"The pig model for biomedical research." W.J. Dodds.
Federation Proceedings 41(2):247-256(1982). NAL call number:
442.9 F3IP
Descriptors: heart disease, lipid metabolism.
CARDIOVASCULAR SYSTEM
17
"Echocardiographic and anatomic correlation of ventricular
septal defect morphology in newborn Yucatan pigs." T.B.
Johnson, D.A. Fyfe, R.P. Thompson, C.H. Kline, M.M. Swindle,
and R.H. Anderson. American Heart Journal
125(4):1067-1072(1993).
Descriptors: heart septal defects, ventricular pathology,
ultrasonography.
18
"An experimental algorithm versus standard advanced cardiac
life support in a swine model of out-of-hospital cardiac
arrest." J.J Menegazzi, E.A. Davis, D.M. Yealy, R.L. Molner,
K.A. Nicklas, G.M. Hosack, E.A. Honingford, and M.M. Klain.
Annals of Emergency Medicine 22(2):235-239(1993). Descriptors:
algorithms, heart arrest therapy, life support care,
bretylium, therapeutic use, cardiopulmonary resuscitation,
epinephrine therapeutic use.
19
"How much `significance' is significant? The transition from
animal models to human trials in resuscitation research." D.M.
Yealy. Annals of Emergency Medicine 22(1):11-16(1993).
Descriptors: resuscitation, emergency medicine, primate, dog,
swine, heart electrophysiology, hemodynamics, reproducibility.
20
"Atherosclerotic Yucatan microswine as a model for novel
cardiovascular interventions and imaging." D. Gal and J.M.
Isner. In: Swine as Models for Biomedical Research M.M.
Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State
University Press, IA; 1992, pp. 118-140. NAL call number:
RB125 S79
Descriptors: atherogenic diet, balloon endothelial denudation,
iliac arteries, iliofemoral arteriograms.
21
"Congenital cardiovascular disease." M.M. Swindle, R.P.
Thompson, B.A. Carabello, A.C. Smith, C.T. Green, and P.C.
Gillette. In: Swine as Models in Biomedical Research M.M.
Swindle, D.C. Moody, and L.D. Phillips (eds.). Iowa State
University Press, IA; 1992, pp. 176-184. NAL call number:
RB125 S79
Descriptors: ventricular septal defect, patent ductus
arteriosus, atrial septal defect, left hypoplastic heart
syndrome.
22
"Effects of chronic tachycardia-induced cardiomyopathy on the
beta-adrenergic receptor system." S.A. Burchell, F.G.
Spinale, F.A. Crawford, R. Tanaka, and M.R. Zile. Journal of
Thoracic and Cardiovascular Surgery 104(4):1006-1012(1992).
Descriptors: supraventricular tachycardia, swine, noradrenalin
blood level, binding kinetics, echocardiography, heart
catheterization.
23
"Intracardiac therapy following emergency thoracotomy in the
accident and emergency department: An experimental model." C.
Moulton, A. Pennycook, R. Crawford. Archives of Emergency
Medicine 9(2):190-195(1992).
Descriptors: thoracotomy, emergency medicine, balloon
catheter.
24
"Myocardial oxygenation and transmural lactate metabolism
during experimental acute coronary stenosis in pigs." P.
Gonschior, G.M. Gonschior, P.F. Conzen, J. Hobbhahn, A.E.
Goetz, K. Peter, and W. Brendel. Basic Research In Cardiology
87(1):27-37(1992).
Descriptors: lactic acid, drug concentration, tissue
oxygenation, coronary artery obstruction, blood sampling,
male, female.
25
"The pig as a model of myocardial ischemia and gradual
coronary artery occlusion." C.M. Bloor, F.C. White, and D.M.
Roth. In: Swine as Models in Biomedical Research M.M. Swindle,
D.C. Moody, and L.D. Phillips (eds.), Iowa State University
Press, IA; 1992, pp. 163-175. NAL call number: RB125 S79
Descriptors: Yucatan, Hampshire, maximal oxygen consumption,
experimental surgery, amaroid occluder.
26
"Review of all studies of cardiopulmonary resuscitation in
animal models reported in the emergency medicine literature
for the past 10 years." C.J. Holliman and M.A. Bates. American
Journal of Emergency Medicine 10(4):347-353(1992).
Descriptors: bicarbonate, phenylephrine, bretylium, swine,
dog, compression therapy, bypass, rat.
27
"The spontaneously hypercholesterolemic pig as an animal model
of human hypercholesterolemia." A.D. Attie, R.J. Aiello, and
W.J. Checovich. In: Swine as Models in Biomedical Research
M.M. Swindle, D.C. Moody and L.D. Phillips (eds.), Iowa State
University Press, IA; 1992, pp. 141-155. NAL call number:
RB125 S79
Descriptors: low density lipoprotein, mutant pigs,
apoproteins, lipid metabolism.
28
"Studies in the physiology of cardiopulmonary bypass using a
swine model." D.E. Cameron, V.K.H. Tam, W. Cheng, and M.
Braxton. In: Swine as Models in Biomedical Research M.M.
Swindle, D.C. Moody and L.D. Phillips (eds.), Iowa State
University Press, IA; 1992, pp. 185-196. NAL call number:
RB125 S79
Descriptors: cardiac surgery, cerebral blood flow, focal
ischemic injury, platelet count.
29
"The Yucatan miniature swine: An atherogenic model to assess
the early patency rates of an endovascular stent." C.J. White,
S.R. Ramee, A.K. Banks, D. Wiktor, and H.L. Price. In: Swine
as Models in Biomedical Research M.M. Swindle, D.C. Moody, and
L.D. Phillips (eds.), Iowa State University Press, IA; 1992,
pp. 156-162.
NAL call number: RB125 S79
Descriptors: balloon expandable endovascular stent,
angiography, stent implantation.
30
"Buffer solutions may compromise cardiac resuscitation by
reducing coronary perfusion pressure." F. Kette, M.H. Weil,
and R.J. Gazmuri. Journal of the American Medical Association
266(15):2121-2126(1991). NAL call number: 448.9 Am 37
Descriptors: coronary artery blood flow, hypertonic solution,
heart arrest, sodium carbonate, sodium chloride.
31
"A closed-chest porcine model of chronic left ventricular
systolic and diastolic dysfunction after myocardial
infarction." K.B. Kern, L.D. Lancaster, M. Olajos, and S.
Goldman. Coronary Artery Disease 2(6):685-690(1991).
Descriptors: hemodynamics, ischemic cardiomyopathy, coronary
occlusion.
32
"Effects of acute right ventricular ischemia on ventricular
interactions during prosthetic left ventricular support." D.J.
Farrar, E. Chow, P.G. Compton, L. Foppiano, J. Woodard, and
J.D. Hill. Journal of Thoracic and Cardiovascular Surgery
102(4):588-595(1991).
Descriptors: assisted circulation, heart function, right
ventricle function, male, female.
33
"Ventricular septal defects in a family of Yucatan miniature
pigs." S.Y. Ho, R.P. Thompson, S.R. Gibbs, M.M. Swindle, and
R.H. Anderson. International Journal of Cardiology
33(3):419-25(1991). Descriptors: heart septal defects,
ventricular epidemiology.
34
"Heritable ventricular septal defect in Yucatan miniature
swine." M.M. Swindle, R.P. Thompson, B.A. Carabello, A.C.
Smith, B.J. Hepburn, D.R. Bodison, W. Corin, A. Fazel, W.W.R.
Biederman, and F.G. Spinale. Laboratory Animal Care
40(2):155-161(1990).
NAL call number: 410.9 P94
Descriptors: heart septal defects, genetics, swine diseases.
35
"Importance of experimental models for the development of
clinical trials on thromboatherosclerosis." V. Fuster, J.H.
Ip, L. Badimon, B. Stein, and J.H. Chesebro. Circulation
83(6):IV-15-IV-25(1991). NAL call number: RC 681 A1C8
Descriptors: coronary artery atherosclerosis, drug therapy,
heparin, acetylsalicylic acid, antithrombocytic agent,
ipyridamole, dipyridamole.
36
"Isovolumic contraction as manifested in the aortic pressure
contour." J.J. Ferguson, P. Sahagian, and M.J. Miller. Journal
of Applied Cardiology 6(6):349-357(1991).
Descriptors: left ventricular contractility, aorta valve,
manometry, m mode echocardiography, heart ventricle
extrasystole, aorta stenosis, vascular resistance.
37
"Methods of cardiac preservation alter the function of the
endothelium in porcine coronary arteries." F.N. Nilsson, V.M.
Miller, P.M. Vanhoutte, and C.G.A. McGregor. Journal of
Thoracic and Cardiovascular Surgery 102(6):923-930(1991).
Descriptors: calcimycin, cardioplegic agent, indomethacin,
talipexole, bradykinin, alpha 2 adrenergic receptor
stimulating pharmacology, heart preservation.
38
"Resuscitation of hypercalcemic arrest. Lack of efficacy of
verapamil, magnesium, and bicarbonate in a swine model." B.A.
Smith, J.G. Reid, G.P. Moore, D.B. Ferguson, and K.C. O'Hair.
Current Therapeutic Research Clinical and Experimental
49(3):458-463(1991).
Descriptors: calcium chloride, calcium antagonist, heart
arrest.
39
"Right ventricular pump dysfunction with acute experimental
septic shock." J.L. Zellner, F.G. Spinale, F.A. Crawford Jr.,
and J.A. Cook. Journal of Surgical Research 50(1):93-99(1991).
Descriptors: thermodilution, heart function, male, female.
40
"Species differences in the infectability of vascular grafts."
M.A. Ricci, R.J. Mehran, D. Petsikas, F. Mohamed, R. Guidoin,
N.V. Christou, A. Graham, and J.F. Symes. Journal of
Investigative Surgery 4(1):45-52(1991).
Descriptors: graft infection, blood vessel graft, dog, swine,
electron microscopy, male, female.
41
"Surgical model of volume overload-induced ventricular
myocardial hypertrophy (VH(vo)) to study a clinical problem in
humans." C. Wittnich, M.P. Belanger, B.S. Oh, and T.A.
Salerno. Journal of Investigative Surgery 4(3):333-338(1991).
Descriptors: microcrystalline collagen, drug therapy, heart
surgery, experimental model, postoperative complication,
hypervolemia, arteriovenous shunt, anastomosis.
42
"Animal model of coronary spasm." H. Tomoike. Journal of
Molecular and Cellular Cardiology 22(Suppl. 2):S25(1990).
Descriptors: human, pig, angina, myocardial infarction,
myocardial ischemia.
43
"Application of a new phased array ultrasound imaging catheter
in the assessment of vascular dimensions in vivo comparison to
cineangiography." S.E. Nissen, C.L. Grines, J.C. Gurley, K.
Sublett, D. Haynie, C. Diaz, D.C. Booth, and A.N. Demar.
Circulation 81(2):660-666(1990). NAL call number: RC681.A1C8
Descriptors: dog, pig, model, stenosis, cross sectional area
diameter.
44
"Atherosclerotic Yucatan microswine: An animal model with
high-grade fibrocalcific, nonfatty lesions suitable for
testing catheter-based interventions." D.Gal, A.J. Rongione,
G.A. Slovenkai, S.T. DeJesus, A. Lucas, C.D. Fields, and J.M.
Isner. The American Heart Journal 119(2 Part
1):291-300(February 1990). Descriptors: arteriosclerosis,
atherosclerosis, angiography, radiography, catheterization,
economics.
45
"Can atherosclerosis plaques regress? Anatomic and biochemical
evidence from nonhuman animal models." R.W. Wissler and D.
Vesselinovitch. American Journal of Cardiology
65(12):33F-40F.(March 20, 1990). NAL call number: RC681 A1A56
Descriptors: arteriosclerosis, atherosclerosis, diet, drug
therapy, blood vessels, macaca mulatta, swine.
46
"Cardiac function and morphology of Hanford miniature swine
and Yucatan miniature and micro swine." A.C. Smith, F.G.
Spinale, and M.M. Swindle. Laboratory Animal Science
40(1):47-50(1990). NAL call number: 410.9 P94
Descriptors: blood pressure, blood vessels, anatomy,
histology, hemodynamics, species specificity, vascular
resistance.
47
"Comparative antithrombotic efficacy of the cycloxygenase
inhibitor aspirin and the thromboxane synthetase inhibitor
CV-4151 after arterial injury in pigs." J.Y.T. Lam, C.
Lachapelle, G.Linton, and D.Waters. Journal of the American
College of Cardiology 15(2 Suppl. A):86A(1990). Descriptors:
E-7 phenyl-7-3-pyridinyl-6-heptenoic acid, anticoagulant,
enzyme inhibitor, platelet deposition, thromboxane,
prostaglandin I2.
48
"Current concepts and animal models of sudden cardiac death
for drug development." P.S. Chan and P. Cervoni. Drug
Development Research 19(2):199-207(1990).
Descriptors: human, dog, pig, propranolol, quinidine,
procainamide, phenytoin, verapamil, clofilium, sotalol,
bretylium, diltiazem, prazosin, mexiletine, nadolol,
flecainide, bethanidine, meobetine, antiarrhythmic drugs,
ischemia, myocardial infarction.
49
"Effect of balloon inflation on smooth muscle cell
proliferation in the porcine carotid artery." M.W.I. Webster,
J.H. Chesebro, M. Heras, J.S. Mruk, D.E. Grill, and V. Fuster.
Journal of the American College of Cardiology 15(2 Suppl.
A):165A(1990).
Descriptors: vascular injury, restenosis.
50
"The effect of coronary collateral recruitment on ventricular
recovery after brief coronary occlusion in dogs and pigs."
S.A. Hanan, M.E. Jessen, G.E. Tuchy, R.P. Maddox, A.S. Abd-
Elfattah, and A.S. Wechsler. Current Surgery
47(1):23-25.(1990).
Descriptors: ischemia, reperfusion, ATP levels.
51
"The effectiveness of bystander CPR in an animal model." J.W.
Hoekstra, K. Rinnert, P. Van Ligten, R. Neumar, H.A. Werman,
and C.G. Brown. Annals of Emergency Medicine
19(8):881-886(August 1990). Descriptors: heart arrest,
resuscitation, coronary circulation, epinephrine,
hemodynamics, swine.
52
"Hemodynamics and coronary blood flow during experimental
aortic valvuloplasty comparison of the dual versus the single
catheter methods." J.W. Moore, M.S. Slack, W.C. Kirby, and
G.M. Graeber. The American Heart Journal 119(1):136-142(1990).
Descriptors: swine, left ventricular occlusion, statistics.
53
"Hyperlipidemic swine as an animal model for coronary artery
plaque hemorrhages." B.Raugaard, B.H. Weiner, J.J. Hoogasian,
P.H. Levine, M. Fisher, I.S. Ockene, and H.F. Cuenoud. The
FASEB Journal 4(4):A1154(1990).
NAL call number: QH301.F3
Descriptors: vessel, abrasion, luminal, myocardial infarction,
lipid rich diet.
54
"Ischemic preconditioning reduces infarct size in swine
myocardium." R.J. Schott, S. Rohmann, E.R. Braun, and W.
Schaper. Circulation Research 66(4):1133-1142(1990). NAL call
number: RC681 A1A57137
Descriptors: oxygen consumption, reperfusion, injury.
55
"Limitation of myocardial infarct size by superoxidase
dismutase as an adjunct to reperfusion after different
durations of coronary occlusion in the pig." U. Naslund, S.
Haggmark, G. Johansson, S.L. Marklund, and S. Reiz.
Circulation Research 66(5):1294-1301(1990).
NAL call number: RC681 A1A57137
Descriptors: cardiovascular drug, oxygen, radical.
56
"Long term pathologic findings after in vivo placement of
percutaneous balloon expandable tantalum stents." S.K Chokshi,
J. Hogan, V. Parsonnet, F. Cross, C. White, and J.M. Isner.
Laboratory Investigation 62(1):19A(1990).
NAL call number: 448.8 L11
Descriptors: dog, pig, angiography, angioplasty, histology.
57
"Measurement of mean circulatory filling pressure and
vascular compliance in domestic pigs." R.I. Ogilvie, D.
Zborowska-Sluis, and B. Tenaschuk. American Journal of
Physiology: Heart and Circulatory Physiology 258(6 Part
2):H1925-H1932(1990).
Descriptors: venous return, circulatory arrest, capacitance.
58
"Nisoldipine improves blood flow to skeletal muscles in
conscious pigs with chronic heart failure." W.J. Van Der
Giessen, L.J. Van Woerkens, P.R. Saxena, J.R.T.C. Roelandt,
and P.D. Verdouw. European Heart Journal 11(6):552-559(1990).
Descriptors: cardiovascular drug, coronary collateral flow,
myocardial infarction.
59
"Paramagnetic pyrophosphate preliminary studies on magnetic
resonance contrast enhancement of acute myocardial
infarction." A.H. Mauer, L.C. Knight, J.A. Siegel, I.B.
Elfenbein, and L.P. Adler. Investigative Radiology
25(2):153-163(1990).
Descriptors: technetium 99M labeled pyrophosphate, toxicology,
respiratory effects.
60
"Pharmacokinetics of lidocaine after intravenous and
endobronchial administration during cardiopulmonary
resuscitation." U. Hoernchen, P.M. Lauven, J. Schuettler, A.
Dorer, and H. Stoeckel. Der Anaesthetist 39(2):107-112(1990).
Descriptors: local anesthetic, cardiac arrest, gas
chromatography, elimination, half life, clearance, absorption,
bioavailability.
61
"Rapid ventricular pacing in pigs: An experimental model of
congestive heart failure." E. Chow, J.C. Woodard, and D.J.
Farrar. American Journal of Physiology
258(5):1603-11605(1990). NAL call number: 447.8 Am3
Descriptors: heart output, heart rate, hemodynamics,
biventricular dilation.
62
"Relationship between myocardial metabolites and contractile
abnormalities during graded regional ischemia phosphorus-31
NMR studies of porcine myocardium in vivo." S. Schaefer, G.G.
Schwartz, J.R. Gober, A.K. Wong, S.A. Camacho, B. Massie, and
M.W. Weiner. The Journal of Clinical Investigation
85(3):706-713(1990). NAL call number: 448.8 J8295
Descriptors: phosphate, creatinine, coronary stenosis.
63
"Recovery after cold cardioplegic arrest of isolated blood-
perfused hearts excised from non-anesthetized pigs." H.H.
Kimose, J. Ravkilde, M.A. Knudesen, P. Helligso, and U.
Baandrup. European Surgical Research 22(6):323-335(1990).
Descriptors: heart ventricle, organ preservation, animal
tissue.
64
"Acetylcholine and carbamylcholine inhibit the sodium
potassium ATPase in sarcolemma from rabbit and porcine hearts
by acting on muscarinic receptors coupled with pertussis toxin
sensitive G-I protein." V.A. Tkachuk, M.P. Panchenko, O.V.
Esyrev, and M.P. Danylenko. Journal of Molecular and Cellular
Cardiology 21(Suppl. 2):S179(1989).
Descriptors: pharmacological tool, GDP, GTP, ATP.
65
"Acute hemodynamic response to intravenous enoximone: An
animal study and preliminary report in infants after cardiac
surgery." D. Schranz, R. Huth, M. Dahm, S. Iversen, E. Hein,
H. Stopfkuchen, and B.K. Jungst. Journal of Cardiovascular
Pharmacology 14(Suppl. 1):s62-s68(1989). Descriptors:
enoximone, dopamine, dobutamine, adrenalin, noradrenalin, drug
therapy, forward heart failure, hemodynamics, venous oxygen
tension, infant.
66
"Adrenocorticoids as major governing factors in incidence of
aortic atherosclerosis in pigs." N. Singh and S.K. Mukherjee.
Journal of Molecular and Cellular Cardiology 21(Suppl.
2):S169(1989). Descriptors: blood cholesterol, corticosterone.
67
"Adverse hemodynamic effects of pericardial closure after
sternotomy and pericardiotomy." A.G. Fraser, G.D. Angelini,
M.M.G. Koning, J.H. Smyllie, I. Zorn, G.R. Sutherland, and
P.D. Verdouw. Circulation 80(4 Suppl. 2):11560(1989).
NAL call number: RC681 A1C8
Descriptors: pig, model, open heart surgery, cardiac output,
stroke volume, systemic vascular resistance, echocardiography.
68
"Angiogenesis in myocardial ischemia." W. Schaper and J.
Schaper. Journal of Molecular and Cellular Cardiology
21(Suppl.2):S165(1989).
Descriptors: canine, porcine, coronary artery occlusion,
vascular, growth.
69
"Can superoxide dismutase alter myocardial infarct size." R.
Engler and E. Gilpin. Circulation 79(5):1137-1142(1989).
NAL call number: RC681 A1C8
Descriptors: dog, pig, rabbit, cardiovascular drug,
reperfusion therapy.
70
"Cardiovascular and metabolic adequacy and survival after
aorto-aortic bypass." A. Borzone, I. Giovannini, C. Iannace,
C. Vulpio, C. Chaiarla, G. D'Andrea, G. Salgarello, G.M.
Sbarra, M. Castagneto, and G.C. Castiglioni. Vascular Surgery
23(5):337-342(1989).
Descriptors: pig, model, hemodynamics, respiration, myocardial
competence, mortality.
71
"Drug therapy of cardiopulmonary resuscitation in children."
A. Zaritsky. Drugs 37(3):356-374(1989). Descriptors:
adrenalin, lidocaine, bretylium, isoprenaline, bicarbonate,
dopamine, methoxamine, phenylephrine, drug therapy,
cardiopulmonary arrest, calcium, blood flow.
72
"Effects of azapropazone on neutrophil migration in
anesthetized swine using a multiblister suction technique."
S.A. Mousa, R. Brown, J. Hsieh, and R.D. Smith. Journal of
Molecular and Cellular Cardiology 21(Suppl. 2):S173(1989).
Descriptors: antiinflammatory drug, immunologic drug,
myocardial cytoprotection, in vivo animal model.
73
"Effects of halothane on arrhythmias induced by myocardial
ischemia." B.A. Macleod, R. McGroarty, R. H. Morton, and
M.J.A. Walker. Canadian Journal of Anaesthesia 36(3 Part
1):289-294(1989). Descriptors: rat, pig, pentobarbital,
antiarrhythmic drug, species dependent.
74
"The effect of ischemic preconditioning on myocardial oxygen
consumption and infarct size and pigs." R. Schott, S. Rohmann,
E. Braun, B. Winkler, S. Juergens, and W. Schaper. Journal of
Molecular and Cellular Cardiology 21(Suppl. 2):S161(1989).
Descriptors: reversible post ischemic ventricular dysfunction,
reperfusion, blood flow.
75
"Effect of various propofol plasma concentrations on regional
myocardial contractility and left ventricular afterload." A.
Coetzee, P. Fourie, J. Coetzee, E. Badenhorst, A. Rebel, C.
Bollinger, R. Ubel, C. Wium, and C. Lombard. Anesthesia and
Analgesia 69(4):473-483(1989).
Descriptors: pig, general anesthetic drug, heart rate, stroke
volume, cardiac output, arterial elastance, systolic pressure.
76
"Glucose dependence of sequential norepinephrine contractions
of vascular smooth muscle." G.R. Adams and P.F. Dillon. Blood
Vessels 26(2):77-83(1989).
Descriptors: pig, force production, NMR.
77
"Importance of vascular effects of different cardiotonic
agents in comparison to its myocardial effects." P. Metzenauer
and R. Dedecke. Naunyn-Schmiedeberg's Archives of Pharmacology
339(Suppl.):R60(1989). NAL call number: 448.8 Ar2
Descriptors: pig, amironine enzyme inhibitor drug,
aliferidine, pirbuterol dihydralazine, cardiovascular drug,
vasodilator, cardiac output, myocardial oxygen consumption,
positive inotropic stimulation, phosphodiesterase activity,
ischemic heart failure.
78
"Mechanisms of arterial thrombosis in nonparallel streamlines:
Platelet thrombi grow on the apex of stenotic severely injured
vessel wall. Experimental study in the pig model." L. Badimon
and J.J. Badimon. The Journal of Clinical Investigation
84(4):1134-1144(1989).
NAL call number: 448.8 J8295
Descriptors: acute coronary syndromes, plaque rupture.
79
"Microvascular and collateral adaption in swine hearts
following progressive coronary artery stenosis." G. Goerge, T.
Schmidt, B.R. Ito, G.A. Pantely, and W. Schaper. Basic
Research in Cardiology 84(5):524-535(1989).
Descriptors: dog, model, myocardial infarction, angiogenesis,
angiogram, collateral blood flow.
80
"Myocardial surface oxygen partial pressure an indicator of
myocardial tissue oxygenation." J. Hobbhahn, P.F.M. Conzen, A.
Goetz, G. Seidl, P. Gonschior, W. Brendel, and K. Peter.
Cardiovascular Research 23(6):529-540(1989).
NAL call number: QM178 A1C38
Descriptors: pig model, oxygen consumption, pacing induced
tachycardia.
81
"New nonisotopic in vivo technique of quantitating cellular
proliferation in arterial media and intima." M.W.I. Webster,
J.H. Chesebro, M. Heras, J.S. Mruk, H. Lamb, B. Wendland, L.
Badimon, and V. Fuster. Circulation 80(4 Suppl.
2):11523(1989).
NAL call number: RC681 A1C8
Descriptors: pig, smooth muscle cell, bromodeoxyuridine,
iododeoxyuridine, model, atherosclerosis, thrombosis,
angioplasty.
82
"Parasympathetic and sympathetic innervation of the heart in
the developing piglet." D.A. Hopkins, J.A. Armour, N. Gootman,
and P.M. Gootman. Society of Neuroscience Abstracts
15(1):592(1989). Descriptors: perikarya, sympathetic ganglia,
sensory ganglia, stellate ganglia, middle cervical ganglia,
brainstem, ventrolateral nucleus ambiguus.
83
"Pharmacology of aprotinin and efficacy during cardiopulmonary
bypass." T.E. Emersen, Jr. Cardiovascular Drug Revues
7(2):127-140(1989).
Descriptors: human, cat, dog, pig, rat, hematologic drug,
cardiovascular drug, reduction in postoperative blood loss.
84
"Pharmokinetics and central hemodynamic effects of doxorubicin
and 4 epidoxorubicin in the pig." M. Andersson, L. Domellof,
S. Eksborg, S. Haggmark, G. Johansson, S. Reiz, and A.
Herslof. Acta Oncologica 28(5):709-714(1989).
Descriptors: Antineoplastic drug, cardiotoxicity, pulmonary
physiology, myocardial oxygenation.
85
"Protection of the myocardium against postischemic reperfusion
damage." W.H. Van Gilst. Journal of Cardiovascular
Pharmacology 14(Suppl. 9):S49-S54(1989).
Descriptors: rat, dog, pig, verapamil, nifedipine diltiazem,
superoxide dismutase, catalase, allopurinol, prostacyclin,
captopril, cardiovascular drug pharmacodynamics, calcium
antagonist, oxygen free radical, angiotensin converting enzyme
inhibition.
86
"Reconstitution of calcium channel CACH purified from porcine
ventricular muscle into liposomes and its characterization."
T. Naitoh, T. Toyo-Oka, and T. Sugimoto. Journal of Molecular
and Cellular Cardiology 21(Suppl. 2):S177(1989).
Descriptors: Bay-K-8644, pharmacology, potassium,
depolarization.
87
"Reduction of cephalic arteriovenous shunting by ergotamine is
not mediated by HT-1 like or 5 HT-2 receptors." A.H. Bom,
J.P.C. Heiligers, P.R. Saxena, and P.D. Verdouw. British
Journal of Pharmacology 97(2):383-390(1989).
NAL call number: 396.8 B77
Descriptors: cat, pig, 5 hydroxytryptamine, ketanserin,
methiothepin, pharmacology, arteriovenous anastomoses, carotid
blood flow.
88
"The regional distribution of adenosine regulating enzymes in
the left and right ventricle walls of control and hypertrophic
heart." V. De Tata, S. Gini, I. Simonetti, V. Fierabracci, Z.
Gori, P.L. Ipata, and E. Bergamini. Basic Research in
Cardiology 84(6):597-605(1989).
Descriptors: rat, ox, pig, models, 5 nucleotidase adenosine
deaminase, amp deaminase adenosine kinase.
89
"Response of myocardial metabolites to graded regional
ischemia phosphorus-31 NMR spectroscopy of porcine myocardium
in vivo." S. Schaefer, S.A. Camacho, J. Gober, R.G. Obregon,
M.A. Degroot, E.H. Botvinick, B. Massie, and M.W. Weiner.
Circulation Research 64(5):968-976(1989). NAL call number:
RC681 A1A57137
Descriptors: coronary stenosis, phosphate, pH, regional blood
flow reduction, ATP phosphocreatine, inorganic phosphate.
90
"The role of neutrophils and free radicals in the ischemic
reperfused heart why the confusion and the controversy." K.A.
Reimer, C.E. Murry, and V.J. Richard. Journal of Molecular and
Cellular Biology 21(12):1225-1240(1989).
Descriptors: dog, rabbit, pig, model, myocardium, myocyte
cell, death, oxygen metabolism, myocardial infarction.
91
"Steroid induced myocardial preservation is associated with
decreased cell membrane microviscosity." R.M. Engleman, M.R.
Prasad, J.A. Rousou, R.H. Breyer, M. Bagchi, and D.K. Das.
Circulation 80(5 Suppl. 3):11136-11143(1989).
NAL call number: RC681 A1C8
Descriptors: pig, dexamethasone, hormone, cardiovascular,
myocardial ischemia, phospholipid degradation.
92
"Stimulatory effect of catalytic subunit of cyclic AMP
dependent protein kinase on lipid methylation in isolated
cardiac sarcolemma." R. Vetter, V. Panagia, J. Dai, Y. Taira,
and N.S. Dhalla. Journal of Molecular and Cellular Cardiology
21(Suppl. 2):S180(1989).
Descriptors: rat, pig, sarcolemmal membrane.
93
"Superoxide dismutase: Possible therapeutic use in
cardiovascular disease." R. Ferrari, C. Ceconi, S. Curello, S.
Ghielmi, and A. Albertini. Pharmacological Research
21(Suppl.2):57-65(1989). Descriptors: heart muscle ischemia,
reperfusion, heat protection, oxygen radical inflammation,
drug bioavailability, osteoarthritis, dog, rabbit, swine.
94
"Transesophageal low energy cardioversion in an animal model
of life threatening tachyarrhythmias." Y.C. Cai, S.L. Fan,
D.X. Feng, S.X. Fan, J.F. Feng, Z.S. Kuang, and Z.F. Li.
Circulation 80(5):1354-1359(November 1989).
NAL call number: RC681.A1C8
Descriptors: electric countershock, tachycardia, dogs, swine,
electrocardiography, ventricular fibrillation.
95
"Ventricular arrhythmias and local electrograms after chronic
regional denervation of the ischemic are in the pig heart." J.
Cinca, A. Bardaji, and A. Salas-Caudevilla. Journal of
American College of Cardiology 14(1):225-232(1989).
Descriptors: coronary artery occlusion, sympathectomy,
ventricular fibrillation, electrocardiogram, animal model.
96
"Antiarrhythmic and antifibrillatory properties of McN-4130 in
several animal models." B.P. Damiano, S.P. Sit, M.A.
Fortunato, M.T. Stranieri, and M.D. Brannan. Journal of
Cardiovascular Pharmacology 11(5):581-590(May 1988).
Descriptors: anti-arrhythmia agents, indoles, anesthesia,
blood pressure, drug effects, coronary disease, dogs,
electrophysiology, heart rate, swine, ventricular
fibrillation.
97
"Bretylium and diltiazem in porcine cardiac procedures." G.P.
Rodgers, D.M. Cromeens, S.T. Minor and M.M. Swindle. Journal
of Investigative Surgery 1(4):321-326(1988). Descriptors:
pharmacology, ventricular fibrillation prevention and control,
cardiovascular system surgery.
98
"Histoire naturelle de la regression de l'atherosclerose: Des
medeles animaux a l'homme. [Natural history of the regression
of atherosclerosis: From animal models to men.]" P.
Hadjiisky, M.C. Bourdillon, and Y. Grosgogeat. Archives des
Maladies du Coeur 81(11)1411-1417(November 1988). Descriptors:
diet therapy, anthropoidea, pathology, dogs, pigeons, poultry,
rabbits, rats, swine.
99
"Lipid burden in ischemic myocardium." A.J. Liedtke. Journal
of Molecular and Cellular Cardiology 20(Suppl. 2):65-74(1988).
Descriptors: oxfenicine, glycidic acid, heart muscle, lipid
metabolism, amphophile fat droplet, carnitine acyltransferase,
ultrastructure.
100
"Mechanism of decreased forward stroke volume in children and
swine with ventricular septal defect and failure to thrive."
W.J. Corin, M.M. Swindle, J.F. Spann, K. Nakano, M. Frankis,
W.W.R. Biederman, A. Smith, A. Taylor, and B.A. Carabello.
Journal of Clinical Investigation 82(2):544-551(1988). NAL
call number: 448.8 J8295
Descriptors: heart output, heart stroke volume, heart output,
body weight, age.
101
"Percutaneous, in vivo excimer laser angioplasty: Results in
two experimental animal models." J.M. Isner, D. Gal, P.G.
Steg, S.T. DeJesus, A.J. Rongione, K.R. Halaburka, G.A.
Slovenkai, and R.H. Clarke. Lasers in Surgery and Medicine
8(3):223-232(1988).
Descriptors: angioplasty, transluminal methods,
arteriosclerosis, atherosclerosis, laser surgery, angiography,
fiber optics, iliac artery, rabbits, silica, miniature swine.
102
"The spontaneously hypercholesterolemic pig as an animal model
for human atherosclerosis." A.D. Attie and M.F. Prescott.
I.L.A.R. News 30(4):5-12(Fall 1988).
NAL call number: QL55.A1143.
Descriptors: lipid, cholesterol, lipoprotein, histopathology.
103
"An animal model to examine the response to environmental
stress as a factor in sudden cardiac death." G.W. Parker, L.H.
Michael, and M.L. Entman. American Journal of Cardiology
60(18):9J-14J(December 28, 1987).
NAL call number, RC681 A1A56
Descriptors: coronary disease, psychological stress,
mortality, environment, frontal lobe physiology, hemodynamics,
propranolol, swine, ventricular fibrillation.
104
"Coronary artery spasm: Definition, clinical characteristics,
prognosis and experimental animal models." M. Nakamura.
Nippon Naika Gakkai Zasshi 76(8):1171-1187(August 1987).
Descriptors: coronary vasospasm, adverse effects of alcoholic
beverages, angina pectoris, dogs, adverse effects of
ergotamine, prognosis, swine, syncope.
105
"Endoscopic laser resection of atherosclerotic plaque in a
live animal model. A preliminary report on some technical
difficulties." P.F. Lawrence, J.M. Kercher, D.J. Dries, L.
Peric-Golia, and J.A. Dixon. Journal of Vascular Surgery
6(5):470-475(November 1987).
Descriptors: arteriosclerosis, atherosclerosis, adverse
effects of laser surgery, catheterization, diet, swine,
endoscopy.
106
"Endurance exercising miniature pigs: A review of
methodology." A.H. Parsons, S.C. Smith, R. Kertzer, and I.A.
Salkovitz. In: Swine in Biomedical Research M.E. Tumbleson
(ed.), Vol. 1. Plenum Press, New York; 1986, pp. 143-151.
NAL call number: RB125.C68 1985.
Descriptors: treadmill, heart rate, electrocardiograph, tissue
damage, heat stress, thermoregulation.
107
"Left ventricular dynamics in a controlled right heart bypass
swine model." W.Y. Moores, T.A. Pfeffer, J.B. Wisniewski, W.Y.
Heydorn, W.Y. Willford, D.C. Dembitsky and P.O. Daily. In:
Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1.
Plenum Press, New York; 1986, pp. 341-349. NAL call number:
RB125.C68 1985.
Descriptors: transducer, ultrasonicmicrometer crystals,
arterial venous shunt, pacemaker.
108
"The pig as a model for myocardial ischemia." F.C. White and
C.M. Bloor. In: Swine in Biomedical Research M.E. Tumbleson
(ed.), Vol. 1. Plenum Press, New York; 1986, pp. 481-490. NAL
call number: RB125.C68 1985.
Descriptors: left circumflex coronary artery, vessel
occlusion, collateral circulation, treadmill, exercise, heart
rate, ECG.
109
"A reproducible, quantitatable and rapidly reversible model of
cardiogenic shock in swine." R.W. Bailey, A. Oshima, W.A.
O'Roark and G.B. Bulkley. In: Swine in Biomedical Research
M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York; 1986,
pp. 363-372.
NAL call number: RB125.C68 1985.
Descriptors: heart output, ketamine, pentobarbital.
110
"Swine as animal models in cardiovascular research." K.T. Lee.
In: Swine in Biomedical Research M.E. Tumbleson (ed.). Vol. 3.
Plenum Press, New York; 1986, pp. 1481-1496. NAL call number:
RB125.C68 1985.
Descriptors: atherogenic diet, spontaneous atherosclerotic
lesions, experimental atherosclerosis, histology,
electrocardiogram.
111
Swine in Cardiovascular Research H.C. Stanton and H.J.
Mersmann (eds.), Vol. 2. CRC Press: Boca Raton, FL; 1986,
177p.
NAL call number: RC669.S87 v.2.
Descriptors: nutrition and cardiovascular disease,
atherosclerosis, arrhythmias, hypertension,intimal cell
masses, effects of aspirin, effects of corn oil and butter,
resting cardiovascular parameters, neuroendocrine control,
hypoxia, in vitro porcine coronary artery, architecture,
protein regulation, myocardial ischemia, blood flow, exercise.
112
Swine in Cardiovascular Research H.C. Stanton and H.J.
Mersmann (eds.), Vol. 1. CRC Press: Boca Raton, FL; 1986,
169p.
NAL call number: RC669.S87 v.1.
Descriptors: evolution, breeds, behavior, husbandry, anatomy,
restraint and handling, disease control, herd health, housing,
anesthesia, physical exercise, stress, lipid metabolism, fatty
acid metabolism, ischemia, heart mitochondria, gravitational
stress, cardiovascular disease, spontaneous and experimental.
113
"Zur herz-kreislaufwirkung von Cordemcura on various animal
models in vivo. [The cardiovascular effect of Cordemcura on
various animal models in vivo.] E. Rhode, P. Muschick, D.
Modersohn, H. Landmann, and H. Lowe. Pharmazie
41(3):194-195(March 1986).
Descriptors: aminopyridines, cardiotonic agents, hemodynamics,
drug effects on blood pressure, cardiac output, cats,
dopamine, heart rate, rats, species specificity, swine,
vascular resistance.
114
"Animal models in atherosclerosis research." M.P. Jokinen,
T.B. Clarkson, and R.W. Prichard. Experimental and Molecular
Pathology 42(1):1-28(February 1985).
NAL call number: RB1 E9
Descriptors: arteriosclerosis, atherosclerosis, birds, dogs,
muridae, primates, rabbits, swine.
115
"Animal models of coronary spasm and the pathophysiological
events in regional vascular hypercontraction." H. Tomoike.
Japanese Circulation Journal 49(1):101-107(January 1985).
Descriptors: coronary vasospasm, smooth and vascular muscle,
cimetidine, radiography, dogs, ergonovine, histamine,
serotonin, miniature swine.
116
"Ventriculoatrial conduction in swine during cardiac pacing:
animal model for retrograde conduction." T.A. Bowman and H.C.
Hughes. The American Heart Journal 108(2):337-341(August
1984). Descriptors: tachycardia, electrocardiography,
electrophysiology, atrium, ventricle, sinoatrial node.
117
"Atherosclerosis regression in animal models: Current concepts
of cellular and biochemical mechanisms." R.W. St Clair.
Progress in Cardiovascular Diseases
26(2):109-132(September/October 1983). Descriptors:
arteriosclerosis, atherosclerosis, anthropoidea, aorta, birds,
calcium metabolism, blood cholesterol, esters, dietary
cholesterol, connective tissue, dogs, elastin metabolism,
smooth and vascular muscle, rabbits, spontaneous remission,
swine.
118
"Development of accelerated atherosclerosis. Concepts derived
from cell biology and animal model studies." R.W. Mahley.
Archives of Pathology and Laboratory Medicine
107(8):393-399(August 1983). Descriptors: arteriosclerosis,
aorta cytology, apolipoproteins, cholesterol, dogs,
fibroblasts, foam cells, lipoprotein, HDL, LDL, VLDL,
macrophages, smooth muscle metabolism, rabbits, rats,
receptors, endogenous substances, swine.
119
"Estimation of instantaneous blood flow through a rigid,
coronary artery stenosis in anaesthetized domestic swine." Y.
Sun, A.S. Most, W. Ohley, and H. Gerwirtz. Cardiovascular
Research 17(8):499-504(August 1983). NAL call number: QM178
A1C38
Descriptors: circulation, adenosine, drug effects on blood
pressure.
120
"Intravenous angiocardiography using digital image processing.
II. Detection of left to right shunts in an animal model."
H.G. Borgren, J.H. Bursch, R. Brennecke, and P.H. Heintzen.
Investigative Radiology 18(1):11-17(January/February 1983).
Descriptors: angiocardiography, ductus arteriosus, heart
septal defects, radiography, computers, administration and
dosage of diatrizoate, intravenous injections, swine,
videotape recording.
121
"Investigations on neonatal cardiopulmonary reanimation using
an animal model." E. Traub, W. Dick, P. Lotz, K.H. Lindner,
and K. Engels. Journal of Perinatal Medicine
11(2):103-113(1983). Descriptors: newborn physiology,
resuscitation, carbon dioxide, heart massage, oxygen, positive
pressure respiration, artificial respiration, swine.
122
"Effect of intraaortic balloon counterpulsation on regional
myocardial blood flow and oxygen consumption in the presence
of coronary artery stenosis: Observations in an awake animal."
H. Gewirtz, W. Ohley, D.O. Williams, Y. Sun, and A.S. Most.
American Journal of Cardiology 50(4):829-837(October 1982).
Descriptors: arterial occlusive diseases, assisted
circulation, intra-aortic pumping, oxygen consumption, blood
pressure, heart rate, myocardium metabolism, swine.
HEMODYNAMICS/HEMATOLOGY
123
"Hemorrhage and hemorrhagic shock in swine: A review." J.P.
Hannon. In: Swine as Models in Biomedical Research M.M.
Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State
University Press, IA; 1992, pp. 197-245.
NAL call number: RB125 S79
Descriptors: arterial pressure, Wiggers model, fixed-volume
procedure, cardiac output, stroke volume, heart rate.
124
"Ratio of hepatic arterial-to-portal venous blood flow-
validation of radionuclide techniques in an animal model."
M.K. O'Connor, R.F. Krom, E.G Carton, L. Sanchez-Urdazpal,
J.E. Juni, D.M. Ferguson, and R.F. Wiesner. Journal of Nuclear
Medicine 33(2):239-245(1992).
NAL call number: Rm845 J78
Descriptors: liver circulation, portal vein, imaging,
technetium Tc 99m pentetate, diagnostic use.
125
"Coagulation factor IX, (human) affinity purified." C.P.
Robinson. Drugs Today 27(5):299-303(1991). Descriptors: blood
factor clotting 9, adverse drug reaction, drug purification,
intravenous drug administration, hemophilia b, surgery,
bleeding prevention, rabbit, swine, human, nonhuman.
126
"Goal directed therapy with dobutamine in a porcine model of
septic shock: Effects on systemic and renal oxygen
transport."
G.A. Haywood, D. Tighe, R. Moss, N. Al-Saady, T.O.A. Foshola,
S.P. Riley, I. Pearson, A. Webb, W.J. McKenna, and E.D.
Bennett. Postgraduate Medical Journal 67(Suppl. 1):s36-
s41(1991). Descriptors: kidney blood flow, oxygen transport,
septic shock therapy, heart output, oxygen consumption,
intravenous drug administration, dobutamine.
127
"Hypertonic fluid resuscitation improves cerebral oxygen
delivery and reduces intracranial pressure after hemorrhagic
shock." J.D. Schmoker, J. Zhuang, and S.R. Shackford. Journal
of Trauma 31(12):1607-1613(1991).
Descriptors: hypertonic solution, intracranial pressure, brain
injury.
128
"Platelet activating factor is one of the mediators involved
in endotoxic shock in pigs." R. Mozes, J.P.C. Jeiligers,
C.J.A.M. Tak, F.J. Zijlstra, S. Ben-Efraim, P.R. Saxena, and
I.L. Bonta. Journal of Lipid Mediators 4(3):309-325(1991).
Descriptors: septic shock, hematology, female, escherichia
coli endotoxin, thrombocyte activating factor, intravenous
drug administration, ginkgolide b, microsphere ce 141,
microsphere sn 113.
129
"External thoracic duct-venous shunt in conscious pigs for
long term studies of connective tissue metabolites in lymph."
L.T. Jensen, P. Olesen, J. Risteli, and I. Lorenzen.
Laboratory Animal Science 40(6):620-624(1990). NAL call
number: 410.9 P94
Descriptors: type I procollagen, type III procollagen,
transport of connective tissue metabolites, hyaluronan.
130
"Hemodynamics and coronary blood flow during experimental
aortic valvuloplasty comparison of the dual versus the single
catheter methods." J.W. Moore, M.C. Slack, W.C. Kirby, and
G.M. Graeber. American Heart Journal 119(1):136-142(1990).
Descriptors: left ventricular occlusion, statistics.
131
"A quantitative study of some factors affecting the outcome of
experimental epidural bleeding in swine." J.C. Ganz and N.N.
Zwetnow. ACTA Neurochirurgica 102(3-4):164-172(1990).
Descriptors: hematoma, intracranial pressure,
electroencephalograph.
132
"On the hemodynamics of the pulmonary circulation of the mini
pig after experimentally produced pulmonary embolism according
to Sedlarik II. Influence of the hemodynamics of heart and
circulation of thoracotomy." E. Ebner, T. Lesser, E. Reidel,
and U. Zwiener. Zeitschrift fur Experimentelle Chirurgie,
Transplantation, und Kunstliche Organe 22(6):347-350(1989).
Descriptors: systolic and diastolic mean arterial blood
pressure, pulmonary arterial pressure.
133
"On the hemodynamics of the pulmonary circulation of the mini
pig after experimentally produced pulmonary embolism according
to Sedlarik 1. The pulmonary embolism model according to
Sedlarik in comparison with existing embolism models." T.
Lesser, E. Ebner and U. Zwiener. Zeitschrift fur
Experimentelle Chirurgie, Transplantation, und Kunstliche
Organe 22(6):342-346(1989). Descriptors: pathophysiological
mechanism.
134
"Resuscitation of conscious pigs following hemorrhage: Oxygen
delivery and demand during fixed-volume hemorrhage and
resuscitation with 7.5% NaCl in 6% dextran." J.P. Hannon, C.E.
Wade, C.A. Bossone, M.M. Junt, and J.A. Loveday. Report No.:
LIAR-369, Letterman Army Institute of Research, Presidio of
San Francisco, CA. (January 1989).
Descriptors: compensation, heart, hemoglobin, sodium chloride,
hemorrhagic shock, oxygen output, ventilators.
135
"Effect of naloxone and ibuprofen on organ blood flow during
endotoxic shock in pig." M.K. Nishijima, M.J. Breslow, C.F.
Miller, and R.J. Traystman. American Journal of Physiology
255(1 Pt 2):H177-H184(1988). Descriptors: hemodynamics,
thromboxane B-2, 6-ketoprostaglandin-F1-alpha, ibuprofen.
136
"Animal models to study the cardiopulmonary effects of
artificial kidney membranes." A.K. Cheung. Blood Purification
5(2-3):155-161(1987).
Descriptors: hemodialysis, hemodynamics, anaphylatoxins
metabolism, arachidonic acid, cellulose analogs and
derivatives, adverse effects of cellulose, complement
activation, leukocytes, thromboxane metabolism, sheep, swine.
137
"Blood biochemical status of miniature swine during submaximal
and exhaustive exercise." J.E. Wilderson, T.M. Sanders, and
C.M. Bloor. Medicine and Science in Sports and Exercise
18(2):180-185(1986). Descriptors: catecholamine, lactate blood
level, blood ph, protein blood level.
138
"The conscious pig as a large animal model for studies of
hemorrhagic hypotension." J.P. Hannon and C.A. Bossone. In:
Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 3.
Plenum Press, New York; 1986, pp. 1413-1428.
NAL call number: RB125.C68 1985.
Descriptors: hypotension, hemorrhage, cannulae, arteries.
139
"Endotoxemic swine as a model for the metabolic response to
sepsis." M.S. Hand, R.W. Phillips, M.J. Fettman, and L.G.
Chandrasena. In: Swine in Biomedical Research M.E. Tumbleson
(ed.), Vol. 1. Plenum Press, New York; 1986, pp. 453-460.
NAL call number: RB125.C68 1985.
Descriptors: gram negative bacteria, metabolic disorders,
disease models, endotoxins.
140
"Hemodynamic characteristics of the conscious pig: A brief
review." J.P. Hannon. In: Swine in Biomedical Research M.E.
Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp.
1341-1352. NAL call number: RB125.C68 1985.
Descriptors: heart rate, cardiac and stroke index values, body
weight, anesthesia, restraint, arterial, pulmonary and atrial
pressure values, epinephrine, norepinephrine, vasopressin,
renin activity, domestic and miniature swine.
141
"Hemodynamic and metabolic consequences of group B beta
streptococcal sepsis in piglets." W.L. Meadow, P. Meus, B.F.
Rudinsky, and E. Strates. In: Swine in Biomedical Research
M.E. Tumbleson(ed.), Vol. 1. Plenum Press, New York; 1986, pp.
461-471.
NAL call number: RB125.C68 1985.
Descriptors: metabolic disorders, streptococcus, blood
picture, heart output.
142
"Swine clinical chemistry." M.E. Tumbleson and D.A. Schmidt.
In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2.
Plenum Press, New York; 1986, pp. 783-807. NAL call number:
RB125.C68 1985.
Descriptors: baseline hematologic values, serum magnesium,
calcium, inorganic phosphorus, sodium, potassium, chloride,
urea nitrogen, glucose, cholesterol, albumin, globulins, serum
animo acids, blood sampling methods, factors affecting blood
values, age, sex, time of fast, time of day, housing, stress.
143
"Swine hematology." D.A. Schmidt and M.E. Tumbleson. In: Swine
in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum
Press, New York; 1986, pp. 767-782.
NAL call number: RB125.C68 1985.
Descriptors: erythrocyte, leukocyte, neutrophil and platelet
counts, packed cell volumes, hemoglobin concentration, base
line hematologic values, factors affecting blood values, sex,
breed, age, laboratory.
144
"Coagulation factor-V and factor-VIII and ceruloplasmin
constitute a family of structurally related proteins." W.R.
Church, R.L. Jernigan, J. Toole, R.M. Hewick, J. Knopf, G.J.
Knutson, M.E. Nesheim, K.G. Mann, and D.N. Fass. Proceedings
of the National Academy of the United States of America
81(22):6934-6937(1984).
Descriptors: bovine, porcine, human, evolutionarily linked
proteins.
145
"Controlled endotoxinemia in pigs. A suitable model for in
vivo studies of some hemodynamic, humoral and cellular
reactions." O.K. Andersen, T. Lundgren, and A. Revhaug. Acta
Chirurgica Scandinavica 150(8):599-606(1984).
Descriptors: blood clotting disorder, blood cell count,
septicemia.
146
"Learning from animal models of bleeding disorders." W.J.
Dodds. Annals of the New York Academy of Sciences
406:59-61(1983).
NAL call number: 500 N484
Descriptors: blood coagulation disorders, von Willebrand's
disease, cat, dog, horse, swine diseases, hemophilia,
thrombosis.
147
"An effective mass screening program for animal models of the
inherited bleeding disorders." W.J. Dodds. Progress in
Clinical and Biological Research 94:117-132(1982). NAL call
number: RC627.8 I56 1981
Descriptors: blood coagulation disorders, von Willebrand's
diseases, dog, cat, swine, cattle diseases, hemophilia.
148
"Joint report of the subcommittees on animal models of
hemorrhagic and thrombotic diseases and on platelets." W.J.
Dodds. Thrombosis and Haemostasis 48(1):106-107(August 24,
1982). Descriptors: blood coagulation disorders, diagnosis,
bleeding time, platelet aggregation, dog, rat, swine.
PULMONARY SYSTEM
149
"Pulmonary function and hemodynamic effects of incremental
positive end-expiratory pressure in ventilated piglets with
normal lungs." T.G. Mundie, D. Easa, K.C. Finn, E.L. Stevens,
G. Hashiro, and V. Balaraman. Clinical Research
41(1):95A(1993).
Descriptors: abstract, pulmonary pediatrics, increased
transmural pulmonary artery pressure, decreased stroke
volume, decreased cardiac output model.
150
"Methodologies, devices, and new surgical concepts. Comparison
of new iron chelating agents in the prevention of
ischemia/reperfusion injury: A swine model of heart-lung
transplantation." A.K Qayumi, W.R.E. Jamieson, A. Poostizadeh,
E. Germann, and K.D. Gillespie. Journal of Investigative
Surgery 5(2):115-127(1992).
Descriptors: drug comparison, deferoxamine, 21 aminosteroid,
tirilazad, drug efficacy, lung alveolus oxygen tension.
151
"Sequential CT in monitoring experimental lung transplant." P.
Hammainen, L. Kivisaari, P. Aarnio, A. Lehtola, L. Heikkila,
E. Taskinen, and A. Harjula. Journal of Computer Assisted
Tomography 16(1):138-147(1992).
Descriptors: ampicillin, ceftriaxone, methylprednisolone,
cyclosporin, azathioprine, drug therapy, graft rejection,
computer assisted tomography, swine, human, male, case report.
152
"On radiation induced pneumopathia." T. Herrmann and D. Schuh.
Bildgebung Imaging 58(Suppl. 1):26-29(1991).
Descriptors: thorax, radiotherapy, lung injury,
histopathology, radiography, histopathology.
153
"Antiasthmatic effects of onions inhibition of 5 lipoxygenase
and cyclooxygenase in vitro by thiosulfinates and cepaenes."
H. Wagner, W. Dorsch, T. Bayer. W. Breu, and F. Willer.
Prostaglandins, Leukotrienes and Essential Fatty Acids
39(1):59-62(1990).
Descriptors: human, sheep, pig, model, bronchial asthma
therapy, anti-inflammatory effect.
154
"Continuous arteriovenous hemofiltration CAVH therapy for
sepsis induced acute lung injury in immature swine." J.
Matson, P. Lee, F. Straughn, R. Pryor, and L. Hinshaw. The
FASEB Journal 4(4):A953(1990). NAL call number: QH301.F3
Descriptors: staphylococcus aureus, model.
155
"Increased survival time after delayed histamine and
prostaglandin blockade in a porcine model of severe sepsis
induced lung damage." K. Byrne, T.D. Sielaff, B. Michna, P.D.
Carey, C.R. Blocher, A. Vasquez, and H.J. Sugerman. Critical
Care Medicine 18(3):303-308(1990).
Descriptors: pseudomonas aeruginosa, cimetidine,
diphenhydramine, ibuprofen, antiinflammatory drug, hypoxia,
cardiovascular collapse, adult respiratory distress syndrome.
156
"Laser light scattering spectroscopy a new method to measure
tracheobronchial mucociliary activity." K. Svartengren, L.G.
Wiman, R. Thyberg, and R. Rigler. Thorax 44(7):539-547(1989).
Descriptors: pig, ciliary beat frequency, in vitro and in vivo
model.
157
"Right ventricular function during acute respiratory distress
syndrome." C. Chartier, J.P. Haberer, and P.N. Dieng.
Agressologie 30(1):39-42(1989).
Descriptors: dog, human, monkey, sheep, pig, model, pulmonary
circulation, positive expiratory pressure.
158
"A simplified method for autoregulation of blood flow in the
extracorporeal membrane oxygenation circuit." J.B. Atkinson,
P. Emerson, R. Wheaton, and C.M. Bowman. Journal of Pediatric
Surgery 24(3):251-252(1989). Descriptors: newborn, blood flow,
cavitation, air embolism, ventilation perfusion ratio.
159
"Sympathetic vascular control of the pig nasal mucosa III. Co-
release of noradrenaline and neuropeptide Y." J.S. Lacroix, P.
Stjarne, A. Anggard, and J.M. Lundberg. Acta Physiologica
Scandinavica 135(1):17-28(1989). Descriptors:
phenoxybenzamine, desipramine, pharmacological tool,
norepinephrine, immunoreactivity, ATP, doppler flowmetry.
160
"Vagally mediated vasodilation by motor and sensory nerves in
the tracheal and bronchial circulation of the pig." R. Matran,
K. Alving, C.R. Martling, J.S. Lacroix, and J.M. Lundberg.
Acta Physiologica Scandinavica 135(1):29-38(1989).
NAL call number: QP1 A2
Descriptors: atropine, guanethidine, chlorisondamine,
capasaicine.
161
"Mechanical properties of fetal minipig lungs after
substitution of surfactant with fluorocarbon and
dipalmitoylphosphatidyl-choline." J. Wuthe, W. Forster, P.
Dangel, B. Widjaja, and R. Rufer. Research in Experimental
Medicine 188(4):247-253(1988).
Descriptors: fluorocarbon, lung surfactant, respiratory
distress syndrome, fetus.
162
"Pulmonary exchange of solutes during experimental lung lavage
in pigs." F.M. Juettner, J. Smolle, H. Popper, P. Rehak, W.
Petek, and G. Friehs. Respiration 54(4):226-234(1988).
Descriptors: serum concentration, fluid level exchange, half
time permeability constants, protein, urea, creatine,
respiratory disease therapy model.
163
"High-frequency ventilation: A study of the mechanisms of
action." J.L. Theissen, P.P. Lunkengeimer, F.J. Mersch, G.
Frieling, K. Redmann, and P. Lawin. Annales Francaises
d'Snesthesie it de Reanimation 7(3):233-238(1987).
Descriptors: intrapulmonary pressure, carbon dioxide,
diffusion, endobronchial aerodynamics.
164
"Lung reflexed affecting the larynx in the pig, and the effect
of pulmonary microembolism." G. Aguggini, M.G. Clement, and
J.G. Widdicombe. Quarterly Journal of Experimental Physiology
72(1):95-104(1987). NAL call number: 447.8 Q1
Descriptors: phenylbiguanide, capsaicin, apnea, blood
pressure, cardiac rhythm, animal experiments, airflow
resistance, pulmonary embolism.
165
"Tracheomalacia: An experimental animal model for a new
surgical approach." I. Vinograd, R.M. Filler, S.J. England, C.
Smith, D. Poenaru, A. Bahoric, and G. Kent. The Journal of
Surgical Research 42(6):597-604(June 1987).
Descriptors: cartilage diseases, transplantation of
periosteum, tracheal diseases, airway resistance, cough,
swine, tibia.
166
"Development of a pneumonia model in pigs using pseudorabies
virus and Pasteurella multocida." C. Pijoan, M. Fuentes, and
E. Noyes. In: Swine in Biomedical Research M.E. Tumbleson
(ed.), Vol. 1. Plenum Press, New York; 1986, pp. 491-498.
NAL call number: RB125.C68 1985.
Descriptors: pasteurella multocida, aujeszky virus.
167
"Effect of reduced ventilation on pneumonia in young pigs."
E.P. Noyes, L.D. Jacobson, C. Pijoan, and J.J. Boedicker. In:
Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1.
Plenum Press, New York; 1986, pp. 209-216.
NAL call number: RB125.C68 1985.
Descriptors: bacteria, isolation, weight gain, feed
conversion.
168
"Fractionated lung irradiation in young pigs with 6.2 MEV
neutrons and cobalt-60." L. Voigtmann, A. Knorr, J. Lorenz, U.
Johannsen, and K. Welker. Radiotherapy and Oncology
7(1):69-76(1986). Descriptors: pneumopathy, hydroxyproline,
effective dose, cancer, radiotherapy.
169
"Host specific lung bacterial clearance and acute respiratory
failure." S.M. Steinberg, S.H. Crocker, B.D. Lowery, and C.T.
Cloutier. In: Swine in Biomedical Research M.E. Tumbleson
(ed.), Vol. 1. Plenum Press, New York; 1986, pp. 499-505.
NAL call number: RB125.C68 1985.
Descriptors: dogs, pigs, pseudomonas aeruginosa, sepsis,
respiratory disease.
170
"The pig as a respiratory model for man." M.C. Clement and G.
Aguggini. Scienza Veterinaria e Biologia Animale
(No.3):33-36(1986).
Descriptors: animal models of human disease, respiratory
system, anatomy.
171
"Technique of right lymphatic duct cannulation for pulmonary
lymph collection in an acute porcine model." G.J. Chuang, C.X.
Gao, D.S. Mulder, and R.C. Chiu. The Journal of Surgical
Research 41(6):563-568(December 1986).
Descriptors: catheterization methods, lung anatomy and
histology, specimen handling, blood protein analysis.
172
"Physiological activity of pulmonary surfactant with low
protein content: Effect of enrichment with synthetic
phospholipids." P. Berggren, T. Curstedt, and G. Grossman.
Experimental Lung Research 8(1):29-51(1985). Descriptors:
hyaline membrane disease, lung compliance,
dipalmitoyllecithin, drug screening, respiratory distress
syndrome, prematurity.
173
"Pulmonary trapping of platelets and fibrin after
musculoskeletal trauma: An experimental model." I. Jansson, L.
Loven, L. Rammer, and S. Lennquist. Journal of Trauma
25(4):288-298(1985). Descriptors: locomotor disease, lung
embolism, thrombocyte, fibrin, adult respiratory distress
syndrome, radioactivity.
GASTROINTESTINAL FUNCTION
174
"Pathogenicity and antigen detection of the Nouzilly strain of
transmissible gastroenteritis coronavirus, in 1-week-old
piglets." M.J. Cubero, S. Bernard, L. Leon, P. Berthon, and A.
Contreras. Journal of Comparative Pathology
106(1):61-72(1992).
NAL call number: 41.8 J82
Descriptors: immunohistochemistry, intestine, virogenesis,
tissue distribution.
175
"Advantages of a narrow-range, medium molecular weight
hydroxyethyl starch for volume maintenance in a porcine model
of fecal peritonitis." A.R. Webb, D. Tighe, R.F. Moss, N. Al-
Saady, J.W. Hynd, and E.D. Bennett. Critical Care Medicine
19(3):409-416(1991).
Descriptors: hetastarch, adult respiratory distress syndrome.
176
"A comparison of portal versus systemic venous drainage in the
pig small-bowel allograft recipient." H. Kaneko, M.A.
Fischman, T.M. Buckley, and R.T. Schweizer. Surgery
109(5):663-670(1991). Descriptors: small intestine,
transplantation, portal vein flow.
177
"Gastritis associated with infection by Helicobacter pylori:
Comparative pathology in humans and swine." T.A. Bertram, S.
Krakowka, and D.R. Morgan. Reviews of Infectious Diseases
13(Suppl. 8):s714-s722(1991). Descriptors: bacterial
infection, stomach mucosa, endoscopy.
178
"Necrotizing enterocolitis in a neonatal piglet model." I.T.
Cohen, S.D. Nelson, R.A. Moxley, M.P. Hirsh, T.C. Counihan,
and R.F. Martin. Journal of Pediatric Surgery
26(5):598-601(1991). Descriptors: autopsy, histology, newborn.
179
"Antisecretory and antiiflammatory properties of bismuth
subsalicylate." C.D. Ericsson, C. Tannenbaum, and T.T.
Charles. Reviews of Infectious Diseases 12(Suppl. 1):S16-
S20(1990). NAL call number: RC111 R4
Descriptors: escherichia coli, vibrio cholerae, rabbit, pig,
rat, pepto bismol, antibacterial drug, drug, inflammatory
diarrhea.
180
"Effect of different fractions of alkaline reflux on the
gastric stump and the esophagus an experimental research on
pigs." G. Clemente, R. Manni, F.M. Vecchio, S. Rizzo, S.
Furgiuele, P. Perrotti, and F. Crucitti. The Journal of
Surgical Research 48(2):121-126(1990).
Descriptors: bile secretion, pancreaticoduodenal secretion,
gastroesophageal reflux, gastritis, histopathology.
181
"Experimental studies on the healing of colonic anastomoses."
M.J. Koruda and R. H. Rolandelli. Journal of Surgical Research
48(5):504-516(1990).
Descriptors: rat, rabbit, dog, pig, models, nutrition,
antineoplastic therapy, radiation, chemotherapy.
182
"Hepatotoxicity of the colon carcinogen azoxymethane in the
Hanford Moore miniature swine." M.J. Wargovich, W.
Satterfield, R. Price, L.C. Stephens, L. Coghlan and B. Levin.
Gastroenterology 98(5 Part 2):A318(1990).
NAL call number: RC799 G37
Descriptors: model, endoscopy, colon cancer, hepatic necrosis.
183
"Inoculation of barrier born pigs with helicobacter pylori: A
useful animal model for gastritis type B." L. Engstrand, S.
Gustavsson, A. Jorgensen, A. Schwan, and A. Scheynius.
Infection and Immunity 58(6):1763-1768(June 1990).
NAL call number: QR1 I57
Descriptors: bacteria, gastritis, inoculation.
184
"Jejunum is preferential for the construction of a bianchi
segment in short bowel syndrome." W.D. Buie, O.G. Thurston,
A.B.R. Thomson, and R.N. Fedorak. Gastroenterology 98(5 Part
2):A162(1990). NAL call number: RC799 G37
Descriptors: pig, model, bowel lengthening method, glucose
transport.
185
"Plasma levels of vasoactive intestinal peptide VIP at birth
in swine." G. Condemi, B.W. Hundley, M. Blank, A.C. Yao, F.T.
Velcek, H.L. Cohen, and P.M. Gootman. Pediatric Research 27(4
Part 2):41A(1990). Descriptors: postnatal development.
186
"Complete occlusion of the intestinal tract with staples an
experimental study and a case report." Y.T.M. Lee, J.A.
Ameika, R.R. Martin, and W.S. Stokes. Digest of Surgery
6(4):185-190(1989). Descriptors: pig model of human knife
wounds, bleeding, necrotic giant ulcer, duodenum, proximal
jejunum, pancreatic fistula, distal ileum, colon, clinical
application.
187
"Establishment of Campylobacter Pylori CP in barrier born pigs
an animal model for CP related human diseases." L. Engstrand,
A. Jorgensen, A. Schwan, and S. Gustavsson. Scandinavian
Journal of Gastroenterology Supplement 159(24):39(1989).
NAL call number: RC799 S33 Suppl.
Descriptors: gastritis, antibody response.
188
"Experimental models in vivo for Campylobacter Pylori." B.J.
Marshall. Gasteroenterologische Clininque et Biologique
13(Suppl.1):50B-52B(1989).
Descriptors: human, pig, macaca mulatta, macaca fascicularis,
macaca nemestrina, gastritis.
189
"Gangliosides are novel gastroprotective and antiulcer
agents." S. Szabo, S. Dipietro, R.E. Morales, I.T. Lippe, and
C. Rogers. Gastroenterology 96(5 Part 2):498(1989). NAL call
number: RC799 G37
Descriptors: rat, porcine, omentum extract, bovine brain
gangliosides, antiulcer agent, ethanol, hydrochloric acid,
aspirin, chemically induced gastritis, mucosal lesion,
ischemic erosion, chronic duodenal ulcer.
190
"Investigations of solutions with a different content of BCAA
to the protein metabolism in the postoperative periods 1.
Report nitrogen 15 tracer kinetic metabolic animal model to
study the influence of parenteral amino acid supply on the
nitrogen metabolism." R. Matkowitz, W. Hartig, R. Ritter, and
H. Betzler. Infusionstherapie 16(3):125-131(1989).
Descriptors: pig, human implications, metabolic drug, branched
chain amino acid, parenteral nutrition.
191
"A large animal model (swine) to study the diagnosis and
treatment of cholelithiasis." S.L. Griffith, B.T. Burney, F.J.
Fry, and T.D. Franklin Jr. Investigative Radiology
24(2):110-114(February 1989). Descriptors: bile acid and salts
analysis, diagnosis and therapy, cholesterol.
192
"A modified thomas cannula for duodenal cannulation in pigs."
B.R. Landers, P.G. Devitt, and G.G. Jamieson. Australian
Veterinary Journal 66(6):182-183(1989). NAL call number: 41.8
Au72
Descriptors: motility, large animal model.
193
"Acetaminophen induced acute hepatic failure in pigs:
Controversial results to other animal models." D. Henne-Bruns,
J. Artwohl, C. Broelsch, and B. Kremer. Research in
Experimental Medicine (Berlin) 188(6):463-472(1988).
Descriptors: acetaminophen toxicity, liver diseases,
acetaminophen administration and dosage, anesthesia, dose
response relationship, methemoglobin.
194
"The miniature pig as an animal model for the study of
intestinal enzyme development." R.J. Shulman, S.J. Henning,
and B.L. Nichols. Pediatric Research 23(3):311-315(March
1988). NAL call number: RJ1.P4
Descriptors: enzyme activity, development, intestinal mucosa.
195
"A technique to study splanchnic metabolism in the
unrestrained conscious pig." C.L. Van Berlo, A.E. Van den
Bogaard, M.C. Bost, and P.B. Soeters. Laboratory Animal
Science 38(4):463-466(August 1988). NAL call number: 410.9
P94
Descriptors: blood specimen collection, indwelling aorta
catheters, intestinal blood supply, portal vein, restraint.
196
"Zur pathogenese des Morbus Chrohn. Bewertungskriterien fur
ein tierexperimentelles modell." [Pathogenesis of Chrohn's
disease. Evaluation criteria for an animal model.] E. Nagel,
E. Guthy, S. Schattenfroh, J. Pohlenz, and R. Pichlmayr.
Schweizerische Medizinische Wochenschrift 118(20):766-769(May
21, 1988).
NAL call number: R51 S35
Descriptors: dietary fat metabolism, swine, intestinal mucosa
pathology.
197
"Absence of beneficial effects of clonidine treatment in a
piglet diarrhoea model." V. Cools, E. Cox, and A. Houvenaghel.
Medical Science Research 15(20):1263-1264(1987). Descriptors:
clonidine, adverse drug reaction, side effects, heart rate,
blood pressure.
198
"Characterization of the Yucatan miniature pig skin and small
intestine for pharmaceutical applications." T. Kurihara-
Bergstrom, M. Woodworth, S. Feisullin, and P. Beall.
Laboratory Animal Science 36(4):396-399(1986). Descriptors:
gastrointestinal tract, caffeine metabolism, anatomy,
histology, human organ system model.
199
"Comparative physiology of the mammalian colon and suggestions
for animal model of human disorders." C.E. Stevens, R.A.
Argenzio, and M.C. Roberts. Clinical Gastroenterology
(England) 15(4):763-785(October 1986).
Descriptors: swine, colonic pathology.
200
"Peptic ulceration--what can be expected from animal models."
R.A. Hinder. Scandinavian Journal of Gastroenterology
Supplement 125:195-202(1986).
NAL call number: RC799 S33 Suppl.
Descriptors: duodenal ulcer, papio, stomach ulcer,
physiopathology, therapy, dogs, swine, species specificity.
201
"The pig in studies of diarrhea pathophysiology." R.A.
Argenzio. In: Swine in Biomedical Research M.E. Tumbleson
(ed.), Vol. 1. Plenum Press, New York; 1986, pp. 441-452. NAL
call number: RB125.C68 1985.
Descriptors: swine dysentery, transmissible gastroenteritis
virus, treponema hyodysenteriae, therapy.
202
"Using the pig to study digestion and fermentation in the
gut." S.E. Fleming and D. Arce. In: Swine in Biomedical
Research M.E. Tumbleson (ed.), Vol. 1. Plenum Press, New York;
1986, pp. 123-142. NAL call number: RB125.C68 1985.
Descriptors: fiber, volatile fatty acids.
203
"Pathophysiology of swine dysentery." R.A. Argenzio. In:
Animal Models For Intestinal Disease (ed.) C.J. Pfeiffer. CRC
Press, Baco Raton, FL; 1985, pp. 3-19.
NAL call number: RC860 A55
Descriptors: swine diseases, bacterial diseases, treponema
hyodysenteriae, intestinal diseases, pathogenesis, human
disease models, colon, absorption.
204
"Necrotizing enterocolitis: A review of animal models." S.L.
Topalian and M.M. Ziegler. The Journal of Surgical Research
37(4):320-336 (October 1984).
Descriptors: newborn physiology, newborn diseases, asphyxia
neonatorum, bacteria physiology, blood volume, breast
feeding, adverse effects of catheterization, dogs, enteral
feeding, chemically induced enterocolitis, exchange
transfusion, whole blood, formulated food, goats, hypertonic
solutions, hypothermia, indomethacin, intestinal mucosa,
necrosis, rats, swine, umbilical arteries.
LIVER AND PANCREAS
205
"Effect of nutritional status on organic anion clearance by
the swine liver." K.A. Kudsk, D.F. Kisor, B. Waters, J.M.
Mirtallo, A.J. Campbell III, and R.A. Wooding-Scott. Surgery
111(2):188-194(1992). Descriptors: liver dysfunction,
malnutrition, liver clearance.
206
"Orthotopic liver transplantation in outbred and partially
inbred swine." M.W. Flye. In: Swine as Models in Biomedical
Research M.M. Swindle, D.C. Moody, and L.D. Phillips (eds.),
Iowa State University Press, IA; 1992, pp. 44-56.
NAL call number: RB125 S79
Descriptors: liver homografts, liver biopsies, Large White,
Wessex, Landrace.
207
"Simultaneous en-bloc allotransplantation of pancreas and
kidney in a large animal-model -- Comparison of en-bloc vs
separate pancreas and kidney-transplantation in the pig." R.
Grussner and D. Sutherland. Zentralblatt Fur Chirurgie
117(11):607-615(1992).
Descriptors: pancreas-kidney transplantation, cystoscopic
transduodenal biopsy, duodenocystostomy.
208
"Swine as a model for pancreatic beta-cell transplantation."
Y. Mullen, Y. Taura, M. Nagata, K. Miyazawa, and E. Stein. In:
Swine as Models for Biomedical Research M.M. Swindle, D.C.
Moody, and L.D. Phillips (eds.), Iowa State University Press,
IA; 1992, pp. 16-34.
NAL call number: RB125 S79 1992
Descriptors: diabetes mellitus, fetal porcine islets, drug
induced diabetes, streptozotocin.
209
"In-situ protection of the liver with the HTK solution of
bretschneider." P. Lamesch, S. Raygrotzki, G. Kehrer, G.
Gubernatis, B. Ringe, B. Evers, E.A. Yacoub, and R.
Pichlamayr. Langenbecks Archiv fuer Chirurgie
376(2):85-92(1991).
Descriptors: ischemia, transaminase, hepatic blood flow,
histidine buffered tryptophan ketoglutarate solution.
210
"Islet xenotransplantationin a pre-clinical large animal
model." P. Morel, D.B. Kaufman, J.Platt, K. Braymann, M.J.
Field, J.K. Lloveras, P.S. Almond, C. Fasola, P. Kyriakides,
and P. Tzardis. Transplantation Proceedings 23(1 Part
1):875-876(February 1991).
Descriptors: islets of langerhans, blood glucose metabolism,
diabetes mellitus, experimental surgery, immunosuppression,
pancreatectomy, dogs, swine.
211
"A new surgical model of acute liver failure in the pig:
Experimental procedure and analysis of liver injury." F.
Filipponi, L.P. Fabbri, M. Marsili, F. Falcini, C. Benassai,
M. Nucera, and P. Romagnoli. European Surgical Research
23(1):58-64(1991).
Descriptors: hepatic coma, liver failure, liver resection,
portocaval shunt, experimental surgery, female.
212
"Rapid liver metabolism, urinary and biliary excretion, and
enterohepatic circulation of 16alpha-radioiodo-17beta-
estradiol." A. Scharl, M.W. Beckmann, J.E. Artwohl, S.
Kullander, and J.A. Holt. International Journal of Radiation,
Oncology, Biology, Physics 21(5):1235-1240(1991). Descriptors:
estradiol, iodine 123, pharmacology, pharmacokinetics,
enterohepatic circulation.
213
"Six-hour porcine liver storage without flushing or
perfusion." B.H. Peinaar, G.N. Stapleton, M. Bracher, Z. Lotz,
C.R. Innes, J. Fourie, and R. Hickman. Transplantation
52(1):38-43(1991). NAL call number: QP89 T73
Descriptors: liver transplantation, adenosine triphosphate,
cardioplegic agent, euro collins solution.
214
"Experimental gallstone dissolution with methyl tert butyl
ether MTBE and transcutaneous ultrasound energy." S.L.
Griffith, B.T. Burney, F.J. Fry and T.D. Franklin.
Investigative Radiology 25(2):146-152(1990). Descriptors:
drug, enzymes, hepatocellular injury, gallbladder ablation.
215
"Extracorporeal shock wave lithotripsy of experimental
gallstones in pigs." R. Capdeville, J. Andre-Bougaran, F.
Barrat, and J. Moreaux. Gastroenterology and Clinical Biology
14(2):120-123(1990). Descriptors: firing frequency,
fragmentation.
216
"Hepatic selenium concentration in pigs with microangiopathy
(mulberry heart disease): An animal model for the study of
oxidative damage." H. Korpela. International Journal of
Vitamin and Nutrition Research 60(2):156-158(1990).
NAL call number: 389.8 Z33
Descriptors: selenium deficiency, liver.
217
"A method for the massive separation of highly purified adult
porcine islets of langerhans." R. Calafiore, F. Calcinaro, G.
Basta, M. Pietropaolo, A. Falorni, M. Piermattei, and T.I.P.
Brunet. Metabolism, Clinical and Experimental
39(2):175-181(1990).
NAL call number: 448.8 M56
Descriptors: model, xenotransplant, diabetes mellitus
hyperglycemia, immunoprotection.
218
"Prostanoid release in experimental liver transplantation." S.
Post, M. Goerig, G. Otto, M. Manner, N. Senninger, B.
Kommerell, and C. Herfarth. Transplantation
49(3):490-494(1990). Descriptors: pig, prostaglandin E2 6,
ketoprostaglandin F1 alpha, thromboxane B2, inflammation,
cardiovascular alteration.
219
"Protease inhibitor gabexate mesilate in experimentally
induced acute pancreatitis with early gram negative infection
in goettigen mini pigs therapeutic efficiency and influence on
hemostasis and fibrinolysis." J. Heitz, B. Semsch, C. Emde, U.
Jansen, and J.H. Schaefer. Zeitschrift fur Gastroenterologie
28(4):192-197(1990). Descriptors: escherichia coli, enzyme
inhibitor, metabolic and drugs, necrotizing pancreatitis.
220
"Animal models of pancreatic transplant." [Modeles animaux de
transplantation pancreatique.] J.J. Duron, P. Imbaud, D.
Dutet, J. Duhault, D. Ravel, L. Oliver, and M. Dubois.
Journ'ees Annuelles de Diabetologie L'Hotel Dieu
115-124(1989).
Descriptors: dogs, swine, primates, review, tutorial, blood
supply, secretions, autologous and homologous transplantation.
221
"Disturbances of reticuloendothelial function following
experimental liver transplantation." G. Lahnborg, M. Bracher,
R. Hickman, and J. Terblanche. European Surgical Research
21(3-4):129-136(1989). Descriptors: carbon clearance,
preservation fluid, pig, model.
222
"The effect of venovenous bypass on portal vein bacteremia in
orthotopic liver transplantation." C. Christophi, B. Morgan,
R. Wale, and I. Mcinnes. Transplantation Proceedings
21(5):3859-3860(1989). Descriptors: pig, anhepatic phase,
portal circulation occlusion, immunosuppressed host, sepsis,
model, mortality rate, morbidity rate.
223
"Experimental chronic pancreatis in the pig." P. Pitkaranta,
L. Kivisaari, S. Nordling, A. Saari, and T. Schroder.
Scandinavian Journal of Gastroenterology 24(8):987-992(1989).
NAL call number: RC799 S33
Descriptors: interstitial fibrosis, chronic inflammation,
diarrhea.
224
"Magnetic resonance imaging in detecting acute oedematous and
hemorrhagic pancreatitis: An experimental study in pigs." P.
Puolakkaienen, L. Kivisaari, J. Sipponen, C.G. Standertskjold-
Nordenstam, P. Nuutinen, and T. Schroder. European Surgical
Research 21(1):25-33(1989). Descriptors: nuclear magnetic
resonance imaging, computer assisted tomography, edema,
bleeding, histology.
225
"Neodymium YAG laser and ethanol ablation of hepatic tissue an
animal model for treatment of hepatic metastasis." A.H.
Dachman, J.A. McGehee, T.E. Beam, and J.A. Burris. Lasers in
Surgery and Medicine 0(Suppl. 1):23(1989).
Descriptors: pig, sonography, yttrium, aluminum, garnet.
226
"No improvement of pancreas transplant endocrine function by
exogenous insulin infusion islet rest in the postoperative
period." D.C. Dafoe, D.A. Campbell Jr., L. Rosenberg, R.M.
Merion, I. Ucros, A.I. Vinik, H. Klandorf, and J.G. Turcotte.
Transplantation 48(1):22-26(1989). NAL call number: QP89 T73
Descriptors: pig, C peptide, glucose tolerance, model,
microanatomical similarity.
227
"Pyridine nucleotide fluorometry in preserved porcine liver
with fluorocarbon emulsion." N. Ozaki, Y. Tokunaga, I. Ikai,
M. Zaima, Y. Sakai, Y. Shimahara, Y. Kamiyama, Y. Yamaoka, K.
Ozawa, and Y. Nakase. Transplantation 48(2):198-201(1989).
NAL call number: QP89 T73
Descriptors: total adenine nucleotide concentration, energy
charge, tissue ketone body ratio, oxidation reduction changes,
liver allograft, survival, clinical applications.
228
"An animal model for radiologic biliary interventional
procedures." C.D. Becker and H.J. Burhenne. Investigative
Radiology 23(1):30-32(January 1988).
Descriptors: cholangiography, cholecystography,
cholecystostomy methods, swine.
229
"Dissolution of gallstones using methyl tertiary butyl ether
in an animal model." J.P. McGahan, H. Tesluk, J.M. Brock, R.
Johnston, and D.B. Shaul. Investigative Radiology
23(8):599-603(August 1988). Descriptors: drug therapy,
cholelithiasis, therapeutic use of ethers, disease model,
swine.
230
"Pancreatectomized swine as a model of diabetes mellitus."
K.C. Stump, M.M. Swindle, C.D. Saudek, and J.D. Strandberg.
Laboratory Animal Science 38(4):439-443(1988). Descriptors:
infections, hypoglycemia, bacteria, experimental diabetes
mellitus, pancreatectomy.
231
"Aprotinin and Nasub 2CaEDTA in experimental hemorrhagic
pancreatitis in pigs." P. Puolakkainen, A. Paananen, and M.
Kaarne. Scandinavian Journal of Gastroenterology
22(1):35-41(1987). Descriptors: drug efficacy, drug toxicity,
chemically induced pancreatitis, aprotinin pharmacology.
232
"The elimination of trypsin-alpha-macroglobulin complexes from
the blood circulation in pigs during acute pancreatitis and
after massive intravenous trypsin infusion." B. Sjolund, A.
Lasson, and K. Ohlsson. Scandinavian Journal of Clinical and
Laboratory Investigation 47(2):131-141(1987). Descriptors:
trypsin, proteinase inhibitor, infusion, alpha 2
macroglobulin.
233
"The pig as an animal model for the study of nitrosamine
metabolism." G.W. Harrington, P.N. Magee, H.M. Pylypiw Jr.,
R.F. Bevill, D.R. Nelson and J.C. Thurmon. IARC Scientific
Publications (84):132-134(1987). NAL call number: RC261 A1I5
Descriptors: bile metabolism, dimethylnitrosamine, liver blood
supply, portal vein, reference values.
234
"Effects of age on hepatic drug metabolism in miniature
swine." J.O. Peggins, L.A. Shipley, and M. Weiner. In: Swine
in Biomedical Research M.E. Tumbleson (ed.), Vol. 1. Plenum
Press, New York; 1986, pp. 39-48. NAL call number: RB125.C68
1985.
Descriptors: liver, pharmokinetics, aniline hydroxylase, p-
chloro-N-methylaniline, demethylase, UDP-
glucuronyltransferase, cytochrome P-450, Hormel-Hanford
miniature swine.
235
"Induction and management of diabetes mellitus in the pig."
J.D. Wilson, D.P. Dhall, C.J. Simeonovic, and K.J. Lafferty.
Australian Journal of Experimental Biology and Medical Science
64(6):489-500(1987). Descriptors: streptozotocin,
pharmacologic tool, pancreatectomy, pancreatic islet
transplant.
236
"Studies of gestational diabetes using the pig as a model."
D.B. Hausman, T.R. Kasser, R.W. Seerley and R.J. Martin. In:
Swine in Biomedical Research (ed.) M.E. Tumbleson. Vol. 1.
Plenum Press, New York. 1986. pp. 561-572.
NAL call number: RB125.C68 1985.
Descriptors: pregnancy, food consumption, glucose tolerance,
lipid metabolism.
237
"A successful technique of in vivo isolated liver perfusion in
pigs." C.J.H. Vand De Velde, B.J.L. Kothius, and H.W.M.
Barenbrug. Journal of Surgical Research 41(6):593-599(1986).
Descriptors: cancer chemotherapy, fluorouracil, cytostatic
agent.
238
"Ultrasound monitored hepatic cryosurgery: Longevity study on
an animal model." J.C. Gilbert, G.M. Onik, W.K. Hoddick. B.
Rubinsky, and L.D. Ferrell. Cryobiology 23(3):277-285(June
1986). Descriptors: cryosurgery methods, liver surgery,
ultrasonic diagnosis, necrosis, disease models, dogs, swine.
239
"Ultrastructure of the piglet liver." A. Singh and E. Shahidi.
In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 1.
Plenum Press, New York; 1986, pp. 77-87.
NAL call number: RB125.C68 1985.
Descriptors: liver cells, cell ultrastructure, hepatocytes,
marginal plate, oligociliated cell function, micrographs,
perinatal biology, Yorkshire piglets.
NUTRITION
240
"Effect of nutritional status on organic anion clearance by
the swine liver." K.A. Kudsk, D.F. Kisor, B. Waters, J.M.
Mirtallo, A.J. Campbell III, and R.A. Wooding-Scott. Surgery
111(2):188-194(1992). Descriptors: liver dysfunction,
malnutrition, liver clearance.
241
"Effects of lactulose and lactitol on protein digestion and
metabolism in conventional and germ free animal models:
Relevance of the results to their use in the treatment of
portosystemic encephalopathy." S.P. Bird, D. Hewitt, B.
Ratcliffe, and M.I. Gurr. Gut: Journal of the British Society
of Gastroenterology 31(12):1403-1406(1990).
NAL call number: RC799 G8
Descriptors: digestion, drug effects, hepatic encephalopathy,
sugar alcohols, diet therapy, urine nitrogen, miniature swine,
inbred strains of rats.
242
"Low selenium and infant health in Christchurch." B.A
Dolamore, K.B. Sluis, J.C. McGrouther, S. Grant, B.A. Darlow,
and C.C. Winterbourn. Proceedings of the Nutrition Society of
New Zealand 15:181-186(1990). Descriptors: infants,
nutritional state, cot death, peroxidation.
243
"The nutritional regulation of growth hormone action." J.M.
Pell and P.C. Bates. Nutrition Research Reviews
3(0):163-192(1990).
NAL call number: QP141 A1N87
Descriptors: human, pig, muscle, connective tissue, adipose
tissue.
244
"Food-induced histaminosis under diamine oxidase (DAO)
blockade in pigs: Further evidence of the key role of elevated
plasma histamine levels as demonstrated by successful
prophylaxis with antihistamines." J. Sattler, W. Lorenz, K.
Kubo, A. Schmal, S. Sauer, and L. Luben. Agents and Actions
27(1-2):212-214(1989). NAL call number: RS122 A3
Descriptors: dimetidene, cimetidine, aminoguanidine,
hypotension.
245
"Investigations of solutions with a different content of BCAA
to the protein metabolism in the postoperative periods 1.
Report nitrogen-15 tracer kinetic metabolic animal model to
study the influence of parenteral amino acid supply on the
nitrogen metabolism." R. Matkowitz, W. Hartig, R. Ritter, and
H. Betzler. Infusionstherapie 16(3):125-131(1989).
Descriptors: branched chain amino acid, human implications,
perenteral nutrition.
246
"Organ changes in pigs after longterm parenteral nutrition."
K. Nordstrand, T.J. Eide, S.M. Almdahl, O. Rokke, and E.
Gierscksky. Clinical Nutrition 8(1):29-34(1989). Descriptors:
spleen, liver, epithelioid cell, pulmonary artery
inflammation, macrophage stimulation.
247
"Vitamin Dsub 3 metabolism in a pig strain with pseudo vitamin
D-deficiency rickets, type I." R. Kaune and J. Harmeyer. Acta
Endocrinologica 115(3):345-352(1987).
Descriptors: drug efficacy, colecalciferol, calcitriol, 24,25
dihydroxyocolecalciferol.
248
"Absence of renal 25-hydroxycholecalciferol-1-hydroxylase
activity in a pig strain with vitamin D-dependent rickets." I.
Winkler, F. Schreiner, and J. Harmeyer. Calcified Tissue
International 38(2):87-94(1986). Descriptors: kidney cortex,
25 hydroxycolecalciferol 1 monooxygenase.
249
"Amino acid metabolism in swine: Applicability to normal and
altered amino acid metabolism in humans." N.J. Benevenga. In:
Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2.
Plenum Press, New York; 1986, pp. 1017-1030.
NAL call number: RB125.C68 1985.
Descriptors: crude protein, homocystinuria, sulfur amino
acids, methionine, tyrosine and monosodium glutamate
metabolism.
250
"Life cycle feeding: Maternal nutrition and progeny
development." W.G. Pond. In: Swine in Biomedical Research M.E.
Tumbleson (ed.), Vol. 2. Plenum Press, New York; 1986, pp.
915-930. NAL call number: RB125.C68 1985.
Descriptors: nutritional requirements for normal reproduction
and lactation, postnatal growth, digestible energy,
metabolizable energy, crude protein, essential amino acids,
human fetal brain development, postnatal learning.
251
"The pig as a model for aberrations associated with
carbohydrate and lipid metabolism." H.J. Mersmann. In: Swine
in Biomedical Research M.E. Tumbleson (ed.), Vol. 2. Plenum
Press, New York; 1986, pp. 981-995. NAL call number:
RB125.C68 1985.
Descriptors: carbohydrate metabolism, diabetes, hypoglycemia,
dietary fiber, lipid metabolism, anabolism, liver, fatty
acids, catabolism, lipolysis.
252
"A piglet model for infant total parenteral nutrition
studies." R.M. Goldstein, T. Hebiguchi, G.D. Luk, T. Fazi,
T.R. Guilarte, F.A. Franklin, P.W. Niemiec and D.L. Dudgeon.
In: Swine in Biomedical Research M.E. Tumbleson (ed.), Vol. 2.
Plenum Press, New York; 1986, pp. 1137-1145. NAL call number:
RB125.C68 1985.
Descriptors: human infants, gastrointestinal disorders,
intestinal resection, malabsorption, mucosal atrophy, mucosal
brush border enzymes, malabsorption, gastrostomy, IV feedings.
253
"Vitamin D metabolism in the pig." G.W. Engstrom and E.T.
Littledike. In: Swine in Biomedical Research M.E. Tumbleson
(ed.), Vol. 2. Plenum Press, New York; 1986, pp. 1091-1112.
NAL call number: RB125.C68 1985.
Descriptors: calcium, phosphorus, D2, D3, ultraviolet light,
metabolic pathway, hydroxylase, age effects on plasma vitamin
D metabolites, maternal neonate vitamin D exchange, toxicity,
calcium binding protein, bone resorption.
254
"Serum lipoproteins in cholesterol-fed pigs after partial
ileal bypass." J.A. Schouten, A.C. Beynen, and H.F.W. Hoitsma.
Laboratory Animals 19(2):98-105(1985).
Descriptors: hypercholesterolemia, lipoprotein blood level,
lipoprotein metabolism.
255
"Description of a new, versatile porcine model to study
mammalian renal hydroxylase regulation in vitro in the D
replete state." E.M. Spencer, T.K. Hunt Jr., and D. Marshall.
In: Vitamin D: Chemical, Biochemical and Clinical
Endocrinology of Calcium Metabolism (eds.) A.W. Norman, K.
Schaefer, D. von Herrath, H.G. Grigoleit. Walter De Gruyter,
Berlin. 1982. pp. 507-510.
NAL call number: QP772.V53W67 1985.
Descriptors: calciferol, nutrition deficiency, 2-5-
hydroxycholecalciferol-1 alpha hydroxylase.
URINARY SYSTEM
256
"The anephric micropig as a model for peritoneal dialysis."
S.K. Webster, M.A. DeLeo, and K.E. Burhop. In: Swine as Models
in Biomedical Research M.M. Swindle, D.C. Moody, and L.D.
Phillips (eds.), Iowa State University Press, IA; 1992, pp.
64-73.
NAL call number: RB125 S79 1992
Descriptors: catheter implantation, Yucatan micropigs, partial
nephrectomy, uremia.t
257
"DOCA-treated Yucatan miniature swine: A neurogenic model of
essential hypertension." E.J. Zambraski, G.D. Thomas and K.P.
O'Hagan. In: Swine as Models in Biomedical Research M.M.
Swindle, D.C. Moody, and L.D. Phillips (eds.), Iowa State
University Press, IA; 1992, pp. 290-301. NAL call number:
RB125 S79
Descriptors: deoxycorticosterone-acetate, sympathetic nervous
system, renal sympathetic nerve activity, mean arterial
pressure.
258
"Renal transplantation in swine." L.R. Pennington. In: Swine
as Models in Biomedical Research M.M. Swindle, D.C. Moody, and
L.D. Phillips (eds.), Iowa State University Press, IA; 1992,
pp. 35-43. NAL call number: RB125 S79 1992
Descriptors: allografts, rejection, orthotopic and heterotopic
techniques.
259
"Simultaneous en-bloc allotransplantation of pancreas and
kidney in a large animal-model -- Comparison of en-bloc vs
separate pancreas and kidney-transplantation in the pig." R.
Grussner and D. Sutherland. Zentralblatt Fur Chirurgie
117(11):607-615(1992).
Descriptors: pancreas-kidney transplantation, cystoscopic
transduodenal biopsy, duodenocystostomy.
260
"Application of P-31 nuclear magnetic resonance spectroscopy
to a new experimental kidney perfusion model using cadaveric
porcine kidneys from slaughterhouse." R. Lietzenmayer, E.
Henze, R. Knorpp, C. Schwamborn, M. Clausen, G. Schnur, and
W.E. Adam. Nephron 57(3):340-348(1991). Descriptors: kidney
perfusion, kidney preservation.
261
"Computed tomography after extracorporeal shock wave
lithotripsy (ESWL) of the kidneys. Part I: Acute findings
with histopathological correlation in an animal model." T.
Schaub, M. Kunisch, M. Stadbaumer, S. Storkel, H. El-
Damanhoury, H.J. Hennes, H. Schild, and M. Thelen. ROFO:
Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Neuen
Bildgebenden Verfahren 154(3):231-237(1991). Descriptors:
extracorporeal lithotripsy, computer assisted tomography,
kidney hemorrhage, histopathology.
262
"Goal directed therapy with dobutamine in a porcine model of
septic shock: Effects on systemic and renal oxygen transport."
G.A. Haywood, D. Tighe, R. Moss, N. Al-Saady, T.O.A. Foshola,
S.P. Riley, I. Pearson, A. Webb, W.J. McKenna, and E.D.
Bennett. Postgraduate Medical Journal 67(Suppl. 1):s36-
s41(1991). Descriptors: kidney blood flow, oxygen transport,
septic shock therapy, heart output, oxygen consumption,
intravenous drug administration.
263
"Image guided localized 31P magnetic resonance spectroscopy of
acute urinary tract obstruction." F. Parivar, P.B. Barker,
P.T. Narasimhan, L.W. Jones, and B.D. Ross. Journal of Urology
145(3):657-662(1991). NAL call number: 448.8 J8234
Descriptors: kidney pelvis, nuclear magnetic resonance
imaging, phosphorus 31.
264
"Induction of kidney transplantation tolerance across major
histocompatibility complex barriers by bone marrow
transplantation in miniature swine." P.C. Guzzetta, T.M.
Sundt, T. Suzuki, A. Mixon, B.R. Rosengard, and D.H. Sachs.
Transplantation 51(4):862-866(1991). NAL call number: QP89 T73
Descriptors: lymphohenatopoietic chimerism, lymphocyte
reaction, miniature swine, T cells, BUN, serum cretinine.
265
"Shock wave lithotripsy-induced renal injury." A.P. Evan, L.R.
Willis, B. Connors, G. Reed, J.A. McAteer, and J.E. Lingeman.
American Journal of Kidney Diseases 17(4):445-450(1991).
Descriptors: kidney injury, nephron, blood pressure, kidney
function, extracorporeal lithotripsy.
266
"An animal model of non-obstructive bladder instability." K.K.
Sethia, A.F. Brading and J.C. Smith. Journal of Urology
143(6):1243-1246(June 1990).
Descriptors: bladder, innervation, neurogenic, muscle
contraction, smooth muscle physiopathology, urodynamics,
miniature swine.
267
"Comparison of bioeffects of open surgery percutaneous surgery
and extracorporeal shock wave lithotripsy on renal function
and morphology in the farm pig creation of an animal model."
R.B. David, G.J. Fuchs, and Z. Barbaric. Journal of
Endourology 49(1):27-36(1990).
Descriptors: renin angiotensin system, nephrogenic
hypertension, nephrotomy stone therapy.
268
"Detection renal scarring by DMSA scanning - An experimental
study." A.J. Arnold, S.M. Brownless, H.M. Carty, and A.M.K.
Rickwood. Journal of Pediatric Surgery 25(4):391-393(1990).
Descriptors: kidney scar complications, kidney scintiscanning,
urinary tract infection, vesicoureteral reflux, diagnostic
value, radioisotope.
269
"Modification of hyperactive xenograft rejection by ex-vivo
xenoantibody adsorption." L.K. Han, M.L. Henry, C.G. Orosz,
D.D. Sedmak, and R.M. Ferguson. Current Surgery
47(1):15-17(1990). Descriptors: pig, dog, model, kidney
immunoadsorption, plasmapheresis, sequential organ transplant,
hemoperfusion.
270
"Renal denervation decreases blood pressure in doca treated
miniature swine with established hypertension." K.P. O'Hagan,
G.D. Thomas, and E.J. Zambraski. American Journal of
Hypertension 3(1):62-64(1990). Descriptors:
deoxycorticosterone, sodium acetate, mean arterial pressure,
surgical denervation.
271
"The application of renal cells in culture in studying drug
induced nephrotoxicity." P.D. Williams. In Vitro Cellular and
Developmental Biology 25(9):800-805(1989).
NAL call number: QH585 A1I58
Descriptors: rabbit, pig, cic diamminedichloroplatinum,
antineoplastic agent, pharmacotoxicity, bidirectional
transport, pathogenesis, in vitro model.
272
"Glomerular basement membrane as a compressible ultrafilter."
G.B. Robinson and H.A. Walton. Microvascular Research
38(1):36-48(1989).
Descriptors: pig, cytochrome C, myoglobin, lysozyme,
ovalbumin, lactoglobulin, serum albumin, in vitro model.
273
"Modulation of noradrenaline and neuropeptide Y NPY release in
the pig kidney in vivo involvement of alpha-2 NPY and
angiotensin II receptors." J. Pernow and J.M. Lundberg.
Naunyn-Schmiedeberg's Archives of Pharmacology
340(4):379-385(1989).
NAL call number: 448.8 Ar2
Descriptors: alpha 2 adrenoceptor, renal blood flow control,
nerve stimulation.
274
"Reducing renal injury during transplantation." J.L.R.
Forsythe, P.M. Dunnigan, G. Proud, T.W.J. Lennard, and R.M.R.
Taylor. British Journal of Surgery 76(10):999-1001(1989).
Descriptors: kidney injury, kidney transplantation,
temperature.
275
"Reproducibility of Iodine-123-Hippuran renoscintigraphy in
the normal pig at various flow rates." J. Frokiaer, L.
Knudsen, C. Flo, H.H. Hansen, B. Eika, J. Mortensen, and F.T.
Jensen. Scandinavian Journal of Urology and Nephrology
Supplement 0(125):87-93(1989).
Descriptors: diagnostic drug, urine flow, parenchyma, pelvis,
transit times, diuresis, renography.
276
"Use of verapamil with conventional immunosuppression after
porcine renal transplantation." D. Kahn, R. Hickman, C.
Dreyer, and C.T. Camp. European Surgical Research
21(3-4):156-161(1989). Descriptors: metabolic drug,
cyclosporin, solumedrol, immunosuppressant drug, histology.
277
"Ablation of free radical-mediated reperfusion injury for the
salvage of kidneys taken from non-heartbeating donors: A
quantitative evaluation of the proportion of injury caused by
reperfusion following periods of warm, cold, and combined warm
and cold ischemia." T. Hoshino, W.R. Maley, G.B. Bulkley, and
G.M. Williams. Transplantation 45(2):284-289(1988).
NAL call number: QP89 T73
Descriptors: kidney transplantation, kidney failure,
creatinine clearance, cadaver kidney.
278
"Modification of sodium potassium-atpase of the pig kidney by
endogenous phospholipids." I.I. Ismailov and Z.U.
Bekmukhametova. Khimiia Prirodnykh Soedinenii
0(6):872-873(1988). NAL call number: QD241 K45
Descriptors: protein lipid relationship, sonication.
279
"A prototype device for nonimmersion shock wave lithotripsy
using ultrasonography for calculus localization." F.F.
Marshall, F. Weiskopf, A. Singh, F. Mark, F. Leo, R. Sanders,
R. Makofski, P.C. Walsh, and N. Smith. Journal of Urology
140(2):249-253(1988).
NAL call number: 448.8 J8234
Descriptors: ultrasound, transducer nephrolithiasis therapy,
extracorporeal lithotripsy, renal calculi, nonoperative
method, dwarf pigs, kidney stones.
280
"Absence of renal 25-hydroxycholecalciferol-1-hydroxylase
activity in a pig strain with vitamin D-dependent rickets." I.
Winkler, F. Schreiner, and J. Harmeyer. Calcified Tissue
International 38(2):87-94(1986). Descriptors: hydroxylase
deficiency, rickets metabolism, vitamin D.
281
"Model for chronic obstruction and hydronephrosis." C.E.
Constantinou, C.J. Djurhuus, L. Vercesi, A.J. Ford and J.D.
Meindl. In: Swine in Biomedical Research M.E. Tumbleson (ed.),
Vol. 3. Plenum Press, New York; 1986, pp. 1711-1724.
NAL call number: RB125.C68 1985.
Descriptors: artificial chronically implanted sphincter,
implantable telemetry system, bladder and renal pelvic
pressure, hydrostatic pressure, EMG.
282
"The pig as a model for studying kidney disease in man." C.J.
Hodson. In: Swine in Biomedical Research M.E. Tumbleson (ed.),
Vol. 3. Plenum Press, New York; 1986, pp. 1691-1709. NAL call
number: RB125.C68 1985.
Descriptors: obstruction, vesicoureteral reflux, papillae,
surgery, ligated ureters, urethral stenosis, reflux
neuropathy, cystography, urogram, kidney stone, histology,
scarring.
283
"Swine as a model in renal physiology and nephrology: An
overview." J.M. Terris. In: Swine in Biomedical Research M.E.
Tumbleson (ed.), Vol. 3. Plenum Press, New York; 1986, pp.
1673-1689. NAL call number: RB125.C68 1985.
Descriptors: human, multipyramidal kidney, renal development
and differentiation, papillary morphology, pyeloureteral
dynamics, vesicoureteral reflux, pyelotubular backflow, renal
lymphatics, renal hemodynamics, diuretics.
284
"The role of Tamm-Horsfall protein in the pathogenesis of
reflux nephropathy and chronic pyelonephritis." V.T. Andriole.
Yale Journal of Biology and Medicine 58(2):91-100(1985).
Descriptors: reflux nephropathy, vesicoureteral reflux,
autoimmunity, rabbit, swine.
285
"Urodynamische Untersuchungen nach anisoperistaltischen end zu
end ureteranastomos en am Tiermodell Schwein. [Urodynamic
studies following anisoperistaltic end to end ureter
anastomoses in the swine animal model.]" D. Oehler, U.
Munnich, J. Schneider, and F. Audorf. Zeitschrift fur Urologie
und Nephrologie 78(3):125-136(March 1985).
Descriptors: ureter surgery, urinary diversion methods,
urodynamics, hydrostatic pressure, muscle contraction.
286
"Description of a new, versatile porcine model to study
mammalian renal hydroxylase regulation in vitro in the D
replete state." E.M. Spencer, T.K. Hunt Jr., and D. Marshall.
In: Vitamin D: Chemical, Biochemical and Clinical
Endocrinology of Calcium Metabolism A.W. Norman, K. Schaefer,
D. von Herrath, H.G. Grigoleit (eds.), Walter De Gruyter,
Berlin. 1982. pp. 507-510.
NAL call number: QP772.V53W67 1985.
Descriptors: hydroxylase activity, kidney function, 1,24
hydroxylase.
REPRODUCTION
287
"The influence of exogenous gonad