Biologics and Vaccine Testing

Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM).

A list of alternative safety testing methods that are accepted by U.S. and international regulatory authorities. These methods can significantly reduce animal use and improve animal welfare.

Leptospira vaccine potency testing

USDA. Animal and Plant Health Inspection Service (APHIS). Center for Veterinary Biologics (CVB).

Search for Scientific Literature on Leptospirosis Vaccine Potency Testing

Click on the following resources for scientific literature about reduction, refinement or replacement (3Rs alternatives) in leptospirosis vaccine potency testing