A report of the February 2016 workshop, In Vitro to In Vivo Extrapolation for High Throughput Prioritization and Decision Making, and the preceding webinar series was published online December 5 by the journal Toxicology In Vitro. Toxicology In Vitro is making the workshop report publicly available to all readers, regardless of subscription status, through February 23. To read the article, go to https://authors.elsevier.com/a/1WKoG39kyQjVLj.
The workshop report discusses activities and resources that promote inclusion of in vitro to in vivo extrapolation (IVIVE) in regulatory decision-making. It considers properties of models that successfully generate predictions of in vivo doses from effective in vitro concentration, areas of success, and areas for improvement to reduce model uncertainty. Finally, the report provides case studies on the uses of IVIVE in safety assessments.
Materials from the workshop, which was co-organized by NICEATM and the U.S. Environmental Protection Agency (EPA) Office of Research and Development, are available at https://ntp.niehs.nih.gov/go/ivive-wksp-2016.