DHHS. Food and Drug Administration.

June 2012- Includes guidance regarding the use of alternatives to the rabbit pyrogen test (RPT) and the bacterial endotoxins test (BET) for detecting pyrogens in pharmaceuticals and other products. Examples of alternative assays cited include the recombinant horseshoe crab Factor C assay and monocyte activation type pyrogen tests (MATs).

U.S. Environmental Protection Agency.

 EPA’s ToxCast uses high-throughput screening methods and computational toxicology approaches to generate data and predictive models on chemicals.

Institute for In Vitro Sciences, Inc.

A searchable citation database and links to full-text documents on alternative methods in toxicology.

Organisation for Economic Co-operation and Development.

Provides internationally agreed testing methods used by government, industry and independent laboratories to characterize potential hazards of new and existing chemical substances.

International Society of Regulatory Toxicology and Pharmacology.

The objective of this workshop [was] to explore progress to date in implementing new, revised and alternative toxicological test methods across regulatory evaluation frameworks and decision-making programs in the U.S., identify barriers to progress and explore potential bridges to facilitate overcoming such barriers. These barriers may be technical, regulatory, economic or societal. Slides and speakers notes for all presentations are also available.

Humane Society of the United States and Proctor & Gamble.

The goal of this web site is to advance non-animal methods of toxicity testing through online discussion and information exchange.

Interagency Coordinating Committee on the Validation of Alternative Methods.

Links to information about the reviews of alternative test methods, the respective categories of toxicity, and/or the ICCVAM Working Group assigned to the assays.