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New Approach to Delist Highly Pathogenic Avian Influenza Viruses from BSL3+ Select Agents to BSL2 Non-Select Status for Diagnostics and Vaccines

New Approach to Delist Highly Pathogenic Avian Influenza Viruses from BSL3+ Select Agents to BSL2 Non-Select Status for Diagnostics and Vaccines.jpg
Highly pathogenic avian influenza viruses (AIVs) are Select Agents in the United States and are required to be handled in bio-containment level-3 enhanced (BSL3+) facilities. Using a reverse genetics system, we attenuated a highly pathogenic virus, with the goal of making it low pathogenic and having it delisted as a Select Agent so that it could…