1 15 1 https://www.nal.usda.gov/exhibits/speccoll/files/original/cba5cc8332e625de238e3affc2bfd0b2.pdf 8e02b5179a3dea6b31380eecd218a5e0 PDF Text Text Item D Number °3074 Author Young, A. L. D Corporate Author Typescript: Abstract: Long-Term Field Studies of a Rodent Population Continuously Exposed to TCDD Journal/Book Title Year 000 ° Month/Day Color D Number of knagee 3 DBSCrtatOn NOtBS Includes letter to Don Lamb from Alvin L. Young, 21 Dec 1979 telling Lamb about the abstract. Tuesday, November 13, 2001 Page 3074 of 3112 �DEPARTMENT OF THE AIR FORCE USAF SCHOOL OF AEROSPACE MEDICINE (AFSC) BROOKS AIR FORCE BASE, TEXAS 78235 21 Dec 79 Dr. Don Lamb Mobay Chemical Corporation P.O. Box 4912, Hawthorn Road Kansas City, MO 64120 Dear Dr Lamb Please find attached our abstract.of a proposed presentation to the 1980 Symposium on Avian and Mammalian Wildlife Toxicology, to be held in Louisville KY, March 1980. We would be pleased to submit a manuscript for publication in an ASTM Symposium Proceedings. For matters of correspondence please use the following address: Dr. Alvin L. Young Epidemiology Division (SAM/EK) USAF School of Aerospace Medicine Brooks AFB TX 78235 Phone: 512- 536-2127 Thank you for your consideration of our presentation for the 1980 Symposium. Sincerely ALVIN L. YOUNG, Major, USAF, Ph.D. Consultant, Environmental Sciences 1 Atch Abstract �LONG-TERM FIELD STUDIES OF A RODENT POPULATION CONTINUOUSLY EXPOSED TO TCDD A.L. Young and C.E. Thalken Epidemiology Division USAF School of Aerospace Medicine Brooks AFB,f&-?8235 (. .vJvi rvJ ,^.v c ' x ,.,, • ' .. Field investigations were conducted during 1973-1978 on populations of the beach mouse, Peromyscus polionotus, from a unique 3.0 km2 military test area (Test Area C-52A, Eglin AFB FL) that was sprayed with 73,000 kg 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) herbicide during the period 1962-1970. No residues of 2,4,5-T were detected at 10 parts per billion in any soil sample collected during 1971-1972. Residues of 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD) were still present in 1978. During 1974-1978, 54 soil samples were collected to a depth of 15 cm on the test area. TCDD levels ranged from <10 to 1,500 parts per trillion (ppt). The median concentration was 30 ppt while the mean was 164 ppt. Liver tissue from 36 individual beachmice inhabiting the test site contained » V," ;.£».». ^ V , 300 to 2,900 ppt TCDD. A close relationship between soil and liver levels of TCDD was observed, i.e., high liver levels of TCDD were consistent with high soil levels of TCDD.; Whole body analysis of fetuses from test area females indicated apparent placenta! transport of TCDD. Histopathological examinations were performed on 255 adult or fetal beachmice from the test area and a control area. Examinations were performed on the heart, lungs, trachea, salivary glands, thymus, liver, kidneys, stomach, pancreas, adrenals, large and small intestine, spleen, genital organs, bone, bone marrow, skin and brain. Initially, the tissues were examined �on a blind study basis. All microscopic changes were recorded including those interpreted as minor or insignificant. The tissues were then reexamined on a control versus test basis, which demonstrated that the test and control mice could not be distinguished histopathologically. The mean number of fetuses per observed pregnancy was 3.1 and 3.4 for the test area and a control area, respectively. A single female beachmouse is capable of producing litters every 26 days. At this frequency, the animals collected in 1978 may have been at least 50 generations removed from the population studied in 1973. A two-factor (treatment and year) disproportional analysis of covariance of organ weights revealed that liver weights for pregnant females were significantly heavier (P<.01) between the control and test area beachmice, and these differences were consistent over the five years of observation. These studies suggest that long-term, low level exposure to TCDD under field conditions has had minimal effect upon the health and reproduction of the beach mouse. � Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Alvin L. Young Collection on Agent Orange Description An account of the resource <p style="margin-top: -1em; line-height: 1.2em;">The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.</p> <p>For more about this collection, <a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a">view the Agent Orange Exhibit.</a></p> Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. Box The box containing the original item. 111 Folder The folder containing the original item. 3074 Series The series number of the original item. Series V Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Young, Alvin L. Thalken C. E. Title A name given to the resource Typescript: Abstract: Long-Term Field Studies of a Rodent Population Continuously Exposed to TCDD