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                    <text>Item 10 Number

°1489

Author

Calcagni, John

Corporate Author

United States Air Force Occupational and Environmental

ROpOrt/ArtlOlO TltlO Summary Flyer to Alert Physicians to the Current
Herbicide Orange Debate

Journal/Book Title
Year

000

°

Month/Day
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Number of Images

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2

Descriptor Notes

Tuesday, May 15, 2001

Page 1489 of 1514

�Summary Flyer to Alert Physicians to the Current Herbicide Orange Debate
As a result of recent television and newspaper publicity on Herbicide
Orange, Air Force physicians may be asked by their patients to respond to
statements made by the media and to investigate symptoms described in the media
publicity. The programs and articles resulted from a number of claims filed by
veterans with the Veterans Administration alleging that present physical disorders are related to exposure to Herbicide Orange.

The following information

is intended to aid the physician 1n managing an active duty patient should the
individual present questions or allege symptoms.
Herbicide Orange (frequently referred to by the media as Agent Orange)
was an equal mixture' of two herbicides; 2, 4, 5~Trichlorophenoxyacetic acid
(2, 4, 5~T) and 2, 4~Dic.hlorophenoxyacetic acid (2, 4-0}. They have been used
worldwide in agriculture since 1947.

Human health hazards associated with

the use of these herbicides have been minimal and primarily related to selfingestion or gross misuse. Herbicide Orange was used extensively in Southeast
Asia from 1962 to 1969 to defoliate jungle vegetation and deprive the enemy of
a refuge.

In most instances, military personnel did not enter treated areas

until 4-6 weeks after treatment, thus greatly minimizing their chance of contracting or inhaling the herbicide. Air Force personnel most likely to have
been exposed were those involved in actual dedrumming and spraying operations.
A contaminant in the mixture was a substance called 2, 3, 7, 8Tetrachlorodibenzo-p-diox1n (TCOD, Dioxin). This highly toxic contaminant
was present in parts per million amounts in most batches of the herbicide.
Symptoms described by the media have been documented only in industrial

�accidents or gross overexposure. Immediate symptoms such as headache, eye
and skin irritation are the result of the herbicide per se and not dioxin (TCDD).
These symptons clear upon removal from exposure.

Central and peripheral

neuropathy, along with skeletal muscle damage have been described in very
high exposure to 2, 4-D alone. Other symptoms are believed to be related to
the dioxin (TCDD). Included are an acneiform rash with hyperpigmentation,
muscular pain, hepatotoxicity, nephrotoxicity, porphyria cutanea tarda,
hirsut.ism, peripheral neuropathy, hyperlipidemia and constitutional symptoms
such as anorexia, fatigue, lassitude, mental depression, and loss of libido.
There is no substantiated evidence for carcinogencity, teratogenicity,
mutagenicity or fetotoxicity in man.
It is emphasized, however, that in all cases displaying the symptoms
mentioned above, the estimated doses of TCDD received were much greater than
would be expected in personnel routinely working with Herbicide Orange. With
the exception of a few persistent cases of acne, there is no evidence for sustained illness except where permanent organ damage had occurred.

Furthermore,

there is no documentation of the development of adverse effects more than a frw
months after expsoure had ceased.
Personnel describing any of the above symptoms should be reassured that
it is unlikely that their present symptoms are related to Herbicide
Orange. They should be thoroughly evaluated to identify the etiology of the
symptoms and treated accordingly.
Further information, if needed, may be obtained by contacting Lt Col John
Calcagni, USAF, MC, at the USAF Occupational and Environmental Health Laboratory,
Brooks AFB, Texas. AUTOVON 240-2001, Commercial 512, 536-2001.

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                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
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