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Young, Alvin L.

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Report/Article Title Handwritten Notes on VA Meeting, Tuesday 3 February

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Thursday, March 28, 2002

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                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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Thursday, March 28, 2002

Page 5766 of 5780

�(

DEPARTMENT OF THE AIR FORCE
USAF SCHOOL OF AEROSPACE MEDICINE (AFSC)
BROOKS AIR FORCE BASE, TEXAS
78235

RliPLY TO
ATTN OF:

_.,
C.K

SUBJECT:

Trip Report - TA-16 (3 Jan 80)

TO:

EK

CEA
CE
CD
CC
TS
IN TURN

1. Place Visited
Veterans Administration Central Office (VACO),
Washington DC, 7-8 Jan 80
2. Personnel Contacted
Dr Paul Haber, Assistant Chief Medical Director
for Professional Services, VACO
Dr Richard Levinson, Deputy for Clinical Support
Services, VACO
Mr. Alex Kutner, Assistant for Clinical Support
Services, VACO
Dr Larry Hobson, Assistant for Research and
Development, VACO
Dr John Castellot, Deputy for Medical Services,
VACO
Dr Jack Walsh, Office of Emergency Planning,
VACO
Dr Abraham Lilienfeld, Professor of Epidemiology,
The John Hopkins School of Hygiene, Baltimore, MD
Dr Raymond Suskind, Director, Department of Environmental
Health, Kettering Laboratory, Cincinnati, OH

�3. Topics Discussed
a. The "Veterans Health Programs Extension and improvement Act of
1979" (Atch 1), enacted 20 Dec 79 stated that:
The Administrator of Veterans' Affair shall cjesign a
protocol for and conduct an epidemiological study of
persons who, while serving in the Armed Forces of the
United States during the period of the Vietnam conflict,
were exposed to any of the class of chemicals known as
"the dioxins" produced during the manufacture of the
various phenoxy herbicides (including the herbicide known
as "Agent Orange") to determine if there may be longterm adverse health effects in such persons from such
exposure.
Accordingly, the present TOY was taken to VACO at the request of
Dr Paul A. Haber, M.D., Assistant Chief Medical Director for
Professional Services, VACO. Dr Haber requested that I brief
members of his staff and two special consultants (Drs Lilienfeld
and Suskind) on the use of herbicides in South Vietnam and on the
environmental fate of the phenoxy herbicides and TCDD. Drs
Lilienfeld and Suskind have been asked to design the protocol for
the epidemiologic study of veterans potentially exposed to Herbicide
Orange during combat operations during the Vietnam conflict. Information on how the herbicides were used and how persistent they
may have been in the environment, is critical in designing an appropriate epidemiologic protocol.
b. Immediately after my briefings, the group discussed the
following problems associated with preparing a protocol:
1. The study should focus on ground troopi; preferably
on both a group of Army personnel and a group of Mafine personnel.
Dr Haber, his staff, and Drs Lilienfeld and Suskind felt strongly
that the VA study should in no way conflict with the Air Force
study on RANCH HAND personnel (I was surprised that everyone
at the meeting thought that the Air Force study had already
received White House and Air Force clearance for sjtudy initiation,
and was in fact, underway). Dr Lilienfeld had high praise for the
Air Force protocol and felt that it was the only st[jdy where a
realistic exposure index could be developed.
2. The study should be prospective in nature. The VA would
make available 15 hospitals strategically located throughout the
United States for use in conducting physical examinations.

�3, The VA had recently completed examinations of 10,000 veterans
who alleged exposure to Herbicide Orange. Drs Lilienfeld and Suskind
were asked to consider (if possible) whether these people and their
exam data could be incorporated into an epidemiologic study.
4. Dr Haber stated that the VA was required to present the
protocol to the Director of the Office of Technology Assessment no
later than 20 Jun 1980. The protocol should have been reviewed by
at least a Committee appointed by the National Academy of Science,
and the VA Advisory Committees on Health-Related Effects of Herbicides
and the Cooperative Studies Guidance Group.
c. I was specifically asked to assist the VA in four areas:
1. Provide Dr Lilienfeld with pertinent literature on TCDD
toxicology and environmental fate (see Atch 2).
2. Obtain data from the Herbs tape on use of herbicides
in South Vietnam by Province, type, quantity, and month.
3. Prepare a literature update on human exposure to the
phenoxy herbicides and TCDD.
4. Prepare a model on the environmental fate of TCDD that may
provide an estimate of potential exposure, given that ground troops
entered a defoliated area at various times after aerial treatment
with Herbicide Orange.
The last three items will be officially requested from the Air Force
by VA. A letter from Dr Haber to HQ USAF/SG should be forthcoming.
A letter has been received by SAM/EK from Dr Haber related to my
assistance at the meeting of 7-8 Jan 80 (Atch 3).
4. Items of interest to procurement and USAFSAM programming: None
5. Information of interest to other USAFSAM divisions or branches: BRM
6. This TOY was performed in support of EPI Ranch project and at the
request of the VA.
7. This report jJo,es not contain information worthy of filing in TSK.

ALVIN L. YOUNG,'Major, USAF,"Ph.D.
Consultant, Environmental Sciences

3 Atch
1. PL 96-151
2. Ltr to Dr Lilienfeld
3. Ltr from Dr Haber

3

Cy to: HQ USAF/SGES

HQ AFSC/SG

�Pi,
H.E.3892

Binetpftth Congress of the United States of America
AT THE FIRST SESSION
Begun and held at the City of Washington on Monday, the fifteenth day of January,
one thousand nine hundred and seventy-nine

an act
To amend title 38, United States Code, to extend the authorizations of appropriations for certain grant programs and to revise certain provisions regarding such
programs, to revise and clarify eligibility for certain health-care benefits, to revise
certain provisions relating to the personnel system of the Department of Medicine
and Surgery, and to assure that personnel ceilings are allocated to the Veterans'
Administration to employ the health-care staff for which funds are appropriated;
to require the Veterans' Administration to conduct an epidemiologies! study
regarding veterans exposed to Agent Orange; and for other purposes.

Be it enacted by the Senate and House of Representatives of the
United States of America in Congress assembled, That (a) this Act
may be cited as the "Veterans Health Programs Extension and
Improvement Act of 1979".
(b) Whenever in this Act (except in section 306) an amendment or
repeal is expressed in terms of an amendment to, or repeal of, a
section or other provision, the reference shall be considered to be
made to a section or other provision of title 38, United States Code.
TITLE I—EXTENSION AND IMPROVEMENT OF CERTAIN EXPIRING VETERANS' ADMINISTRATION HEALTH PROGRAMS
GRANTS TO STATE HOME FACILITIES

SEC. 101. (a) Section 5033(a) is amended by striking out "and a like
sum for the succeeding fiscal year" and inserting in lieu thereof "a
like sum for each of the two succeeding fiscal years, and such sums as
may be necessary for the fiscal years ending September 30, 1981, and
September 30, 1982".
(bXD Section 641(a) is amended by striking out "$5.50", "$10.50",
and "$11.50" and inserting in lieu thereof "$6.35", "$12.10", and
"$13.25", respectively.
(2) The amendments made by paragraph (1) shall take effect on
January 1, 1980, but, with respect to fiscal year 1980, shall take effect
only to such extent and in such amounts as may be specifically
provided for such purpose in appropriation Acts.
EXCHANGE OF MEDICAL INFORMATION

SEC. 102. (a) Section 5054 is amended by adding at the end the
following new subsection:
"(c) The Administrator is authorized to enter into agreements with
public and nonprofit private institutions, organizations, corporations,
and other entities in order to participate in cooperative health-care
personnel education programs within the geographical area of any
Veterans' Administration health-care facility located in an area
remote from major academic health centers.".
(b) Section 5055(cXD is amended by inserting "and for each of the
three succeeding fiscal years" after "fiscal year 1979".

A^

�a R 8892-2
AMBIANCE TO HEALTH MANPOWER TRAINING mBTITOTIONS

SBC. 108. (a) Subsection (b) of section 5070 is amended to read as
follows:
"(b) The Administrator may not enter into any agreement under
•ubchapter I of this chapter after September 30,1979. .
(bXD Subsection (a) of section 6082 is amended to read as follows:
"(a) There is authorized to be appropriated for carrying out
programs authorized under this chapter $50,000,000 for the fiscal
year ending June 30,1973; a like sum for each of the six succeeding
fiscal years; $15,000,000 for the fiscal year ending September 30,1980;
$25,000,000 for the fiscal year ending September 30, 1981; and
$30,000,000 for the fiscal year ending September 30,1982.".
(2) Clause (1) of section 5083(b) is amended by striking out "and will
result" and all that follows in such clause through "at such school".
TITLE H—MODIFICATION OF VETERANS HEALTH CARE
AND RELATED BENEFITS
BENEFICIARY TRAVEL REIMBURSEMENT

SEC. 201. (a) Section lll(eX2XA) is amended byCD striking out "based on an annual declaration and certification by such person" and inserting in lieu thereof "pursuant to
regulations which the Administrator shall prescribe"; and
(2) striking out "a veteran" and all that follows through "title"
and inserting in lieu thereof "a person receiving benefits for or in
connection with a service-connected disability under this title, a
veteran receiving or eligible to receive pension under section 521
of this title, or a person whose annual income, determined in
accordance with section 503 of this title, does not exceed the
maximum annual rate of pension which would be payable to such
person if such person were eligible for pension under section 521
of this title".
(b) Section 601 is amended byCD striking out "transportation" in paragraph (5XA) and
inserting in lieu thereof "travel";
(2) striking out subclause (ii) of paragraph (5XO and inserting
in lieu thereof "(ii) travel and incidental expenses for such
dependent or survivor under the terms and conditions set forth
in section 111 of this title"; and
(3) striking out "necessary expenses of travel and subsistence"
in paragraph (6XB) and inserting in lieu thereof "travel and
incidental expenses".
(c) Section 614 is amended byCD striking out "necessary travel expenses" in subsection (a)
and inserting in lieu thereof "travel and incidental expenses
(under the terms and conditions set forth in section 111 of this
title)"; and
(2) striking out "all necessary travel expenses" in subsection
(b) and inserting in lieu thereof "travel and incidental expenses
(under the terms and conditions set forth in section 111 of this
title)".
(d) Section 628(a) is amended by striking out "the necessary travel"
and inserting in lieu thereof "travel and incidental expenses under
the terms and conditions set forth in section 111 of this title".

�H.R. 8892-3
CONTRACT HOSPITAL CARE

SEC. 202. Section 601(4XCXiii) IB amended byCD striking out "hospital care" the second place it appears and
inserting in Beu thereof "medical services"; and
(2) inserting "until such time as the veteran can be safely
transferred to any such facility" after "of this paragraph .
LIMITATION ON FURNISHING CONTRACT CARE DENTAL TREATMENT

SEC. 203. Section 612(b) is amended by adding at the end below the
last clause the following new sentence: "The total amount which the
Administrator may expend for furnishing, during any twelve-month
period, outpatient dental services, treatment, or related dental appliances to a veteran under this section through private facilities for
which the Administrator has contracted under clause (i), (ii), or (y) of
section 60K4XC) of this title may not exceed $500 unless the Administrator determines, prior to the furnishing of such services, treatment, or appliances and based on an examination of the veteran by a
dentist employed by the Veterans' Administration (or, in an area
where no such dentist is available, by a dentist conducting such
examination under a contract or fee arrangement), that the furnishing of such services, treatment, or appliances at such cost is reasonably necessary.".
HEALTH BENEFITS FOR VETERANS OF MEXICAN BORDER PERIOD AND
WORLD WAR I AND FOR CERTAIN SEVERELY DISABLED VETERANS

SEC. 204. Section 612(g) is amended by—
(1) striking out "Where any veteran" and inserting in lieu
thereof "In the case of any veteran who is a veteran of the
Mexican border period or of World War I or who"; and
(2) adding at the end thereof the following new sentence: "The
Administrator may also furnish to any such veteran home health
services under the terms and conditions set forth in subsection (f)
of this section.".
AMENDMENTS TO CHAMPVA PROGRAM

SEC. 205. (aXl) Section 613(a) is amended by—
(A) striking out "wife" in clause (1) and inserting in lieu
thereof"spouse";
(B) striking out "and" at the end of clause (1);
(C) striking out "widow" in clause (2) and inserting in lieu
thereof "surviving spouse";
(D) inserting "and at the end of clause (2); and
(E) inserting after clause (2) the following new clause:
"(3) the surviving spouse or child of a person who died in the
active military, naval, or air service in the line of duty and not
due to such person's own misconduct,".
(2) Section 613 is further amended by adding at the end the
following new subsection:'
"(c) For the purposes of this section, a child between the ages of
eighteen and twenty-three (1) who is eligible for benefits under
subsection (a) of this section, (2) who is pursuing a full-time course of
instruction at an educational institution approved under chapter 36
of this title, and (3) who, while pursuing such course of instruction,
incurs a disabling illness or injury (including a disabling illness or
injury incurred between terms, semesters, or quarters or during a

�H.R. 8892-4
vacation or holiday period) which is not the result of such child's own
willful misconduct and which results in such child's inability to
continue or resume such child's chosen program of education at an
approved educational institution shall remain eligible for benefits
under this section until the end of the six-month period beginning on
the date the disability is removed, the end of the two-year period
beginning on the date of the onset of the disability, or the twentythird birthday of the child, whichever occurs first.".
(b) The amendments made by subsection (a) shall take effect with
respect to fiscal year 1980 only to such extent and for such amounts as
may be specifically provided for such purpose in appropriation Acts.
DATE

SEC. 206. Except as otherwise provided in section 205(b), the
amendments made by this title shall take effect on January 1,1980.
TITLE HI—VETERANS' ADMINISTRATION MEDICAL PERSONNEL AMENDMENTS AND MISCELLANEOUS PROVISIONS
MEDICAL PERSONNEL STAFFING LEVELS

SEC. 301. (a) Section 5010(a) is amended by adding at the end the
following new paragraph:
"(4XA) With respect to each law making appropriations for the
Veterans' Administration, there shall be provided to the Veterans'
Administration the funded personnel ceiling defined in subparagraph (D) of this paragraph and the funds appropriated therefor.
"(B) In order to carry out the provisions of subparagraph (A) of this
paragraph, the Director of the Office of Management and Budget
shall, with respect to each such law (i) provide to the Veterans'
Administration for the fiscal year concerned such funded personnel
ceiling and the funds necessary to achieve such ceiling, and (ii)
submit to the appropriate committees of the Congress and to the
Comptroller General of the United States certification that the
Director has so provided such ceiling. Not later than the thirtieth day
after the enactment of such a law or, in the event of the enactment of
such a law more than thirty days prior to the fiscal year for which
such law makes such appropriations, not later than the tenth day of
such fiscal year, the certification required in the first sentence of this
subparagraph shall be submitted, together with a report containing
complete information on the personnel ceiling that the Director has
provided to the Veterans' Administration for the employees
described in subparagraph (D) of this paragraph.
"(C) Not later than the forty-fifth day after the enactment of each
such law, the Comptroller General shall submit to the appropriate
committees of the Congress a report stating the Comptroller General's opinion as to whether the Director of the Office of Management
and Budget has complied with the requirements of such subparagraph in providing to the Veterans' Administration such funded
personnel ceiling.
"CD) For the purposes of this paragraph, the term 'funded personnel ceiling' means, with respect to any fiscal year, the authorization
by the Director of the Office of Management and Budget to employ
(under the appropriation accounts for medical care, medical and
prosthetic research, and medical administration and miscellaneous
operating expenses) not less than the number of employees for the

�H.R. 3892-5
employment of which appropriations have been made for such fiscal
(b) The amendment made by subsection (a) shall take effect with
respect to Public Law 96-103, but, with respect to such Public Law,
the certification and report required by subparagraph (B) of paragraph (4) of section 5010 of title 38, United States Code (as added by
sucn amendment), and the report required by subparagraph (C) of
such paragraph (as added by such amendment) shall be submitted to
the appropriate committees of the Congress not later than January 15,1980, and February 1,1980, respectively.
QUALIFICATIONS OF CERTAIN HEALTH PROFESSIONALS EMPLOYED IN THE
DEPARTMENT OF MEDICINE AND SURGERY

SEC. 302. (a) Section 4104(2) is amended by inserting "psychologists," after "Pharmacists,".
(bXD Subsection (a) of section 4105 is amended by—
(A) striking out the period at the end of clause (9) and inserting
in lieu thereof a semicolon; and
(B) adding at the end the following new clause:
"(10) Psychologist—
"hold a doctoral degree in psychology from a college or
university approved by the Administrator, have completed
study for such degree in a specialty area of psychology and
an internship which are satisfactory to the Administrator,
and be licensed or certified as a psychologist in a State,
except that the Administrator may waive the requirement of
licensure or certification for an individual psychologist for a
period not to exceed two years on the condition that such
psychologist provide patient care only under the direct
supervision of a psychologist who is so licensed or certified,".
(2) Subsection (b) of such section is amended by inserting "podiatrist, optometrist," after "dentist,".
(c) The amendment made by subsection (bXD to require that a
psychologist appointed to a position in the Department of Medicine
and Surgery of the Veterans Administration be licensed or certified
as a psychologist in a State shall not apply to any person employed as
a psychologist by the Veterans' Administration on or before December 81,1979.
REDUCTION OF PROBATIONARY PERIOD FOR CERTAIN HEALTH PROFESSIONALS EMPLOYED IN THE DEPARTMENT OF MEDICINE AND SURGERY

SEC. 303. Section 4106(b) is amended by striking out "three years"
and inserting in lieu thereof "two years".
COOPERATIVE USE AGREEMENTS FOR SPECIALIZED MEDICAL RESOURCES

SEC. 304. Section 5053(a) is amended by inserting "or organ banks,
blood banks, or similar institutions" after "facilities".
SPECIAL MEDICAL ADVISORY GROUP AMENDMENTS

SEC. 305. Section 4112(a) is amended by—
(1) inserting in the first sentence "and a disabled veteran"
after "professions"; and
(2) inserting in the second sentence "and, not later than
February 1 of each year, shall submit to the Administrator and

�H.R. 3892-6
the Congress a report on its activities during the preceding fiscal
year" after "Administrator".
TECHNICAL AMENDMENT

SEC. 306. (a) Section 601(aX2) of the Veterans' Disability Compensation and Survivors' Benefits Amendments of 1979 (Public Law
96-128) is amended by striking out "clause (1)" and inserting in lieu
thereof "clause (11)".
(b) The amendment made by subsection (a) shall take effect as of
November 28,1979.
AGENT ORANGE STUDY

SEC. 307. (aXl) The Administrator of Veterans' Affairs shall design
a protocol for and conduct an epidemiological study of persons who,
while serving in the Armed Forces of the United States during the
period of the Vietnam conflict, were exposed to any of the class of
chemicals known as "the dioxins" produced during the manufacture of
the various phenoxy herbicides (including the herbicide known as
"Agent Orange") to determine if there may be long-term adverse
health effects in such persons from such exposure. The Administrator
shall also conduct a comprehensive review and scientific analysis of
the literature covering other studies relating to whether there may
be long-term adverse health effects in humans from exposure to such
dioxins or other dioxins.
(2XAXi) The study conducted pursuant to paragraph (1) shall be
conducted in accordance with a protocol approved by the Director of
the Office of Technology Assessment.
(ii) The Director shall monitor the conduct of such study in order to
assure compliance with such protocol.
(BXi) Concurrent with the approval or disapproval of any protocol
under subparagraph (AXi), the Director of the Office of Technology
Assessment shall submit to the appropriate committees of the Congress a report explaining the basis for the Director's action in
approving or disapproving such protocol and providing the Director's
conclusions regarding the scientific validity and objectivity of such
protocol.
(ii) In the event that the Director has not approved such protocol
during the one hundred and eighty days following the date of the
enactment of this Act, the Director shall (I) submit to the appropriate
committees of the Congress a report describing the reasons why the
Director has not given such approval, and (II) submit an update
report on such initial report each sixty days thereafter until such
protocol is approved.
(C) The Director shall submit to the appropriate committees of the
Congress, at each of the times specified in the second sentence of this
subparagraph, a report on the Director's monitoring of the conduct of
such study pursuant to subparagraph (AXii). A report under the
preceding sentence shall be submitted before the end of the six-month
period beginning on the date of the approval of such protocol by the
Director, before the end of the twelvemonth period beginning on
such date, and annually thereafter until such study is completed or
terminated.
(3) The study conducted pursuant to paragraph (1) shall be continued for as long after the submission of the report under subsection
(bX2) as the Administrator may determine reasonable in light of the
possibility of developing through such study significant new information on the long-term adverse health effects of exposure to dioxins.

�H.R. 3892-7
(bXD Not later than twelve months after the date of the enactment
of this Act, the Administrator shall submit to the appropriate
committees of the Congress a report on the literature review and
analysis conducted under subsection (aXl).
(2) Not later than twenty-four months after the date of the approval
of the protocol pursuant to subsection (aX2XAXi) and annually thereafter, the Administrator shall submit to the appropriate committees
of the Congress a report containing (A) a description of the results
thus far obtained under the study conducted pursuant to such
subsection, and (B) such comments and recommendations as the
Administrator considers appropriate in light of such results.
(c) For the purpose of assuring that any study carried out by the
Federal Government with respect to the adverse health effects in
humans of exposure to dioxins is scientifically valid and is conducted
with efficiency and objectivity, the President shall assure that—
(1) the study conducted pursuant to subsection (a) is fully
coordinated with studies which are planned, are being conducted, or have been completed by other departments, agencies,
and instrumentalities of the Federal Government and which
pertain to the adverse health effects in humans of exposure to
dioxins; and
(2) all appropriate coordination and consultation is accomplished between and among the Administrator and the heads of
such departments, agencies, and instrumentalities (that may be
engaged, during the conduct of the study carried out pursuant to
subsection (a), in the design, conduct, monitoring, or evaluation
of such dioxin-exposure studies.
(d) There are authorized to be appropriated such sums as may be
necessary for the conduct of the study required by subsection (a).

Speaker of the House of Representatives.

Vice President of the United States and
President of the Senate.

�DEPARTMENT OF THE AIR FORCE
USAF SCHOOL OF AEROSPACE MEDICINE (AFSC)
BROOKS AIR FORCE BASE, TEXAS
76235

11 Jan 80

Dr Abraham Lilienfeld, M.D.
Professor Epidemiology
The John Hopkins School of Hygiene
615 North Wolfe Street
Baltimore MD 21205
Dear Dr Lilienfeld
It was a pleasure to have again met with you on the Herbicide
Orange issue. I hope my discussions with you on the use of
herbicides in South Vietnam, and on the environmental fate of
dioxin, were of value in developing ideas for designing the
epidemiologic study. I have attached the following source
material for potential use in the protocol:
Atch 1. IRAC Report of PCDD and PCDF.
Atch 2. Chapter III, Effects of Herbicides in South
Vietnam.
Atch 3. Position Paper on Criteria for Estimating Exposure.
Atch 4. Technical Report OEHL-TR-78-92 (3 copies).
If I can provide you further assistance in the development of a
protocol, please contact me.
Sincerely

ALVIN L. YOUNG, Major, USAF, Ph.D.
Environmental Sciences Consultant

4 Atch
1. IRAC Report

2. Effects of Herbicides
3. Position Paper
4.

OEHL-TR-78-92

Cy to: Dr. R. Levinson

U t.

�Department of Medicine
and Surgery

Washington, D.C. 20420

Veterans
Administration
January 9, 1980
Col. George B. Lathrop, USAF, MC
C h i e f , Epidemiology

Division

USAFSAM/EK
Brooks Air Force Base, TX 78235
Dear Colonel Lathrop:
I wish to express my deep appreciation to you for permitting Major Alvin Young to participate in our January 7th
meeting on the design of our Agent Orange epidemiology
s tudy.
Major Young's detailed knowledge about the scope and
purpose of the Agent Orange spraying missions and on the
environmental fate of dioxins was invaluable to our
deliberations. In fact, I can unequivocally state that as
a result of Major Young's consultations, we will be able
to significantly expedite the study's development.
I sincerely hope that we might be able to make use of
Major Young's services again in the future. In addition,
I would like to invite you to give us the benefit of your
personal epidemiological expertise when we have proceeded
further in the study's preliminary design.
I confidently predict that the epidemiological studies
being planned by the Air Force and the Veterans
Administration will resolve the question of Agent Orange
effects on human health. By combining resources, we
should be enabled to meet our respective goals sooner.
Best wishes.
Sincerely yours,

PAUL A. L. HABER, M.D.
Assistant Chief Medical Director
for Professional Services

In Reply Refer To:

A.4, flu

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                    <text>Item D Number

°5761

Author

Young, Alvin L.

D Not Scanned

Corporate Author
Report/Article HUB Letter from Alvin L. Young to C. P. V. DeJesus,
November 6, 1979

Journal/Book Title
Year
Month/Day
Color

D

Number of Images

°

DOSGrlptOn Notes

Enclosures missing.

Thursday, March 28, 2002

Page 5761 of 5780

�EKS/Major Young/dd/3471/6 Nov 79

6 Nov 79

Or. C.P.V. DeJesus
Neurology Service
Audie L. Murphy Memorial Hospital
Veterans Administration
7400 Merton Mlnton
San Antonio, TX 78284
Dear Dr. DeJesus
In reference to your request for literature on human
and animal effects of 2,4,5-T and TCDD, please find enclosed a recent A1r Force Technical Report and two
bibliographies that may be of Interest to you.
If I can provide additional Information, please contact
me at 536-3471.
Sincerely
ALVIN L. YOUNG, Major, USAF, Ph.D.
Consultant, Environmental Sciences

3 Atch
1. OEHL-TR-78-92

2. Bibliography MP-1323
3. Bibliography MP-1343

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Use of

Herbicides in South Vietnam, 1961 -1971

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Tuesday, March 26, 2002

Page 5727 of 5743

�USE OF HERBICIDES IN SOUTH VIETNAM, 1961-1971*
Alvin L. Young
MAJOR, USAF, PHD
Epidemiology Division
USAF School of Aerospace Medicine
Brooks AFB, San Antonio TX 78235
Herbicides used in support of tactical military operations in South Vietnam from
1961 to 1971 are today, ten years after the last herbicide mission, the center of
intense scientific debate involving not only medical but also legal, political and
ecological issues. This paper reviews the historical and operational concepts and
some potential human exposure considerations involving the military use of herbicides
in the Southeast Asian Conflict.
Herbicides Used in South Vietnam
Synthesis technology, efficacy data, and field application techniques were developed
for the two major phenoxy herbicides, 2,4-dichlorophenpxyacetic acid (2,4-D) and
2,4,5-trichlorophenoxyacetic acid (2,4,5-T) during World War II at Fort Detrick,
Frederick, Maryland. Following World War II, the iAcoij^rcial use of these two
"synthetic" organic herbicides revolutionized Ameri.cJiKagri culture. In 1950, more
than 10 million pounds of these materials were used annually for weed and brush
control in the United States. By 1960, in excess of 36 million pounds were used.
In May 1961, the Office of the Secretary of Defense requested the Fort Detrick
personnel to determine the technical feasibility of defoliating jungle vegetation
in the Republic of Vietnam. By early fall, 1961, 18 different aerial spray tests
(defoliation and anticrop) had been conducted with various formulations of
commercially-available herbicides. The choice of these herbicides was based upon
the chemicals that had had considerable research, proven performance, and practical
background at that period in time. Also, such factors as availability in large
quantity, costs and known or accepted safety in regard to their toxicity to humans
and animals was considered. The results of these tests were that significant
defoliation and anticrop effects could be obtained with two different mistures of
herbicides. The first was a mixture of the n-butyl esters of 2,4-D and 2,4,5-T
and the iso-butyl ester of 2,4,5-T. This mixture was code-named "Purple." The
second "military" herbicide was code-named "Blue" and consisted of the acid and
sodium salt of cacodylic acid. The colored bands which were painted around the
center of the 55-gallon drums served as aid to the identification by support
personnel.
The first shipment of Herbicides Purple and Blue was recieved at Tan Son Nhut
Air Base, Republic of Vietnam, on 9 January 1962. These were the first military
herbicides used in Operation RANCH HAND, the tactical military project for the
aerial spraying of herbicides in South Vietnam. Two additional phenoxy herbicide
formulations were received in limited quantities in South Vietnam and evaluated
during the first two years of Operation RANCH HAND. These were code-named Pink
and Green. By January 1965, two additional military herbicides, code-named Orange
and White, had been evaluated and brought into the spray program. Herbicide Orange
*A synopsis of Information from Chapters I and III of The Toxicology, Environmental
Fate, and Human Risk of Herbicide Orange and Its Associated Dioxin, Air Force
Technical Report OEHL-TR-78-92, USAF Occupational and Environmental Health Laboratory,
Brooks Air Force Base, Texas. (Authors: A. L. Young, J. A. Calcagni, C. E. Thalken,
and J. W. Tremblay.) 1978.

�Herbicides used in support of tactical military operations in South Vietnam from
1961 to 1971 are today, ten years after the last herbicide mission, the center of
intense scientific debate involving not.only medical but also legal, political and
ecological issues. This paper reviews the historical and operational concepts and
some potential human exposure considerations involving the military use of herbicides
in the Southeast Asian Conflict.
Herbicides Used in South Vietnam
Synthesis technology, efficacy data, and field application techniques were developed
for the two major phenoxy herbicides, 2,4-dichlorophenoxyacetic acid (2,4-D) and
2,4,5-trichlorophenoxyacetic acid (2,4,5-T) during World War II at Fort Detrick,
Frederick, Maryland. Following World War II, the commercial use of these two
"synthetic" organic herbicides revolutionized American*agriculture. In 1950, more
than 10 million pounds of these materials were used annually for weed and brush
control in the United States. By 1960, in excess of 36 million pounds were used.
In May 1961, the Office of the Secretary of Defense requested the Fort Detrick
personnel to determine the technical feasibility of defoliating jungle vegetation
in the Republic of Vietnam. By early fall, 1961, 18 different aerial spray tests
(defoliation and anticrop) had been conducted with various formulations of
commercially-available herbicides. The choice of these herbicides was based upon
the chemicals that had had considerable research, proven performance, and practical
background at that period in time. Also, such factors as availability in large
quantity, costs and known or accepted safety in regard to their toxicity to humans
and animals was considered. The results of these tests were that significant
defoliation and anticrop effects could be obtained with two different mistures of
herbicides. The first was a mixture of the n-butyl esters of 2,4-D and 2,4,5-T
and the iso-butyl ester of 2,4,5-T. This mixture was code-named "Purple." The
second "military" herbicide was code-named "Blue" and consisted of the acid and
sodium salt of cacodylic acid. The colored bands which were painted around the
center of the 55-gallon drums served as aid to the identification by support
personnel.
The first shipment of Herbicides Purple and Blue was recieved at Tan Son Nhut
Air Base, Republic of Vietnam, on 9 January 1962. These were the first military
herbicides used in Operation RANCH HAND, the tactical military project for the
aerial spraying of herbicides in South Vietnam. Two additibnal phenoxy herbicide
formulations were received in limited quantities in South Vietnam and evaluated
during the first two years of Operation RANCH HAND. These were code-named Pink
and Green. By January 1965, two additional military herbicides, code-named Orange
and White, had been evaluated and brought into the spray program. Herbicide Orange
*A synopsis of Information from Chapters I and III of The Toxicology, Environmental
Fate, and Human Risk of Herbicide Orange and Its Associated Dioxin, Air Force
Technical Report OEHL-TR-78-92, USAF Occupational and Environmental Health Laboratory,
Brooks Air Force Base, Texas. (Authors: A. L. Young, J. A. Calcagni, C. E. Thalken,
and J. W. Tremblay.) 1978.

�replaced all uses of Purple,.Pink, or Green, and eventually became the most widely
used military herbicide in South Vietnam. The composition of the three major
herbicides used in South Vietnam were as follows:
1. Herbicide Orange
Orange was a reddish-brown to tan colored liquid soluble in diesel fuel and
organic solvents, but insoluble in water. One gallon of Orange theoretically contained
4.21 pounds of the active ingredient of 2,4-D and 4.41 pounds of the active ingredient
of 2,4,5-T. Orange was formulated to contain a 50:50 misture of the n-butyl esters
of 2,4-D and 2,4,5-T. The percentages of the formulation typically were:
n-butyl ester of 2,4-D
free acid of 2,4-D
n-butyl ester of 2,4,5-T
Free acid of 2,4,5-T
inert ingredients (e.g.,
butyl alcohol and ester
moieties)

49.49
0.13
48.75
1.00
0.62

2. Herbicide White
White was a dark brown viscous liquid that was soluble in water but insoluble
in organic solvents and diesel fuel. One gallon of White contained 0.54 pounds of
the active ingredient of 4-amino-3,5,6-trichloropicolinic acid (picloram) and 2.00
pounds of the active ingredient of 2,4-D. White was formulated to contain a 1:4
mixture of the triisopropanoamine salts of picloram and 2,4-D. The percentages of
the formulation were:
triisopropanolamine salt of picloram
triisopropanolamine salt of 2,4-D
inert ingredient (primarily the
solvent triisopropanolamine)

10.2
39.6
50.2

3. Herbicide Blue
Blue was a clear yellowish-tan liquid that was soluble in water, but insoluble
in organic solvents and diesel fuel. One gallon of Blue contained 3.10 pounds of
the active ingredient hydroxydimethyarsine oxide (cacodylic acid). Blue was
formulated to contain cacodylic acid (as the free acid) and the sodium salf of
cacodylic acid (sodium cacodylate). The percentages of the formulation were:
cacodylic acid
sodium cacodylate
surfactant
sodium chloride
water
antifoam agent

4.7
26.4
3.4
5.5
59.5
0.5

As previously noted, not all of the herbicides used in South Vietnam were used
throughout the entire 10 years (1962-1971) encompassed by the Department of Defense
defoliation program. In addition, 2,4,5-T formulations used early in the program
are believed to have contained higher levels of the toxic contaminant TCDD
(2,3,7,8-tetrachlorodibenzo-p-dioxin or "dioxin") than did the formulations used in
the later years. The three time periods shown in Table 1 can be differentiated on
the basis of specific herbicides used and the mean dioxin content.
10

�TABLE 1

THE DIFFERENTIATION OF THREE TIME PERIODS DURING THE US MILITARY DEFOLIATION
PROGRAM IN SOUTH VIETNAM AND MEAN DIOXIN CONTENT

PERIOD

HERBICIDES USED
(CODE NAMES)

MEAN DIOXIN CONTENT
(PARTS PER MILLION)*

January 1962 June 1965

Purple, Pink, Green
Blue

July 1965 June 1970

Orange
White, Blue

2+
0

July 1970 October 1971

White, Blue

0

32**
0

*Found only in 2,4,5-T containing formulations.
**Value based on analyses of five samples.
•fValue based on the analyses of 488 samples.
Herbicide Orange was the most extensively used herbicide in South Vietnam. Orange
accounted for approximately 10.7 million gallons of the total 17.7 million gallons
of herbicide used (Table 2). It was used from mid-1965 to June 1970. However, as
noted in Table 2, Orange was not the only 2,4,5-T containing herbicide used in the
defoliation program. Small quantities of Purple, Pink, and Green, all containing
2,4,5-T were used from 1962 through mid-1965. In subsequent sections of this
document, the term "herbicide Orange" will refer to all of the 2,4,5-T containing
herbicides used in Vietnam (Purple, Pink, Green, and Orange).
TABLE 2 NUMBER OF GALLONS OF MILITARY HERBICIDE PROCURED BY THE US DEPARTMENT OF
DEFENSE AND DISSEMINATED IN SOUTH VIETNAM DURING JANUARY 1962 - OCTOBER 1971

Code Name

Quantity

Herbicide

Period of Use

Orange

2,4-D; 2,4,5-T

10,646,000

1965-1970*

White

2,4-D; Picloram

5,633,000

1965-1971**

Blue

Cacodylic Acid

1,150,000

1962-1971**

Purple

2,4-D; 2,4,5-T

145,000

1962-1965

Pink

2,4,5-T

123,000

1962-1965

Green

2,4,5-T

8,200

1962-1965

Total

17,705,200

*Last fixed-wing mission of Orange 16 April 1970; last helicopter mission of
Orange 6 June 1970.
**Last fixed-wing mission 9 January 1971; all herbicides under US control stopped
31 October 1971.
11

�Use Patterns of Individual Herbicides
Each of the three major herbicides (Orange, White, and Blue) had specific uses.
Ninety-nine percent of Herbicide White was applied in defoliation missions. It was
not recommended for use on crops because of the persistence of Picloram in soils.
Because the herbicidal action on woody plants was usually slow, full defoliation
did not occur for several months after spray application. Thus, it was an ideal
herbicide for use in the inland forests in areas where defoliation was not
immediately required, but where it did occur it would persist longer than if the
area were sprayed with Orange or Blue.
Herbicide Blue was the herbicide of choice for crop destruction missions
involving cereal or grain crops. Approximately 50 percent of all Blue was used
in crop destruction missions in remote or enemy controlled areas with the remainder
being used as a contact herbicide for control of grasses around base perimeters.
Ninety percent of all Herbicide Orange was used for forest defoliation and it
was especially effective in defoliating mangrove forests. Eight percent of
Herbicide Orange was used in the destruction of broadleaf crops (beans, peanuts,
ramie, and root or tuber crops). The remaining 2 percent was used around base
perimeters, cache sites, waterways, and communication lines.
Table 3 shows the number of acres sprayed with herbicides in South Vietnam
within the three major vegetational categories.
TABLE 3 THE NUMBER OF ACRES TREATED IN SOUTH VIETNAM, 1962-1971, WITH MILITARY
HERBICIDES WITHIN THE THREE MAJOR VEGETATIONAL CATEGORIES

Vegetational Category

Areas Treated*

Inland forest

2,670,000

Mangrove forests

318,000

Cultivated crops

260,000
Total

3,248,000

*Areas receiving single or multiple coverage.
Certain portions of South Vietnam were more likely to have been subjected to
defoliation. Herbicide expenditures for the four Combat Tactical Zones of South
Vietnam are shown in Table 4. These data were obtained from the HERBS tape (a
computer listing of all herbicide missions in South Vietnam from 1965 through 1971).
Total volume is in close agreement with the actual procurement data shown in
Table 2.

12

�TABLE 4 US HERBICIDES EXPENDITURES IN SOUTH VIETNAM, 1962-1971; A BREAKDOWN
BY COMBAT TACTICAL ZONE*
Herbicide Expenditure
(gallons)
Orange
White
Blue

Combat Tactical Zones

CTZ I

2,250,000

363,000

298,000

CTZ II

2,519,000

729,000

473,000

CTZ III
(includes Saigon)

5,309,000

3,719,000

294,000

CTZ IV

1.227.000

435.000

62.000

11,305,000

5,246,000

1,127,000

Subtotals
Grand Total

17.678.000

*Source: HERBS tape
In addition to the herbicides, numerous other chemicals were shipped to South Vietnam
in 55-gallon drums. These included selected fuel additives, cleaning solvents,
cooking oils, and a variety of other pesticides. The insecticide Malathion was
widely used for control of mosquitoes and at least 400,000 gallons of it were used
from 1966 through 1970. In addition, much smaller quantities of Lindane and DDT
were used in ground operations throughout the war in Southeast Asia. The
distribution of the herbicides within Vietnam after their arrival did not occur
randomly. About 65 percent was shipped to the 20th Ordnance Storage Depot, Saigon,
and 35 percent was shipped to the 511th Ordnance Depot, Da Nang.
Military Aircraft and Vehicles Used in the Dissemination of Herbicides
Numerous aircraft were used in the air war in Vietnam, but only a few of these
aircraft were used for aerial dissemination of herbicides. The "work horse" of
Operation RANCH HAND was the C-123, "Provider." This cargo aircraft was adapted
to receive a modular spray system for internal carriage. The module (the A/A 45 Y-l)
consisted of a 1,000-gallon tank pump, and engine which were all mounted on a frame
pallet. Ah operator's console was an integral part of the unit, but was not mounted
on the pallet. Wing booms ( . inches in diameter, 22 feet long) extended from the
15
outboard engine nacelles toward the wing tips. A short tail boom (3 inches in
diameter, 20 feet long) was positioned centrally near the aft cargo door. Each
aircraft normally had a crew of three men: the pilot, co-pilot (navigator), and
flight engineer (console operator). During the peak activity of RANCH HAND
operations ( 9 8 1 6 ) approximately 30 U C-123K aircraft were employed. However,
16-99,
many other squadrons of non-RANCH HAND C-123 aircraft were routinely used throughout South Vietnam in transport operations.

13

�The control of malaria and other mosquito-borne diseases in South Vietnam
necessitated an extensive aerial insecticide application program in order to control
these vector insects. From 1966 through 1972, three C-123 aircraft were used to
spray Malathion, an organophosphate insecticide. These aircraft could be
distinguished from the Herbicide-spraying aircraft because they were not camouflaged.
These aircraft routinely sprayed insecticide adjacent to military and civilian
installations, as well as in areas where military operations were in progress, or
about to commence.
Approximately 10 to 12 percent of all herbicides used in South Vietnam was
disseminated by helicopter or ground application equipment. Generally, helicopter
crews were not assigned to herbicide spray duties on a full-time basis and rotated
the spraying duties with other mission requirements. The military UH-1 series of
helicopters, deployed by the Air Force, the Army, and Navy units, generally sprayed
the herbicides. The most common spray system used was the AGRINAUTICS unit. This
unit was installed in or removed from the aircraft in a matter of minutes because
it was "tied down" to installed cargo shackles and aircraft modifications were not
required for its use. The unit consisted of a 200-gallon tank and a collapsible
32-foot spray boom. The unit was operated by manual -controls to control the flow
valve and a windmill brake. Generally, each helicopter had three crew members.
A summary of the aircraft used in herbicide and insecticide operations is
shown in Table 5.
TABLE 5 US MILITARY AIRCRAFT USED IN THE DISSEMINATION OF HERBICIDES AND
INSECTICIDES IN SOUTH VIETNAM

Aircraft

Camouflaged

Chemical Disseminated

UC-123/UC-123K

Yes

All Herbicides

UC-123K

No

Malathion

Yes

Orange, Blue

Helicopter
Air Force UH-1
Army UH-1B/UH-1D
Navy UH/1E
Various ground delivery systems were also used in South Vietnam for control of
vegetation in limited areas. Most of these units were towed or mounted on vehicles.
One unit that was routinely used was the Buffalo-turbine. It developed a wind
blast with a velocity up to 150 MPH at 10,000 ft /minute volume. When the
herbicide was injected into the air blast, it was essentially "shot" at the
foliage. The buffalo turbine was useful for roadside spraying and applications of
perimeter defenses. The herbicides of choise in these operations were Blue and
Orange.

�Exposure Considerations; Applications and Environmental Parameters
There were relatively few military operations that involved the handling of herbicides
by military personnel. A review of operations involving Herbicide Orange in South
Vietnam from January 1962 to April 1970 revealed that there were essentially three
groups of US military personnel potentially exposed to Herbicide Orange and its
associated dioxin contaminant. These three groups were:
*
1. "Operation RANCH HAND" personnel actively involved in the defoliation
program. This group included aircrew members and maintenance and support personnel
directly assigned to the RANCH HAND squadrons.
2. Personnel assigned to selected support functions that may have resulted in
exposure to Herbicide Orange. This group included, for example, personnel who
sprayed herbicides, using helicopters or ground application equipment; personnel who
may have delivered the herbicides to the units performing the defoliation missions;
aircraft mechanics who were specialized and occasionally provided support to
RANCH HAND aircraft; or, personnel who may have flown contaminated C-123 aircraft,
but were not assigned to RANCH HAND (e.g., during the Tet Offensive, all RANCH HAND
aircraft were reconfigured to transport supplies and equipment, and were assigned
to non-RANCH HAND squadrons).
3. Ground personnel who may have been inadvertently sprayed by defoliation
aircraft or who, during combat operations, may have entered an area previously
sprayed with Herbicide Orange.
The total number of US military personnel exposed to Herbicide Orange is not
known. Approximately 1,200 RANCH HAND personnel were exposed in direct support of
the defoliation operations; however, there are no data on the number of non-RANCH
HAND personnel who may have been exposed. The actual number of people may be in the
thousands since at least 100 helicopter spray equipment units were used in South
Vietnam, and most military bases had vehicle-mounted and backpack spray units
available for use in routine vegetation control programs. The number of military
ground personnel who may have inadvertently been sprayed by RANCH HAND aircraft,
or who may have entered areas recently sprayed with Herbicide Orange during combat
operations is not known. Approximately 10 percent of South Vietnam was sprayed
with herbicides, and most of this area was contested and/or controlled by enemy
forces. Most areas sprayed were remote, unpopulated and forested. Because of the
dense canopy cover, the target of the defoliation operation, the amount of
herbicide penetrating to the forest floor would have been small. The exposure
of personnel could have occurred by essentially three routes:
1. Percutaneous absorption and inhalation of vapors/aerosols by direct
exposure to sprays.
2. Percutaneous absorption and inhalation of vapors by exposure to treated
areas following spray application, and
3. Ingestion of foods contaminated with the material.
The chemical and physical characteristics of Herbicide Orange and the spray,
as it would have occurred following dissemination from a C-123, are important
factors in assessing relative exposure to the Herbicides and TCDD.

15

�Table 6 reviews the pertinent chemical and physical characteristics of Herbicide
Orange. Table 7 reviews both the application parameters, of the spray system used
in the UC-123K aircraft and the characteristics of the spray itself. Generally,
herbicides were sprayed in the early morning or late afternoon, so as to minimize
the effects of air movement on particle dispersion.
TABLE 6

PERTINENT CHEMICAL AND PHYSICAL CHARACTERISTICS OF HERBICIDE ORANGE

Formulation Concentrated

( . Ib ai/gal)*
86

Water Insoluble

Density « 1.28
-4
o
3.6 x 10
mm Hg at 30 C

Vapor Pressure
NBE** 2,4-D

:

NBE 2,4,5-T

:

1.2 x 10~A
-4
0.4 x 10

TCDD

:

1 x 10~4

Viscous

40 centipoises at 20 C
4

Noncorrosive to metal
Deleterious to paints, rubber, neoprene
Long Shelf life
*Pounds active ingredient (2,4-D and 2,4,5-T) per gallon.
**NBE - Normal Butyl ester.

16

�TABLE 7. APPLICATION PARAMETERS AND SPRAY CHARACTERISTICS OF THE
C-123 MODULAR INTERNAL SPRAY SYSTEM

Aircraft speed

130 KIAS*

Aircraft altitude

150 feet

Tank -volume

1,000 gallons

Spray time

3.5-4 minutes

Particle size:
100 microns: 1.9%
100-500 microns: 76.2%
500 microns: 21.9%
87% impacted within 1 min
13% drifted or volatilized
Mean particle volume

0.61 microliters

Spray swath

260 + 20 feet

Mean deposition

3 gallons/acre

Total area/tank

340 acres

*Knots indicated air speed

17

�Ground combat forces norjnally would not have been expected to have enter.ed a
previously treated area for'several weeks after treatment, during which
time numerous environmental factors would have reduced the potential for exposure to
military personnel. An indepth review of the environmental fate of Herbicide Orange
and TCDD concluded that the vast majority of the phenoxy herbicides would have
impacted forest canopy, the intended target.
Rapid uptake (e.g., within a few hours) of the ester formulations of 2,4-D and
2,4,5-T would have occurred. Most of the herbicide probably would have undergone
rapid degradation (weeks) within the cellular matrix of the vegetation. However, some
of the herbicide may have remained unmetabolized and would have been deposited on the
forest floor at the time of leaf fall.. Soil microbial and/or chemical action would
likely have completed the degradation process. Herbicide droplets that impacted
directly on soil or water would have probably hydrolyzed rapidly (within hours).
Biological and nonbiological degradative processes would have further occurred to
significantly reduce these residues. Some volatilization of the esters of 2,4-D and
2,4,5-T would have occurred during and immediately after application. The volatile
material most likely would have dissipated within the foliage of the target area.
Photodecomposition of TCDD would have minimized the amount of biologically active
volatile residues moving downwind of the target area.
Accumulation of phenoxy herbicides in animals may have occurred following
ingestion of treated vegetation. The magnitude of this accumulation would have likely
been at nontoxic levels. Herbicide residues in animals would have rapidly declined
after withdrawal from treated feed.
Most TCDD sprayed into the environment during defoliation operations would have
probably photodegraded within 24 hours of application. Moreover, recent studies
suggest that even within the shaded forest canopy, volatilization and subsequent
photodecomposition of TCDD can occur. Since translocation into vegetation would be
minimal, most TCDD that escaped photodegradation would probably have entered the soilorganic complex on the forest floor following leaf fall. Soil chemical and microbial
processes would have further reduced TCDD residues. Bioconcentration of the remaining
minute levels of TCDD may have occurred in liver and fat of animals ingesting
contaminated vegetation or soil. However, there are no field data available that
indicate that the levels of TCDD likely to have accumulated in these animals would
have had a biological effect.
The environmental generation of TCDD from 2,4,5-T residues, through thermal or
photolytic processes, would have been highly unlikely and of no consequence.
SUMMARY

The choice of herbicides used in South Vietnam in Operation RANCH HAND, 1962-1971,
was based upon those herbicides that had been widely used in world agriculture, shown
to be effective in controlling a broad spectrum of vegetation, and proven safe to
humans and animals. The major herbicides used in South Vietnam were by phenoxy
herbicides 2,4-D and 2,4,5-T. These two herbicides were formulated as the water
insoluble esters and code-named by the military as Purple, Orange, Pink and Green.
A water soluble amine formulation of 2,4-D was used in Herbicide White. Two other
herbicides were extensively used by the military, picloram (in White) and cacodylic
acid (in Blue).

18

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RBDOrt/ArtiGlB TltlB Outline Report of the Agent Orange Working Group
Science Panel Subcommittee on Exposure, November
1982

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Desorlpton Notes

Tuesday, March 19, 2002

Page 5591 of 5611

�Outline Report of the
Agent Orange Working Group
Science Panel
Subcommittee on Exposure
Alvin L. Young
VA/AOPO
November 1982

Factors that must be considered m the development of an exposure index
model include nature of the chemical and target, time after application of
the herbicide and distance from application site.
I. Factors that Influenced Exposure to Herbicide:
0

Herbicide Formulation
Chemical/Physical Characteristics
Solubility
Vapor Pressures

8

Dissemination of Herbicides
Application Parameters
Target Vegetation

0

Route of Exposure

Dermal
Inhalation
Ingestion
0

Environmental Fate
In
On
In
In

Air
Vegetation
Soil
Water

II. Dissemination System
1. RANCH HAND

KC 123/A/A45Y-1 Dispenser Internal Defoliant

2. UH-1B/D Helicopter Spray System (Agrinautics)
3. Buffalo Turbines

�4. Power-Driven Decontamination Apparatus (PDDA)
5. Back-Pack Sprayers ( 2 and 5 gallons)
6. "Jerry-Rigged" or Field Expedient Devices.
III. Factors described by Weighted Systems
A.

Toxicity of Herbicide

B.

Fate of TCDD

Location of Mission
Jungle
Mangrove
Crop
Other
C. Type of Mission
RANCH HAND

Perimeter
Herbicide Abort occurrence
D. Time After Exposure
Days
e
0
0

within 1
within 2
within 3

E. Distance from Exposure Type
(Application Site)
0
0

0
0

within 0.5 km
within 1.0 km

within 1.5 km
within 2.0 km

IV. Assignments of Weights
0

Toxicity of Herbicides

Orange

Weight Score

600 mgAg

5

Blue

2600 mgAg

2

White

3100 mg/kg

1

�Location of Mission
Defoliation
Jungle (Heavy Canopy)
Mangrove (Light Canopy)
Crop/Abort Missions
Perimeter Applications

10% Penetration 1
32%
3
100% '
10
70%
7

Time/Distance Matrix*

Distance (km)

Time
Days
&lt;0.5

1.0

1.5

2.0

70

15

10

5

i

1
,l

'

2

35

8

5

3

3

18

4

3

RANCH HAND
Application

1

t. t

Perimeter
Application

* Values in Time/Distance matrix established in percent of herbicide
particles falling within specified distance from height of release (RH
Mission) and impact of environmental degradation or binding over specified
time intervals.

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Alvin L. Young filed these documents together with others
under the label, "Agent Orange Exposure Project."

Tuesday, March 19, 2002

Page 5556 of 5611

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Tuesday, March 19, 2002

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�i

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RBpOPt/ArtlClB TItiB Typescript: Hazardous Wastes: Problems,
Perspectives and Policy

Journal/Book Tttla

Yoar

000

°

Month/Day

Color

D

Descrlpton Notes

Friday, March 15, 2002

Page 5483 of 5571

�HAZARDOUS WASTES;
PROBLEMS, PERSPECTIVES AND POLICY
ALVIN L- YOUNG, PH.D.
SENIOR POLICY ANALYST FOR LIFE SCIENCES
OFFICE OF SCIENCE AND TECHNOLOGY POLICY
EXECUTIVE OFFICE OF THE PRESIDENT
WASHINGTON, D.C.
PRESENTATION

TO:

HAZARDOUS WASTE LITIGATION SYMPOSIUM
GARDEN CITY, NEW YORK
SEPTEMBER 24, 1984

THE PAST TWO DECADES HAVE USHERED IN A SHIFT OF ALMOST
REVOLUTIONARY PROPORTIONS

IN THE STUDY OF HEALTH AND DISEASE.

THE PREOCCUPATION WITH INFECTIOUS DISEASE HAS BEEN REPLACED WITH
A HEAVY COMMITMENT TO THE STUDY OF CHRONIC, LIFE THREATENING
ILLNESSES.

INCREASINGLY, MORE INVESTIGATORS HAVE

RECOGNIZED

THAT BEHAVIORS THAT PLACE AN INDIVIDUAL AT R I S K FOR DEVELOPING
PHYSICAL

I L L N E S S SELDOM

ACTIVITIES.

ALTHOUGH

OCCUR

IN ISOLATION FROM OTHER P A T H O G E N I C

THE PUBLIC ACKNOWLEDGES THAT LIFE STYLE

AND DISEASE ARE RELATED

(E'G« SMOKING MAY BE DETRIMENTAL TO

YOUR HEALTH), THE FEAR OF M A L I G N INFLUENCES IN OUR E N V I R O N M E N T
IS SO WIDESPREAD TODAY THAT THE GENERAL PUBLIC BELIEVES THAT
IT IS THOSE FACTORS THEY CANNOT CONTROL
THEIR EARLY DEMISE*

THAT WILL B R I N G ABOUT

THE PRESENCE OF ANY TRACE OF DIOXIN,

PESTICIDES, R A D I A T I O N (EVEN BACKGROUND RADIATION), OR INDUSTRIAL
WASTE PRODUCT IS TAKEN AS AN OMEN OF DEATHSTATING
PUBLIC

THIS

PERHAPS, I'M OVER-

ISSUE - HOWEVER AS A SCIENTIST NOW CONCERNED WITH

POLICY ITS BECOMING I N C R E A S I N G L Y A P P A R E N T TO ME THAT WE

ARE F A C I N G A C R I S I S AS TO W H E R E WE EXPEND R E S O U R C E S FOR GENERATING S C I E N T I F I C DATA
HEALTH

RISKS-

USEFUL IN THE M A N A G E M E N T OF E N V I R O N M E N T A L AND

�As AN E N V I R O N M E N T A L SCIENTIST, I AM ACUTELY
PUBLIC'S CONCERN

A W A R E OF THE

OVER THE POSSIBLE DEVELOPMENT OF CANCER

BECAUSE

OF COMMUNITY EXPOSURE TO C A R C I N O G E N S IN LOW DOSES FROM A W I D E
V A R I E T Y OF SOURCES SUCH AS HAZARDOUS

WASTE DEPOSITS, PESTICIDE

RESIDUES, AIR POLLUTANTS AND FOOD ADDITIVESREPORTS

TWO RECENT

P R E P A R E D BY THE N A T I O N A L RESEARCH COUNCIL

(NRC) OF THE

N A T I O N A L ACADEMY OF SCIENCES ARE NOTEWORTHY-

THE F I R S T REPORT "GROUNDWATER C O N T A M I N A T I O N "

EMPHASIZED

THAT T H E W I D E S P R E A D U S E O F C H E M I C A L PRODUCTS, C O U P L E D W I T H T H E
DISPOSAL OF LARGE VOLUMES OF WASTE M A T E R I A L S

POSES THE

FOR WIDELY DISTRIBUTED GROUNDWATER CONTAMINATIONPOTENTIAL SOURCES OF C O N T A M I N A T I O N OF G R O U N D W A T E R
OF SOLID AND L I Q U I D WASTESPROTECTION

AGENCY

I N 1980, T H E U - S -

(EPA) ESTIMATED

POTENTIAL

THE LARGEST
IS THE DISPOSAL

ENVIRONMENTAL

THAT THERE W E R E 200,000 LANDFILLS

AND DUMPS R E C E I V I N G 150 M I L L I O N TONS PER Y E A R OF M U N I C I P A L SOLID
W A S T E S A N D 240 M I L L I O N S T O N S P E R Y E A R O F I N D U S T R I A L S O L I D W A S T E S I N A D D I T I O N T O L A N D F I L L S , 176,000 S U R F A C E

IMPOUNDMENTS RECEIVE

10 T R I L L I O N GALLONS PER YEAR OF L I Q U I D I N D U S T R I A L WASTESNOT ALL WASTES ARE HAZARDOUS, THE EPA HAS

ALTHOUGH

I D E N T I F I E D AN ESTIMATED

50,000 S I T E S T H A T H A V E B E E N U S E D , A T S O M E T I M E , F O R T H E D I S P O S A L
OF H A Z A R D O U S W A S T E S -

OF T H E S E , 1200 TO 2000 ARE T H O U G H T TO P O S E

THREATS TO THE E N V I R O N M E N T W H E R E WASTE-DISPOSAL

SOME OF THESE LATTER SITES ARE A R E A S

P R A C T I C E S H A V E RESULTED

C O N T A M I N A T I O N OF G R O U N D W A T E R .

IN I R R E V E R S I B L E

THE E X A M P L E S OF LOVE CANAL, NEW YORK

AND THE ROCKY M O U N T A I N A R S E N A L , COLORADO,

I N D I C A T E THE M A G N I T U D E

OF THE R E S U L T I N G G R O U N D W A T E R C O N T A M I N A T I O N PROBLEMS WITH P O S S I B L E
HEALTH HAZARDS

AND OTHER D E L E T E R I O U S E F F E C T S -

THE R E P O R T NOTED

�3

THAT THE COST ESTIMATED FOR D E C O N T A M I N A T I O N OF JUST THE ROCKY
M O U N T A I N A R S E N A L R A N G E FROM $800 M I L L I O N TO $1 BILLION.

THE

QUESTION OF COST/BENEFIT TRADEOFFS TO SOCIETY IN THESE CASES
NEEDS TO BE E X A M I N E D C A R E F U L L Y j SOME SITES MAY PROVE TO BE SO
E X P E N S I V E TO RESTORE THAT THEY MAY HAVE TO BE DESIGNATED AS
PERMANTLY CONTAMINATED-

THE SECOND REPORT RECENTLY RELEASD BY THE NRC WAS "TOX1CITY
TESTING - STRATEGIES TO DETERMINE NEEDS AND PRIORITIES."
N A T I O N A L TOXICOLOGY P R O G R A M ASKED
(1)

NRC:

To C H A R A C T E R I Z E THE TOXIC ITY'TESTING NEEDS

TO W H I C H THERE

FEDERAL A G E N C I E S R E S P O N S I B L E FOR THE

To DEVELOP

AND VALIDATE U N I F O R M L Y APPLICABLE AND W I D E - R A N G I N G

To D E F I N E TOXICITY-TESTING NEEDS
E N V I R O N M E N T , IT WAS

NECESSARY

FOR THE

OF THE U N I V E R S E THAT WOULD

THE C O N S T R U C T I O N OF THIS
THAT W O U L D

SEARCH

BE THE

FOR SUBSTANCES

IN THE HUMAN

NRC TO SELECT A M A N A G E A B L E

I N C L U D E MOST OF THE

SUBSTANCES

IN THE U N I T E D STATES-

"SELECT U N I V E R S E " OF SUBSTANCES"A

R E F E R E N C E FOR THE S T U D Y " R E L I ED ON A

FOR LISTS OF SUBSTANCES

POTENTIAL AND COMPUTERIZED
LISTS USED

SUBSTANCES

IMPACT.

TO WHICH H U M A N S ARE L I K E L Y TO BE EXPOSED

CORE

HEALTH

NEEDS-

POTENTIALLY ADVERSE PUBLIC-HEALTH

SUBSET

SO THAT

NEEDED TO ANTICIPATE THE

C R I T E R I A BY W H I C H TO SET P R I O R I T I E S FOR RESEARCH ON
WITH

SUBSTANCES

PROTECTION OF PUBLIC

WILL HAVE THE APPROPRIATE INFORMATION

(2)

FOR

IS K N O W N OR A N T I C I P A T E D H U M A N EXPOSURE,

EXTENT OF TESTING

THE

PRESELECTED

FOR REASONABLY

INCLUDED THE TOXIC SUBSTANCES

FOR HUMAN
EASY

EXPOSURE

ACCESS-

CONTROL

ACT

THE

(TSCA)

�INVENTORY OF 48,523 CHEMICAL SUSTANCES IN COMMERCE; A LIST OF
3,350 PESTICIDES

(ACTIVE

AND INERT I N G R E D I E N T S ) R E G I S T E R E D FOR

USE BY THE EPAj A LIST OF 1,815 PRESCRIPTION

AND NONPRESCRIP'

TION DRUGS A P P R O V E D

BY THE FOOD AND DRUG A D M I N I S T R A T I O N (FDA)

AND E X C I P I E N T S USED

IN DRUG F O R M U L A T I O N S ; AND A LIST OF 3,410

COSMETIC

I N G R E D I E N T S FROM THE COSMETIC, TOILETRY

AND F R A G R A N C E

ASSOCIATION-

THIS SELECT U N I V E R S E DID NOT SYSTEMATICALLY I N C L U D E

ENVIRONMENTAL

D E C O M P O S I T I O N PRODUCTS, M A N U F A C T U R I N G

OR N A T U R A L SUBSTANCES

( E - G - , PLANT

CONTAMINANTS,

POLLENS AND FOODS).

THE SUM

OF THE ABOVE, 65,725 E N T R I E S FROM THE LISTS, WAS T A K E N AS THE
SELECT U N I V E R S E FOR THE PURPOSES
MENT

FOR D U P L I C A T I O N S

OF STUDY-

STATISTICAL

ADJUST-

I N D I C A T E D THAT THE SELECT U N I V E R S E

CONTAINED ABOUT 53,500 DISTINCT ENTITIES-

OBVIOUSLY,

IT WAS NOT POSSIBLE

TO E X A M I N E I N F O R M A T I O N ON

ALL 53,500 SUBSTANCES, T H E R E F O R E U S I N G A S T R A T I F I E D R A N D O M
PROCESS, 675 SUBSTANCES WERE SELECTED-

A RANDOM

SUBSAMPLE OF

100 SUBSTANCES WAS F U R T H E R SELECTED THAT R E P R E S E N T E D
C A T E G O R I E S OF S U B S T A N C E S ACCEPTED STANDARDS
IN THIS

W H E N JUDGED

SEVEN

AGAINST CURRENTLY

FOR TOXICITY TESTING, ONLY 8% OF THE TESTS

F I N A L SUBSAMPLE MET THE STANDARDS OF THE R E F E R E N C E

PROTOCOL G U I D E L I N E S AND A N O T H E R 19% OF TESTS P E R F O R M E D W E R E
JUDGED TO BE A D E Q U A T E -

ON THE GREAT M A J O R I T Y OF THE SUBSTANCES,

DATA C O N S I D E R E D TO BE E S S E N T I A L

FOR C O N D U C T I N G A HEALTH-HAZARD

ASSESSMENT W E R E L A C K I N G -

SO WHAT

IS THE

POINT OF THE TWO

WE H A V E G E N E R A T E D V E R Y LITTLE

REPORTS THAT I JUST CITED?

S C I E N C E ABOUT THE C H E M I C A L S IN

�OUR E N V I R O N M E N T AND WE H A V E L I T T L E OR NO IDEA W H A T R I S K S THEY
POSE!
0

THE S I T U A T I O N is COMPLEX:
THERE ARE 4-2 M I L L I O N COMPOUNDS REGISTERED
THAT N U M B E R
TOXIC

IS G R O W I N G BY 10% A Y E A R .

EFFECT

INFORMATION

TODAY, AND

OF T H E S E , S O M E

IS A V A I L A B L E ON 100,000-

IS L I M I T E D I N F O R M A T I O N ON LONG-TERM

TOXIC

EFFECTS

THERE
FOR

ALMOST 4000 COMPOUNDS.
0

THERE ARE 220 SEPARATE
TOXIC WASTES.

A RECENT C O O R D I N A T I N G EFFORT R E Q U I R E D

18 D I F F E R E N T DATABASES.
ON TOXIC
0

I N F O R M A T I O N SYSTEMS C O N C E R N I N G

SUBSTANCES

STATE AND LOCAL

THERE

IS NO C E N T R A L DATA BANK

TO O R G A N I Z E THIS

A G E N C I E S PRESENTLY

INFORMATION-

H A V E NO WAY TO Q U I C K L Y

OBTAIN

INFORMATION AND ASSISTANCE TO RESPOND IN AN OPTIMAL
*
FASHIONTHE T I M E R E Q U I R E D FOR P U B L I C POLICY D E C I S I O N

AND THE TIME R E Q U I R E D FOR G E N E R A T I N G S C I E N T I F I C INFORMATION
ARE R A R E L Y THE SAME.
0

THE FEDERAL EFFORT TO COPE WITH THE PROBLEMS POSED BY
HAZARDOUS

WASTE

HAS, H I S T O R I C A L L Y , BEEN DEVELOPED

ALMOST C R I S I S - B Y - C R I S I S B A S I S R A T H E R THAN
EFFICIENT MANNER.

IN AN

ON AN

ORDERLY,

As A RESULT THERE ARE O V E R 30 S E P A R A T E

STATUTES, A D M I N I S T E R E D BY 10 FEDERAL A G E N C I E S T H R O U G H
AT LEAST
0

30 B U R E A U S , I N S T I T U T E S , AND CENTERS.

COORDINATION,
NIGHTMARE

MUCH

IS ALMOST

LESS MANAGEMENT, OF THIS

BUREAUCRATIC

I M P O S S I B L E AS E V I D E N C E D BY THE 80

I N T E R A G E N C Y COMMITTEES A N D F I V E SEPARATE,

HIGH-LEVEL,

C O O R D I N A T I O N ATTEMPTS M A D E IN THE LAST DECADE.

�0

OF THE ALMOST B I L L I O N DOLLARS W H I C H GOES INTO RESEARCH ON
T O X I C S U B S T A N C E S , C O N D U C T E D BY 12 D I F F E R E N T A G E N C I E S , 55%
GOES TO THE D I S C O V E R Y OF POSSIBLE NEW PROBLEMS R E S U L T I N G
F R O M C H E M I C A L E X P O S U R E , 45% T O T H E D I S C O V E R Y O F T H E M E C H A N I S M
OF HOW THESE C H E M I C A L S ACT AND ALMOST N O T H I N G TO S O L V I N G
ALREADY

0

THERE

IDENTIFIED PROBLEMS-

is LITTLE

OR NO G O V E R N M E N T A L EFFORT DIRECTED

AT THE

DEVELOPMENT OF A C O O P E R A T I V E APPROACH C O M B I N I N G THE
OF

INDUSTRY, ACADEMIA, PUBLIC

TO R E S O L V E THE

INTEREST GROUPS, AND

EXPERTISE
GOVERNMENT

P R O B L E M S POSED BY THE D E L E T E R I O U S EFFECTS OF

TOXIC SUBSTANCES.
0

T H E R E is LITTLE OR NO PREPARATION AT FEDERAL,

STATE OR LOCAL

LEVELS FOR THE RATIONAL TREATMENT OF PERSONS I N V O L U N T A R I L Y
EXPOSED TO TOXIC WASTES, AND THE FOLLOWUP OF THESE PERSONS
IS H A P H A Z A R D AT BEST-

PERHAPS

THE GREATEST

F R U S T R A T I O N TO THE S C I E N T I S T is THAT

THE SCARCE RESOURCES A V A I L A B L E FOR PROBLEM S O L V I N G GO INTO CHEMICALS W H E R E THE R I S K TO THE POPULATION IS M I N I M A L , NOT BECAUSE THESE
C H E M I C A L S ARE NOT TOXIC BUT R A T H E R BECAUSE H U M A N EXPOSURE JJ5 M I N I
SUCH AN EXAMPLE
DIOXIN)'

IS 2,3,7,8-TETRACHLORODIBENZQ-p-DIOXIN

D l O X I N IS A HIGHLY TOXIC CHEMICAL AND

(TCDU OR

IS A CONTAMINAN

OF PRODUCTS MADE FROM T R I C H L O R O P H E N O L AND FROM LOW T E M P E R A T U R E
I N C I N E R A T I O N O F WASTES

C O N T A I N I N G CHLORINATED PRECURSORS*

IS AT THE CENTER OF C O N T R O V E R S I E S OVER
ORANGE

DlOXIN

(1) THE USE OF A G E N T

IN V I E T N A M AND THE HEALTH OF V E T E R A N S , (2) THE USE OF

2,4,5-T H E R B I C I D E IN A G R I C U L T U R E , AND (3) THE DEVELOPMENT OF
TECHNOLOGY

FOR THE

I N C I N E R A T I O N OF M U N I C I P A L AND I N D U S T R I A L

�7

WASTES.

IT HAS BEEN ASSOCIATED WITH THE E V A C U A T I O N OF HUMAN

POPULATIONS

IN SEVESQ, iTALYj TlMES BEACH,, M I S S O U R I ; AND

LOVE CANAL, NEW Y O R K -

THE UNITED

STATES G O V E R N M E N T

HAS

I N I T I A T E D AN EXTENSIVE LONG'TERM RESEARCH PROGRAM ON THE
CHEMISTRY, TOXICOLOGY, AND E N V I R O N M E N T A L FATE OF D I O X I N OF THIS WORK

IS INTENDED TO HELP E V A L U A T E THE

ALL

IMPACT OF D I O X I N

ON H U M A N HEALTH-

T H I S P R O G R A M ENCOMPASSES
FEDERAL A G E N C I E S -

S C I E N T I F I C RESOURCES FROM TEN

WHAT ARE THE SPECIFIC ACCOMPLISHMENTS TO

DATE:
0

S I N C E 1970,

THE UNITED STATES G O V E R N M E N T HAS SPONSORED

RESEARCH RESULTING

IN MORE THAN 500 M A J O R P U B L I C A T I O N S

ON TOXICOLOGY, E N V I R O N M E N T A L FATE AND H U M A N R I S K S OF
DIOXIN.
0

THE F E D E R A L G O V E R N M E N T HAS U N D E R T A K E N A $130
RESEARCH P R O G R A M ON H U M A N HEALTH

EFFECTS

MILLION

I N C L U D I N G STUDIES

ON B I R T H DEFECTS, MORTALITY, M O R B I D I T Y , C A N C E R , AND D I O X I N
IN H U M A N TISSUE.
°

IN A S S O C I A T I O N WITH STATE G O V E R N M E N T S , FEDERAL A G E N C I E S
HAVE

I N I T I A T E D E X T E N S I V E PROGRAMS TO DEVELOP

FOR CLEAN-UP
WITH D I O X I N .
OF HUNDREDS

TECHNOLOGY

AND D E C O N T A M I N A T I O N OF A R E A S C O N T A M I N A T E D
CLEAN-UP

EFFORT MAY WELL

INVOLVE E X P E N D I T U R E S

OF M I L L I O N S OF DOLLARS.

HOW HAS ALL OF THIS " G E N E R A T I O N OF SCIENCE" CONTRIBUTED
THE RESOLUTION OF THE D I O X I N C O N T R O V E R S Y HAVE SHOWN THAT ACTUAL

FlRST, THE

TO

STUDIES

E X P O S U R E TO D I O X I N S IS M I N I M A L , THAT IS,

�8

HUMAN

EXPOSURE TO DIOXIN OCCURS P R I M A R I L Y IN "HOT SPOTS", AND

THE N U M B E R OF I N D I V I D U A L S EXPOSED IS V E R Y LOW.

SECONDLY, THE

DATA COLLECTED TO DATE N E I T H E R IMPACTS

ACTIONS ON

PROPOSED

CLEAN-UP (E.G., TIMES BEACH) NOR IMPEDES CONGRESSIONAL
TO LEGISLATE P R E S U M P T I V E C O M P E N S A T I O N OBTAINED
DIOXIN

FROM COMBUSTION

ACTION

THIRDLY, THE DATA

STUDIES SHOW THAT THE PRODUCTION

IS M I N I M A L AND E A S I L Y CONTROLLED

YET THE FEAR OF D I O X I N HAS PARALYZED

WITH

OF

PRESENT TECHNOLOGY,

INCINERATION

TECHNOLOGY

AND ITS A P P L I C A T I O N .

IT IS A P P A R E N T THAT OUR F A I L U R E TO PROPERLY APPLY

SCIENCE

HAS CREATED A C R I S I S OF CONFIDENCE IN OUR ABILITY TO NOT ONLY
DEAL WITH PROBLEMS BUT ALSO TO
B E L I E V E THAT SCIENCE,

IDENTIFY THEM-

NEVERTHELESS, I

GOOD S C I E N C E , MUST BE USED BY THE D E C I S I O N

MAKERS••..
*.•
BBSO HOW DO WE PROVIDE R A T I O N A L E G U I D E L I N E S FOR H A N D L I N G THE
ISSUE OF TOXIC C H E M I C A L S
MUST S I M U L T A N E O U S

IN OUR

ENVIRONMENT?

I S U G G E S T THAT WE

I N I T I A T E AND ENCOURAGE THE DEVELOPMENT OF

RESEARCH AND TECHNOLOGY

INTO THE M A N A G M E N T

OF TOXIC WASTES WHILE

AT THE SAME TIME E D U C A T I N G THE PUBLIC AND LAW M A K E R S ON THE
ASSOCIATED ISSUES°

LET ME ADDRESS THE LATTER A R E A FIRST:

THE P U B L I C M U S T U N D E R S T A N D THAT USE OF THE P R O D U C T S OF
TECHNOLOGY C A R R I E S WITH IT THE R E S P O N S I B I L I T Y FOR SAFE
D I S P O S A L OF THAT T E C H N O L O G Y ' S W A S T E WITH WASTE DISPOSAL

A PERVASIVE DIFFICULTY

IS THAT I N D I V I D U A L S DO NOT WANT THE

W A S T E S , E S P E C I A L L Y T O X I C WASTES, D I S P O S E D O F I N T H E I R
NEIGHBORHOODOCEAN

I AM R E M I N D E D OF THE

INCINERATION

RECENT ACTION

IN THE tULF OF M E X I C O -

WlTHIN

INVOLVING
THE

�PAST FEW MONTHS, EPA REFUSED TO ISSUE THE NECESSARY
B U R N I N G PERMITS FOR THE DISPOSAL OF 80 M I L L I O N GALLONS
OF HAZARDOUS WASTE BY OCEAN
6000 PEOPLE PRESENTED

I N C I N E R A T I O N P R I M A R I L Y BECAUSE

INTENSE OPPOSITION TO THE B U R N I N G -

THIS IN SPITE OF THE O V E R S H E L M I N G S C I E N T I F I C DATA SHOWING
THAT THE

I N C I N E R A T O R SHIP WAS CAPABLE OF DESTROYING THE

WAST AT AN E F F I C I E N C Y OF 99-9999%, AND HAD DONE SO ON MANY
OCCASIONS

IN THE SAME A R E A -

THE PERCEPTION THAT WASTES

CANNOT BE SAFELY HANDLED HAS BEEN AN IMPORTANT C O N S I D E R A T I O N
IN WASTE M A N A G M E N T -

IN THE CASE OF HIGHLY TOXIC WASTES, T R A N S P O R T A T I O N BY
R A I L OR ROADWAY I N V O L V E S R I S K S THAT CANNOT BE
N A T I O N S NEED TO MOVE TOWARD

IGNORED-

P O L I C I E S R E Q U I R I N G STATES

OR R E G I O N S TO DISPOSE OF WASTES W I T H I N THE REGION/STATE
IN W H I C H THEY ARE G E N E R A T E D -

THUS G O V E R N M E N T A L AND

I N D U S T R I A L O R G A N I Z A T I O N S NEED TO A G R E E THAT V A R I O U S
CLASSES OF WASTES SHOULD BE DISPOSAL OF LOCALLY

OR IN

REGIONALLY DESIGNATED REPOSITIES°

PUBLIC C O N F I D E N C E IN WASTE DISPOSAL T E C H N I Q U E S W I L L BE
ENHANCED IF WASTES ARE R E S P O N S I B L Y AND SAFELY HANDLED, IF
THE LAWS ARE STRICTLY A D H E R E D TO AND IF THE C O M P A N I E S / A G E N C I E S
INVOLVED IN THE O P E R A T I O N S KEEP THE PUBLIC A W A R E OF THE
ACTIVITIES.

WE CANNOT DELETE THE PUBLIC'S OVERSIGHT OF

WASTE DISPOSAL-

THE FEAR OF THE " M I D N I G H T HAULERS" IS

STILL FRESH IN THE M I N D S OF M A N Y P E O P L E -

�10

LET ME NOW ADDRESS AREAS OF RESEARCH AND TECHNOLOGY DEVELOPMENTTHE CHALLENGE

IS BEFORE

US'

IN THE UNITED STATES, WE HAVE

I D E N T I F I E D AND P R I O R I T I Z E D MORE THAN

1800

ABANDONED

OR I N A C T I V E

SITES THAT HAVE BEEN USED TO IMPROPERLY DISPOSE OF TOXIC WASTESVIE ARE NOW

I N I T I A T I N G AN EFFORT WHICH WILL EXTEND OVER THE NEXT

10 YEARS AND W I L L COST M O R E THAN
$9-7 M I L L I O N PER SITE-

$10-5 B I L L I O N DOLLARS - ROUGHLY

IN ORDER TO SUCCESSFULLY

TASK WE WILL NEED TREMENDOUS SUPPORT

COMPLETE THIS

FROM THE S C I E N T I F I C COMMUNITY.

NEW METHODS OF CLEAN'UP TECHNOLOGY WILL BE R E Q U I R E D *

NEW METHODS

OF M O N I T O R I N G AND M O D E L L I N G E N V I R O N M E N T A L POLLUTANTS WILL BE
NEEDED.

FOR EXAMPLE, M O V E M E N T OF TOXICS THROUGH

THE GROUND

A Q U I F E R S IS EXTREMELY DIFFICULT, IF NOT IMPOSSIBLE,

OR IN

TO PREDICT-

MOREOVER, HOW DO WE D E C O N T A M I N A N T AN A Q U I F E R -

WE WILL NEED TO ESTABLISH
GREATEST

HAZARDS.

OBVIOUSLY

P R I O R I T I E S ON WHAT CHEMICALS

THE INTENSE C O N C E R N OVER THE

OF C H E M I C A L S IN THE E N V I R O N M E N T CENTERS ON PUBLIC HEALTHI D E N T I F Y E N V I R O N M E N T A L POLLUTANTS

POSE THE

IMPACT
WE CAN

W I T H I N C R E D I B L E A C C U R A C Y BUT

AS TO T H E I R S I G N I F I C A N C E AS POTENTIAL THREATS TO H U M A N HEALTH,
WE H A V E ONLY VAGUE S U G G E S T I O N S -

A C C O R D I N G L Y WE MUST

BETTER

DEVELOP

THE CONCEPT OF R I S K ASSESSMENT'

LET ME FOCUS ON THIS SUBJECT FOR A M O M E N T IS IMPORTANT THAT WE B R I N G SCIENCE BACK
RISKS?

HOW DO WE DO THIS?

OF R I S K ASSESSMENT-

As

I NOTED B E F O R E IT

INTO THE MANAGEMENT OF

THE A N S W E R HAS TO BE THROUGH

THE USE

�11

0

WE MUST STREN6HTEN

THE QUALITY OF S C I E N C E TO THE POINT

THAT R I S K C H A R A C T E R I Z A T I O N S ARE R E L I A B L E AND C R E D I B L E *

THIS IN T U R N WILL

I N C R E A S E THE DEGREE TO WHICH DECISION

M A K E R S ARE W I L L I N G TO ACCEPT THESE CHARACTERIZATIONS AS
THE P R I N C I P A L BASIS FOR REGULATORY D E C I S I O N S THE BEST WAYS OF S T R E N G T H E N I N G THE SCIENCE
THE USE OF CONSENSUS

WORKSHOPS-

IS AN EVOLVING PROCESS WHERE

ONE OF

IS THROUGH

THE CONSENSUS

WORKSHOP

SCIENTISTS FROM ACADEMIA,

GOVERNMENT,, INDUSTRY, AND PUBLIC INTEREST GROUPS CAN
MEET AND R E S O L V E S C I E N T I F I C QUESTIONS ON THE BASIS OF
THE BEST S C I E N C E C U R R E N T L Y A V A I L A B L E -

RECENTLY THIS OFFICE SPONSORED A CONSENSUS WORKSHOP ON
FORMALDEHYDE.

MORE THAN 70 I N T E R N A T I O N A L L Y RENOWNED SCIENTISTS

MET AND DISCUSSED

IN AN OBJECTIVE AND NON'ADVERSIAL F A S H I O N THE

RELEVANT S C I E N T I F I C E V I D E N C E ON FORMALDEHYDE IN THE G E N E R A L A R E A S
OF EPIDEMIOLOGY, EXPOSURE, TOXICOLOGY AND RISK ESTIMATIONEMPHASIS OF THE WORKSHOP WAS TO DEVELOP CONSENSUS

ON THE S C I E N T I F I C

ISSUES C O N C E R N I N G FORMALDEHYDEj H O W E V E R , THE RESULTS
USED TO ASSIST
PLEASED

THE

MAY ALSO BE

IN F U T U R E REGULATORY D E C I S I O N M A K I N G -

TO A N N O U N C E THAT THE REPORT OF THE WORKSHOP,

I AM
ENTITLED

D E L I B E R A T I O N S OF THE CONSENSUS WORKSHOP ON FORMALDEHYDE. WILL BE
PUBLISHED THIS

FALL

IN THE S C I E N T I F I C J O U R N A L E N V I R O N M E N T A L HEALTH

PERSPECIVIES-

0

WE MUST DEVELOP U N I F O R M G U I D E L I N E S FOR USE IN THE R I S K
ASSESSMENT

PROCESS-

A C C O R D I N G L Y , THE NAS 1983

REPORT,

�12

"RISK ASSESSMENT IN THE FEDERAL GOVERNMENT:

MANAGING

THE PROCESS/' is A START IN THE RIGHT D I R E C T I O N MAJOR

ISSUE LEFT UNADDRESSED IN THIS REPORT

A

IS HOW WE

ESTABLISH THE A P P R O P R I A T E WAY OF OVERSEEING THE

GOVERNMENT'S

USE OF RESEARCH IN THE "EVOLVING* FIELD OF R I S K ASSESSMENT.
THIS R E M A I N S TO BE DETERMINED:

FOUR AGENCIES ARE ACTIVELY

R E S E A R C H I N G "RlSK ASSESSMENT" METHODOLOGY*
°

IN A S I M I L A R V E I N , REGULATORY A G E N C I E S U S I N G R l S K
ASSESSMENT

MUST USE THE SAME S C I E N C E IN THE D E T E R M I N A T I O N

OF THE R I S K S *

MANY OF YOU ARE ONLY TOO A W A R E THAT THIS

IS ESPECIALLY A PROBLEM

IN THE

E S T I M A T I O N OF CANCER R I S K S -

A C C O R D I N G L Y , THE OFFICE OF SCIENCE AND TECHNOLOGY
A NEW DOCUMENT

TITLED "CHEMICAL

SCIENCE AND ITS ASSOCIATED

CARCINOGENS!

PRINCIPLES-"

A R E V I E W OF THE

THE T H I R D DRAFT W H I C H

IN THE MAY 22, 1984 ISSUE OF THE FEDERAL REGISTER
UPDATE OF THE

I N F O R M A T I O N AND

A C H E M I C A L COMPOUND

IDEAS USED

IS TO H U M A N S -

HAS RELEASED

APPEARED

PROVIDES AN

IN E S T A B L I S H I N G HOW D A N G E R O U S

IT DEVELOPS FROM THESE DATA A

C U R R E N T AND BALANCED SET OF P R I N C I P L E S TO BE R E F E R R E D TO IN
E S T A B L I S H I N G THE POTENTIAL

C A N C E R - C A U S I N G D A N G E R FROM C H E M I C A L S -

LOOKING TO THE FUTURE, THE D O C U M E N T ALSO
OF SCIENCE EXPECTED TO
PLANNED

PREDICTS THE E M E R G I N G AREAS

IMPACT ON REGULATORY ACTIONS, A L L O W I N G

I N C O R P O R A T I O N OF THESE DEVELOPMENTS R A T H E R THAN MERELY A

REACTION TO T H E M -

THE REPORT REFLECTS

THE C O M B I N E D EFFORTS OF S E N I O R

FROM N I N E FEDERAL HEALTH-RELATED
D I R E C T I O N OF MY O F F I C E -

SCIENTISTS

U N I T S O P E R A T I N G UNDER T H E

THE PUBLIC C O M M E N T S ARE NOW B E I N G

�13

INCORPORATED

INTO A F I N A L REPORT TO BE RELEASED LATE THIS

FALL0

INDEED, TO R E I N T E R A T E , IT is THE PUBLIC'S P A R T I C I P A T I O N
AND EDUCATION THAT CONSTITUTE MY C O N C E R N U N D E R S T A N D I N G AND CONFIDENCE

PUBLIC

IN E N V I R O N M E N T A L R E G U L A T I O N S

R E Q U I R E S THAT S C I E N T I F I C L I T E R A C Y IS ESSENTIAL
CITIZEN

IS TO CHOOSE

WISELY.

THE EDUCATIONAL

IF THE
PROCESS

MUST ALSO EXTEND TO THE NEWS MEDIA AND LAW M A K E R S °

ON ISSUES OF SCIENCE THAT HAVE SOCIETAL CONCERNS
AND E M O T I O N A L ) WE MUST DEVISE A BETTER
THEM THAN

IN THE COURTROOM-

THAT C U R R E N T L Y EXISTS

(REAL

WAY OF R E S O L V I N G

THE ADVERSAL R E L A T I O N S H I P

W I T H I N THE WHOLE SYSTEM

IS A

H I N D E R A N C E TO THE RESOLUTION OF PROBLEMS-

IN SUMMARY, THE SCIENCE O F F I C E OF THE PRESIDENT

IS

DEDICATED

TO THE TASKS OF P L A C I N G THE VERY BEST S C I E N C E INTO THE HANDS OF
DECISION MAKERS-

THESE TASKS I N V O L V E THE

I D E N T I F I C A T I O N OF

RESEARCH NEEDS, THE DEVELOPMENT OF THE R I S K ASSESSMENT
CONSENSUS

PROCESS, THE

WORKSHOP AND THE EFFORTS OF A G R O U P OF DEDICATED

PUBLIC

SERVICE-ORIENTED SCIENTIST-

THE NEXT TEN YEARS, W I L L BE C R I T I C A L YEARS TO THOSE OF US
CHARGED WITH THE R E S P O N S I B I L I T Y OF D E T E R M I N I N G THE D I R E C T I O N AND
SUPPORT

FOR THE PROPER H A N D L I N G OF TOXIC M A T E R I A L S BY OUR SOCIETIES

�THE C H A L L E N G E S ARE GREAT!

A GREAT EFFORT WILL BE REQUIRED 1 ,

THIS REMINDS ME OF THE TWO MEN WHO FIND THEMSELVES FACING A WIDE
R A V I N E WITH SOME DANGER RAPIDELY A P P R O A C H I N G FROM BEHIND*

THEY

HAVE THE CHOICE EITHER OF ATTEMPTING TO LEAP THE R A V I N E OR OF
T U R N I N G TO FACE THE DANGER.

A GOOD CASE CAN BE MADE FOR BOTH,

BUT THEY CANNOT A G R E E W H I C H TO CHOOSE'

tACH F A I L I N G TO C O N V I N C E

THE OTHER, THEY RESOLVE THEIR DIFFERENCES BY DECIDING TO JUMP
HALFWAY*
TASK-

WE MUST NOT DO THE JOB HALFWAY-

WE MUST COMPLETE THE

�</text>
                  </elementText>
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    </fileContainer>
    <collection collectionId="30">
      <elementSetContainer>
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          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="4687">
                  <text>Alvin L. Young Collection on Agent Orange</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="49809">
                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
                </elementText>
              </elementTextContainer>
            </element>
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        </elementSet>
      </elementSetContainer>
    </collection>
    <itemType itemTypeId="1">
      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
      <elementContainer>
        <element elementId="52">
          <name>Box</name>
          <description>The box containing the original item.</description>
          <elementTextContainer>
            <elementText elementTextId="47958">
              <text>194</text>
            </elementText>
          </elementTextContainer>
        </element>
        <element elementId="53">
          <name>Folder</name>
          <description>The folder containing the original item.</description>
          <elementTextContainer>
            <elementText elementTextId="47959">
              <text>5483</text>
            </elementText>
          </elementTextContainer>
        </element>
        <element elementId="54">
          <name>Series</name>
          <description>The series number of the original item.</description>
          <elementTextContainer>
            <elementText elementTextId="47961">
              <text>Series VIII Subseries I</text>
            </elementText>
          </elementTextContainer>
        </element>
      </elementContainer>
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      <elementSet elementSetId="1">
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        <elementContainer>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47957">
                <text>Young, Alvin L.</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="47960">
                <text>Typescript: Hazardous Wastes: Problems, Perspectives and Policy</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
      </elementSet>
    </elementSetContainer>
    <tagContainer>
      <tag tagId="2">
        <name>ao_seriesVIII</name>
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    </tagContainer>
  </item>
  <item itemId="6460" public="1" featured="0">
    <fileContainer>
      <file fileId="2291">
        <src>https://www.nal.usda.gov/exhibits/speccoll/files/original/6120d57649c8ba8db8b570075d209158.pdf</src>
        <authentication>651f91607242ddd9ef5ae98075ea89f1</authentication>
        <elementSetContainer>
          <elementSet elementSetId="4">
            <name>PDF Text</name>
            <description/>
            <elementContainer>
              <element elementId="60">
                <name>Text</name>
                <description/>
                <elementTextContainer>
                  <elementText elementTextId="64240">
                    <text>Item D Number

05«2

Author

D MotScannBfl

Young, Alvin L

United States District Court, Eastern District of New Yor

RODOrt/ArtlOlO Tltlfl Declaration of Alvin L. Young, In re: "Agent Orange"
Product Liability Litigation, All Cases, August 30,1984

Journal/Book Title
Year

000

°

Month/Day
Color
Number of bnagos

D

°

Descrlpton Notes

Friday, March 15, 2002

Page 5482 of 5571

�UNITED STATES DISTRICT COURT
EASTERN DISTRICT OF NEW YORK

I-» "RE T|fAGENT ORANGE

)

PRODUCT LIABILITY LITIGATION

)

ALL CASES

)

fc

DECLARATION OF ALVIN L. YOUNG
I, Alvin L. Young, being duly sworn, depose and state that
based on the records, files and documents to which I have access,
control and supervision, the following is true to the best of my
knowledge, information and belief:
(1)

I am a Senior Staff Scientist (AFSC 2616) with the United
States Air Force, currently detailed as Senior Policy Analyst,
Office of Science and Technology Policy, Executive Office
of the President, Washington, D.C.

Since 1968, I have

served as an expert for the government in areas of science
related to the military herbicide Agent Orange.

Specific

areas of expertise include formulation, equipment design,
application, military use, dioxin contamination, environmental
fate, toxicology and human risks to exposure.

(2)

Agent Orange, as formulated and procurred for the Department
of Defense, consisted of approximately a 50:50 mixture of
the normal-butyl esters of 2,4-dichlorophenoxyacetic
and 2,4,5-trichlorophenoxyacetic acid.

acid

The product was

formulated to contain approximately 8.6 pounds active
ingredient (acid equivalents of 2,4-D and 2,4,5-T) per
gallon of liquid.

Thus the product contained roughly

4 pounds of each herbicide in the acid

form.

�(3)

The herbicides 2,4-D and 2,4,5-T have been commercially
available and widely used since the late 1940's.

Numerous

formulations including the iso-butyl and normal-butyl
formulations were used commercially

ester

in the United States

prior to, during, and after the use of Agent Orange in
Vietnam.

In the 1960 Farm Chemicals Handbook, formulations

of the normal-butyl ester of 2,4-D containing 4 and 6 pounds
per gallon active ingredient were recommended
control

in wheat and other field grains.

for weed

In the same

handbook, formulations of the normal-butyl esters of both
2,4-D

and 2,4,5-T (as a mixture) were recommended for brush

control on rangelands and in reforestation.

Typically these

latter formulations contained the active ingredient at 4
and 6 pounds per gallon.

As late as 1980 normal-butyl

esters of 2,4-D were commercially available (DOW ESTERON
76BE) containing 6 pounds (acid equivalents) per gallon.
4.

Analyses in the early 1970's of archived samples of commercial
formulations of 2,4,5-T and archived samples of Agent Orange
showed similar levels of dioxin (2,3,7,8-tetrachlorodibenzo-pdixoin) contamination (See Young, A.L. et al. 1978.

The

Toxicology, Environmental Pate, and Human Risk of Herbicide
Orange and Its Associated Dioxin, Air Force Technical
Report OEHL - 78-92).

I declare under penalty of perjury that the ^above ijs true and
correct.

�CD

». ( / &gt;

ACTIVE INGREDIENT:
2,4-Dichlorophenoxyacetic Acid, Butyl Esters
INERT INGREDIENTS:
2,4-D Acid Equivalent 63.2%-6 pounds per gallon
E.P.A. Registration No. 464-279 ^

SB 8

tug

USE DIRECTIONS
Use ESTERON 76 BE herbicide to control bitterweed, croton, dandelion, docks, galinsoga,
henbit, kochia, lambsquarters, morshelder, mustards, peppergrass, pigweed, plantains,
ragweed, shepherdspurse, thistles, vetch, wild radish, and many other broadleaf weeds,
without injury to most established grasses; also for control of 2,4-0 susceptible woody
plants such as coastal sage, sandsage, elderberry, hazel, locust, poison oak, sumac and
willow. Use in small grains, corn, sorghum, grass seed crops, pastures, rangeland and in
non-crop areas.
Apply ESTERON 76 BE as a water or oil spray during warm weather when weeds or brush
are actively growing. Application under drought conditions often will give poor results.
Use low spray pressure to minimize spray drift. On cropland and along roadsides, do not
exceed 20 psi pressure. Apply enough spray volume to provide uniform coverage of weeds
and brush, usually 5 to 20 gallons per acre by ground equipment and 3 to 5 gallons by aircraft. Higher gallonage may be used if desired to improve spray coverage and to reduce the
hazard from spray drift.
Generally, the lower dosages recommended on this label will be satisfactory for young,
succulent growth of sensitive weed species. For less sensitive species and under conditions
where control is more difficult, the higher dosages will be needed. For crop uses, do not mix
with oil or other adjuvants unless specifically recommended on this label. Deep-rooted
perennial weeds such as Canada thistle and field bindweed and many woody plants usually
require repeated applications for maximum control. Do not apply ESTERON 76 BE where
spray drift may contact nearby susceptible crape or other desirable plants or may contaminate water for irrigation or domestic use. Do not apply in the vicinity of 2,4-D sensitive crops or ornamental plants since vapors from this product may cause injury to such
crops or plants. Read and follow all Use Precautions given on this label.
NOTE: If there are uncertainties concerning special local use situations or specific crop
variety tolerances to 2,4-D, consult local Extension Service or University Specialists for advice.
TO PREPARE THE SPRAY: (1) Fill the spray tank about half full with water, then add the required amount of ESTERON 76 BE, with agitation, and finally the rest of the water. NOTE:
ESTERON 76 BE in water forms an emulsion which tends to separate unless the mixture is
kept agitated. (2) If oil is added, first mix the ESTERON 76 BE and the oil and then add this
mixture to the water with agitation. However, with adequate agitation, the oil can be added
after the ESTERON 76 BE is mixed in the water if strong agitation is provided. (3) If straight
oil is used, a solution is formed and separation does not occur. Do not allow any water to get
into the oil-herbicide mixture to avoid formation of an invert emulsion.
WEED CONTROL IN SMALL GRAINS NOT UNDERSEEDED WITH A LEGUME: NOTE: Water is
recommended to make up the spray. If oil is used, there is a greater risk of crop injury and
of spray drift. Do not permit dairy animals or meat animals being finished for slaughter to
forage or graze treated grain fields within 2 weeks after treatment.
Spring Wheat and Barley: Apply Va to % pint per acre by air or ground equipment. A '/2
pint per acre rate of ESTERON 76 BE is an average dosage, effective on many weeds. Spray
when grain is in full tiller stage (usually 4 to 8 inches tall) but before the boot stage and
when weeds are small. Do not apply before the tiller stage nor from early boot to the dough
stage. Higher rates (up to IVs pints per acre) may be required to control certain weeds but
crop injury may result.
Winter Wheat and Rye: Apply &gt;/3 to Vz pint per acre in the spring at the full tiller stage
but before the early boot stage. See more complete use directions under Spring Wheat
and Barley.
Spring Seeded Oats: Apply '/3 pint per acre at the full tiller stage but before the early
boot stage. Oats are less tolerant to 2,4-D than wheat or barley and are more likely to suffer
some injury, especially if higher rates (Vi to 2/3 piAt) are used to control difficult weeds.
Preharvest Treatment: Apply 3/3 to l'/3 pints per acre when grains are in the hard dough
stage to control large weeds that may interfere with harvest. Best results will be obtained
when soil moisture is sufficient to cause succulent weed growth. NOTE: Do not feed treated
straw to livestock.
WEED CONTROL IN CORN: Use one of the following three programs: Preemergence: Apply
1'/3 to 22/3 pints per acre to soil anytime after planting but before corn emerges. Do not
use on light sandy soil. Emergence: Apply 2/3 pint per acre just as corn plants are breaking
ground. Postemergence: After emergence of corn, use '/3 pint per acre. Application of '/2
to 2/3 pint per acre may be needed for maximum control of some weeds but such rates are
more likely to injure the corn. If corn is over 8 inches tall, use drop nozzles to keep the spray
off the corn foliage as much as possible. Do not apply from the tasseling to dough stage. Do
not use with oil, atrazine or adjuvants. Crop injury is more likely to occur if corn is growing
rapidly under high temperature and high soil moisture conditions. To reduce breakage of
stalks from temporary brittleness caused by 2,4-D, delay cultivation for 8 to 10 days after
treatment. NOTE: Hybrids vary in response to 2,4-D and some are easily injured. Spray only
varieties known to be tolerant to 2,4-D. Contact seed company and Extension Service Weed
Specialists for this information.

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05159

G Not Scanned

Author

Young, Alvin L.

Corporate Author
Report/Article TItlfl Abstract: Dioxin: A Case Study: Report from the Office
of Science and Technology Policy

Journal/Book Title
Year

000

°

Month/Day
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1

Descriptor! Notes

See ltem 139

Monday, February 25, 2002

°

Page 5159 of 5167

�DIOXIN-A CASE STUDY; REPORT FROM THE OFFICE OF SCIENCE AND TECHNOLOGY POLICY.
A; L. Young, Office of Science and Technology Policy, Executive Office
of the President, Washington, D.C. 20506
The highly toxic chemical 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or
dioxin) is a contaminant of products made from trichlorophenol and from
low temperature incineration of wastes containing chlorinated precursors.
Dioxin is at the center of controversies over (1) the use of Agent Orange
in Vietnam and the health of veterans, (2) the use of 2,4,5-T herbicide
in Agriculture, and (3) the development of technology for the incineration
of muncipal and industrial wastes. It has been associated with the
evacuation of human populations in Seveso, Italy; Times Beach, Missouri;
and Love Canal, New York. The United States Government has initiated an
extensive long-term research program to evaluate the impact of dioxin on
human health. This program encompasses scientific resources from ten
federal agencies. Risk assessments on dioxin are predicated on laboratory
animal toxicologic data and on estimated bioavailability, but the reality
of actual human exposure suggests that these assessments are too conservative.
Moreover, questions remain as to whether science alone can resolve an issue
that has attracted enormous societal interest.

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05139

Author

G

Young, Alvin L.

Gorporita Author
ROOOTt/ArttClO TldO Abstract: A Bioassay Technique for Determination of
Arsenic and the Differentiation of Cacodylic Acid from
Arsenic Trioxide

Journal/Book Title
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Monday, February 25, 2002

Page 5139 of 5167

�A BIOASSAY TECHNIQUE FOR DETERMINATION OF ARSENIC AND Till:
DIFFERENTIATION OF CACODYLIC ACID FROM ARSENIC TRIOXIDE
A. L. Young and B. C. Wolverton
Air Force Armament Laboratory (ATMA)
Eglin Air Force Base, Florida

Determination of arsenic in soils by atomic absorption techniques does
not differentiate organic arsenic (e.g., cacodylic acid) from an inorganic
form of arsenic (e.g., arsenic trioxide). Since cereal crops arc more
sensitive to organic forms of arsenic than to inorganic forms, a bioassay
technique was developed.
Cacodylic acid or arsenic trioxide, expressed as ppm elemental
arsenic, was uniformly mixed (V/V) with soil at rates of 0, 5, 10, 20, 40,
CO, 80, 100, 120, and 160 ppm, A Gulf Coast Flatwood soil consisting of
93.9-0 sand, 3.7% silt, 2.4% clay, and 0.3% organic matter was used for all
bioassay determinations. Ten seeds of sorghum, Sorghum .vulgarc
L. var. Mor-Su, were planted per cup and the experiment replicated five
times. All cups were maintained under greenhouse conditions.
Number of seeds germinated and height (cm) of all plants (soil surface
to tip of longest blade) were obtained after 10 days.
Statistical analysis of the data indicated that height (in cm on a per
cup basis) responded to a concentration range of 5-20 ppm As from cacodylic
acid and 20-120 ppm As from arsenic trioxide. The average height of sorghum
at 20 ppm As from cacodylic acid was 0.2 cm, while average height for 20
ppm As from arsenic trioxide was 5.2 cm. Average height of control plants
was 6.2 cm. The multiple regression coefficients were .96 and .89,
respectively. Equations for predicting concentration of arsenic Were as
follows:
1.331 - O.QSh
Where T » ppm As from cacodylic acid

h = average height (cm) of sorghum (per treatment)
Std, Error of Bst. • 0,076
AND

Log10T = 2.041 - 0.093h
Where T - ppm As from As^O,
h = average height (Cm) of sorghum (per treatment)
Std. Error of Est. = 0.123
Since there was virtually no overlap in the effective concentration
range of the two arsenicals, an approximate value (ppm) could be obtained
for the form of arsenic present when combined with data for total arsenic
from atomic absorption analysis.

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Letter from Alvin L

-- Young to Raymond A. Freeman,

May 3, 1985

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DeSGriptOD NOtBS

Young thanks Freeman for his hospitality during a recent visit.

Friday, February 22, 2002

Page 5088 of 5115

�EXECUTIVE OFFICE OF THE PRESIDENT
OFFICE OF SCIENCE AND TECHNOLOGY POLICY
WASHINGTON, O.C. 20506

May 3, 1985

Dear Dr. Freeman:
Please accept my thanks and appreciation for your gracious
hospitality shown to me, Dr. Flicker and to my Italian guests.
We thoroughly enjoyed the evening of fellowship and scientific
dialogue on the critical science issues associated with the
dibenzo-p-dioxins. The work that you, and Mr. Schroy are
involved in is essential if we are to understand the environmental fate of TCDD. I applaud you for your scientific zeal
and for the dedication to doing the job rightl
Sincerely,

Alvin L. Young, Ph.D.
Senior Policy Analyst for
Life Sciences

Dr. Raymond A. Freeman
Engineering Specialist
Engineering Technology Department
Monsanto Company
800 North Lindbergh Boulevard
St. Louis, Missouri 63166

cc:

Dr. Will Carpenter

�</text>
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