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                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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                <text>Shannon, Peter</text>
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                <text>Letter: from Peter Shannon to Alvin L. Young, 9 December 1983</text>
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                    <text>Item D Number

01959

Author

Young, Alvin L.

Corporate Author
RBpOrt/APtiClBTltb Letter: to Hon. Mr. Justice Phillip Evatt, from Dr. Alvin
L. Young, December 22, 1983.

Journal/Book Title
Year

000

°

Month/Day
Color
Number of Images

"

DOSCPtatOn NotBS

ln tne letter

Monday. July 30. 2001

- Young expresses his thanks for the opportunity
of serving as a scientific consultant to the Australian Royal
Commission. He also summaries the briefings he gave and
shares his specific concerns and suggestions on a morbidity
study.

Page 1959 of 1993

�Alvin L. Young, Lt. Col., U.S.A.F., PhD.,
Senior Policy Analyst for Life Sciences,
Executive Office of the President,
Office for Science &amp; Technology Policy,
WASHINGTON, D.C., 20500,
U.S.A.
22 December, 1983.
The Hon. Mr. Justice Phillip Evatt, D.S.C.,
Royal Commissioner,
Royal Commission on the Use b Effects of Chemical
Agents on Australian Personnel in Vietnam,
G.P.O. Box 4842,
SYDNEY, N.S.W., 2001,
AUSTRALIA.
Dear Judge Evatt,
I want to express to you my appreciation for having had the opportunity
of serving as a scientific consultant to the Royal Commission on the
very complex issues related to Agent Orange and the Vietnam experience.
I believe that the week (14-22 December, 1983) spent working with
you and your staff has been beneficial to both of our nations. The
issues associated with Agent Orange transcend national boundaries,
political parties and governmental agencies. Indeed, the success
to which our respective governments resolve this controversy satisfactorily
will have significant impact on the public's perception of both "responsible
government" and the obligations associated with military service.
During my visit I provided briefings in the following areas:
* The use of herbicides &amp; insecticides in Vietnam, 1961-71;
* Development of the Agent Orange controversy in the United States :
Scientific and social issues;
* Disposition of Agent Orange, 1972-77;
* Environmental fate of 2,3,7,8-TCDD;
* Exposure analyses of Seveso, Italy; Vietnam and Missouri :
Results of Adipose Tissue Analysis;
* On going health studies on Agent Orange Exposure and the Vietnam
experience in the United States.
Each of these topics was thoroughly discussed with your staff and members
of the staff of the Australian Veterans Health Studies (A.V.H.S.).
Perhaps the most important role that I have played, however, this
past week is in my assessment of the need for a Morbidity Study.
Accordingly, 1 wish to share with you some specific concerns and suggestions
that I have discussed with Mr. John Coombs Q.C. during my service
as a consultant to you.
The Australian Forces that served in Vietnam provide a unique population
for epidemiologic study of the Vietnam experience. Whereas, United
States troops were very hetergeneous as to race, socio-economic class,
military service tasks and in-country locations, Australian Forces
were more homogenous for these characteristics. For example, Australian
personnel served primarily in one area of South Vietnam and they functioned
as a unit for tour of duty. U.S. units moved extensively in a large
area of operation and rotation for tour of duty was based only on
the individual. Thus, I am suggesting that these differences may
mean that epidemiologic studies of U.S. veterans as to Vietnam experience

�- 2may not provide information sufficiently applicable to Australian
veterans. I do not wish to imply, however, that the U.S. studies
won't be of value. Indeed these studies may provide some indications
to you of the impact of Vietnam service.
Another important as[x?ct of the Australian Forces is that of population
size. You have a readily jdentiliabJo population of sufficient sJze
for conducting valid epidemiologic studies of the Vietnam experience,
but I do not believe that your population is large enough to identify
cohorts (groups) having distinctly different magnitudes of chemical
exposure (to herbicides or insecticides). Thus, a study of cohorts
selected on the basis of exposure to Agent Orange is unlikely to have
scientific value. It is my opinion that the United States Air Force
Health Study, a carefully conducted epidomiological study of the RANCH
HAND personnel, may provide sufficient data on which to identify an
Agent Orange Syndrome given that such a syndrome can be identified.
If the disease is rare, then the Centers For Disease Control's Agent
Orange Epidemiologic Study of Ground Troops will have sufficient population
size (18,000) to detect it.
In summary, a scientifically valid epidemiologic study of the Vietnam
experience on the morbidity of Australian veterans can be conducted.
Moreover, since A.V.H.S. has a study team in-place and the veteran
population identified, such a study can be conducted on an acceptable
time frame (within two years). To add the necessary assurance that
the Scientific and Veteran community will accept such a study, I strongly
recommend that a recognised Australian Epidemiologist be appointed
principal investigator. Such a superb candidate would be Dr. John
D. Mathews. In addition, a Scientific Advisory Panel should be appointed
by you that would serve to monitor the scientific progress and assist
in the evaluation of the results. I would suggest that you select
a small group of scientists representing the Australian, New Zealand
and United States experts in the appropriate disciplines.
The careful conduct of this study is critical. Any "short-cuts" or
"lack of support" will only decrease the quality of the study. Moreover,
only an excellently conducted study will serve the concerns of the
nations whose troops fought in Vietnam and who now share in the health
concerns of those troops.
Lastly, I wish to express to you my admiration for the superb manner
in which Mr. John Coombs, has interacted with me this past week.
His concerns for all parties participating in the Royal Commission
is worthy of your praise. I also wish to offer my services to you
should you feel that I can further contribute to the Commission.

Yours sincerely,

Alvin L. Young.

�APPENDIX 3

DESCRIPTIONS OF MAJOR EPIDEMIOLOGIC
OF U.S.

VETERANS,

STUDIES

AGENT ORANGE

EXPOSURE AND THE VIETNAM EXPERIENCE
CURRENTLY ON-GOING IN THE UNITED STATES

A.L. Young

�1)

The U.S. Air Force Health Study

a)

Description of the Study

In 1979, the U.S. Air Force established the protocol for a comprehensive
epidemiologic study of RANCH HAND personnel, a group of approximately 1260 men
who conducted the fixed-wing aerial herbicide spraying missions in Vietnam
from 1962 through 1971.

The study is designed around the question, "Have

there been, are there now, or will there be in the reasonably foreseeable
future, any adverse health effects among RANCH HAND personnel caused by
repeated exposure to Herbicide Orange?"

The investigation is composed of three integrated elements:

1) a mortality

study of those individuals who have died since their exposure, 2) a morbidity
study to examine the current health status of the study subjects, and 3) a
follow-up study to look for delayed effects over the next 20 years.

The

mortality and morbidity study elements are being conducted simultaneously on
RANCH HAND personnel and on a group of very carefully matched controls using
personnel tracking procedures employing the following means:

a) an extensive

review of military medical personnel records; b) a detailed face-to-face
interview using questionnaires to ascertain current and past health events as
well as occupational and family data; and c) comprehensive physical
examinations, psychological testing, and diagnostic laboratory studies to
determine exact health status.

Additional questionnaires and physical

examinations are to be administered periodically during the follow-up phase.

b)

Preliminary Results

In June 1983, a report was released comparing the mortality experience of 1247
RANCH HAND personnel and 6171 comparison subjects.

The comparison subjects

were individuals assigned to selected Air Force units with the mission of

�flying cargo to, from, and in Vietnam during the same period.

As of

December 31, 1982, 50 RANCH HAND and 250 comparison subjects had died.

The

mortality experience, including deaths caused by malignant neoplasms, of the
RANCH HAND population was almost the same as that of the comparison group.
soft tissue sarcoma deaths were detected in either group.

No

Although there was

no indication that the RANCH HAND subjects suffered from any increased
mortality or any unusual patterns of death, the study results should not be
regarded as final because of the small sample consisting of young, healthy
individuals and the relatively short follow-up period.

The results of the

initial questionnaire, current health status, and reproductive histories are
to be released in early

2)

1984.

Vietnam Veteran Mortality Study

The US Veterans Administration has initiated a large mortality study that will
compare cause-of-death profiles between veterans with service in Vietnam and
comparable veterans with no service in Vietnam.

Because there are no

estimates of the population at risk, the study will provide only proportionate
mortality ratio (PMR) data.

The study will use existing records to identify a

group of approximately 60,000 deceased veterans and determine cause of death
and Vietnam service status.

The study will also include independent

validation of the computer data base used to identify deaths.

Although this study will not provide information specifically related to a
reason for greater or lesser relative frequency or specific cause of death,
the study will provide a large amount of potentially useful information on
Vietnam veteran mortality.
research.

In addition, it will provide ideas for future

The results are to be reported in late 1984.

�3)

Vietnam Experience Twin Study

a)

Description of the Study

The Vietnam Experience Twin Study was begun by a group of research staff
members at the US Veterans Administration Medical Center, St Louis, Missouri.
The study will identify pairs of identical twin veterans of which one twin
served in Vietnam during the period of Agent Orange spraying and the other
served in an area other than Southeast Asia.

Approximately 600 pairs of twins

will be examined using a series of psychologic, physiologic, and biochemical
tests.

b)

Present Status

The protocol for the study has been completed and approved by a Scientific
Advisory Panel.

The Twin Registry from which participants will be solicited

is being established by the Medical Follow-up Agency of the U.S. National
Academy of Sciences.

The study will focus primarily on the total Vietnam

experience rather than any single factor such as Agent Orange.

If sufficient

identical twin pairs are identified, there may be an opportunity to draw some
conclusions regarding the effects of specific aspects of the Vietnam
experience such as combat, herbicide exposure, or use of insecticides.
study is to begin in January 1984.

The

A report on the results is planned for

early 1986.

4)

Agent Orange Epidemiologic Study of Ground Troops

a)

Description of the Study

Public Law 96-151 charged the US Veterans Administration to "design a protocol
for and conduct an epidemiological study of persons, who while serving in the

�Armed Forces of the United States during the period of the Vietnam conflict,
were exposed to any of the class of chemicals known as 'the dioxins1 produced
during the manufacture of the various phenoxy herbicides (including the
herbicide known as 'Agent Orange1) to determine if there may be long-term
adverse health effects in such persons from such exposure."

The Centers for

Disease Control (through an interagency agreement with the VA) has completed a
protocol for the conduct of this study.

This will be a huge research effort

that will include interviews and examinations involving 18,000 U.S. Vietnam
veterans.

b)

Present Status

A major problem in the conduct of such a study is that there are very few
records maintained that link specific ground troops to herbicide exposure.
Nevertheless, an effort is being made to identify three cohorts, each
containing 6,000 veterans.

The cohorts will differ by likelihood of exposure

to herbicides (high and low) and to combat activity.

The pilot study will

begin early in 1984 and the study is to be completed by 1987.

5)

Epidemiologic Study of the Vietnam Experience

The "exposure" of military service in Vietnam comprises numerous factors, many
of which are unknown, poorly defined, or not quantifiable.

Nevertheless, the

Vietnam "experience" could have influenced anyone who served there.

The

Centers for Disease Control, Atlanta, Georgia, have initiated a study of two
cohorts of U.S. Army draftees and single-term enlistees who served in the
infantry.

Each cohort will consist of six thousand men.

For the Vietnam

service cohort, soldiers will be selected so as to provide a year-of-tour
distribution which is proportional to the year by year Army troop strength in
Vietnam over the period 1966-1971.

The selection procedure for the control

cohort will be such that its period of service distribution is equivalent to

�the Vietnam cohort.

However, this latter group will have served either in the

U.S., Europe or Korea.
determined.

6)

The morbidity of the men in both cohorts will be

The study is to be completed in 1987.

Centers for Disease Control Birth Defects Study

In 1981, the Centers for Disease Control (CDC) in Atlanta, Georgia, began a
study designed to determine if U.S. veterans are at an increased risk of
having children with birth defects.

Since 1968, CDC has maintained a registry

of all babies born with structural or functional defects in the greater
metropolitan Atlanta area.

Of the more than 15,000 children in this registry,

approximately 7,500 had significant anatomical defects at birth.

The

investigators will locate and interview both parents of approximately 5,400 of
the children in this group.

In addition, the parents of 3,000 matched control

normal babies born during the same time period will be interviewed.

Since the major objective of this study will be to determine whether an
unusually high proportion of fathers of babies born with defects served in
Vietnam, information will be gathered about Vietnam service, as well as on
other factors that may be associated with occurrence of birth defects.

If

results demonstrate that a Vietnam veteran has an increased risk of fathering
a child with a defect, then an attempt will be made to determine whether the
increase is associated with Agent Orange exposure or with some other
factor(s).
study.

An index of herbicide exposure has been prepared for use in this

The study is scheduled to be completed by the end of 1983 and results

are to be reported in early 1984.

�7)

Soft Tissue Sarcoma Studies

a)

Kansas Study

In view of concern raised by many veterans that their contact with phenoxy
herbicides and TCDD during Vietnam service may increase the risk of developing
soft tissue sarcoma (STS), and because of the conflicting research findings
reported in the scientific literature regarding association between exposure
to phenoxy herbicides and STS, many epidemiological studies have been
initiated in the US to determine host and environmental risk factors for STS.
The National Cancer Institute is conducting a case-control study in the state
of Kansas to evaluate the effects of occupational and environmental risk
factors including herbicide exposure on the development of STS, non-Hodgkin's
lymphoma, and Hodgkin's disease.

A minimum of 100 white male cases of each

type of such cancers drawn from the Cancer Data Service of the University of
Kansas Medical Center will be compared to controls matched to each case (3:1)
by age, race, sex, and area of residence.

Results of this study are due in

mid-1984.

b)

U.S. Veterans' Administration/Armed Forces Institute of Pathology Study

The VA, in collaboration with the Armed Forces Institute of Pathology (AFIP),
has started a case-control study of STS.

A minimum of 500 STS cases selected

from the AFIP registries will be compared to controls matched (2:1) to each
case by age (+_ 5 years) , race, sex, and place of initial diagnosis.

Phase I

of the study will investigate whether military service in Vietnam increases
the risk of developing STS.

Phase II of the study will investigate other host

and environmental risk factors for STS based on information obtained from
interviews with subjects or their next of kin.

Phase I of the study is

scheduled for completion in the fall of 1984; Phase II will be completed in
late 1985.

�c)

NIOSH Dioxin Registry Study

Since 1979, NIOSH has begun to develop a registry of US workers involved in
production of herbicides possibly contaminated with dioxin.

As of May 1,

1983, about 4,000 workers have been included in the registry.

The enrollment

of an expected number of 6,000 workers will be completed by the end of 1983,
and their mortality pattern, including deaths caused by STS, will be available
in early

8)

1985.

Studies of Chlorinated Dioxins and Furans in Adipose Tissue in the
U.S.A.

The U.S. Veterans Administration in cooperation with the US Environmental
Protection Agency (EPA) has initiated a study of the levels and the frequency
of occurrence of 2,3,7,8-TCDD in adipose tissue from a selected group of U.S.
males.

Since 1968, the EPA has been collecting adipose tissue from the US general
population by region, age, sex, and race in a National Adipose Tissue Bank
which now contains specimens from over 12,000 individuals. Adipose tissue
from approximately 550 males born between 1937 and 1953 is available from this
bank.

Many of these men served in the military during the Vietnam era, and

some served in Vietnam during the period of Agent Orange use.

A retrospective

study of their adipose tissue may establish data on background levels of
2,3,7,8-TCDD in the U.S. male population, as well as whether service in the
military and especially in Vietnam has had an effect on the levels of TCDD in
adipose tissue.

The study will be conducted in three phases.

Phase I will obtain the name and

social security number for the approximately 550 males noted above.
information will be used to determine military service status.

This

Phase II will

�be the development of analytic methods for the determination of selected
chlorinated dioxins (especially 2,3,7,8-TCDD) and furans in human adipose
tissue.

The method will be subjected to rigorous interlaboratory validation

by an independent analytic referee, such as the Association of Official
Analytical Chemists.

Phase III will be the analysis of the adipose tissue and

the preparation of a final report.

Phases I and II should be completed within

the 1983 calendar year, and the report from Phase III should be available in
early 1985.

�</text>
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                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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                    <text>ftemU Number

0197

Author

Young. Alvin L.

°

Executive Office of the President, Office of Science and

RBPOrt/ArtiClB Tlth

Lettor to

6, 1984

Mrs. Pat Bragg from Alvin L. Young. February

Journal/Book Title
Year

000

°

Month/Day
Color
Number of Images

1

Letter discusses the telephone conversation that Bragg and
Young had the previous week regarding the official visit of Mr.
John Coombs and Dr. John Matthews from the Australian
Royal Commission on the Use and Effects of Chemical
Agents on Australian personnel in Vietnam. The mentioned
attached itinerary is missing. See item 1966 for proposed
itinerary for this visit.

Monday. July 30. 2001

Page 1970 of 1993

�EXECUTIVE OFFICE OF THE PRESIDENT
OFFICE OF SCIENCE AND TECHNOLOGY POLICY
WASHINGTON. D C 20600

February 6, 1984

Dear Mrs./Bragg:
This is to confirm our telephone conversation of last week
informing you of the official visit of Mr. John Coombs and
Dr. John Matthews from the Australian Royal Commission on the
Use and Effects of Chemical Agents on Australian Personnel
in Vietnam (itinerary attached). Dr. Matthews is the principal
investigator of the Australian Serviceman's Health Study and
Mortality Study. The two men will be in Washington for the
release of the Air Force Health Study, February 24, 1984,
and requested that arrangements be made with the Air Force
for them to meet with the Air Force Principal Investigators.
Mr. Coombs and Dr. Matthews have suggested either a late
afternoon or an evening meeting on February 24, or a meeting
on Saturday morning, February 25. Dr. Barclay Shepard,
Veterans Administration, has offered to provide an office for
the meeting. I would appreciate your assistance in coordinating
the meeting between these two scientific teams. If you have
any questions or if I can be of assistance, please contact
me at 395-3125.
Sincerely,

to

Alvin Young"
LT COL USAF, Ph.D
Senior Policy Analyst
for Life Sciences

Mrs. Pat Bragg
HQ USAF/SGI
Boiling, AFB, D.C.

cc:

20332

Dr. Barclay Shepard

�</text>
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