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                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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Hobson, Lawrence B.

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Veterans Administration

RBpOPt/ArtfClB TltlB Memorandum: from Clinical Assistant (102A) to Acting
Dir. Agent Orange Projects Office (10A7), with subject
Ranch Hand, Advisory Committee, September 28,1982.

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Wednesday, May 23, 2001

Page 1567 of 1608

�Veterans
Administration
Date:

October 20, 1982

Memorandum
From:

Clinical Assistant (102A)

Acting Dir. Agent Orange
lo:

Projects Office (10A7)

Subj.

Ranch, Hand, Advisory Committee
September 28, 1982

1. On September 28, 1982, the Advisory Committee on Special Studies
Relating to the Possible Long-term Health Effects of Phenoxy
Herbicides and Contaminants (the Air Force Ranch Hand study) met at
NIEHS, Research Triangle Park, NC. The purpose was to review the
progress of the study.
2. Dr. J.A. Moore chaired the session with Drs. I. Selikoff,
R. Monson, A. Poland, G. Comstock, and N. Nelson, members in
attendance. Aside from Air Force personnel and me, the only
attendees were Maureen Corcoran and Margaret Warner, the latter a
lawyer from Carr, Jordan, Coyne, and Savits.
3. To date more than 1,000 participants have been examined with
only one serious complaint (nature unspecified). An attempt is
underway to obtain military records and private medical records for
all.
4. Serum (20+cc.) and urine (100 cc.) from each participant are
being retained at - 70°C. Selikoff suggested needle fat biopsies to
obtain 500 mg, of material for storage. This suggestion was
rejected, as it had been before, despite Poland's skeptical report
that Rappe claims measurement in tissue with less than 1 ppt. (less
than 0.1 nanagram) of TCDD. Nelson believes that even smaller
amounts (1 femtogram) can be measured by immunological techniques.
He suggested that red blood cells should be stored since hemoglobin
has proved to be an effective long-term adsorbant for a variety of
chemicals.
5. The morality study, as expected, is showing a death rate below
that for the U.S. population control and equal among Ranch Handers
and their Air Force controls. Analysis of causes of death is not
yet complete and, in any event, the numbers are very small, limiting
the significance of differences (all P's equal to or greater than
0.05).
6. Only 3 Ranch Handers have died from malignant neoplasms, less
than half the rate among controls; 5 died of gastrointestinal
diseases, more than twice the rate among controls. Three
participants are 5 year post-operative survivors of testicular
carinoma but the code has not been broken to determine whether they
are in the exposed or the control cohort.

�7. No chloracne has been observed. Selikoff said that 50 percent
(sic) of the the chemical workers at Nitro who had cloracne
initially still had it 30 years later and that this indicates severe
exposure; laborers who cleared a dump site at Jacksonville,
Arkansas, had no chloracne.
8. An attempt is being made to develop an exposure index for Agent
Orange. The Ranch Banders include individuals who were exposed to
320,000 to 1 million gallons of all herbicides a maximum to 100
gallons as a minimum.
9. Of 1,265 Ranch Banders, 22 were killed in action, 38 are dead of
other causes, and 1,205 were alive on December 31, 1981. The search
for these has resulted in 1,160 cooperative participants, 39 who
refused participation, and 6 who are still not located. The
corresponding numbers for controls are 1,149, 81, and 10. Of the
Ranch Banders it is anticipated that 90 percent will complete the
examination at best, 75 percent at worst; for controls the
percentages are 82 and 65. Lack of time and interest is the most
common reason given for refusal.
10. The immunology testing of a subset of 600 participants was
discussed at length. The Air Force has not included skin tests as
unreliable or dangerous; Selikoff believes that the decision should
be reconsidered.
11. Among laboratory tests, BDL is the least reliable, although BUN,
total and conjugated bilirabins are also poor,. Electrophoresis
studies are also variable but this was shown to be within the
accepted limits of general experience.
12. The study remains on schedules Mortality results will be
available in March, 1983; an interim report on morbidity in April to
June 1983* The next Committee meeting will be in March, 1983, to
consider the mortality data and perhaps the exposure index
determinations.

\ ••.&lt;.,*&lt;:&lt; ''O.
&amp;
LAWRENCE B. HOBSON, M.D.,

Ph.D.

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01543

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Lathrop, George D.

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ROpOrt/ArtiClO TitlO Memorandum: from Colonel George D. Lathrop to Lt.
Col. Moynahan, Lt. Col. Wolfe, Maj. Rhode, and Maj.
Young, with subject Out of Channel Communications
with the VA, 19 March 1980.

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DOSCrlptOH NOtOS

Memo directs that all VA phone calls be sent to Lathrop
for response. Reply to memo requested by
endorsement. This copy includes Major Alvin L.
Young's reply.

Wednesday, May 23, 2001

Page 1544 of 1608

�MEMORANDUM FOR RECORD

19 Mar 80,

Subject: Out of Channel Conpuni cations with the VA
To:

Lt Col Moynahan
Lt Col Wolfe
Maj Rhode
Maj Young

1. Recently the Veteran's Administration has inappropriately
contacted members of this Division directly, both by phone and
letter, requesting our assistance in sensitive areas related
to Herbicide Orange studies. I am concerned that in our
posture of expertise and willingness to help other investigators,
we can inadvertently create political problems that could
compromise both the VA study efforts as well as the Ranch Hand
study.
2. Henceforth, refer all VA phone calls and letters to me for
response. If the matter 1s purely technical, I will ask appropriate individuals to assist me in a conference call. If the
VA inquiry concerns the complex aspects of how to conduct or
interprete studies, resources, or policy, I will refer the call
to Higher Headquarters. In my absence, Maj Rhode will make this
decision; if we are jointly unavailable, the inquiry should be
referred to Lt Col Moynahan.
3. Reply by endorsement.
GEORGE D. LATHROP, Colonel, lSAF, MC
Chief, Epidemiology Division

ALVIN L. YOUNG, Major, USAF
Consultant, Environmental Sciences

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Report/Article Title Photographs: Meeting of Veterans Administration's
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000

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          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
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                <text>Photographs: Meeting of Veterans Administration's Advisory Committee on Health-Related Effects of Herbicides, September 1983</text>
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            <name>Subject</name>
            <description>The topic of the resource</description>
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                <text>international cooperation</text>
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                <text>VA</text>
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  <item itemId="1807" public="1" featured="0">
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          <name>Dublin Core</name>
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            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
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                  <text>Alvin L. Young Collection on Agent Orange</text>
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              <name>Description</name>
              <description>An account of the resource</description>
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                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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          <name>Box</name>
          <description>The box containing the original item.</description>
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              <text>035</text>
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          <name>Folder</name>
          <description>The folder containing the original item.</description>
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              <text>0754</text>
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          <description>The series number of the original item.</description>
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              <text>Series III Subseries I</text>
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          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
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              <elementText elementTextId="10539">
                <text>Hobson, Lawrence B.</text>
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          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
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                <text>April 11 1983</text>
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          </element>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
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                <text>Porphyria Cutanea Tarda</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
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                <text>dioxin</text>
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              <elementText elementTextId="10546">
                <text>health effects</text>
              </elementText>
              <elementText elementTextId="10547">
                <text>VA</text>
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              <elementText elementTextId="10548">
                <text>industrial exposure</text>
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        <name>ao_seriesIII</name>
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