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Author

Rogers, Jim

Corporate Author
ROpOrt/ArtlClO TltlO Typescript: Agent Orange Research in Vietnam

Journal/Book Title
Year

™M

Month/Day

A r|

Color

n

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3

P i 26

DescNpton Notes

Thursday, May 03, 2001

Page 1384 of 1403

�.Agent Orange Kesparch_ in Vietnam
The Vietnamese have been investigating the environmental and medical effects
of herbicidal defoliants since 19GG. TheVarly investigations were based on clinical
observations made by Vietnamese physicians. During the same period, American
biologists began to comment on the destruction of plant life resulting from the
Hader and Ranch Hand .defoliation operations.
..j1'
In 1970 the effects of phenoxy herbicides and their dioxin contaminants were
debated at a scientific conference in Orsay, France. Soon afterward the defoliation
missions were discontinued, or at least sharply curtailed.
f
Following the end of the Vietnam War in 1975, the Vietnamese continued
their studies. In January, 1983, an international symposium was held in Ho Chi
Minh City. The work done by the Vietnamese was presented and debated for
several days. The participants concluded t h a t the results obtained by the Vietnamese
were generally consistent w i t h studies done in other countries.
The complexity of the problems under study in Vietnam was explicitly recognized.
Recommendations were made which may f u r t h e r improve the methodology of
f u t u r e studies. There WHS also an interest in applying methods which might develop
a causal (as opposed to statistical) link between dioxin exposure and the medical
and environmental problems which have been identified.
J,! !£ J '•

.

A scries of ecological studies has been completed. Additional studies in other
areas of the country are in the planning stages. The environmental impact of
phenoxy herbicide application has been convincingly demonstrated in:
1) The Ma Da forest, located about 100 kilometers northeast of Ho Chi M i n h City.
2) The Ca Man region, located in" the southeastern tip of the Mekong Delta.
This is largely mangrove forest.
3) Areas of Quang Tri province
4) The A Luoi region, about fiO kilometers from Hue.
A number of environmental effects has been noted. The physical characteristics
and chemical composition of soil has been drastiely altered. In mountainous
areas extensive erosion and flooding has resulted. Because the defoliated nnd
eroded mountainsides can no longer contain moisture, evaporation of streams
and rivers during the dry season has been accelerated. This had led in t u r n to
the death of many aquatic and forest animals.
In most heavily defoliated areas the natural flora'has not yet returned. Sparse
grasses now grow in areas which were once heavily forested. This profound change
in habitat, together w i t h the direct toxic effect of the chemicals, has resulted
in the local and regional disappearance of many species of large predatory animals
and birds.

�Page 2
Small rodents .survived the e n v i r o n m e n t a l changes well, and the elimination
of n a t u r a l predators led to an increa-.o in t h e i r numbers. In south Vietnam, an
increased number of rats and an increased incidence of plague has been correlated
w i t h t h e defoliation.
In some areas reforestation work has begun. There have been some initial
successes in the mangrove forest of the Mekong Delta, but it is too early to know
just how successful these e f f o r t ? will ultimately be.
Reproductive Effects
A number of detailed epidemiologic studies have been carried out which indicate
that the effect of chemical exposure on normal human reproduction has been
profound. Much of the evidence suggests t h a t the primary mechanism involves
rnutation (alteration of genetic material) rather than _t_er_atoge.ncsls (in-utero
injury of the embryo or fetus). In practical terms this means:
1) Effects on reproduction can result from exposure of either the male or
the female parent.
2) Abnormalities in reproduction may occur many years following exposure.
3) The possibility exists that defective genetic material may be passed on
to succeeding generations.
A large number of specific reproductive abnormalities have been observed
in exposed male and female Vietnamese. These include:
1) An increased rate of spontaneous abortion
2) An increase in molar pregnancies
3) An increased number of still-born children
4) High rates of s t e r i l i t y in exposed males; as high as 2196 in one study.
Vietnamese physicians and researchers say t h a t prior to the defoliation, V i e t n a m
had a low rate of birth defective children. Since t h a t t i m e the number of tr'rth
defective children has increased, although the precise parameters of that increase
are not clear.
The types of defects encountered include eranio-facial abnormalities, malformations
of the extremities, neural tube malformations, malformations of the trunk, and
conjoined twins. A large number of non-viable "monsters'' have been collected
by Vietnamese researchers. We saw such a display at the obstetric-gynecologic
hospital in Ho Chi Minn City.
I must say that the malformations we saw were very bizarre. Despite several
years of involvement with neo-natal surgery and neonatal intensive care, I had
never before seen such astounding fetal malformations.
Some additional evidence has been collected, f u r t h e r implicating herbicide
use as a cause of mutation and reproductive problems. Well controlled studies
have shown an increased incidence of chromosomal damage in those exposed
to spraying and in the children of those exposed. Teslicular biopsies carried
out in some exposed males showed a failure of normal germ cell maturation.

�Pago 3

The quality of the reproductive studies was generally good. Improvements
are always possible, but I believe that improved studies will further refine the
information thus far developed. It is not likely that improvements in rncthodoloj.
will alter the basic content of that devolping fund of information.

Primary cancer of the liver has been extensively studied. The increased incidence
of that particular tumor in Vietnamese exposed to defoliants was first reported
in 1973. Subsequent studies have strengthened the correlation. Studies in the
West have not focused on this type of cancer.
Chorio carcinoma, probably related to the increased occurence of hydotiforrn
mole, also seems to be increasing in frequency. The extent of increase of this
highly malignant reproductive cancer is far from door.
General Health E f f e c t s
Other less specific, but nevertheless serious, health effects have been observed
at an increased rate in the exposed population. Those include, gastric disorders.
chronic hepatitis, dental and oral diseases, and psychological disorders.
Few studies have been done on these more general h e a l t h effects. It would
require additional, larger samples to confirm the i n i t i a l impressions and to sort
out the causative factors.
Coriclusinsan&lt;J
Relevance of the Vietnamese work to the concerns of American veterans
and the general American public should be clear. The effects of dioxin on humans
and on the environment is a major national issue.
VVA should now take the lead in organizing the necessary scientific cooperation
between Vietnamese researchers and American scientists. The Vietnamese are
eager to cooperate simply because the resolution of existing medical and environmental
problems (nnd the prevention of future damage) is a major point in their national
reconstruction. The valuable information which could be available to American
veterans and the American public will simply be lost if effective scientific cooperation
is not initiated.
Additionally it is clear that, in certain specific and focused areas, the studies
being conducted on Vietnamese veterans ore superior to any similar studies now
being conducted in the United States. VVA should undertake consultations with
leading medical researchers in the United States to determine the relevance
of portions of the Vietnamese protocols to research currently underway on veterans
in the United States,
I hope 'hat VVA Directors nnd other individuals receiving this report will.
feel free to communicate directly to me their comments and questions.
Submitted 4-26-84

Jim Rogers, M. D.

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