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                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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01406

Author
Corporate Author
Report/Article TttlO Press Release: Arkansas Scientist Reports on
Herbicide Exposure Studies, May 2,1985

Journal/Book Title
Year
Mouth/Day
Color

H

Number of Images

2

Descripton Notes

Tuesday, May 15, 2001

Page 1406 of 1514

�For release after 4 p.m., May 2, 1985.
Arkansas Scientist Reports on Herbicide Exposure Studies

MIAMI--Findings from studies that determined how much herbicide
was absorbed into the bodies of forest workers applying herbicides
were presented Thursday (May 2) by Dr. Terry L. Lavy, professor of
agronomy at the University of Arkansas - Fayetteville, at the American
Chemical Society's 189th national meeting here.
Lavy, director of the Pesticide Residue Laboratory at the
University of Arkansas, reported on applicator exposure to the commonly used forest herbicides 2,4-D, dichlorprop and picloram. The
research was conducted with the cooperation of 80 forest pesticide
applicators in nine locations in Arkansas, Mississippi and Oklahoma.
The applicators provided the researchers with all of the urine they
excreted during the 12 day study period.
Research has shown that at least 90 percent of the amount of these
compounds that is absorbed through the skin is excreted in the urine
within five days, Lavy said. Therefore, analysis of the urine of the
applicators provides a measure of the amount of chemical absorbed
through the skin. Lavy also stated that the amount applicators
absorb through the skin is much greater than the amount inhaled.
The toxicological significance of the amounts of herbicides
absorbed by the workers was determined using the "no observed effect
levels" that are widely accepted by regulatory agencies, researchers
and the industry. A margin of safety was determined by dividing the
"no observed effect level" by the dose absorbed by workers.

�The most exposed workers were those using backpack sprayers. The
margin of safety for 2,4-D ranged from 245 for the backpack crew to
5,581 for the injection bar crew. If a worker has a margin of safety
of 245, this means he could have absorbed 245 times more than he did
before he would reach the "no observed effect level". Picloram
margins of safety were as high as 943,400.
The study was designed to compare exposure levels of workers
applying the herbicides with ground application tools who took no special precautions to those who used a set of simple preventive
measures, which included wearing new leather gloves and boots each
day. The new gloves and boots significantly reduced exposure for all
workers except those using backpack sprayers, apparently due to the
high degree of spray contact with other parts of their bodies.
Lavy has conducted nine worker exposure studies with eight different herbicides and insecticides.

Workers involved with mixing or

batching pesticide concentrates received a higher absorbed dose than
those applying diluted sprays. In each case he has found that healththreatening levels of expoure did not occcur.
He adds, however, that it is always wise to limit expoure to
chemical products. Practices to reduce exposure include washing hands
before eating, before using tobacco, and before using the bathroom;
immediately washing with soap and water any skin on which pesticide is
spilled; showering and changing clothing soon after exposure; and
wearing clean clothing, including waterproof boots and gloves, during
application.

�</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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                <text>agricultural exposure</text>
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                <text>protective clothing</text>
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01425

AllthOT

Doherty, Joyce

Corporate Author

United States Department of Health and Human Service

Roport/Artldo TltlO

Press Release

Announcing Possible Link Between
Herbicides and Non-Hodgkin's Lymphomas

Journal/Book Title
Year

1986

Month/Day
Color

Au ust 14

9

n

Number of Imaoes

f

DOSOrlptOU NotOS

A'so includes questions and answers to be used by
OCC to respond to press inquiries on the agricultural
use of herbicides study.

Tuesday, May 15, 2001

Page 1425 of 1514

�HHS MHWi)

D

RAFT

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES

EMBARGOED FOR RELEASE
4:30 p.m. EST
Thursday, August 14, 1986 (tentative)

National Cancer Institute
Joyce Doherty
(301)

A National Cancer Institute (NCI) and University of Kansas study has found that
Kansas farmworkers who used herbicides had a higher risk for developing non-Hodgkin's
lymphomas than nonfarmers in the state. The farmers, however, did not have a higher
than normal risk for soft-tissue sarcomas and Hodgkin's disease, as studies in Sweden had
found. The Journal of the American Medical Association published the study results
August 15,1986 (tentative).
Farmers exposed to the herbicides for more than 20 days each year had six times
the risk of developing non-Hodgkin's lymphoma compared to nonfarmers. Among these
frequent users, those who mixed or applied the herbicides themselves had eight times the
risk. These above-normal rates were associated with the use of phenoxy herbicides,
especially 2,4-dichlorophenoxyacetic acid (2,4-D). Phenoxy herbicides are frequently
used on pastureland and in growing wheat, corn, sorghum, and rice.
Exposure to chemicals in herbicides is widespread in the United States. In addition
to farming and forestry use, these chemicals are found in lawn and garden herbicides,
blue stain retardants used in sawmills, slime control substances in paper and pulp
manufacturing, cutting oils, wood preservatives, waterproofing agents for leathers and
textiles, and medications. Phenoxy herbicides were also used in Agent Orange in
Vietnam.
Because of scientific and public concern about the chemicals, NCI conducted a
population-based, case-control study of three cancers that earlier studies had linked to

(more)

�-2-

herbicide exposures. The NCI scientists, led by Shelia K. Hoar, Ph.D., collaborated with
scientists from the University of Kansas, led'by Frederick F. Holmes, M.D. NCI chose
Kansas because the farmers frequently use herbicides on wheat, the state's major crop,
and because Kansas has a statewide cancer reporting system.
Dr. Hoar and her colleagues studied 424 male residents with soft-tissue sarcoma
(133 cases), Hodgkin's disease (121), and non-Hodgkin's lymphoma (170) that had been
newly diagnosed between 1976-1982. A panel of three pathologists confirmed the
histology of each diagnosis.
The scientists also studied 948 controls from the general white male population of
Kansas. In telephone interviews, the subjects or close relatives of deceased subjects
were asked detailed questions about farming practices, including herbicide and
insecticide use. For a sample of the subjects, the scientists also located herbicide and
insecticide suppliers to corroborate exposure information given in the interviews.
The investigators found that, compared to nonfarmers, the farmers had about equal
risk of developing soft-tissue sarcoma and a slightly lower than expected risk of
Hodgkin's disease. Even after detailed analyses, they found no consistent patterns of
excess risk for either of these cancers associated with length of time working or living on
a farm, the crop or the acreage farmed, or the duration or frequency of herbicide use.
For non-Hodgkin's lymphoma, the risk was slightly higher (about 30 percent) for all
farmers compared to nonfarmers. The risk, however, increased significantly for farmers
who used herbicides. Compared to nonusers, the risk increased to sixfold (600 percent)
for farmers who were exposed to herbicides for more than 20 days per year. The level of
risk was not related to the total years of herbicide use.
Farmers who began using the herbicides before 1946 had a greater than 70 percent
higher risk for non-Hodgkin's lymphoma compared to farmers who began use in the 1950s
and 1960s. Use of insecticides did not increase the risk for non-Hodgkin's lymphoma.

(more)

�-3-

The farmers who did not use protective equipment (gloves, masks, etc.) while using
herbicides had a 40 percent higher risk fur non-Hodgkin's lymphoma than those who
protected themselves. Similarly, farmerjs who used spray equipment that exposed them
to more of the chemicals had an 80 percent higher risk than those who used safer
application methods.
The scientists also investigated possible causes for the above-normal non-Hodgkin's
lymphomas other than the herbicides. They assessed the more established factors such as
immune-altering conditions and drugs and the family history of cancer. They also
assessed speculative factors such as cigarette smoking, coffee consumption, and ionizing
radiation. None of these was found to change the herbicide association.
The finding of excess non-Hodgkin's lymphoma associated with herbicide use in this
study is consistent with earlier research done in Sweden and in some other U.S. states
with heavy concentrations of agriculture.

�The following Questions and Answers are to be used by OCC to repond to press
inquiries on the agricultural use of herbicides study.
They are not part of the .press release.

�QUESTIONS AND ANSWERS

1. What types of herbicides were evaluated in this study?

The scientists evaluated the use of phenoxyacetic acids, triazines, amides, benzoics,
carbamates, trifluralin, and uracils. The farmers also reported nonspecific herbicide
use such as liquids, sprays, and dusts.

2. Were insecticides also evaluated?

Yes, the scientists asked detailed questions about use of insecticides. After they
accounted for the herbicide use, they found no association between insecticide use
and non-Hodgkin's lymphoma.

3. Dioxin contaminants are found in some herbicides. Did this study find any effects
of dioxin in the herbicides?

The study subjects reported most frequent use of 2,4-dichlorophenoxyacetic acid (2,4D), an herbicide that does not contain 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD),
the most carcinogenic dioxin isomer. The herbicide 2,4-D, however, may contain
other, less toxic dioxin isomers. Very few subjects reported that they used 2,4,5trichlorophenoxyacetic acid (2,4,5-T), the herbicide known to be contaminated by the
carcinogenic dioxin isomer, so the dioxin effects could not be effectively evaluated.

�4. Are current herbicide and insecticide formulations safe if used as directed?

Unknown. Until enough time has elapsed to allow for the latency period of nonHodgkin's lymphoma, the risks for use of current formulations will not be known. If
the risks continue to drop, one can assume that current formulations, if applied
according to directions, are safer than in the past. The farmers who began using the
herbicides before 1946 had a higher risk than those who began their use later;
however, even those who began to use the herbicides after 1965 had almost twice the
expected number of lymphomas.

5. Do homeowners who use insecticides and herbicides on their property run a higher
risk for cancer?

This study did not show any excess risk associated with reported home or garden use
of either insecticides or herbicides. NCI is currently collaborating with the
University of Nebraska on a new study investigating this question.

6. What precautions can a farmer or homeowner use to protect against possible cancer
risks?

Although not designed to answer this question, the study did show that the risk for
lymphoma decreased when the farmers used protective equipment to minimize their
exposure to the herbicide. Homeowners should do the same. Most chemicals for
home or garden use have warnings on labels about how the products should be used.

�7. What about the danger to small children and pets who play on lavMhs that have been
treated with herbicides or insecticides?

-

The population studied was adults only. It did not address risks for children.

8. Do Vietnam veterans who were exposed to Agent Orange have an increased risk for
developing cancer?

This study focused on agricultural use of herbicides. The methods of application, the
amounts used, the climate, and the elimination of herbicides from the environment,
might be very different in Kansas and Vietnam. Studies of Vietnam veterans to date
do not report excess non-Hodgkin's lymphoma; however, these studies have been too
small to detect moderate excesses, if they exist.

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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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