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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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01892

Author
Corporate Author
Report/Article Title Transcript: Interview given by Dr. William McBride on
ABC Radio, January 9, 1980.

Journal/Book Title
Year
Month/Day
Color
Number of limps
DBSCNpton Notes

'tem includes a cover memo from K. A. Watson at Dow
Chemical (Australia) Limited, and a routing slip From Alvin
Young to Peter Kahn.

Wednesday, July 18, 2001

Page 1892 of 1908

�R'OUTING AND TRANSMITTAL SUP

Data

11

TO: (Name, office symbol, room number,
building. Agency/Post)

Initials

Date

i. -flSHfifiwa?2.

Mr Peter Kahn

8.

7 EliEabeth Avenue

4.

Bast Brunswick. UJ 08816

B.
Action
Approval
As Requested
Circulate
Comment
Coordination

File
For Clearance
For Correction
For Your Information
Investigate
Justify

Note and Return
Per Conversation
Prepare Reply
See Me
Signature

REMARKS

Dear Peters Per our conversation of 5 May
a* the Veterans Administration, attached
please find a copy of the ABC radio interview on Agent Orange originating from
Australia, Although they listed you as
"peter Cwnen. Dow Chemical identified it
aa&gt; "Peter Kahn% a biaihomistefroni
I enjoyed meeting yov. and I look forward
to worHng with you in the
Sincerely,
AL YCOT*
DO NOT use this form as a RECORD of approvals, concurrences, disposals,
clearances, and similar actions
FROM: (Name, org. symbol. Agency /Post)

Room No.—Bldg.

Phone No.
8041-102
*U.S. QPO. 1«7t-a«1-647/332t

OPTIONAL FORM 41 (Rev. 7-76)
PmeribMt by GSA
FPMR (41 CFR) 101-11.208

�DOW
TELEX: AA20442
TELEPHONE: 929-8-133
CABLE: DOW1NTAL-SYDNEY

CHEMICAL

(AUSTRALIA)

LIMITED

3BD FLOOR. M.L.C. BVILWXG. NORTH SYDNEY

P.O. BOX 384
NORTH SYDNEY, N.S.W. 2060

January 23, 1980

B.A. SCHEWTZ
- 1803 Bldg MIDLAND
J.H.'DAVIDSON - 9001 Bldg MIDLAND
cc: M.J. BLANKENSHIP - Altona
G . R . WEATE
- Sydney

SUBJECT:

DR. W. McBRIDE

Attached is a transcript of an interview given by
Dr. William McBride on ABC radio. The text gives
some idea of M c B r i d e f s thinking on the subject of
Agent Orange and TCDD which could be useful when
you meet him next month.
Regards,

K . A WATSON
Attach:
bs

T» 0 -

Kfirtf,
• ; ^ llL

•' L

. - A . . j..^-

..( •'

.. s. '/ »-•

,'_ _

' . ^ l -'

�ABC CURRENT AFFAIRS PROGRAM
CITY EXTRA - JAN 9, 1980

To discuss the medical aspect of the possible harmful effects of
Agent Orange I have on the line Dr. William McBride, founder of
Foundation 41. The Australian doctor who told the world of the
effects of thalidomide and who now devotes his working life to the
health of children in the first 41 weeks of their life.
C.E. speaks firstly to American biochemist before speaking to
Dr. McBride.
Dr. Peter Carne, a biochemist from Rutger's University in New Jersey
speaks to Margaret McKay and is asked how long has he been involved
in evaluating the herbicides used in the Vietnam war;
Carne 'During the Vietnam war,, beginning about 1968, perhaps 1969,
I•accumulated all the literature that existed up until that time and
then I left that area until about a year ago, and when at the request
of veterans groups in New Jersey, where I live and work, I was asked
to go out and speak to a number of groups because of their fears that
the exposure to the defoliants was affecting them. And they wanted to
know what was the state of Dow Chemical with medical evidence on it;
and at that time I began to review the literature that had come out
since 1970. I've worked my way back now through 1975 or so in the
literature, and on the basis of that, I went out to various veteran
groups to tell them what the state of the report was'.
C.E. 'What was some of the worries, or some of the questions of the
American veterans'.
Carne 'There were two kinds. One is that a considerable number of
them have low grade chronic symptoms; nervousness, fatigue, dizziness
and inability to concentrate. Sometimes their ill-tempered for
reasons that they don't understand and they were not ill-tempered
before they went to Vietnam. A great many complain of these and often
there will be no two people having exactly the same set of symptoms
but they are a form of a related constellation. The other kind of

�- 2 -

thing is that some of them have fathered deformed children and
we're afraid that there may be a connection between that and the
exposure to defoliants in Vietnam 1 .
C.E.

'Could you tell us exactly what Agent Orange is?1

Carne 'It's an equal mixture of two compounds which are usually
designated 2,4-D and 2,4,5-T and they have very long names and you'll
find them in organic chemical literature. The problem doesn't arise
from the defoliants themselves but from the contaminant, usually
called dioxin present in the manufacture, primarily of the 2,4,5-T.
The material used in Vietnam had dioxin contamination of rather
high levels'.
C.E. 'What sort of results have occured in laboratory tests with
dioxin1.
Carne 'Its terribly, terribly toxic in minute quantities. In fact
one of the problems is being able to analyse the material at the
*
low levels at which toxic effects are found. Of course in a
laboratory study where you start with a bottle of dioxin on the
shelf, for example, you can make up any concentration you wish and
you know the concentration because you diluted the concentrated stock.
In the case of animals collected in the rivers or analysing the human
tissue; your analysing there in a very different situation, where the
material may be toxic at an extremely low level, in fact it is, but
its below the level of detection of most analytical instruments.
There are only a few laboratories, perhaps half a dozen in the world,
that are capable of analysing at the extremely low levels that are
necessary. Its very hard to track it down1.
C.E.
Carne

'It is a very costly venture as well?.1
'Typically vetween $500 and $1,000 a shot for an analysis'

C.E. 'If we were going to examine the veterans in the United States
and in Australia that would come into a great deal of money?'

�- 3 -

Game
C.E.
Carne

'You certainly would not do that type of examination1.
'You couldn't?.'
'No, that would be out of the question'.

C.E. 'Could dioxin be detected in veterans who, for example, were
in Vietnam ten or eleven years ago?'
Carne 'Probably not. I think that the nature of work there would
be quite different. I think the analytical question there is so hard
that it can't even be attempted. I think what ought to be done with
the veterans is a statistical survey. I would call on every veteran
who has served in Vietnam, even a significant number who did not
serve but were in the military at that time. I would call them in
for medical examination and a questionnaire on the medical consequences
in their families. And you really have a very large number of men
brought in because of the nature of the evidence you would have to
seek is statistical advice for nature. And you would have to have
at least two groups - those who are known to be exposed to the
defoliant by having been in sprayed areas, and those who are known
not to have been exposed. And only by comparing two groups of that
kind, and large ones at that, could you assemble sufficient statistical
evidence to make a case one way or the other'.
C.E. 'From your contact with the American veterans, is there enough
statistical evidence to link any of the deformities or ill-health
with Agent Orange or with any of the herbicides used in Vietnam?'
Carne 'Firm statistical evidence, no. There is a great deal of
suggestive and circumstantial evidence collected. But you have to
understand the nature of scientific proof, its suggestive at the
moment and its not conclusive. It certainly makes me very suspicious'.
C.E. 'Well statistical evidence, you mean for example in the case of
smoking and cancer, is that purely statistical evidence. And that's
beyond doubt?'

�- 4 -

Carne 'Yes that's beyond doubt, and right now the statistical
evidence, in the case of Agent Orange, is simply not enough to
make a critical evaluation*.
C.E. 'Could that be because not enough have come forward, not
enough veterans have come forward? So we have yet to see the
full extent of the damage of Agent Orange?'
Carne
C.E.

'Yes, I think that's the case1.
'The other herbicides used in Vietnam.

How many were there'.

Carne 'There were thre principal ones that were used. There was
Agent Orange which was by far the most heavily used. There were
two others; Agent Blue and Agent White. The names arise from the
coloured bands which were painted on the drums in which the material
was shipped; and one of the others, its active ingredient was an
organic arsenical compound. Containing arsenic. Its not the arsenic
poison, in fact, its not even very toxic. It was used primarily
against grasses, heavily against rice1.
C.E.

'Could that have accidentally been sprayed on friendly troops?'

Carne 'Yes, it certainly could have. I don't think it would have
the damaging consequences of dioxin that's found in 2,4,5-T. For
one thing it contains no dioxin1.
C.E.

'So there wouldn't be any genetic problems with it'.

Carne

'No there wouldn't be any problems of that kind'.

C.E. 'To establish any direct link between Agent Orange and genetic
defects, as you say would be purely statistical, is that not enough,
is that not sufficient1.

�- 5 -

Game 'Certainly with regard to health benefits for veterans, yes
that would be sufficient; and as far as establishing that it can
cause genetic abnormalities the biochemical work is not very
difficult'.
C.E. 'Laboratory tests with dioxin, what sort of deformaties occurred
in rats for example 1 .
Carne 'Cleft palate, kidney abnormalities, deformities of the
limbs. All these are the same kind of things that are being found
in children1.
C.E. 'Is that still circumstantial evidence, or could that said to
be statistical evidence?1
Carne 'That is straight biochemical evidence. The stuff is
administered and the consequences are found. There is no question
of abnormality there. Those are carefully controlled studies. The
difficulty is that the material is administered to female rats who
are in pregnancy. We are working with primates now and there are
definite chronic effects of low levels of dioxin on both male and
female animals and there are definite effects on reproductive capacity
of the females. The problem is that the administration of the drug
in the laboratory tests done so far has been to females. Whereas it
is the men who are exposed in Vietnam and the question then is what
do they transmit in their germ cells. That's more difficult to pin
down, and those studies havn't been done'.
C.E. 'Exposure seems to be a matter of concern in that 2,4,5-T and
2,4-D was used in the United States as a herbicide. Can it be proven
that the exposure of the veterans wasn't to various herbicides used
in the United States as opposed to, in its form in Agent Orange in
Vietnam?'
is
Carne 'Yes, thisif statistical work is properly done that can be
N
controlled out because that, in fact, would effect both groups.
Those who were exposed in Vietnam and those who weren't. I think
that factor could be controlled out relatively easily. I'm very

�- 6 suspicious that there is a connection. I'd be surprised if
there weren't, based on what I've seen so far'.
C.E.

'And how will you pursue that when you get back to the States'

Came 'The state government of New Jersey is putting together an
investigative commission to look into the effects of defoliant
chemicals on Vietnam veterans and the related chemicals on anybody
else, because of a great many similar chemicals that are used in the
petrochemical industry nearby. The State commission is not yet
formed, when it is formed I would offer any help that it will ask.
I believe that it is the first such commission of any kind in the
United States'.
C.E.

'Is there anything that you would like to add?1

Game 'I oppose the use of these chemicals in warfare. But that's
a completely separate issue. I think the worst problem for the
veterans is the uncertainty. They don't know and often the man goes
to the Veteran's Administration for medical help with the few symptoms
that are hard to pin down to any specific organic cause right now,
and they send him to a psychiatrist because they can't find an
immediate organic cause. Why pan him out and tell him that he has
some sort of a character defect or that he is a malingerer and that
may not be the truth. Its demoralising to a man to be sent out with
that kind of uncertainty thinking there is something wrong with his
head and there may very well not be'.
C.E. now speaks to Dr. W. McBride
'Dr. McBride, is there any point made by Dr. Carne with which
you perhaps disagree or which you want to pursue immediately?1
McBride 'No. I thought Dr. Carne spoke very well and I think we
could elaborate on some of the problems. I agree the only way you
can tackle this is a statistical study. I have a friend \vho is
working with dioxins in the United States. It is very toxic and it
does produce deformities in animals.

�- 7 -

Now say 50,000 Australian's served in Vietnam (C.E. states 70,000).
O.K. forget about Vietnam now. 50,000 young Australian's got married
this year, 50,000 couples, and they all decided to try and have a
family. 5,000 or 10% would have great difficulty in getting pregnant,
45,000 would get pregnant, say within 18 months. Now, from our
knowledge of birth defects, 1,200 babies born of that 45,000 or 3%
would have some or quite severe physical abnormalities. So this is
the problem, you've got to find that if the incidence of deformities
is higher amongst veterans from Vietnam than say 3%, then perhaps you
might get a pattern. Now we know from our statistical studies, over
the years, that the commonest congenital abnormality is congenital
heart ^disease and they run down, we've got the twelve most common
listed from there; that's almost 1%. So one in every 100 babies
would have congenital heart disease. So if there is any specific
higher incidence than our tables, say of cleft palate which was
mentioned, then we could see there was a higher incidence of cleft
palate among offspring of Vietnam veterans. So this is the situation.
You would have to do a statistical study. Now to my knowledge, it
has not been shown that dioxin affects genes. Now any drug that you
take or anyone takes, for instance an aspirin; its got what we call
half life, within two hours half the amount you've taken has been
excreted by the body. Now some of the chemicals with the longest
half life are the heavy metals such as lead or gold, things like
that which last three months. Now for dioxin to still be acting
after many years in a veteran would have to have a very long half
life, or the only other way it could produce an effect would be to
effect the genetic constitution of the germ cells in the testes.
This has not been shown to occur. So you have to have a statistical
study to see if the incidence of deformities is higher in the offspring
of Vietnam veterans. Not one of us could say that we are going to
have a normal healthy child, no matter who you are or what you've
done in the past. So there is an incidence of deformities for
reasons for which we do not know, some are genetic and some are
environmental contaminants. Now as to the effects on the veteran
himself I'm not going to comment on those because we know dioxin

�- 8 -

does cause skin conditions and it could produce other things,
I'm not confident to comment there. I think that the birth defects
are very vague at present. I know there is going to be a study,
set up by the Australian government. But it would be a fairly slow
process and on first principles it would surprise me if Agent Orange
does produce birth defects1..
C.E. 'It would surprise you if it does produce birth defects or
would it surprise you if the scientific evidence can be marshalled
to show that it is so'.
McBride 'No, it would surprise me that it does. I could see the
difference if it were the pregnant women in Vietnam who were sprayed
with it, that's different, because they are.pregnant and its an
environmental chemical. But to effect the x germ cells of the testes
to produce genetic changes is unlikely. I'm not saying its not
possible, but I'm saying on the evidence we have of studies we've
carried out, I think its unlikely'.
C.E. 'Dr. McBride I thought one of the points Carne made was that
in the tests on rats the dioxin was seen to have genetic effects
which could continue for generations. Did I misunderstand that?'
McBride 'You misunderstood that, yes. I've certainly seen no
report that dioxin has been proven to produce genetic changes. Now
radiation, certainly, but I haven't seen any evidence of dioxin
causing changes'.
C.E. 'Now the other point arising, surely is, that if we had
access to the Vietnamese records we may well find some interesting
occurrences there because in the late sixties, if I remember properly,
there were bitter complaints of birth defects in the Vietnamese
population, whether or not they were properly documented, they were
certainly mentioned. And there was some concern, presumably in war
time and with the shifting population and with all the disruption
they had, maybe those records would no longer be accessible1.

�- 9 -

McBride 'As I said, that's different^ that's exposure to pregnant
women and that's an environmental contaminant. Now I could believe
very likely that this Agent Orange was fairly impure, its not like
commercial 2,4-D or 2,4,5-T, it was pretty impure, so it had a fairly
high content of dioxin. Now exposure to a pregnant woman is quite
different, that's an 'environmental contaminant and I wouldn|t be at
all surprised if it did cause birth defects amongst the population of
the war area. But its a different matter to say that it effects the
genes of the germ cells of the male testes'.
C.E. 'But do we know it was the environmental affect on the women
in that situation rather than those fathers of these Vietnamese
children?'
McBride 'Well you don't. You've got me there. You don't know but
its more likely to be that if a woman is pregnant and she inhales the
stuff that's been sprayed around, or takes it in the food or drinking
water it would go straight across to the foetus'.
C.E.

'But the authorities here don't even recognise that yet do they?1

McBride 'I don't know \vhat they acknowledge. I have read these
claims, and counter-claims have been made that this is not true, but
I can imagine that if dioxin was sprayed around the pregnant women in
the war zone that they would more likely to have babies with congenital
deformities. But I think that its a different matter to the babies of
women who are now married to veterans of the war. We had quite a
number of calls to the Foundation yesterday, people who are worried
that should they have a baby or should they have another child. We
can only say at this stage, yes, they should because today there is
no evidence of an increase in incidence of birth defects over the 3%'.
C.E. 'Presumably what you are saying about the environmental impact
of dioxin would, you'd think, be sufficient reading to make sure that
the 2,4-D and 2,4,5-T were not used again in that situation, I mean
the effects on the Vietnamese population alone'.

�- 10 -

McBride 'Look I think any war is terrible and I don't like the
idea of using defoliants in the war. I think it is a terrible
thing to do to a country. Still it was done and I'm not going to
go into that. This question has to be considered and I think the
government are going to enquiry into this but it will be a slow
business. You would have to contact the veterans who are married,
who have had children, and see how many incidences of birth defects
they have had in their family.
C.E. 'Won't the method used in such a study be similar to the method
used in the study of thalidomide and its effects?'
McBride 'Just the same. Only on a bigger scale. You said there
were 70,000 so there would be 70,000 questionnaires. But of course
this could be done, its not difficult, its just sending out 70,000
letters and I'd imagine the Veteran's Affairs department would know
the addresses of these people'.
C.E. 'Then having sent out these questionnaires and getting the
answers you believe then it would be'possible to establish a result
one way or the other?'
McBride

'Definitely yes'.

C.E. 'Because I seem to recall someone saying, was it a Melbourne
biochemist yesterday saying that it may never be possible to establish
scientifically that there is this cause and effect relationship
between the dioxin and the birth defects, but you would believe, in
fact, it would be possible1.
McBride 'I know dioxin does produce birth defects in animals, that
is well established, it's very toxic; so we know that. Now if you
did a survey and found the incidence of birth defects was 5% or that
the incidence of congenital heart disease was 2% instead of a II of
the rest of the population you know there is a higher incidence of
birth defects among the offspring of veterans of the Vietnam-war. So
you could say that, fairly simply, it would take some time to get the
replies in but it is not insurmountable'.

�- 11 C.E. 'Had you thought of any possible connection before this last
burst of publicity?'
McBride 'Yes. In 1971 I was at a meeting in Paris when this was very
topical, it was debated very fiercely by the American's themselves.
There were two factions of American scientists, some thought that
the war was still going on and some thought that Agent Orange was
causing deformities. Others said that there was no p r o o f . So that
this was hotly debated, the meeting almost came to blows. I had never
seen anyone in a scientific meeting get so violent. So it has been
thought for a long time that this was a possibility but not in the
offspring of veterans certainly. Now we take histories of the parents
of the children w e ' r e s t u d y i n g ' .
C.E.

'But that wouldn't be one of the questions would it?'

McBride 'I was just going to say, we certainly don't ask about war
service. But you could always find out something you have missed out
and we can easily check up on the effects of children by writing to
the parents and asking did the husband have war service and if so
where'.
C . E . 'One other thing that occurs to me, lets say that the study were
done, lets say that it was discovered that there was some higher
incidence of defects in the babies of Vietnam veterans, that still
wouldn't be enough would it,to say the cause was dioxin. Someone
might say, well they ate a very special sort of food which had
certain preservatives in it, or whatever. I mean could there be other
factors?'
McBride
C.E.

'Well there could be other factors, certainly'.

'Wouldn't that confuse the issue again? 1

McBride 'Perhaps slightly but you would know. You then have to work
out the chances that there are other complicating factors or dioxin 1 .

�- 12 -

C.E. 'So at the moment it could grow into another thalidomide or
it could be laid to rest'.
McBride 'I don't think so. I think that there is a big monitoring
centre in Atlanta in the U.S. and they are monitoring birth defects
all the time. I think it would have shown up because there are
certainly more veterans.in the U.S.A. than here and I think people
have been aware of this since 1971 and I think that it would have
shown up in the monitoring'.
C.E. 'Except that Carne says that the veteran population of the
United States hasn't been fully covered statistically.'
McBride 'Yes, but the centres that do the monitoring in the United
States are very thorough and they monitor a certain area. The
Atlanta one in Georgia I think there would be a lot of veterans in
that area, I think there should have been a pickup'.
C.E. 'Any other point at this stage, could we take it any further
Dr. McBride, or not at the moment; in your opinion?1
McBride 'No, not at the moment. I think it should be investigated
but I don't think there is any undue cause for alarm for Vietnam
veterans and their wives, whether they should have their children.
I would say on the evidence to-date there is no reason why they
shouldn't have children'.
C.E. 'Say a link was proven, what then would we be saying to people
about having families in the future'.
McBride 'Well that's a bit like crossing your bridges before you
come to them, isn't it? You have to prove that there is a genetic
defect and on the evidence and first principle I think it is unlikely'

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°1596

Author
Corporate Author
Report/Article Tltlfl Typescript: [Notes onj Air Force Health Study

Journal/Book Title
Year

000

°

Month/Day
Color

n

Number of Images

«

DOSOrlptOU NOtBS

Includes a few handwritten notes as well.

Wednesday, May 23, 2001

Page 1597 of 1608

�AIR FORCE HEALTH STUDY
0
0
0
0

WHITE HOUSE DIRECTED
STUDY DESIGN EXTENSIVELY PEER REVIEWED
UNIQUE STUDY POPULATION
STUDY DESIGN
- MORTALITY
- MORBIDITY: QUESTIONNAIRES, PHYSICAL EXAMS
(KEYED TO KNOWN AND REPORTED EFFECTS)
- FOLLOW-UP

�STUDY RESULTS

No Soft Tissue Sarcoma (STS), Porphyria Cutanea
Tarda (PCT), or Chloracne Diagnosed in RANCH
HANDERS

�FERTILITY/REPRODUCTIVE

0

No SIGNIFICANT RANCH HAND OR OFFSPRING
FINDINGS IN:
- SPERM COUNT, OR DEFECTIVE SPERM
- FIVE FERTILITY/INFERTILITY MEASURES
- MISCARRIAGE, STILLBIRTH, LIVE BIRTH
- SEVERE BIRTH DEFECTS
- MODERATE BIRTH DEFECTS

�NEONATAL DEATHS

(UNVERIFIED SELF REPORTS; MEDICAL RECORDS, DEATH
CERTIFICATES PENDING)
RATE/1000

BEFORE RVN
AFTER RVN

�I? U T / 0 / /

F EC

/_•
RH

e

Rv*

C

i

^,
V
w

SE ft

o +

^ i
//! i

l^oi
!•
i

,

Si ft

i
1

i&gt;.
!i

'•*

k
)

KN
^
f

\

i

- " !

/•

4

OF

�CANCER
0

No Difference In The Occurrence
Of "Systemic" Cancer

0

No Soft Tissue Sarcoma Found In RANCH HANDERS

0

More Verified Skin Cancer In RANCH HAND Group
Not Adjusted For Sun Exposure

M

\

�LIVER

0

RANCH HANDERS Self Reported More Liver And PCT-like
Symptoms
Not Verified As Yet By Medical Records
Not Confirmed At Physical Exam (No PCT)
Not Substantiated By Lab Tests

0

Several Minor Lab Test Differences, But Most Tests
Were Similar Between Groups

0

More Verified Miscellaneous Disorders In RANCH HANDERS;
Significance Unknown

�OTHER OBSERVATIONS
0
0
0
0
0

POORER SELF PERCEPTION OF HEALTH IN RANCH HANDERS
Two LEG PULSES DIMINISHED IN RANCH HANDERS; SIGNIFICANCE
UNCLEAR
NERVOUS, KIDNEY, IMMUNE AND BLOOD SYSTEMS WERE
ESSENTIALLY NEGATIVE
No MEANINGFUL RELATIONSHIPS BETWEEN EXPOSURE AND STUDY
FINDINGS
EFFECTS OF CLASSICAL RISK FACTORS (AGE, SMOKING,
ALCOCHOL, EDUCATION, ETC-) OBSERVED THROUGHOUT STUDY

�CONCLUSIONS
0
0
0
0

STUDY MEASURED TRUE HEALTH STATUS To MAXIMUM EXTENT
POSSIBLE
ALL IMPORTANT FINDINGS ARE BEING FOLLOWED UP
INSUFFICIENT EVIDENCE To SUPPORT HERBICIDE CAUSALITY
FINDINGS To DATE SHOULD BE REASSURING To RANCH HANDERS
No CHLORACNE MEANS LOW EXPOSURE VERSUS CHEMICAL
WORKER POPULATIONS
No MAJOR CLINICAL HEALTH PROBLEMS
OVERALL GOOD GENERAL HEALTH FOR AGE

�STUDY COMPLEXITIES

0

Enormous Data Base (4 million items)

0

Validity of Self Reporting in Absence
of Complete Medical Record Verification

0

Effects of Multiple Risk Factors
(age, smoking, etc.)

0

Potential Biases

0

Study Schedule

�INTERPRETIVE

COMPLEXITIES

0

Statistical Associations Do Not Mean Causation

0

No Analogous Human Studies

0

Many Statistically Significant RANCH HAND-Comparison
Group Differences Are Not Of Clinical Relevance

0

Exposure Index Analyses Are Unrefined

0

Positive And Negative Findings Require Follow-up

�CATEGORIZED BIRTH DEFECTS BEFORE AND AFTER VIETNAM

Before Vietnam
Birth Defect

RANCH HAND

All Comparisons

Number

%

Number

%

Severe

51

56.5

62

51

Moderate

32

35.5

40

33

8

20

16

Limited

7

After Vietnam
Severe

32

40

34

40

Moderate

22

27.5

34

40

Limited

26

32.5

18

20

�VERIFIED SKIN AND 5YSTEMIC CANCER

RANCH HAND
Number
Skin Cancer

Original
Comparisons
Number

35

(%)

(3.3)

11

(%)

(1.4)

All
Comparisons
Number

25

(%)

(2.1)

Systenac Sitt?
Lip, Mouth, Throat

4

2

2

Digestive System

0

4

5

Respiratory

3

1

2

Genitourinary

6

2

3

Rlood, Lymph

0

0

1

Other

1

1

1

Total

14

(1.3)

10

(1.3)

14

(1.2)

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