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                    <text>Item ID Number

01733

Author
Corporate Author
Roport/Artido TltlB

CDC

Study Still at Square One

Journal/Book Title Nature
Year

1986

Month/Day

A ril 10

Color

L1

Number of Imaoes

1

P

Descripton Notes

Monday, June 11, 2001

Page 1739 of 1793

�1 III APKII IVXt.

----NEWS--

protocol, calling for only two cohorts of
6,000 subjects each. CDC planned to start
interviewing prospective study participants in January this year, with extensive
Washington
to carry out the study. But those con- physical examinations to follow. But OTA
A $60 million epidemiologies! study of the cerned about conflicts of interest argued balked, saying that CDC had failed to
health consequences of exposure to con- that the study should be moved to the establish adequate exposure criteria and
taminated defoliants by dioxin used dur- control of the Center* for Disease Control did not address problems associated with
ing the Vietnam war has been suspended, (CDC) at Atlanta, Georgia.
mis-classification of an individual's exInitially. CDC were alarmed that it posure history. At OTA'i suggestion
and may be cancelled before it can ever
get under way. Who will make the final might be impossible to find a large enough CDC agreed to postpone further activity
decision to proceed, and even when the cohort of soldiers who had not been ex- until these issues could be resolved.
f\
posed to Agent Orange. As things worked
decision will be made, is still unclear.
AOWG't efforts to help CDC settle the
Agent Orange was the code name for a out, just the opposite was the case. exposure issues seems to have backfired.
defoliant agent used by US forces during Records of troop movements failed to AOWG formed a subpanel, chaired by
the Vietnam war. One contaminant of yield easily intcrpretablc data for assess- Alvin Young of the White House Office of
Agent Orange is known to have been the ing the exposure of individual soldiers.
Science and Technology Policy, to review
dioxin isomer 2,3,7,8-TCDD, a known
Carl Keller, chairman of the science possible solutions, but the selection of V
carcinogen in animals. But the health ef- panel of the Agent Orange Working Young raised concern that the moment um I
fects of dioxins in humans have been the Group (AOWG), says the difficulties arc of the Agent Orange study might be wan- \
subject of long and heated debates. Even "horrendous". AOWG is the executive ing. Young, who is described as having
\
studies of acuic hiph-lcvcl exposures have branch group charged with looking into grave doubts thai any workable exposure
\
measurements can be found, declines to
I
given equivocal it-suits. confirming that the lonp-u-rm health effects of herbicides
the possible health e f f e c t s of long-term The Under Secretary of the Department comment on the dclitx'raiicms of his panel
Finding an acceptable exposure mealow-level exposure to toxic agents cannot of Health and Human Services (HHS)
chairs AOWG, and ultimate responsi- sure is crucial to the CDC study, but noeasily be answered.
Although the skin disease chloracnc bility for seeing that the Agent Orange body thinks that will be easy. Peter Laydc,
is the only clear-cut health problem in study is "scientifically valid" falls to him. acting director of the Agent Orange prohumans, studies have implicated liver Donald Newman, who joined HHS last gramme at CDC, says that there is no obdisease, soft-tissue sarcomas and birth year is still awaiting Senate confirmation vious reason why one measure should be
defects in children of exposed adults. But as under secretary.
more meaningful than another, and that
Meanwhile, Congress charged the Of- the many exposure estimates used so far
an Air Force study of soldiers actually
involved with Agent Orange spraying, fice of Technology Assessment (OTA) have so much variability that they are
termed the Ranch Hand study, failed to with the assessment of CDC's protocols. meaningless.
has
uncover health problems unequivocally By law, no study can proceed without
.
\mtM lllllll«lii IPHIHilllliHH iili» i H
associated with the defoliant.
OTA's blessing CDC's proposed study
rustratinc
Still, anecdotal evidence for the effects had originally consisted of three groups of
of Agent Orange from Vietnam was 6,000 subjects each; a high-exposure
strong. Under pressure from veterans' group, an uncxpostd combat control
^
ilsiflF"
Toils to have a study that peopie~will listen
groups. Congress in 1979 declared that a group and a non-combat unexposcd
study should be done to provide definitive group. But finding combat controls to even if they do not agree with it.
Some new information oh the health .
answers. The Veterans Administration proved easier than expected, so last Novwas the natural first choice for the agency ember, CDC presented OTA with a new e fleets of Agent Orange exposure will
come from other studies under way at
CDC. The Vietnam Experience study
compares 2,000 in one group of people
Washington
Although space attractions have yet to who served in Vietnam with another 2,000
IN one of the more generous gestures of be worked out, university planners expect whose military service was elsewhere. A
alumni appreciation, William Hewlett last to tear out 300,000 square fr«t of the case control study of soft-tissue sarcomas
week gave Stanford University $50 campus's 725,000 total building area, and will shed some light on possible links bemillion, the largest individual commit- to add 800,000 square fret of floor space tween Agent Orange exposure and
ment the California institution has re- specifically designed for the new equip- cancer.
CDC would like to begin physical exceived in Its 100-year history. The gift ment included in renovation blueprints.
Stanford's research rejuvenation will aminations of participants in the Agent
from the co- founder of the HewlettFftckut d company will Kelp to revive Stan- cost $.250 million in total, and will be com- Orange study in June, when the Lovelace
ford's sagging research facilities and in- pleted within &gt; decade. The university will Clinic in New Mexico will be finished with
crease financial awards for the university's use the remaining $10 million of Hewlett's the Vietnam Experience Study examin12,000 students.
pledge to establish endowed undcr- ations. Bui after Young's group makes its
Hewlett's pl'-dge will also be used to gntefuale scholarships and graduate recommendations, AOWG must approve
them and transmit them to CDC. CDC
mark (he inauguration of his university's fellowships.
centennial campaign, which formall) beWilliam Hewlett has « history of bene- must then change to a new protocol, and
gins in 1987. Hewlett and Stanford's presi- ficence to Stanford, whose endowment OTA must then evaluate it. For all that to
dent, Donald Kemved), have been dts- •Irtadj t«carsS2,000 million. But the 1934 happen by June needs unusually quick
cwnsing its db,(xrufctk»n for at least two graduate may have good reasons for his action.
years, with some rtearly defined results. gratitude: it *a&amp; at Stanford (hat Hewlett
ncedes that AOWG
Ml but SIC milfion of Hewlett's gift wilt be first «»et David Packard and forged
plough into the 41-sucre Star W«t cam- friendship that has grown into * billioi
pus, brlwten the main campus and Stan- dollar business whose headquarters
fy can be undertaken But if that is the
ford's rru-dic-al re-starch f-cilitics.
w miles aw a \ .
K.irtn Wriphl
jj

CDC study still at square one

l

l

Hewlett thanks Stanford University

St-

l

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&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
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            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="21892">
                <text>April 13 1983</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="21893">
                <text>Clipping: Times Beach residents meet with governor</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="21895">
                <text>government liability</text>
              </elementText>
              <elementText elementTextId="21896">
                <text>human exposure</text>
              </elementText>
              <elementText elementTextId="21897">
                <text>popular press</text>
              </elementText>
              <elementText elementTextId="21898">
                <text>compensation</text>
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  </item>
  <item itemId="3015" public="1" featured="0">
    <collection collectionId="30">
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        <elementSet elementSetId="1">
          <name>Dublin Core</name>
          <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
          <elementContainer>
            <element elementId="50">
              <name>Title</name>
              <description>A name given to the resource</description>
              <elementTextContainer>
                <elementText elementTextId="4687">
                  <text>Alvin L. Young Collection on Agent Orange</text>
                </elementText>
              </elementTextContainer>
            </element>
            <element elementId="41">
              <name>Description</name>
              <description>An account of the resource</description>
              <elementTextContainer>
                <elementText elementTextId="49809">
                  <text>&lt;p style="margin-top: -1em; line-height: 1.2em;"&gt;The Alvin L. Young Collection on Agent Orange comprises 120 linear feet and spans the late 1800s to 2005; however, the bulk of the coverage is from the 1960s to the 1980s and there are many undated items. The collection was donated to Special Collections of the National Agricultural Library in 1985 by Dr. Alvin L. Young (1942- ). Dr. Young developed the collection as he conducted extensive research on the military defoliant Agent Orange. The collection is in good condition and includes letters, memoranda, books, reports, press releases, journal and newspaper clippings, field logs and notebooks, newsletters, maps, booklets and pamphlets, photographs, memorabilia, and audiotapes of an interview with Dr. Young.&lt;/p&gt;&#13;
&lt;p&gt;For more about this collection, &lt;a href="/exhibits/speccoll/exhibits/show/alvin-l--young-collection-on-a"&gt;view the Agent Orange Exhibit.&lt;/a&gt;&lt;/p&gt;</text>
                </elementText>
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            </element>
          </elementContainer>
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      </elementSetContainer>
    </collection>
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      <name>Text</name>
      <description>A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.</description>
      <elementContainer>
        <element elementId="52">
          <name>Box</name>
          <description>The box containing the original item.</description>
          <elementTextContainer>
            <elementText elementTextId="21815">
              <text>085</text>
            </elementText>
          </elementTextContainer>
        </element>
        <element elementId="53">
          <name>Folder</name>
          <description>The folder containing the original item.</description>
          <elementTextContainer>
            <elementText elementTextId="21816">
              <text>2132</text>
            </elementText>
          </elementTextContainer>
        </element>
        <element elementId="54">
          <name>Series</name>
          <description>The series number of the original item.</description>
          <elementTextContainer>
            <elementText elementTextId="21822">
              <text>Series IV Subseries I</text>
            </elementText>
          </elementTextContainer>
        </element>
      </elementContainer>
    </itemType>
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      <elementSet elementSetId="1">
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        <description>The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.</description>
        <elementContainer>
          <element elementId="39">
            <name>Creator</name>
            <description>An entity primarily responsible for making the resource</description>
            <elementTextContainer>
              <elementText elementTextId="21814">
                <text>Grimes, Charlotte</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="48">
            <name>Source</name>
            <description>A related resource from which the described resource is derived</description>
            <elementTextContainer>
              <elementText elementTextId="21817">
                <text>St. Louis Post-Dispatch</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="40">
            <name>Date</name>
            <description>A point or period of time associated with an event in the lifecycle of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="21818">
                <text>February 28 1983</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="50">
            <name>Title</name>
            <description>A name given to the resource</description>
            <elementTextContainer>
              <elementText elementTextId="21820">
                <text>News Analysis: Orange Lining in Dioxin Cloud?</text>
              </elementText>
            </elementTextContainer>
          </element>
          <element elementId="49">
            <name>Subject</name>
            <description>The topic of the resource</description>
            <elementTextContainer>
              <elementText elementTextId="21824">
                <text>Ranch Hand</text>
              </elementText>
              <elementText elementTextId="21826">
                <text>herbicide poisoning</text>
              </elementText>
              <elementText elementTextId="21828">
                <text>popular press</text>
              </elementText>
              <elementText elementTextId="21830">
                <text>government liability</text>
              </elementText>
            </elementTextContainer>
          </element>
        </elementContainer>
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    </elementSetContainer>
  </item>
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