An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Acute Toxicity of Iron Compounds in Young Mice and Rats (CFSAN)

Investigators
Ali, Sayed
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective
  1. Compare acute toxicity in young animals using two forms of iron commonly used in iron supplements and one form that is to be used in fortification.
  2. Determine if acute high doses of iron compounds produce reactive/oxygen species, and alteration in the lipid peroxidation and changes in antioxidant enzymes in different regions of brain and liver of young mice and rat.
  3. Determine the effect of acute high doses of iron compounds on CBC, MCV, MCHC, TIBC and the distribution of iron and ironbinding proteins in different regions of brain and other visceral organs in young animals.
  4. Determine if acute high doses of iron compounds produce significant changes in neurotransmitter concentrations and activity of nitric oxide synthase in different regions of brain in young mice and rats
  5. Determine if acute high doses of iron compounds produce pathological alteration in brain and other visceral organs in young mice.
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0703801
Categories
Legislation and Regulations