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Antimicrobial Properties of Zinc Oxide (ZnO) and Titanium Oxide (TiO2) Nanoparticles (NPs) Against Multidrug-Resistant Staphylococcus and Enterococcus spp. and Their Cytotoxic and Genotoxic Potential in Bacteria and Normal Human Epidermal Keratinocytes (N

Investigators
Khan, Saeed
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective

  1. Study the mechanism of antimicrobial properties of TiO2 and ZnO Nanoparticles (NPs) in multidrug-resistant Staphylococcal and Enterococcal spp.
  2. Study synergy between NPs and antibiotics.
  3. Evaluate the cytotoxic and genotoxic potential of NPs in bacterial, and normal human epidermal keratinocytes (NHEK) and primary intestinal-cell lines.
  4. Study the transcriptomic gene expression in NHEK and intestinal-cell lines.
More information
Responsible Division: Microbiology
Funding Source
Nat'l. Center For Toxicological Research
Project source
View this project
Project number
E0751501
Categories
Parasites
Natural Toxins
Viruses and Prions
Bacterial Pathogens
Chemical Contaminants
Antimicrobial Resistance
Staphylococcus