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Assessment of the Nephrotoxic Effect of a Combined Exposure to Melamine and Cyanuric Acid

Investigators
Gamboa da Costa, Goncalo
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective
  1. Conduct a pharmacokynetic study on F344/N rats on the absorption and disposition of melamine and cyanuric acid when administered individually by gavage, simultaneously as a separate base and acid, and simultaneously as a preformed salt (melamine cyanurate).
  2. Determine the NOAEL of a combined exposure to melamine and cyanuric acid in F344/N rats for 28 and 90 days.
  3. Investigate the occurrence of early metabonomic and proteomic biomarkers of melamine + cyanuric acid-induced nephrotoxicity obtainable by noninvasive methods.
  4. Investigate the pharmacokinetics and determine the NOAEL of a combined exposure to melamine and cyanuric acid in a mini-pig model deemed to be representative of the human-kidney anatomy and physiology.
More information
Responsible Division: Biochemical Toxicology
Collaborating Division(s): Systems Biology, Microbiology
Collaborating FDA Center(s): CDRH, CFSAN, CVM
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0216901
Categories
Natural Toxins
Chemical Contaminants
Parasites
Viruses and Prions
Bacterial Pathogens