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Beneficial and Adverse Effects of Natural, Bioactive Dietary Chemicals on Human Health and Food Safety (From W1122)

Investigators
Nerurkar, Pratibha
Institutions
University of Hawaii
Start date
2007
End date
2012
Objective
  1. Consumption of food-borne bioactive compounds can protect against human diseases such as cancer, inflammation, birth defects, and microbial infection. We will determine the mechanisms by which selected compounds exert their protective action.
  2. Food-borne toxins and carcinogens are present per se or are induced by processing, preparation, and other post-harvest steps. We will identify mechanisms of action and develop biomarkers of natural and induced toxicants in food for human risk assessment and disease prevention.
  3. Selected classes of bioactive compounds show potential for beneficial or adverse effects on human health. We will discover bioactive compounds that have beneficial or adverse effects on human health.
More information
NON-TECHNICAL SUMMARY: Obesity-associated metabolic disorders are escalating world-wide. Changes in life style, such as dietary recommendations form the cornerstone of treatment. The essential challenge for nutritional science is to identify not only nutritious foods, but (functional foods÷, that may provide health benefits beyond basic nutrition. The rationale for the proposed research is that understanding molecular events of functional foods has strong potential to identify effective nutritional intervention strategies and update dietary recommendation for a healthier living.

APPROACH: Investigate the ani-obesity, anti-diabetic and hypolipidemic properties of momordica charantia (bitter melon), using cell culture and animal model systems.

Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
HAW00586-R
Accession number
212347
Categories
Sanitation and Quality Standards
Parasites
Natural Toxins
Viruses and Prions
Bacterial Pathogens
Chemical Contaminants
Risk Assessment, Management, and Communication