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Bioassay of BSE Infectivity in Non-neural Tissues by Intracerebral Inoculation of Cattle

Institutions
Veterinary Laboratories Agency, UK
Start date
1996
End date
2013
Objective
To determine qualitatively infectivity in certain tissues, including Specified Bovine Material (SBM), of cattle infected orally with 100 grams BSE-affected brain and killed at specified times after exposure, using a within-species bioassay.

This provides the most sensitive means of detection of infectivity in the tissues in order to identify public health risks from exposure to bovine tissues.

More information
The study provides the most sensitive available assay of BSE infectivity in bovine tissues which form a potential human health risk or have been identified as SBM. The results will indicate qualitative differences in the use of cattle versus mice for bioassay of BSE infectivity in experimentally, orally infected cattle.

They will also provide information for use in quantitative analysis of risks of human exposure to infected bovine tissues and necessity to retain restrictions on SBM entering the human food chain. To date transmissions that have occurred in the cattle are consistent with previous mouse bioassay data. Only positive control tissues (ileum and CNS) have transmitted so far.

Find more about this project and other FSA food safety-related projects at the Food Standards Agency Research webpage.

Funding Source
Food Standards Agency
Project source
View this project
Project number
M03006
Categories
Risk Assessment, Management, and Communication
Bacterial Pathogens