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Biomarkers of Low Dose Immunotoxicity of Deoxynivalenol in Mice

Investigators
Walker-Simmons, M. Kay
Institutions
Iowa State University
USDA - Agricultural Research Service
Start date
2006
End date
2009
Objective
Develop methods to lessen the toxicity of foodborne fungal toxins in humans.
More information
APPROACH: Develop animal models that are increasingly relevant to humans, in exposure dose and potential biomarkers. Use suppression of peripheral blood lymphocyte (PBL) counts as a sensitive biomarker for dietary DON exposure. Feed mice varying amounts of DON for 2 and 4 weeks, and assess PBL total and subpopulation counts to determine the utility of PBL counts as biomarkers of DON exposure that could be readily adapted to human epidemiology of DON toxicity.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
0500-00053-002-61G
Accession number
410624
Categories
Sanitation and Quality Standards
Chemical Contaminants
Natural Toxins