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Campylobacter as model system to understand emergence and spread of antimicrobial resistance

Investigators
Kathariou, Sophia
Institutions
North Carolina State University
Start date
2018
End date
2021
Objective
The major goal of this project is to further understand emergence, lateral gene transfer-mediated spread and resilience of antimicrobial resistance (AMR) in agricultural ecosystems. To pursue this, in the current project we will employ Campylobacter as model system with the following objectives:Objective 1. To characterize the genetic basis of AMR emergence upon stepwise selection to macrolidesObjective 2. To investigate AMR spread via lateral gene transfer of MGE-associated resistance determinants in vivo, in feces and in farm water microcosmsObjective 3. To investigate fitness costs that may impact AMR spread and resilience
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
NC09846
Accession number
1015320
Categories
Escherichia coli
Salmonella