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Characterization of Plasmid-Associated Antimicrobial Resistance in Salmonella enterica Serovars Associated with Poultry and Human infections

Investigators
Foley, Steven
Institutions
DHHS/FDA - National Center for Toxicological Research
Start date
2010
End date
2011
Objective

 

  1. Identify and understand the genetic mechanisms associated with plasmids that facilitate the spread and persistence of virulence and multidrug in Salmonella from poultry-and-egg- associated serovars.
  2. Sequence the plasmids from multidrug-resistant S. enterica serovar Enteritidis, Heidelberg, and Typhimurium strains to identify genes likely associated with virulence and antimicrobial resistance.
  3. Determine the relative selective potential of antimicrobial agents to trigger the dissemination of antimicrobial resistance and virulence factors to susceptible Salmonella.
  4. Determine the contribution of plasmids transferred via conjugation to virulence in Salmonella strains

 

More information
Responsible Division: Microbiology
Funding Source
Nat'l. Center For Toxicological Research
Project source
View Project >>
Project number
E0733501
Categories
Antimicrobial Resistance
Bacterial Pathogens
Salmonella
Commodities
Meat, Poultry, Game