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Cockle Cell Extracts: An In Vitro Cytotoxicity Study of Effects on Lactate Dehydrogenase Leakage, ATP Levels and Apoptosis Induction in Balb/c 3T3 and HepG2 Cells

Institutions
Centre for Environment, Fisheries and Aquaculture Sciences (CEFAS)
Start date
2004
End date
2004
Objective
This research project aims to examine the potential cytotoxicity of cockle extract that gives rise to the atypical response in the diarrhetic shellfish poisoning (DSP) mouse bioassay (MBA).

This research project aims to examine, using conventional cell-based assays, any potential cytotoxicity of cockle extracts that gives rise to the atypical response in the DSP assay.

The study will determine cytotoxicity by investigating whether the cockle extracts adversely affect the capacity of cells to function normally, degrade cell membranes and/or initiate programmed cell death.

More information
Since June 2001, atypical responses have been observed during the diarrhetic shellfish poisoning (DSP) mouse bioassay (MBA) used within the UK statutory biotoxin monitoring programme.

These have occurred primarily from cockles from England, Wales and Northern Ireland, but also from small numbers of mussels from England and Wales.

This project will examine the potential cytotoxicity of cockle extract that give rise to the atypical response in the DSP MBA.

Find more about this project and other FSA food safety-related projects at the Food Standards Agency Research webpage.

Funding Source
Food Standards Agency
Project number
B16006
Categories
Natural Toxins
Commodities
Seafood