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A Collaborative Research Proposal to Assess Cancer Risk Posed by Intermittent Exposure to Aflatoxin B1 in Rats

Investigators
Harris, Angela
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective
1. To test the hypothesis that a chemically induced tumor incidence is a function of the accummulated lifetime exposure, and is predictable from the average daily dose for various dosing regimens, such as continous and intermittent dosing; 2. To study correlations between the chemically-induced tumor incidence and various biomarkers of the initiation and the promotion stage of carcinogenesis for continuous and intermittent dosing.
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0688801
Categories
Sanitation and Quality Standards
Mycotoxins