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DEVELOPMENT OF ALTERNATIVE STRATEGY FOR JOHNE�S DISEASE CONTROL IN DAIRY COWS

Investigators
Danelishvili, Li, .; Vande Voorde, Re, .
Institutions
Oregon State University
Start date
2020
End date
2022
Objective
Johne's disease is a wasting disease characterized by chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP). The disease affects ruminant animals and is an economically important problem for dairy farmers. MAP is highly infectious and difficult to control in the dairy herd environment. One potential alternative is to use bacteriophages (phages) because they present one of the most promising new opportunities 1) to treat MAP infection in dairy cows and reduce bacterial shedding, 2) for prophylaxis in newborn calves to prevent MAP infection, and 3) to control and prevent MAP transmission in herds by biologically suppressing pathogenic bacterial contamination in the farm setting (soil, water, milk).Specific Aims of this project are:1. To identify lytic phages againstMycobacterium avium subsp. paratuberculosis isolates of Johne's Disease2. To characterize isolated MAP-phages and design broad-range phage cocktails for therapeutic application in dairy cows.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
ORE00185
Accession number
1024956
Categories
Bacterial Pathogens