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Development of Chemical Methods to Provide Pure Authenticated Standards for Toxic Dehydropyrrolizidine Alkaloids (DHPAs) and their N-oxides

Investigators
Panter, Kip
Institutions
USDA - Agricultural Research Service
Start date
2015
End date
2016
Objective
Demonstrate and validate a standardized method for the quantitative analysis of toxic dehydropyrrolizidine alkaloids (DHPAs) from plants poisonous to livestock and humans by ; 1) Developing extraction, identification and quantitative methods; 2) validating the analytical process in different matrices according to the AOAC International Guidelines for Single Laboratory Validation of chemical Methods for Botanicals; and 3) establish and validate response factors for “difficult to manage” DHPAs relative to “easy to manage” secondary standards. 4) provide purified DHPA’s for toxicology testing and verification.
Funding Source
Agricultural Research Service
Project source
View this project
Project number
2080-32630-012-03S
Accession number
428459
Categories
Sanitation and Quality Standards
Natural Toxins
Parasites
Viruses and Prions
Bacterial Pathogens
Chemical Contaminants