An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Development of Detection and Control Strategies for Bovine Babesiosis and Equine Piroplasmosis

Investigators
Ueti, Massaro; Suarez, Carlos; Scoles, Glen; Knowles, Donald; Kappmeyer, Lowell; Cunha, Cristina
Institutions
USDA - Agricultural Research Service
Start date
2016
End date
2021
Objective

The goals of this project are to develop multivalent bovine babesiosis subunit vaccines targeting antigens expressed in different B. bovis life cycle stages, to develop serological diagnostic assays to aid in bovine babesiosis and equine piroplasmosis diagnosis and surveillance, and to characterize vector competence and drug susceptibility for a new protozoan parasite of horses. These goals will be addressed in the following objectives: Objective 1: Develop diagnostic assays and vaccines for bovine babesiosis by targeting antigens from multiple parasite stages. Subobjective 1A: Determine if immunization with B. bovis blood stage subdominant antigens reduces disease severity and impacts tick infection. Subobjective 1B: Identify B. bovis tick stage specific targets for development of a vaccine to reduce or block tick infection. Subobjective 1C: Develop a multivalent vaccine targeting tick and B. bovis parasite proteins to decrease clinical disease and B. bovis transmission. Subobjective 1D: Develop a B. bovis serological assay to determine infection prevalence. Objective 2: Develop improved diagnostic assays and control strategies for emerging equine piroplasmosis organisms. Subobjective 2A: Identify diagnostic targets for detection of horses infected with Theileria-like parasite. Subobjective 2B: Determine competent tick vectors of the new Theileria-like parasite. Subobjective 2C: Determine Theileria-like parasite drug susceptibility.

Funding Source
Agricultural Research Service
ARS (NP108)
Project source
View this project
Project number
2090-32000-039-00D
Accession number
431742
Categories
Bacterial Pathogens