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Development of a Model for the Transmission Kinetics of Infection by Cryptosporidium parvum with Acquistion of Data on Key Parameters

Investigators
Turturro, Angelo
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective
  1. To standardize the virulence of doses of Cryptosporidium parvum used in this and subsequent studies.
  2. To investigate the suitability of the Brown-Norway rat as a model for Cryptosporidium parvum infectivity in humans or the C57Bl/6 mouse chemically suppressed with dexamethasone if BN is unsuitable.
  3. To compare Cryptosporidium parvum infectivity for model animals with age andpegnancy which may influence immunocompetence.
  4. To compare Cryptosporidium parvum infectivity for model animals with chemical immunosuppression other than by dexamethasone.
  5. To compare Cryptosporidium parvum infectivity in animals with immunosupression models similar to the effects of AIDS.
  6. To compare Cryptosporidium parvum infectivity in animals with physiological stress and nutritional immunosupresssion models.
  7. To use these data in pathogen virulence and host susceptibility in a model for the transmission dynamics of Cryptosporidium parvum in human outbreaks.
More information
FY 2000 Accomplishments:
  1. Prepared a protocol to develop information for use in risk assessment models of microbial pathogens.
  2. Worked with models of pathogen secondary transmission.

FY 2001 Plans:

  1. Present interim results to EPA.
  2. Work on model.
  3. Start animal work.
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0708201
Categories
Cryptosporidium
Risk Assessment, Management, and Communication
Bacterial Pathogens