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Development of a tetracycline-inducible gene expression system for the study of Campylobacter jejuni pathogenesis

Investigators
Konkel, Michael
Institutions
Washington State University
Start date
2020
End date
2021
Objective
AcuteC. jejuniillness, which is characterized by the presence of blood and leukocytes in stool samples, is associated withC. jejuniinvasion and replication within intestinal epithelial cells. Colonic biopsy specimens from C. jejuni-infected humans and C. jejuni-infected animals have revealed invasion and intracellular C. jejuni. Compared to other gastrointestinal bacterial pathogens, little is known about C. jejuni intracellular replication. Specifically, it is not known how C. jejuni modifies normal cellular trafficking to support intracellular replication. The goal of this proposal is to determine if secreted bacterial proteins contribute to C. jejuni replication in a host.
Funding Source
Nat'l. Inst. of Food and Agriculture
Project source
View this project
Project number
WNV092020
Accession number
1024649
Categories
Campylobacter
Bacterial Pathogens