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Dose-response and Mixture Response of Pesticides In Vitro and In Vivo

Institutions
Health and Safety Laboratory, Derbyshire UK
Start date
2005
End date
2007
Objective
This research project aims to investigate potential interactions of mixtures of pesticides.

In its report on Risk Assessment of Mixtures of Pesticides and Similar Substances, the Committee on Toxicity of Chemicals in Food Consumer Products and the Environment (COT) recommended a need for investigation of the nature and dose-response relationships for combined actions of chemical mixtures.

This project focuses on possible combined actions of anticholinergic pesticides.

More information
An in vitro model based on cholinesterase depression will be used to investigate the nature and dose-response relationships of anticholinergic carbamates and organophosphates that may be found in foodstuffs.

These studies will determine whether effects are additive or otherwise. The effect of subsequent exposures will also be investigated.

Should any significant interactions be observed, these will be investigated further in controlled human volunteer studies.

Find more about this project and other FSA food safety-related projects at the Food Standards Agency Research webpage.

Funding Source
Food Standards Agency
Project number
T10008
Categories
Sanitation and Quality Standards
Risk Assessment, Management, and Communication
Natural Toxins