An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

DOSE RESPONSE OF LISTERIA MONOCYTOGENES IN PREGNANT GUINEA PIGS FOR USE IN RISK ASSESSMENT

Investigators
Tamplin, Mark
Institutions
University of Georgia
Start date
2003
End date
2006
Objective
The overall objective of the research is to use pregnant guinea pigs to develop additional dose response information for L. monocytogenes-induced human stillbirths or abortions. The specific objectives are to: 1) conduct a range-finding experiment to determine the region of dose response overlap with the existing non-human primate study, 2) determine the dose response for adverse fetal effect after maternal exposure to L. monocytogenes, particularly low dose exposures resulting in 10-20% fetal illness or death, and determine endpoints that predict adverse pregnant outcome such as L. monocytogenes invasion of maternal liver, maternal spleen, placenta and fetus, and 3) compare the dose response curve developed in pregnant guinea pigs to mouse, primate and human dose response curves, and evaluate the guinea pig as a surrogate model for humans.
Funding Source
Agricultural Research Service
Project source
View this project
Project number
1935-42000-057-02G
Accession number
407284
Categories
Listeria
Risk Assessment, Management, and Communication
Commodities
Meat, Poultry, Game