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The Effects of the Salmonella Newport SRP Vaccine in Feedlot Cattle

Investigators
Thomson, Dan; Renter, David; Nagaraja, Tiruvoor G
Institutions
Kansas State University
Start date
2008
End date
2009
Objective
Salmonella bacteria can result in adverse health effects in both cattle and humans. In some cattle populations, Salmonella can affect health and production efficiency, but these effects are poorly defined for feedlot cattle. Salmonella are a significant cause of foodborne illness in the U.S., but human salmonellosis has been associated with many foods. Salmonella can be found on hides and in feces of cattle at harvest, which occasionally may lead to the contamination of beef. Consumption of contaminated beef has been associated with occasional human infections and few multi-state outbreaks due to drug-resistant Salmonella.

Preharvest interventions that would reduce the prevalence of Salmonella in the feedlot environment may enhance beef safety, and also may improve cattle health and performance. One potential preharvest strategy employs a novel vaccine technology, based on Siderophore Receptor and Porin (SRP®) proteins, which has been shown to be efficacious in controlling Salmonella in certain production systems. Although a commercial Salmonella Newport SRP® vaccine may decrease fecal shedding and improve the health and performance of animals, there are no data on the effects of the vaccine in a commercial feedlot environment. Therefore: objectives were 1) to determine the effect of the commercially available Salmonella Newport SRP® vaccine on prevalence of Salmonella in feces of commercial feeder cattle, and 2) to determine the potential vaccine effects on cattle health and performance outcomes in the feedlot

More information
Findings: Steer calves (average weight 546 lbs) originating from livestock markets and ranches in KS, OK, TX and SD were enrolled into the two treatment groups of the study. Overall, Salmonella were recovered from 10.75% (215/2000) of the fecal samples. Salmonella were recovered from all ten pairs of pens, with overall prevalence (all sampling times combined) ranging from 1.5% to 22%. Salmonella prevalence was affected by sampling time (P < 0.01), but not by vaccine treatment (P = 0.89). There was no significant treatment by sampling time interaction (P = 0.12).
Funding Source
Nat'l. Cattlemen's Beef Assoc.
Project number
BC-2008-8
Categories
Natural Toxins
Bacterial Pathogens