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Effects of SRP Vaccine on Pre-Harvest Control of E. coli O157 in Feedlot Cattle

Thomson, Dan; Nagaraja, Tiruvoor G
Kansas State University
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Examine the use of the SRP E. coli O157:H7 vaccine to control fecal shedding and reduce fecal carriage on the hides of E. coli O157:H7 in feedlot cattle. Also, another objective of this study was to determine the effects on this vaccine on performance of feeder cattle.
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Findings: Cattle are a reservoir for E. coli O157:H7 and consequently, beef can become contaminated with this bacteria. The Center for Disease Control estimates that E. coli O157:H7 causes 73,000 illnesses in humans annually in the United States, resulting in over 2,000 hospitalizations and 60 deaths.

Researchers at Kansas State University, in cooperation with scientists from Epitopix, LLC and funding from America�s Beef Producers, have conducted a study to examine the utilization of a novel vaccine technology to improve the safety of beef. Siderophore receptors and porin proteins (SRP®) located on the surface of bacteria allow iron to enter E. coli. E. coli need iron as much as humans need oxygen. Vaccinating against SRP decreases E. coli�s ability to acquire iron and the bacteria subsequently die.

This study proved that vaccinating cattle with SRP technology decreased the fecal shedding of E. coli and decreased the carriage of E. coli on cattle. As a matter of fact, vaccinating with SRP E. coli vaccine reduced the percentage of cattle positive for E. coli by 60% relative to cattle given a placebo. SRP vaccine technology may be another tool for preventing food-borne illnesses resulting from E. coli O157:H7 contamination of beef products.

Funding Source
Nat'l. Cattlemen's Beef Assoc.
Bacterial Pathogens
Escherichia coli