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Establish a Correlative Dose-Response Model for Human Cryptosporidiosis

Investigators
Tzipori, Saul
Institutions
Tufts University
Start date
2000
End date
2003
Objective
The goal of this proposal is to provide data to confirm strain variation effects on illness severity of volunteers challenged with different Cryptosporidium parvum strains, and to investigate whether these same differences are observed in animal models, using the gamma interferon knockout (GO) mouse model. Three strains previously used to challenge volunteers will be tested in the GO mouse model. In addition, two more strains will be tested both in volunteers and in the mice. Volunteer studies will be performed at the University of Texas medical Center, and the animal work at Tufts University.
Funding Source
Center For Food Safety and Applied Nutrition
Project number
FD-R-001621
Categories
Cryptosporidium
Sanitation and Quality Standards