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Evaluation of the Applicability of In vivo Micronucleus Assays for Assessing Genotoxicity of Engineered Nanomaterials

Investigators
Chen, Tao
Institutions
DHHS/FDA - National Center for Toxicological Research
DHHS - Centers for Disease Control and Prevention (CDC)
Start date
2012
End date
2013
Objective

 

  1. Assess the genotoxicity of four types of nanoscale materials, carbon nanotubes, nanoscale titanium dioxide, nanoscale gold, and nanoscale silver in three standard tests suggested by FDA; Salmonella Ames test, mouse lymphoma assay, and in vivo mouse micronucleus assay.
  2. Evaluate the possible mechanisms of nanomaterial-induced genotoxicity using a transgenic mutation system comet assay, and genomic analysis.

 

More information
Responsible Division: Genetic and Molecular Toxicology
Funding Source
Nat'l. Center For Toxicological Research
Project source
View this project
Project number
E0731001
Categories
Salmonella
Natural Toxins
Bacterial Pathogens