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Exploitation of Host Cells by Burkholderia Pseudomallei

Start date
2004
End date
2007
Objective
Burkholderia pseudomallei, a facultative intracellular bacterium that causes meliodoisis, has evolved novel strategies to subvert eukaryotic cell functions. The bacteria promote their uptake by non-phagocytic cells, escape from endocytic vesicles, and are propelled within cells and from cell-to-cell by polar nucleation of actin. Uniquely, B.pseudomallei also induces cell fusion.

We will assess the role of B.pseudomallei type III and type V secreted proteins in these processes and identify bacterial and cellular factors involved in actin-based motility. By studying B.pseudomallei-host cell interactions we will add to understanding of the intracellular trafficking and survival of bacterial pathogens and the cellular processes they exploit.

Funding Source
Biotechnology and Biological Sciences Research Council
Project number
BBS/E/I/00001105