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Field Studies of Immunity to Amebiasis in Bangladesh

Investigators
Petri, William
Institutions
University of Virginia
Start date
1998
End date
2002
Objective
The applicant hypothesis is that immunity to Entamoeba histolytica infection is acquired from previous infection. In specific aim 1, a 3 years prospective study will measure E. histolytica infection and invasion in cohorts of children ages 2-5 in the Mirpur district of Dhaka.
More information

If the hypothesis is correct they would predict that following outcomes:

  1. Children who had prior E. histolytica infection will be less likely to have future of invasive amebiasis;
  2. it is possible that they will also be less likely to be reinfected with E. histolytica; and,
  3. if reinfected may clear infection more rapidly.

If their hypothesis is correct they would predict that clearance of E. histolytica infection will be associated with the development of an adherence-inhibitory antibody response against the carbohydrate-binding domain of the lectin.

Completion of these studies should provide a foundation for understanding the mechanisms of protective immunity to amebiasis, and provide a baseline for evaluating the efficacy of vaccines as they enter clinical trails.

Funding Source
Nat'l. Inst. of Allergy and Infectious Diseases
Project number
5R01AI043596-03
Categories
Bacterial Pathogens
Chemical Contaminants