- Petri, William
- University of Virginia
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- The applicant hypothesis is that immunity to Entamoeba histolytica infection is acquired from previous infection. In specific aim 1, a 3 years prospective study will measure E. histolytica infection and invasion in cohorts of children ages 2-5 in the Mirpur district of Dhaka.
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If the hypothesis is correct they would predict that following outcomes:
- Children who had prior E. histolytica infection will be less likely to have future of invasive amebiasis;
- it is possible that they will also be less likely to be reinfected with E. histolytica; and,
- if reinfected may clear infection more rapidly.
If their hypothesis is correct they would predict that clearance of E. histolytica infection will be associated with the development of an adherence-inhibitory antibody response against the carbohydrate-binding domain of the lectin.
Completion of these studies should provide a foundation for understanding the mechanisms of protective immunity to amebiasis, and provide a baseline for evaluating the efficacy of vaccines as they enter clinical trails.
- Funding Source
- Nat'l. Inst. of Allergy and Infectious Diseases
- Project number
- Bacterial Pathogens
- Chemical Contaminants