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Further Development and Refinement of the FDA Endocrine Disruptor (ED) Knowledge Base (EDKB) for Assessing Endocrine Disrupting Potential of Drugs and Food Additives (E0741501)

Investigators
Hong, Huixiao
Institutions
DHHS/FDA - National Center for Toxicological Research
Objective

  1. Improve EDKB by including the ED data that will be generated by NTP and NCTR as well as estrogen receptor and androgen receptor data generated at EPA, and data that have been published in the past eight years.
  2. Conduct meta-analyses of the large datasets accumulated in the EDKB to gain a better understanding of chemical structure requirement and mechanisms related to EDs.
  3. Investigate various chemoinformatics/bioinformatics approaches to develop effective predictive models for assessing the potential of drugs and food additives.
More information
Responsible Division: Bioinformatics and Biostatistics
Funding Source
Nat'l. Center For Toxicological Research
Project source
View this project
Project number
E0741501
Categories
Antimicrobial Resistance
Chemical Contaminants