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Genetic and Environmental Factors Controlling Aflatoxin Biosynthesis

Investigators
Moore, Geromy; Lebar, M D; Gilbert, M K; Chang, Perng; Cary, Jeffrey; Bhatnagar, Deepak
Institutions
USDA - Agricultural Research Service
Start date
2016
End date
2021
Objective

Objective 1. Identify key genes, using transcriptome analysis of Aspergillus flavus and Aspergillus flavus-crop interaction that are involved in fungal growth, morphogenesis, toxin production and virulence which can be used as targets for intervention strategies. Objective 2. Identify metabolites produced by predicted secondary metabolic gene clusters in Aspergillus flavus, characterize the molecular regulation of their biosynthesis, and determine if they contribute to the fungus? ability to survive, colonizes host crops and produce aflatoxin. Objective 3. Examine the role of climatic and environmental pressures on the growth, virulence, toxigenic potential, geographical distribution and aflatoxin production by Aspergillus flavus.

Funding Source
Agricultural Research Service
ARS (NP108)
Project source
View this project
Project number
6054-41420-008-00D
Accession number
430859
Categories
Mycotoxins