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High Pressure-Temperature Inactivation of TSE Agents in Specified Risk Materials (SRMs)

Investigators
Pocchiari, Maurizio; Meyer, Richard; Cardone, Franco; Brown, Paul
Institutions
Meyer and Associates, Inc
Start date
2006
End date
2007
Objective
Determine infectivity titers on selected SRM samples subjected to high pressure/temperature compared to untreated controls.
More information
Findings: Government precautions against the spread of Bovine Spongiform Encephalopathy (BSE, or �mad cow disease�) include a ban on the use of highly contaminated tissues (so-called Specified Risk Materials, or SRMs) from slaughtered cattle, which must therefore be destroyed. Heating contaminated meat products under ultra-high pressure had been shown in earlier studies to reduce infectivity by up to a hundred thousand-fold. We have now used the same process on rendered SRMs and shown that a maximum infectivity reduction of one hundred to one thousand-fold. It is possible that the dehydrated powder form of rendered SRM inhibited pressure-temperature inactivation, and that crude (unrendered) SRM would be more susceptible to the process. However, even if infectivity could be totally eliminated in unrendered SRM, the huge tonnage of such material would make the ultra-high pressure process impractical as a means to �recover� SRM for commercial use.
Funding Source
Nat'l. Cattlemen's Beef Assoc.
Project number
BC-2006-14
Categories
Bacterial Pathogens
Viruses and Prions