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Host Factors Involved in Listeria Monocytogenes Spread from Cell to Cell

Investigators
Agaisse, Herve
Institutions
Yale University
Start date
2010
End date
2011
Objective
Various intracellular pathogens have evolved the ability to manipulate host cell processes in order to spread from infected cells into the neighboring cells. Most of he host factors contributing to the cell-to-cell spread of pathogens are unknown.

In this proposal, we present our plans to develop the first genetic approach of its kind to uncover these host factors. The proposed approach will contribute to our general understanding of the mechanisms underlying microbial pathogenesis and may therefore constitute the foundation for the rational design of preventive and therapeutic interventions.

Funding Source
Nat'l. Inst. of Allergy and Infectious Diseases
Project number
1R56AI084964-01A1
Categories
Listeria
Bacterial Pathogens